CATH Domain 1a8rA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1130	GTP Cyclohydrolase I, domain 2
	3.30.1130.10	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

Domain Context

CATH Clusters

Superfamily	3.30.1130.10
Functional Family	GTP cyclohydrolase 1

Enzyme Information

3.5.4.16

GTP cyclohydrolase I.

based on mapping to UniProt P0A6T5

GTP + H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)-dihydropteridine triphosphate.

-!- The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic. -!- Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 4.2.3.12.

UniProtKB Entries (1)

P0A6T5

GCH1_ECOLI

Escherichia coli K-12

GTP cyclohydrolase 1

PDB Structure

PDB	1A8R
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I. Rebelo, J., Auerbach, G., Bader, G., Bracher, A., Nar, H., Hosl, C., Schramek, N., Kaiser, J., Bacher, A., Huber, R., Fischer, M. J.Mol.Biol.