CATH Domain 1cjaA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1010	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
	3.30.1010.10	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4

Domain Context

CATH Clusters

Superfamily	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
Functional Family

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P80197

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P80197

AFK_PHYPO

Physarum polycephalum

Actin-fragmin kinase

PDB Structure

PDB	1CJA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The crystal structure of the Physarum polycephalum actin-fragmin kinase: an atypical protein kinase with a specialized substrate-binding domain. Steinbacher, S., Hof, P., Eichinger, L., Schleicher, M., Gettemans, J., Vandekerckhove, J., Huber, R., Benz, J. EMBO J.