CATH Domain 1d8mA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.390	Collagenase (Catalytic Domain)
	3.40.390.10	Collagenase (Catalytic Domain)

Domain Context

CATH Clusters

Superfamily	Collagenase (Catalytic Domain)
Functional Family	Collagenase 3

Enzyme Information

3.4.24.17

Stromelysin 1.

based on mapping to UniProt P08254

Preferential cleavage where P1', P2' and P3' are hydrophobic residues.

-!- Extracellular endopeptidase of vertebrate tissues. -!- Degradation of proteoglycans, fibronectin, collagen type III, IV, V and IX and activates procollagenase. -!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P08254

MMP3_HUMAN

Homo sapiens

Stromelysin-1

PDB Structure

PDB	1D8M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Heterocycle-based MMP inhibitors with P2' substituents. Pikul, S., Dunham, K.M., Almstead, N.G., De, B., Natchus, M.G., Taiwo, Y.O., Williams, L.E., Hynd, B.A., Hsieh, L.C., Janusz, M.J., Gu, F., Mieling, G.E. Bioorg.Med.Chem.Lett.