CATH Domain 1bueA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt P52663

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P52663

BLAN_ENTCL

Enterobacter cloacae

Imipenem-hydrolyzing beta-lactamase

PDB Structure

PDB	1BUE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	X-ray analysis of the NMC-A beta-lactamase at 1.64-A resolution, a class A carbapenemase with broad substrate specificity. Swaren, P., Maveyraud, L., Raquet, X., Cabantous, S., Duez, C., Pedelacq, J.D., Mariotte-Boyer, S., Mourey, L., Labia, R., Nicolas-Chanoine, M.H., Nordmann, P., Frere, J.M., Samama, J.P. J.Biol.Chem.