Search CATH

Sulfolobus shibatae, MHC class II protein complex binding, TPR domain binding, endocytic vesicle lumen, membrane, telomere maintenance via telomerase, DNA topoisomerase 4 subunit B, Streptococcus pneumoniae R6, Anti-sigma F factor, Non-specific serine/threonine protein kinase., Protein phosphokinase. Protein serine kinase. Protein serine-threonine kinase. Protein-serine kinase. Serine kinase. Serine protein kinase. Serine(threonine) protein kinase. Serine-specific protein kinase. Serine/threonine protein kinase. Threonine-specific protein kinase., -!- This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). -!- A number of histones can act as acceptor., Histidine kinase., cellular response to magnesium starvation, ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate., protein homodimerization activity, regulation of cellular response to heat, -!- Can introduce negative superhelical turns into double-stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.99.1.2)., Saccharomyces cerevisiae S288C, protein refolding, response to osmotic stress, DNA gyrase subunit B, DNA topoisomerase type II (ATP-hydrolyzing) activity, Other protein kinases., Protein phosphotransferase ChpT, Staphylococcus aureus, Histidine protein kinase. HK1. Protein histidine kinase. Protein kinase. Protein kinase (histidine)., plasma membrane, mitochondrial matrix, peptidyl-serine phosphorylation, protein binding, regulation of response to osmotic stress, Redox sensor histidine kinase response regulator DevS, intracellular, Staphylococcus aureus subsp. aureus COL, synaptonemal complex, endoplasmic reticulum lumen, endoplasmic reticulum membrane, mismatch repair, regulation of DNA recombination, ATF6-mediated unfolded protein response, Sensor protein DivL, sugar mediated signaling pathway, positive regulation of single stranded viral RNA replication via double stranded DNA intermediate, chemotaxis, glucocorticoid receptor binding, response to biotin, Streptococcus mutans UA159, Chemotaxis protein CheA, protein domain specific binding, integral component of plasma membrane, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, negative regulation of reactive oxygen species biosynthetic process, HSP90, Sensor protein VraS, DNA topoisomerase 2, Sensor histidine kinase, Enterococcus faecalis V583, heat shock protein binding, positive regulation of phosphoprotein phosphatase activity, DNA polymerase binding, GTPase binding, chaperone-mediated protein complex assembly, extracellular region, neutrophil degranulation, nitric-oxide synthase regulator activity, positive regulation of telomerase activity, receptor-mediated endocytosis, telomerase holoenzyme complex assembly, ATP-dependent breakage, passage and rejoining of double-stranded DNA., Trypanosoma brucei brucei TREU927, chromosome organization, protein autophosphorylation, Endoplasmin, [Pyruvate dehydrogenase (acetyl-transferring)] kinase., mitochondrion, 'de novo' protein folding, cytoplasm, positive regulation of telomere maintenance via telomerase, regulation of telomere maintenance, manganese ion binding, Accessory gene regulator protein C, cellular response to ATP, response to endoplasmic reticulum stress, Osmolarity sensor protein EnvZ, vasculature development, ubiquitin binding, detection of chemical stimulus, Sensor histidine kinase CpxA, response to heat, plasmid partitioning, positive regulation of transforming growth factor beta receptor signaling pathway, Bacillus subtilis subsp. subtilis str. 168, Sensor histidine kinase DesK, Sensor protein FixL, ethylene receptor activity, response to ethylene, response to insect, regulation of fatty acid biosynthetic process, cellular response to fatty acid, extracellular exosome, ficolin-1-rich granule lumen, Geobacillus stearothermophilus, Phosphotransferases with a nitrogenous group as acceptor., phosphorelay sensor kinase activity, Heat shock protein 81-3, regulation of transcription, DNA-templated, regulation of nitrogen compound metabolic process, Endoplasmin homolog, putative, chromatin remodeling at centromere, regulation of mitotic recombination, virion binding, extracellular matrix, regulation of phosphoprotein phosphatase activity, response to hypoxia, ubiquitin-dependent ERAD pathway, Sensor histidine kinase WalK, single base insertion or deletion binding, protein complex binding, Putative histidine kinase CovS VicK-like protein, Plasmodium falciparum 3D7, Histidine protein kinase sensor protein, mitochondrial inner membrane, negative regulation of cellular respiration, cell proliferation, intrinsic apoptotic signaling pathway in response to oxidative stress, Xanthomonas oryzae pv. oryzae KACC 10331, mitochondrial alpha-ketoglutarate dehydrogenase complex, Caulobacter crescentus CB15, Dictyostelium discoideum, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, glucose metabolic process, cadherin binding, histone methyltransferase binding, negative regulation of cell cycle arrest, negative regulation of transforming growth factor beta activation, protein dimerization activity, regulation of interferon-gamma-mediated signaling pathway, regulation of type I interferon-mediated signaling pathway, supramolecular fiber organization, Ethylene receptor 1, defense response, defense response by callose deposition in cell wall, defense response to bacterium, detection of ethylene stimulus, endoplasmic reticulum, DNA ligation, chromosome segregation, cytosol, nucleoplasm, protein tyrosine kinase binding, regulation of protein ubiquitination, vascular endothelial growth factor receptor signaling pathway, Leishmania major, magnesium ion binding, Brucella abortus 2308, Homo sapiens, PDH kinase. PDHK. PDK. Pyruvate dehydrogenase kinase. Pyruvate dehydrogenase kinase (phosphorylating)., pyruvate dehydrogenase (acetyl-transferring) kinase activity, chromatin assembly or disassembly, Thermus thermophilus HB8, focal adhesion, retrograde protein transport, ER to cytosol, Two-component system histidine protein kinase, Acting on ester bonds., P-body, endonuclease activity, microtubule cytoskeleton, protein phosphorylation, Blue-light-activated histidine kinase 2, protein export from nucleus, growth involved in symbiotic interaction, translational attenuation, Staphylococcus aureus subsp. aureus Mu50, ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] = ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate., DNA topoisomerase complex (ATP-hydrolyzing), DNA-dependent ATPase activity, transcription, DNA-templated, Heat shock protein HSP 90-beta, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, protein complex, phosphoprotein phosphatase activity, calcium ion binding, response to molecule of bacterial origin, Francisella tularensis subsp. holarctica LVS, DNA topoisomerase 2-alpha, protein kinase C binding, protein targeting to mitochondrion, disordered domain specific binding, histone deacetylase binding, Type 2 DNA topoisomerase 6 subunit B, growth, peptidyl-aspartic acid modification, -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70., identical protein binding, proteasome assembly, unfolded protein binding, Heat shock protein HSP 90-alpha, chaperone-mediated autophagy, protein stabilization, regulation of nitric-oxide synthase activity, secretory granule lumen, DNA gyrase. DNA topoisomerase II. Type II DNA topoisomerase., alkaline phosphatase activity, TNF receptor-associated protein 1, DNA mismatch repair protein Mlh1, meiotic mismatch repair, detection of redox state, Heat shock protein 75 kDa, mitochondrial, protein kinase binding, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial, cellular protein metabolic process, Escherichia coli, Bradyrhizobium diazoefficiens USDA 110, oxygen sensor activity, Cell cycle histidine kinase CckA, cytokinin metabolic process, negative regulation of ethylene-activated signaling pathway, response to gibberellin, Cytosolic heat shock protein 90, chromatin binding, Caenorhabditis elegans, chemotaxis to cAMP, perinuclear region of cytoplasm, response to inorganic substance, Sensor-type histidine kinase PrrB, cellular response to DNA damage stimulus, Other isomerases., sister chromatid cohesion, Uncharacterized protein, Rattus norvegicus, [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase., DNA binding, ATP-dependent protein binding, aryl hydrocarbon receptor complex, double-stranded RNA binding, kinase binding, positive regulation of cell differentiation, positive regulation of protein localization to cell surface, aggregation involved in sorocarp development, Canis lupus familiaris, Fc-gamma receptor signaling pathway involved in phagocytosis, ciliary basal body docking, ATP + protein L-histidine = ADP + protein N-phospho-L-histidine., Escherichia coli K-12, Sensor protein PhoQ, integral component of membrane, nucleolus, protein serine/threonine kinase activity, regulation of acetyl-CoA biosynthetic process from pyruvate, cytoplasmic side of plasma membrane, Myxococcus xanthus DK 1622, Streptococcus pneumoniae, response to redox state, phosphatase activity, Danio rerio, low-density lipoprotein particle receptor binding, Mismatch repair endonuclease PMS2, Virulence sensor histidine kinase PhoQ, Lactobacillus plantarum JDM1, apicoplast, reciprocal meiotic recombination, detection of hypoxia, nitric oxide binding, Caulobacter vibrioides, Arabidopsis thaliana, regulation of stomatal movement, DNA binding, bending, drug binding, positive regulation of apoptotic process, protein heterodimerization activity, Heat shock protein 90, Thermotoga maritima MSB8, BCK. BCKD kinase. BCODH kinase. Branched-chain 2-oxo acid dehydrogenase kinase. Branched-chain alpha-ketoacid dehydrogenase kinase. Branched-chain keto acid dehydrogenase kinase. Branched-chain oxo acid dehydrogenase kinase (phosphorylating)., phosphorylation, response to drug, intrinsic apoptotic signaling pathway by p53 class mediator, peptide binding, xenobiotic metabolic process, Heat shock cognate 90 kDa protein, Escherichia coli O157:H7, Phosphoric monoester hydrolases., metal ion binding, -!- Has no activating compound but is specific for its substrate. -!- A mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. -!- Phosphorylation inactivates EC 1.2.4.1. -!- Formerly EC 2.7.1.99., [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial, cellular response to starvation, ATP-dependent molecular chaperone HSP82, Oryza sativa Japonica Group, Uncharacterized protein Rv1364c, Methanosarcina mazei Go1, phosphorelay signal transduction system, DNA mismatch repair protein PMS1, MutLalpha complex, Trypanosoma brucei brucei, Streptococcus pneumoniae TCH8431/19A, DNA strand elongation involved in DNA replication, mitotic DNA integrity checkpoint, replication fork progression beyond termination site, DNA mismatch repair protein MutL, mismatch repair complex, midbody, post-translational protein modification, toll-like receptor signaling pathway, Lactobacillus plantarum 16, Hypoxia sensor histidine kinase response regulator DosT, protein histidine kinase activity, cell division, response to abscisic acid, enzyme binding, positive regulation of viral genome replication, Hordeum vulgare, pyruvate dehydrogenase complex, dauer larval development, membrane raft, protein dephosphorylation, protein phosphatase 5 binding, regulation of chemotaxis, ATP + a protein = ADP + a phosphoprotein., -!- Has no activating compound but is specific for its substrate. -!- A mitochondrial enzyme associated with the branched-chain 2-oxoacid dehydrogenase complex. -!- Phosphorylation inactivates EC 1.2.4.4. -!- Formerly EC 2.7.1.115., [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, branched-chain amino acid catabolic process, response to salt stress, regulation of glucose metabolic process, regulation of reactive oxygen species metabolic process, reactive oxygen species metabolic process, ATPase activity, G2/M transition of mitotic cell cycle, RNA binding, nucleotide binding, Heat shock protein 83-1, Heat shock protein 83, DNA supercoiling activity, Mycobacterium tuberculosis H37Rv, cell wall, DNA gyrase, B subunit, truncated, DNA topoisomerase 4 subunit A, Nitrogen regulation protein NR(II), DNA replication termination region, Staphylococcus aureus subsp. aureus MRSA252, actin rod assembly, negative regulation of apoptotic process, protein folding in endoplasmic reticulum, protein phosphatase binding, cellular response to iron ion, ethylene binding, hydrogen peroxide biosynthetic process, regulation of seedling development, response to auxin, Blue-light photoreceptor, apoptotic chromosome condensation, protein C-terminus binding, protein sumoylation, Osmosensitive K+ channel histidine kinase KdpD, Erythrobacter litoralis HTCC2594, chaperone-mediated protein folding, determination of adult lifespan, nematode larval development, cell adhesion involved in biofilm formation, Mycobacterium smegmatis, Chaperone protein HtpG, DNA topological change, cellular response to reactive oxygen species, [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity, virion attachment to host cell, phagocytic vesicle, Sensor protein QseC, heme binding, oxygen binding, ATP binding, hypoxia-inducible factor-1alpha signaling pathway, peroxisome proliferator activated receptor signaling pathway, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial, ERBB2 signaling pathway, lysosomal lumen, mitochondrial transport, nucleus, protein import into mitochondrial outer membrane, ATPase activity, coupled, box C/D snoRNP assembly, protein maturation