CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.505 | SHC Adaptor Protein |
|
3.30.505.10 | SH2 domain |
Domain Context
CATH Clusters
| Superfamily | SH2 domain |
| Functional Family | Tyrosine-protein kinase Lck |
Enzyme Information
| 2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P06239
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
| P06239 |
LCK_HUMAN
Homo sapiens
Tyrosine-protein kinase Lck
|
PDB Structure
| PDB | 1CWE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
J.Mol.Biol.
|