CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Bifunctional protein FolD |
Enzyme Information
| 6.3.4.3 |
Formate--tetrahydrofolate ligase.
based on mapping to UniProt P11586
ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
-!- In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity.
|
| 3.5.4.9 |
Methenyltetrahydrofolate cyclohydrolase.
based on mapping to UniProt P11586
5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.
|
| 1.5.1.5 |
Methylenetetrahydrofolate dehydrogenase (NADP(+)).
based on mapping to UniProt P11586
5,10-methylenetetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH.
|
UniProtKB Entries (1)
| P11586 |
C1TC_HUMAN
Homo sapiens
C-1-tetrahydrofolate synthase, cytoplasmic
|
PDB Structure
| PDB | 1DIA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase.
Biochemistry
|