CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.420 | Nucleotidyltransferase; domain 5 |
|
3.30.420.10 | Ribonuclease H-like superfamily/Ribonuclease H |
Domain Context
CATH Clusters
| Superfamily | Ribonuclease H-like superfamily/Ribonuclease H |
| Functional Family | Gag-Pol polyprotein |
Enzyme Information
| 2.7.7.49 |
RNA-directed DNA polymerase.
based on mapping to UniProt O92956
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
|
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt O92956
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
| 3.4.23.- |
Aspartic endopeptidases.
based on mapping to UniProt O92956
|
| 2.7.7.- |
Nucleotidyltransferases.
based on mapping to UniProt O92956
|
| 3.1.26.4 |
Ribonuclease H.
based on mapping to UniProt O92956
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
|
| 3.1.-.- |
Acting on ester bonds.
based on mapping to UniProt O92956
|
UniProtKB Entries (1)
| O92956 |
POL_RSVSB
Rous sarcoma virus - Schmidt-Ruppin B
Gag-Pol polyprotein
|
PDB Structure
| PDB | 1A5W |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.
Proc.Natl.Acad.Sci.USA
|
