CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.120 | 6 Propeller |
|
2.120.10 | Neuraminidase |
|
2.120.10.30 | TolB, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | TolB, C-terminal domain |
| Functional Family |
Enzyme Information
| 1.1.5.2 |
Quinoprotein glucose dehydrogenase (PQQ, quinone).
based on mapping to UniProt P13650
D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol.
-!- Integral membrane protein containing PQQ as prosthetic group. -!- It also contains bound ubiquinone and Mg(2+) or Ca(2+). -!- Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. -!- Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed 'propeller' structure. -!- It occurs in a wide range of bacteria. -!- Catalyzes a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. -!- Oxidizes other monosaccharides including the pyranose forms of pentoses. -!- Formerly EC 1.1.99.17.
|
UniProtKB Entries (1)
| P13650 |
DHGB_ACICA
Acinetobacter calcoaceticus
Quinoprotein glucose dehydrogenase B
|
PDB Structure
| PDB | 1CQ1 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure and mechanism of soluble quinoprotein glucose dehydrogenase.
EMBO J.
|
