CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.220 |
Domain Context
CATH Clusters
| Superfamily | 3.20.20.220 |
| Functional Family | Methylenetetrahydrofolate reductase |
Enzyme Information
| 1.5.1.20 |
Methylenetetrahydrofolate reductase (NAD(P)H).
based on mapping to UniProt P0AEZ1
5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.
-!- Menadione can also serve as an electron acceptor. -!- Formerly EC 1.1.1.68, EC 1.1.1.171, EC 1.1.99.15 and EC 1.7.99.5.
|
UniProtKB Entries (1)
| P0AEZ1 |
METF_ECOLI
Escherichia coli K-12
5,10-methylenetetrahydrofolate reductase
|
PDB Structure
| PDB | 1B5T |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia.
Nat.Struct.Biol.
|
