CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.572 | Thymidylate Synthase; Chain A | |
3.30.572.10 | Thymidylate synthase/dCMP hydroxymethylase domain |
Domain Context
CATH Clusters
Superfamily | Thymidylate synthase/dCMP hydroxymethylase domain |
Functional Family |
Enzyme Information
2.1.1.45 |
Thymidylate synthase.
based on mapping to UniProt P00469
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
|
UniProtKB Entries (1)
P00469 |
TYSY_LACCA
Lactobacillus casei
Thymidylate synthase
|
PDB Structure
PDB | 1BO8 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry
|