CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.80 | Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module |
Domain Context
CATH Clusters
| Superfamily | Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module |
| Functional Family | NADPH--cytochrome P450 reductase 1 |
Enzyme Information
| 1.6.2.4 |
NADPH--hemoprotein reductase.
based on mapping to UniProt P00388
NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
-!- This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. -!- It also reduces cytochrome b5 and cytochrome c. -!- The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
|
UniProtKB Entries (1)
| P00388 |
NCPR_RAT
Rattus norvegicus
NADPH--cytochrome P450 reductase
|
PDB Structure
| PDB | 1AMO |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes.
Proc.Natl.Acad.Sci.USA
|
