CATH Domain 1aldA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	Fructose-bisphosphate aldolase

Enzyme Information

4.1.2.13

Fructose-bisphosphate aldolase.

based on mapping to UniProt P04075

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

-!- Also acts on (3S,4R)-ketose 1-phosphates. -!- The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc. -!- Formerly EC 4.1.2.7.

UniProtKB Entries (1)

P04075

ALDOA_HUMAN

Homo sapiens

Fructose-bisphosphate aldolase A

PDB Structure

PDB	1ALD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Activity and specificity of human aldolases. Gamblin, S.J., Davies, G.J., Grimes, J.M., Jackson, R.M., Littlechild, J.A., Watson, H.C. J.Mol.Biol.