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CATH Superfamily 3.40.50.10210

Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (CobT), large domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (CobT), large domain

Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) plays a central role in the synthesis of alpha-ribazole-5'-phosphate, an intermediate for the lower ligand of cobalamin PMID:8206834. It is one of the enzymes of the anaerobic pathway of cobalamin biosynthesis, and one of the four proteins involved in the synthesis of the lower ligand and the assembly of the nucleotide loop PMID:12101181,PMID:7592411.

CobT is made up of a large and a small domain. The large domain is built from six strands of a parallel beta-sheet and surrounding alpha-helices PMID:10587435. This entry represents bacterial- and archaeal-type nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase enzymes involved in dimethylbenzimidazole synthesis, as well as a group of proteins of unknown function.

PMID:8206834 PMID:12101181 PMID:7592411 PMID:10587435

GO Diversity

Unique GO annotations
2 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
6920 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 56
Domain clusters (>95% seq id): 7
Domain clusters (>35% seq id): 4
Unique PDBs: 44
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC: 1
Unique GO: 2
Taxonomy
Unique Species: 6920