CATH Domain 1d8vA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.420	Ricin (A subunit); domain 1
	3.40.420.10	Ricin (A subunit), domain 1

Domain Context

CATH Clusters

Superfamily	Ricin (A subunit), domain 1
Functional Family

Enzyme Information

3.2.2.22

rRNA N-glycosylase.

based on mapping to UniProt P24817

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P24817

RIP3_MOMCH

Momordica charantia

Ribosome-inactivating protein beta-momorcharin

PDB Structure

PDB	1D8V
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Solution structure of anti-HIV-1 and anti-tumor protein MAP30: structural insights into its multiple functions. Wang, Y.X., Neamati, N., Jacob, J., Palmer, I., Stahl, S.J., Kaufman, J.D., Huang, P.L., Huang, P.L., Winslow, H.E., Pommier, Y., Wingfield, P.T., Lee-Huang, S., Bax, A., Torchia, D.A. Cell(Cambridge,Mass.)