CATH Classification

Domain Context

CATH Clusters

Superfamily Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 2
Functional Family

Enzyme Information

1.2.7.5
Aldehyde ferredoxin oxidoreductase.
based on mapping to UniProt Q51739
An aldehyde + H(2)O + 2 oxidized ferredoxin = a carboxylate + 2 H(+) + 2 reduced ferredoxin.
-!- This is an oxygen-sensitive enzyme. -!- Catalyzes the oxidation of aldehydes (including crotonaldehyde, acetaldehyde, formaldehyde and glyceraldehyde) to their corresponding acids. -!- However, it does not oxidize glyceraldehyde 3-phosphate (see EC 1.2.7.6). -!- Can use ferredoxin or methylviologen but not NAD(P)(+) as electron acceptor.

UniProtKB Entries (1)

Q51739
AOR_PYRFU
Pyrococcus furiosus DSM 3638
Tungsten-containing aldehyde ferredoxin oxidoreductase

PDB Structure

PDB 1AOR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase.
Chan, M.K., Mukund, S., Kletzin, A., Adams, M.W., Rees, D.C.
Science
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