CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.30 | Roll | |
2.30.29 | PH-domain like | |
2.30.29.30 | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) |
Domain Context
CATH Clusters
Superfamily | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) |
Functional Family | Tyrosine-protein kinase |
Enzyme Information
2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q06187
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
Q06187 |
BTK_HUMAN
Homo sapiens
Tyrosine-protein kinase BTK
|
PDB Structure
PDB | 1BWN |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate.
Structure Fold.Des.
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