CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.510 | Transferase(Phosphotransferase); domain 1 | |
1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
Superfamily | Transferase(Phosphotransferase) domain 1 |
Functional Family | Cyclin-dependent kinase 2 |
Enzyme Information
2.7.11.22 |
Cyclin-dependent kinase.
based on mapping to UniProt P24941
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
P61024 |
CKS1_HUMAN
Homo sapiens
Cyclin-dependent kinases regulatory subunit 1
|
PDB Structure
PDB | 1BUH |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Trichoplusia |
Primary Citation |
Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.
Cell(Cambridge,Mass.)
|