CATH Classification

Domain Context

CATH Clusters

Superfamily Microbial ribonucleases
Functional Family Guanyl-specific ribonuclease T1

Enzyme Information

3.1.27.3
Ribonuclease T(1).
based on mapping to UniProt P00651
Two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in G-P with 2',3'-cyclic phosphate intermediates.
-!- Formerly EC 2.7.7.26 and EC 3.1.4.8.

UniProtKB Entries (1)

P00651
RNT1_ASPOR
Aspergillus oryzae RIB40
Guanyl-specific ribonuclease T1

PDB Structure

PDB 1B2M
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Three-dimensional structure of ribonuclease T1 complexed with an isosteric phosphonate substrate analogue of GpU: alternate substrate binding modes and catalysis.
Arni, R.K., Watanabe, L., Ward, R.J., Kreitman, R.J., Kumar, K., Walz Jr., F.G.
Biochemistry
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