The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"ASAP complex, SAP18 subunit
".
3.10.20.550
superfamily
Functional Families
Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
Superfamily: ASAP complex, SAP18 subunit
This superfamily includes of several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex which is responsible for the repression of transcription via the modification of histone polypeptides PMID:9150135. SAP18 [UBL domain] is one of the three three ASAP subunits (along with Acinus [beta-hairpin motif] and RNPS1 [RRM domain]) that play a role in programmed cell death, transcriptional regulation, pre-mRNA splicing and mRNA quality control PMID:12665594,PMID:22388736. The ASAP complex interacts with the exon-junction complex (EJC), a messenger ribonucleoprotein complex involved in post-transcriptional regulation.
According to literature, the high degree of evolutionary conservation and the fortuitous crystal contacts at the alpha-beta groove suggest that this surface of SAP18 is a hot spot for interactions. Possible binding partners targeting this surface of SAP18 are transcription factors (such as Bicoid and Kruppel) and/or Sin3a-HDAC subunits.
GO Diversity
Unique GO annotations
30 Unique GO terms
EC Diversity
Unique EC annotations
0 Unique EC terms
Species Diversity
Unique species annotations
1206 Unique species
Sequence/Structure Diversity
Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.
Superfamily Summary
A general summary of information for this superfamily.
| Structures | |
|---|---|
| Domains: | 5 |
| Domain clusters (>95% seq id): | 3 |
| Domain clusters (>35% seq id): | 1 |
| Unique PDBs: | 4 |
| Alignments | |
| Structural Clusters (5A): | 1 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 2 |
| Function | |
| Unique EC: | |
| Unique GO: | 30 |
| Taxonomy | |
| Unique Species: | 1206 |
