CATH Domain 1bgoA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.38

Cathepsin K.

based on mapping to UniProt P43235

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

-!- Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P43235

CATK_HUMAN

Homo sapiens

Cathepsin K

PDB Structure

PDB	1BGO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Use of X-Ray Co-Crystal Structures and Molecular Modeling to Design Potent and Selective Non-Peptide Inhibitors of Cathepsin K Desjarlais, R.L., Yamashita, D.S., Oh, H.J., Uzinskas, I.N., Erhard, K.F., Allen, A.C., Haltiwanger, R.C., Zhao, B.G., Smith, W.W., Abdel-Meguid, S.S., Dalessio, K., Janson, C.A., Mcqueney, M.S., Tomaszek, T.A., Levy, M.A., Veber, D.F. J.Am.Chem.Soc.