CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1170 | Aldehyde Oxidoreductase; domain 3 |
|
3.90.1170.30 | Pyrimidine nucleoside phosphorylase-like, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Pyrimidine nucleoside phosphorylase-like, C-terminal domain |
| Functional Family |
Enzyme Information
| 2.4.2.2 |
Pyrimidine-nucleoside phosphorylase.
based on mapping to UniProt P77836
(1) Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. (2) Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. (3) 2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate.
-!- Unlike EC 2.4.2.3 and EC 2.4.2.4, this enzyme can accept both the ribonucleoside uridine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine. -!- The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction. -!- Formerly EC 2.4.2.23.
|
UniProtKB Entries (1)
| P77836 |
PDP_GEOSE
Geobacillus stearothermophilus
Pyrimidine-nucleoside phosphorylase
|
PDB Structure
| PDB | 1BRW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation.
Structure
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