CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.10210 | Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (CobT), large domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.10210 |
| Functional Family | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase |
Enzyme Information
| 2.4.2.21 |
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase.
based on mapping to UniProt Q05603
Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.
-!- Also acts on benzimidazole, and the clostridial enzyme acts on adenine to form 7-alpha-D-ribosyladenine 5'-phosphate. -!- The product of the reaction, alpha-ribazole 5'-phosphate, forms part of the corrin biosynthesis pathway and is a substrate for EC 2.7.8.2. -!- It can also be dephosphorylated to form alpha-ribazole by the action of EC 3.1.3.73.
|
UniProtKB Entries (1)
| Q05603 |
COBT_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
|
PDB Structure
| PDB | 1D0V |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The three-dimensional structures of nicotinate mononucleotide:5,6- dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella typhimurium complexed with 5,6-dimethybenzimidazole and its reaction products determined to 1.9 A resolution.
Biochemistry
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