CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.309 | Aldehyde Dehydrogenase; Chain A, domain 2 |
|
3.40.309.10 | Aldehyde Dehydrogenase; Chain A, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Aldehyde Dehydrogenase; Chain A, domain 2 |
| Functional Family | 4-trimethylaminobutyraldehyde dehydrogenase isoform X1 |
Enzyme Information
| 1.2.1.3 |
Aldehyde dehydrogenase (NAD(+)).
based on mapping to UniProt P56533
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
-!- Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. -!- Formerly EC 1.1.1.70.
|
| 1.2.1.8 |
Betaine-aldehyde dehydrogenase.
based on mapping to UniProt P56533
Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
-!- In many bacteria, plants and animals, the osmoprotectant betaine is synthesized in two steps: (1) choline to betaine aldehyde and (2) betaine aldehyde to betaine. -!- This enzyme is involved in the second step and appears to be the same in plants, animals and bacteria. -!- In contrast, different enzymes are involved in the first reaction. -!- In plants, this reaction is catalyzed by EC 1.14.15.7, whereas in animals and many bacteria, it is catalyzed by either membrane-bound EC 1.1.99.1 or soluble EC 1.1.3.17. -!- In some bacteria, betaine is synthesized from glycine through the actions of EC 2.1.1.156 and EC 2.1.1.157.
|
UniProtKB Entries (1)
| P56533 |
BADH_GADMC
Gadus morhua callarias
Betaine aldehyde dehydrogenase
|
PDB Structure
| PDB | 1BPW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of betaine aldehyde dehydrogenase at 2.1 A resolution.
Protein Sci.
|
