CATH Domain 1au2A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.38

Cathepsin K.

based on mapping to UniProt P43235

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

-!- Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P43235

CATK_HUMAN

Homo sapiens

Cathepsin K

PDB Structure

PDB	1AU2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Structure and Design of Potent and Selective Cathepsin K Inhibitors Yamashita, D.S., Smith, W.W., Zhao, B., Janson, C.A., Tomaszek, T.A., Bossard, M.J., Levy, M.A., Oh, H.-J., Carr, T.J., Thompson, S.K., Ijames, C.F., Carr, S.A., Mcqueney, M., D'Alessio, K.J., Amegadzie, B.Y., Hanning, C.R., Abdel-Meguid, S., Desjarlais, R.L., Gleason, J.G., Veber, D.F. J.Am.Chem.Soc.