CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.50 | Rossmann fold | |
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
Superfamily | NAD(P)-binding Rossmann-like Domain |
Functional Family | 4-hydroxy-tetrahydrodipicolinate reductase |
Enzyme Information
1.17.1.8 |
4-hydroxy-tetrahydrodipicolinate reductase.
based on mapping to UniProt P04036
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)(+) + H(2)O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.
-!- Studies of the enzyme from the bacterium Escherichia coli have shown that the enzyme accepts (2S,4S)-4-hydroxy-2,3,4,5- tetrahydrodipicolinate and not (S)-2,3-dihydrodipicolinate as originally thought. -!- Formerly EC 1.3.1.26.
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UniProtKB Entries (1)
P04036 |
DAPB_ECOLI
Escherichia coli K-12
4-hydroxy-tetrahydrodipicolinate reductase
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PDB Structure
PDB | 1DIH |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase.
Biochemistry
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