CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1970 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.1970 |
| Functional Family | N5-carboxyaminoimidazole ribonucleotide mutase |
Enzyme Information
| 5.4.99.18 |
5-(carboxyamino)imidazole ribonucleotide mutase.
based on mapping to UniProt P0AG18
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate.
-!- In eubacteria, fungi and plants, this enzyme, along with EC 6.3.4.18, is required to carry out the single reaction catalyzed by EC 4.1.1.21 in vertebrates. -!- In the absence of EC 6.3.2.6, the reaction is reversible. -!- The substrate is readily converted into 5-amino-1-(5-phospho-D- ribosyl)imidazole by non-enzymic decarboxylation.
|
UniProtKB Entries (1)
| P0AG18 |
PURE_ECOLI
Escherichia coli K-12
N5-carboxyaminoimidazole ribonucleotide mutase
|
PDB Structure
| PDB | 1D7A |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway.
Structure Fold.Des.
|
