CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.930 | Syk Kinase; Chain A, domain 2 |
|
1.10.930.10 | Syk Kinase; Chain A, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Syk Kinase; Chain A, domain 2 |
| Functional Family | Tyrosine-protein kinase |
Enzyme Information
| 2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P43405
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
| P07766 |
CD3E_HUMAN
Homo sapiens
T-cell surface glycoprotein CD3 epsilon chain
|
PDB Structure
| PDB | 1A81 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.
J.Mol.Biol.
|
