CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450-Terp, domain 2
Functional Family Citrate synthase

Enzyme Information

2.3.3.1
Citrate (Si)-synthase.
based on mapping to UniProt P23007
Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA.
-!- The stereospecificity of this enzyme is opposite to that of EC 2.3.3.3, which is found in some anaerobes. -!- Citrate synthase for which the stereospecificity with respect to C(2) of oxaloacetate has not been established are included in EC 2.3.3.16. -!- Formerly EC 4.1.3.7.

UniProtKB Entries (1)

P23007
CISY_CHICK
Gallus gallus
Citrate synthase, mitochondrial

PDB Structure

PDB 1CSR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
alpha-Fluoro acid and alpha-fluoro amide analogs of acetyl-CoA as inhibitors of citrate synthase: effect of pKa matching on binding affinity and hydrogen bond length.
Schwartz, B., Drueckhammer, D.G., Usher, K.C., Remington, S.J.
Biochemistry