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pyridoxine biosynthetic process, Yersiniabactin biosynthetic protein YbtU, Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids., Putative oxidoreductase with NAD(P)-binding Rossmann-fold domain, Staphylococcus aureus subsp. aureus COL, Pseudomonas sp. CF600, Leuconostoc mesenteroides, Lin2262 protein, Thermus thermophilus HB27, -!- NAD(+) and NADP(+) can be used as cofactors with similar efficiency, unlike EC 1.2.1.12 and EC 1.2.1.13, which are NAD(+)- and NADP(+)- dependent, respectively., NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase. Triosephosphate dehydrogenase (NAD(P)(+)). Triosephosphate dehydrogenase (NAD(P))., Sulfolobus solfataricus P2, 1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + NADPH., NADPH binding, Inositol 2-dehydrogenase, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, response to sucrose, Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase, Myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + NADH., Clostridium tetani E88, Bacillus anthracis, glucose metabolic process, glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity, gluconeogenesis, nucleus, regulation of macroautophagy, Staphylococcus aureus M1064, Acetaldehyde dehydrogenase, Oxidoreductase, Gfo/Idh/MocA family, L-aspartate dehydrogenase, -!- Studies of the enzyme from the bacterium Escherichia coli have shown that the enzyme accepts (2S,4S)-4-hydroxy-2,3,4,5- tetrahydrodipicolinate and not (S)-2,3-dihydrodipicolinate as originally thought. -!- Formerly EC 1.3.1.26., aspartate-semialdehyde dehydrogenase activity, homoserine biosynthetic process, Haemophilus influenzae Rd KW20, heme transport, lipopolysaccharide biosynthetic process, protein tetramerization, Enterococcus faecalis V583, Synechococcus elongatus PCC 7942, Glyceraldehyde-3-phosphate dehydrogenase A, nucleolus, response to cadmium ion, growth, N-acetyl-gamma-glutamyl-phosphate reductase, Cryptosporidium parvum, Homo sapiens, extracellular exosome, pentose-phosphate shunt, ribose phosphate biosynthetic process, NAD binding, chloroplast envelope, Cryptosporidium parvum Iowa II, -!- Catalyzes the first step in NAD biosynthesis from aspartate. -!- Strictly specific for L-aspartate as substrate. -!- Has a higher affinity for NAD(+) than NADP(+)., Kluyveromyces marxianus, Lysine-2-oxoglutarate reductase., Glyceraldehyde-3-phosphate dehydrogenase B, chloroplastic, Actinomadura kijaniata, seed development, Inositol dehydrogenase, -!- Also acts, more slowly, on L-arabinose and D-ribose., Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase., Uncharacterized oxidoreductase YhhX, Trypanosoma cruzi, D-erythrose 4-phosphate + NAD(+) + H(2)O = 4-phosphoerythronate + NADH., D-erythrose-4-phosphate dehydrogenase, Thermoplasma volcanium GSS1, Aspartate-semialdehyde dehydrogenase 2, Inositol-3-phosphate synthase, Staphylococcus aureus, RNA binding, Clostridioides difficile 630, positive regulation of glycolytic process, glycolytic process, 1L-myo-inositol-1-phosphate lyase (isomerizing). D-glucose 6-phosphate cycloaldolase. Glucocycloaldolase. Glucose 6-phosphate cyclase. Inositol 1-phosphate synthetase. Myo-inositol-1-phosphate synthase., D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate., Staphylococcus aureus subsp. aureus MRSA252, Bradyrhizobium diazoefficiens USDA 110, Symbiobacterium thermophilum IAM 14863, 319aa long hypothetical homoserine dehydrogenase, [LysW]-L-2-aminoadipate 6-phosphate reductase, Methanothermus fervidus, Saccharomyces cerevisiae S288C, homoserine dehydrogenase activity, 1,5-anhydro-D-fructose reductase, Glyceraldehyde-3-phosphate dehydrogenase, testis-specific, Inositol 2-dehydrogenase., Meso-2,6-diaminoheptanedioate + H(2)O + NADP(+) = L-2-amino-6- oxoheptanedioate + NH(3) + NADPH., protease binding, -!- Also acts, more slowly, on glycolaldehyde, propanal and butanal. -!- In several bacterial species this enzyme forms a bifunctional complex with EC 4.1.3.39. -!- The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.87. -!- Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols. -!- NADP(+) can replace NAD(+) but the rate of reaction is much slower., defense response to fungus, Mus musculus, Streptococcus pneumoniae D39, Homoserine dehydrogenase (Hom), Sugar 3-ketoreductase, biliverdin reductase activity, Thermomonospora curvata DSM 43183, sperm principal piece, Saccharopine dehydrogenase (NAD(+), L-lysine-forming)., Trichophyton rubrum BMU01672, Magnetospirillum magnetotacticum MS-1, Yersinia enterocolitica, Plasmodium falciparum, Biliverdin reductase A, vacuolar membrane, Yersinia pestis, Probable dehydrogenase, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Oryza sativa Japonica Group, Lipopolysaccaride biosynthesis protein wbpB, -!- The enzyme, found in the bacterium Bacillus subtilis, has no activity with NAD(+) (cf. EC 1.1.1.370)., inositol biosynthetic process, Glyceraldehyde-3-phosphate dehydrogenase 3, Thermosynechococcus elongatus BP-1, UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate + NAD(+) = UDP-2- acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + NADH., Rhizobium etli CFN 42, Pyrococcus horikoshii OT3, Pseudomonas aeruginosa PAO1, 1,5-anhydro-D-fructose reductase. AFR., killing by host of symbiont cells, killing of cells of other organism, lipid particle, negative regulation of endopeptidase activity, vesicle, Streptococcus agalactiae, Vibrio cholerae O1 biovar El Tor str. N16961, Putative oxidoreductase YceM, diaminopimelate biosynthetic process, Saccharopine dehydrogenase [NADP(+), L-glutamate-forming], N-acetyl-glutamate semialdehyde dehydrogenase. NAGSA dehydrogenase., GAPDH. NAD-dependent glyceraldehyde-3-phosphate dehydrogenase. Triosephosphate dehydrogenase., Thermus thermophilus HB8, D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH., Glucose-6-phosphate 1-dehydrogenase, cellular response to oxidative stress, cytoplasmic side of plasma membrane, glucose binding, glucose-6-phosphate dehydrogenase activity, DCI 1-dehydrogenase., Aspergillus fumigatus Af293, Candida albicans SC5314, Pectobacterium atrosepticum SCRI1043, D-galactose + NAD(+) = D-galactono-1,4-lactone + NADH., D-galactose-1-dehydrogenase protein, N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD(+) + H(2)O = L-lysine + 2-oxoglutarate + NADH., Saccharopine dehydrogenase, lysine biosynthetic process via diaminopimelate, Predicted dehydrogenases and related proteins, glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity, response to redox state, USG-1 protein homolog, Aspartate-semialdehyde dehydrogenase 1, Shigella flexneri, Macaca fascicularis, Mycobacterium tuberculosis CDC1551, scyllo-inositol 2-dehydrogenase (NADP(+)), Trypanosoma brucei brucei TREU927, Alpha-N-acetylgalactosaminidase, inositol-3-phosphate synthase activity, NADP binding, erythrocyte maturation, glucose 6-phosphate metabolic process, Thermus aquaticus, Burkholderia pseudomallei 1710b, protein homotetramerization, stromule, Conserved Archaeal protein, Streptococcus agalactiae NEM316, Sus scrofa, Bordetella bronchiseptica RB50, Escherichia coli K-12, identical protein binding, Saccharopine dehydrogenase (NADP(+), L-glutamate-forming)., Anabaena variabilis ATCC 29413, response to heat, response to oxidative stress, mycothiol biosynthetic process, pathogenesis, Francisella tularensis subsp. tularensis, Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic, Methanocaldococcus jannaschii DSM 2661, -!- This enzyme participates in the biosynthetic pathway for UDP-alpha-D- ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. -!- The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the the enzyme catalyzing the next step the pathway (EC 2.6.1.98). -!- The enzyme also possesses an EC 1.1.99.2 activity, and utilizes the 2-oxoglutarate produced by EC 2.6.1.98 to regenerate the tightly bound NAD(+). -!- The enzymes from Bordetella pertussis and Chromobacterium violaceum do not bind NAD(+) as tightly and do not require 2-oxoglutarate to function., polysaccharide biosynthetic process, Klebsiella pneumoniae 342, threonine biosynthetic process, Aquifex aeolicus VF5, 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming)., Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic, copper ion binding, NADH binding, spermatid development, Bacillus cereus ATCC 14579, negative regulation of kinase activity, Desulfitobacterium hafniense DCB-2, motile cilium, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, Bordetella pertussis Tohama I, D-chiro-inositol 1-dehydrogenase., Myo-inositol 2-dehydrogenase., Meso-diaminopimelate D-dehydrogenase, Meso-diaminopimelate D-dehydrogenase., Sulfolobus acidocaldarius DSM 639, Malonyl CoA reductase (malonate semialdehyde-forming)., cellular response to interferon-gamma, negative regulation of translation, plasma membrane, positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction, Corynebacterium glutamicum ATCC 13032, GAIT complex, canonical glycolysis, Homoserine dehydrogenase related protein, (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)(+) + H(2)O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H., L-aspartate 4-semialdehyde + phosphate + NADP(+) = L-4-aspartyl phosphate + NADPH., cellular amino acid biosynthetic process, Aminoadipate semialdehyde-glutamate reductase. Aminoadipic semialdehyde-glutamate reductase. Aminoadipic semialdehyde-glutamic reductase. Saccharopine reductase., N-acetyl-gamma-glutamyl-phosphate reductase., Thermotoga maritima MSB8, Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)., Homoserine dehydrogenase., -!- The enzyme catalyzes a step of the pentose phosphate pathway. -!- The enzyme is specific for NADP(+), cf. EC 1.1.1.363 and EC 1.1.1.388., flagellated sperm motility, [Pseudomonas syringae] pv. tomato str. DC3000, Sinorhizobium meliloti 1021, Elizabethkingia meningoseptica, Myo-inositol 2-dehydrogenase-like (Promiscuous), Scyllo-inositol + NADP(+) = 2,4,6/3,5-pentahydroxycyclohexanone + NADPH., Yersinia enterocolitica subsp. enterocolitica 8081, Alpha-galactosidase B. Alpha-GalNAcase. Alpha-NAGA., Malonyl-CoA reductase, positive regulation of cytokine secretion, Geobacillus stearothermophilus, Listeria innocua Clip11262, Inositol-3-phosphate synthase., Probable oxidoreductase protein, Streptococcus pneumoniae TIGR4, Glucose-6-phosphate dehydrogenase (NADP(+))., oxidation-reduction process, pentose biosynthetic process, pentose-phosphate shunt, oxidative branch, substantia nigra development, Uncharacterized protein, Klebsiella pneumoniae subsp. pneumoniae MGH 78578, -!- The enzyme, found in the bacterium Bacillus subtilis, also catalyzes the reaction of EC 1.1.1.18 and can also use D-glucose and D-xylose. -!- It shows trace activity with D-ribose and D-fructose. -!- It is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA. -!- Formerly EC 1.1.1.n6., Bacillus subtilis subsp. subtilis str. 168, response to light stimulus, Streptococcus pneumoniae R6, -!- This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose., ASA dehydrogenase. Aspartic semialdehyde dehydrogenase. L-aspartate-beta-semialdehyde dehydrogenase., -!- D-mannose, D-xylose, D-galactose, 2-deoxy-D-glucose and L-arabinose will function as aldose substrates, but with low affinities. -!- The ketose substrate must be in the open-chain form. -!- The apparent affinity for fructose is low, because little of the fructose substrate is in the open-chain form. -!- Xylulose and glycerone (dihydroxyacetone) will replace fructose, but they are poor substrates. -!- The enzyme from Zymomonas mobilis contains tightly bound NADP(+)., D-glucose + D-fructose = D-gluconolactone + D-glucitol., Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821, cytosol, Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic, response to hydrogen peroxide, Biliverdin reductase., Bartonella henselae, sperm fibrous sheath, Aspartate dehydrogenase., L-aspartate + H(2)O + NAD(P)(+) = oxaloacetate + NH(3) + NAD(P)H., NAD-dependent aspartate dehydrogenase. NADH(2)-dependent aspartate dehydrogenase. NADP(+)-dependent aspartate dehydrogenase., Probable L-aspartate dehydrogenase, UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase., aromatic compound catabolic process, Lactobacillus casei, saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity, Trypanosoma cruzi strain CL Brener, D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH., Ensifer adhaerens, NADP+ binding, -!- Present in some but not all Rhizobium species. -!- Differs from hepatic 1,5-anhydro-D-fructose reductase, which yields 1,5-anhydro-D-glucitol as the product (see EC 1.1.1.263). -!- In Sinorhizobium morelense, the product of the reaction, 1,5-anhydro- D-mannitol, can be further metabolized to D-mannose. -!- Also reduces 1,5-anhydro-D-erythro-hexo-2,3-diulose and 2-ketoaldoses (called osones), such as D-glucosone (D-arabino-hexos-2-ulose) and 6-deoxy-D-glucosone. -!- Does not reduce common aldoses and ketoses, or non-sugar aldehydes and ketones., Bos taurus, E4P dehydrogenase. E4PDH. Erythrose 4-phosphate dehydrogenase., pyridoxal phosphate biosynthetic process, Glucose-fructose oxidoreductase, extracellular matrix, nuclear membrane, Synechococcus sp., Kluyveromyces lactis NRRL Y-1140, Myo-inositol-1-phosphate synthase (Ino1), Glyceraldehyde-3-phosphate dehydrogenase 1, D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH., Glyceraldehyde-3-phosphate dehydrogenase, D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = 3-phospho-D- glyceroyl phosphate + NADPH., Spinacia oleracea, G6PD. G6PDH. Glucose-6-phosphate 1-dehydrogenase. Glucose-6-phosphate dehydrogenase. GPD., lipid metabolic process, protein homodimerization activity, heme catabolic process, Kribbella flavida DSM 17836, Mycobacterium avium 104, cilium, Dehydrogenase, Brugia malayi, Inositol-1-phosphate synthase, mitochondrial envelope, Porphyromonas gingivalis W83, Bilirubin + NAD(P)(+) = biliverdin + NAD(P)H., Scyllo-inositol 2-dehydrogenase (NADP(+))., Panulirus versicolor, negative regulation of transcription from RNA polymerase II promoter, Lactobacillus plantarum WCFS1, Erythrose-4-phosphate dehydrogenase., erythrose-4-phosphate dehydrogenase activity, -!- The human lysosomal enzyme is involved in the degradation of blood type A epitope., Oryctolagus cuniculus, Brucella abortus 2308, fungal-type cell wall, Acetaldehyde dehydrogenase (acetylating)., Acylating acetaldehyde dehydrogenase. Aldehyde dehydrogenase (acylating)., Leishmania mexicana, -!- The NAD(+) dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1; finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form., NADP-dependent glyceraldehyde-3-phosphate dehydrogenase. Triosephosphate dehydrogenase (NADP(+)). Triosephosphate dehydrogenase (NADP+)., N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5- glutamyl phosphate + NADPH., With NAD(+) or NADP(+) as acceptor., L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H., negative regulation of protein glutathionylation, protein binding, glutathione metabolic process, Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic, apoplast, chloroplast stroma, chloroplast thylakoid membrane, response to cold, supramolecular complex, -!- Catalyzes the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutyrate cycles, autotrophic CO(2) fixation pathways found in some green non-sulfur phototrophic bacteria and some thermoacidophilic archaea, respectively. -!- The enzyme from Sulfolobus tokodaii has been purified, and found to contain one RNA molecule per two subunits. -!- The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyzes the next reaction in the pathway, EC 1.1.1.298., Malonyl CoA reductase (NADP). NADP-dependent malonyl CoA reductase., Sulfolobus tokodaii str. 7, D-galactose 1-dehydrogenase., Thermus thermophilus, Aspartate-semialdehyde dehydrogenase, Glucose--fructose oxidoreductase, fruit development, response to salt stress, Thiobacillus denitrificans ATCC 25259, Ureibacillus thermosphaericus, Bartonella henselae str. Houston-1, Achromobacter xylosoxidans, zinc ion binding, Streptococcus pneumoniae, UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase, Oxidoreductase, NAD binding, acetaldehyde dehydrogenase (acetylating) activity, lysine biosynthetic process via aminoadipic acid, RNA polymerase II activating transcription factor binding, galactose metabolic process, -!- Was originally thought to be an EC 1.2.1.12, but this has since been disproved, as glyceraldehyde 3-phosphate is not a substrate. -!- Forms part of the pyridoxal-5'-phosphate coenzyme biosynthesis pathway in Escherichia coli, along with EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5., Alpha-N-acetylgalactosaminidase., reactive oxygen species metabolic process, Uncharacterized oxidoreductase At4g09670, Oxidoreductase, putative, Galactose/lactose metabolism regulatory protein GAL80, D-glyceraldehyde 3-phosphate + phosphate + NAD(P)(+) = 3-phospho-D- glyceroyl phosphate + NAD(P)H., methionine biosynthetic process, Oxidoreductase domain protein, Rattus norvegicus, Homarus americanus, D-xylose 1-dehydrogenase (NADP(+))., Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH., Arabidopsis thaliana, disordered domain specific binding, Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH., Caulobacter crescentus CB15, Transferring other nitrogenous groups., antimicrobial humoral immune response mediated by antimicrobial peptide, aspartic-type endopeptidase inhibitor activity, intracellular ribonucleoprotein complex, Glyceraldehyde-3-phosphate dehydrogenase, glycosomal, Trypanosoma brucei brucei, cellular response to DNA damage stimulus, Magnaporthe oryzae 70-15, Glucose-fructose oxidoreductase., Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating)., NADP metabolic process, NADPH regeneration, cholesterol biosynthetic process, cytoplasm, membrane, apoptotic process, mitochondrion, Bacteroides fragilis NCTC 9343, Borrelia burgdorferi B31, Malonate semialdehyde + CoA + NADP(+) = malonyl-CoA + NADPH., Burkholderia thailandensis E264, intracellular membrane-bounded organelle, Lactobacillus casei BL23, Oxidoreductase, Archaeoglobus fulgidus DSM 4304, Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)., cell wall, acrosomal vesicle, chloroplast, Putative oxidoreductase, 1D-chiro-inositol + NAD(+) = 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH., Oxidoreductases., Probable oxidoreductase, Diaminopimelate dehydrogenase., Mycobacterium tuberculosis H37Rv, Wolinella succinogenes DSM 1740, Streptococcus agalactiae 2603V/R, Thermoplasma acidophilum DSM 1728, N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP(+) + H(2)O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH., 4-hydroxy-tetrahydrodipicolinate reductase, 4-hydroxy-tetrahydrodipicolinate reductase., Dihydrodipicolinate reductase., Aspartate-semialdehyde dehydrogenase., Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic, -!- Also acts very slowly on D-glyceraldehyde and some other aldehydes. -!- Thiols can replace phosphate., -!- The enzyme from Saccharomyces cerevisiae acts most rapidly with NAD(+); the Neurospora enzyme with NADP(+). -!- The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 2.7.2.4., Homoserine dehydrogenase

Streptomyces collinus, ATP-citrate synthase, -!- In the reverse reaction, a 2'-hydroxyisoflavone is reduced to an isoflavanone; 2'-hydroxypseudobaptigenin also acts. -!- Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain., mycothiol biosynthetic process, UDP-rhamnose biosynthetic process, WbpP, Glycerate dehydrogenase, Hyphomicrobium methylovorum, Trypanosoma cruzi strain CL Brener, (-)-menthone:(+)-neomenthol reductase, Chorismate mutase., 3-oxoacyl-[acyl-carrier-protein] synthase activity, UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate + NAD(+) = UDP-2- acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + NADH., polysaccharide biosynthetic process, Tartronic semialdehyde reductase, -!- This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyzes only the reduction of oxaloacetate, and can use NAD(+) and NADP(+) with similar specific activity. -!- Different from EC 1.1.1.37, EC 1.1.1.82 and EC 1.1.5.4., (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD(+) = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH., 15-hydroxyprostaglandin dehydrogenase (NAD+) activity, Streptomyces platensis, Tropinone reductase I., -!- Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. -!- This enzyme catalyzes the first step in galactose metabolism by converting beta-D-galactose into alpha-D-galactose, which is the substrate for EC 2.7.1.6., response to flooding, BH1520 protein, Probable ornithine cyclodeaminase, macromolecular complex, Putative oxidoreductase YceM, Maltose-6'-phosphate glucosidase., Rickettsia felis URRWXCal2, Putative dTDP-4-keto-L-rhamnose reductase, Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose., Burkholderia ambifaria MC40-6, Thermus sp. ATN1, polyketide biosynthetic process, GDP-4-dehydro-6-deoxy-D-mannose reductase., Probable 2-dehydropantoate 2-reductase, Adenosylhomocysteinase 3, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, -!- This bacterial enzyme is involved in the 7-dehydroxylation process associated with bile acid degradation. -!- The enzyme has very little activity with unconjugated bile acid substrates. -!- It has similar activity with choloyl-CoA, chenodeoxycholoyl-CoA, deoxycholoyl-CoA, and lithocholoyl-CoA. -!- Formerly EC 1.17.98.1., Bile acid 7-dehydroxylase 2, 3-ketoacyl-(Acyl-carrier-protein) reductase, Putative NADH-flavin reductase, Putative oxidoreductase protein, Probable dehydrogenase protein, 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming)., Burkholderia pseudomallei K96243, NADH-dependent reductase for 4-deoxy-L-erythro-5-hexoseulose uronate, Tartronate semialdehyde reductase., -!- Highly specific for (R)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.269, which is highly specific for the (S)-enantiomer. -!- Forms component III of a four-component enzyme system (comprising EC 4.4.1.23 (component I), EC 1.8.1.5 (component II), EC 1.1.1.268 (component III) and EC 1.1.1.269 (component IV)) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2., NADPH:adrenodoxin oxidoreductase, mitochondrial, -!- NAD(+) appears to oxidize the substrate to UDP-4-dehydroglucose, which dehydrates to UDP-4-dehydro-6-deoxygluc-5-enose, to which sulfite can add; the reaction is completed when the substrate is rehydrogenated at C-4. -!- The enzyme from Arabidopsis thaliana is specific for UDP-Glc and sulfite., Malonyl-CoA + 6 (2S)-methylmalonyl-CoA + 5 NADPH = narbonolide + 7 CoA + 7 CO(2) + 5 NADP(+) + 2 H(2)O., negative regulation of protein glutathionylation, pentose biosynthetic process, Predicted dehydrogenases and related proteins, enzyme activator activity, D-beta-hydroxybutyrate dehydrogenase, negative regulation of histone H4 acetylation, Ornithine cyclodeaminase, Putative 2-dehydropantoate 2-reductase, Eubacterium barkeri, Streptococcus agalactiae 2603V/R, Sugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family, Putative oxoacyl-(Acyl carrier protein) reductase, phenylacetate catabolic process, Uncharacterized oxidoreductase At4g09670, Squalus acanthias, dTDP-glucose 4,6-dehydratase 2, purine nucleobase biosynthetic process, Streptococcus pneumoniae D39, Peptide synthetase, Thiobacillus sp. KNK65MA, SUMO-activating enzyme subunit 2, Methionine synthase. O-acetyl-L-homoserine acetate-lyase (adding methanethiol). O-acetyl-L-homoserine sulfhydrolase. O-acetylhomoserine (thiol)-lyase. O-acetylhomoserine sulfhydrolase. OAH sulfhydrylase., Lambda-crystallin, Azotobacter vinelandii DJ, Ferredoxin--NADP(+) reductase., Homarus americanus, Xanthomonas campestris pv. campestris str. ATCC 33913, oviposition, Champsocephalus gunnari, UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity, -!- The enzyme acts on androsterone and other 3-alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. -!- Si-specific with respect to NAD(+) or NADP(+) (cf. EC 1.1.1.213)., 3-alpha-hydroxysteroid dehydrogenase, -!- The human lysosomal enzyme is involved in the degradation of blood type A epitope., Alpha-galactosidase B. Alpha-GalNAcase. Alpha-NAGA., D-mannitol + NAD(+) = D-fructose + NADH., -!- Some members of this group oxidize only primary alcohols; others act also on secondary alcohols. -!- May be identical with EC 1.1.1.19, EC 1.1.1.33 and EC 1.1.1.55. -!- Re-specific with respect to NADPH., An alcohol + NADP(+) = an aldehyde + NADPH., Putative acetoin(Diacetyl) reductase, Moraxella sp. TAE123, Phenylalanine dehydrogenase, Panulirus versicolor, Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))., (6E)-8-oxogeranial + NAD(P)H = cis-trans-nepetalactol + NAD(P)(+)., -!- Isolated from the plant Catharanthus roseus. -!- The reaction may involve cyclization via a Diels-Alder or Michael reaction. -!- Iridoids are involved in the biosynthesis of many indole alkaloids. -!- The cyclic hemiacetal is readily hydrolyzed to the corresponding dial., monoterpenoid biosynthetic process, oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor, -!- The reaction occurs in the opposite direction to that shown above. -!- Participates in the menthol-biosynthesis pathway of Mentha plants. -!- (+)-pulegone, (+)-cis-isopulegone and (-)-menthone are not substrates. -!- Has a preference for NADPH as the reductant, with NADH being a poor substitute. -!- Highly regioselective for the reduction of the endocyclic 1,2-double bond, and is stereoselective, producing only the 1R-configured product., Mentha x piperita, menthol biosynthetic process, ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate., NADP metabolic process, NADPH:quinone reductase activity, negative regulation of peptidyl-serine phosphorylation, -!- Represents, along with EC 1.1.1.206, a branch point in tropane alkaloid metabolism. -!- Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines. -!- Both enzymes are always found together in any given tropane-alkaloid- producing species, have a common substrate, tropinone, and are strictly stereospecific., Tropinone reductase 2, Methylococcus capsulatus str. Bath, Klebsiella pneumoniae, Glyoxylate/hydroxypyruvate reductase A, -!- Catalyzes the oxidation of the 7-alpha-hydroxy group of bile acids and alcohols both in their free and conjugated forms. -!- The Bacteroides fragilis and Clostridium enzymes can also utilize NADP(+)., Yersinia enterocolitica subsp. enterocolitica 8081, (-)-trans-carveol dehydrogenase., Short-chain dehydrogenase, Bradyrhizobium diazoefficiens USDA 110, PbgP3 protein, -!- Activated by light., Probable oxidoreductase protein, Saccharopolyspora spinosa, Streptococcus pyogenes serotype M1, regulation of mitochondrial membrane potential, cytoplasmic microtubule, Ruegeria pomeroyi DSS-3, Glucose 1-dehydrogenase 4, 9-keto-prostaglandin E(2) reductase. 9-ketoprostaglandin reductase. PGE(2) 9-ketoreductase. PGE(2) 9-oxoreductase. Prostaglandin-E(2) 9-oxoreductase. Prostaglandin-E2 9-reductase., cellular aldehyde metabolic process, Desulfitobacterium hafniense DCB-2, Streptococcus thermophilus LMG 18311, L-serine + NADP(+) = 2-aminoacetaldehyde + CO(2) + NADPH., methylglyoxal reductase (NADH-dependent) activity, Uncharacterized oxidoreductase YIR035C, Pyridoxal + NAD(+) = 4-pyridoxolactone + NADH., Pyridoxal 4-dehydrogenase, CDP-abequose epimerase. CDP-D-abequose 2-epimerase. CDP-paratose epimerase. CDP-tyvelose 2-epimerase. Cytidine diphosphate paratose-2-epimerase. Cytidine diphosphoabequose epimerase. Cytidine diphosphodideoxyglucose epimerase. Cytidine diphosphoparatose epimerase., -!- The enzyme completes each cycle of fatty acid elongation by catalyzing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl- carrier protein, in an NADPH-dependent manner. -!- This entry stands for enzymes whose stereo-specificity with respect to NADP(+) is not known (cf. EC 1.3.1.39, EC 1.3.1.10 and EC 1.3.1.9)., (S)-acetoin + NAD(+) = diacetyl + NADH., (S,S)-butanediol dehydrogenase activity, D-mannose = D-fructose., D-mannose isomerase., Probable NADP-dependent mannitol dehydrogenase, Sulfitobacter sp. NAS-14.1, 2-deoxy-D-gluconate 3-dehydrogenase., Amycolatopsis orientalis HCCB10007, retinal metabolic process, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, Methylenetetrahydrofolate dehydrogenase (NAD(+))., methylenetetrahydrofolate dehydrogenase (NADP+) activity, 2-methylene-furan-3-one reductase, UDP-D-glucuronate = UDP-D-xylose + CO(2)., Thermosynechococcus elongatus BP-1, Streptomyces kanamyceticus, Malonyl CoA reductase (malonate semialdehyde-forming)., Enoyl-CoA hydratase 2., cellular response to organic cyclic compound, testosterone dehydrogenase [NAD(P)] activity, response to endoplasmic reticulum stress, glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity, response to ethanol, retinol binding, 5,10-methylenetetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH., Methylenetetrahydrofolate dehydrogenase (NADP(+))., Thermococcus kodakarensis KOD1, Acinetobacter baumannii, Corynebacterium diphtheriae NCTC 13129, Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446, Sphingomonas sp. A1, Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase), D-mandelate dehydrogenase, cellular protein modification process, proteolysis, D-octopine dehydrogenase., kinase inhibitor activity, Bacillus megaterium, 3-hydroxybutyrate dehydrogenase activity, Glyoxylate/succinic semialdehyde reductase 1, Arthrobacter sp. FB24, D-isomer specific 2-hydroxyacid dehydrogenase, anaerobic respiration, malate dehydrogenase activity, Ketol-acid reductoisomerase, chloroplastic, alpha-linolenic acid metabolic process, isoleucine biosynthetic process, (-)-lariciresinol reductase., GDP-mannose 4,6 dehydratase, Lactobacillus casei, Vibrio fischeri ES114, -!- The enzyme purified from Saccharomyces cerevisiae catalyzes the reduction of a number of straight-chain and branched aldehydes, as well as some aromatic aldehydes., 3-methylbutanol + NAD(P)(+) = 3-methylbutanal + NAD(P)H., NADPH-dependent methylglyoxal reductase GRE2, 3-ketoacyl-acyl carrier protein reductase (FabG), doxorubicin metabolic process, 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH., Imine reductase, L-xylulose reductase, -!- Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline., -!- Responsible for the chain-elongation step of dissociated (type II) fatty-acid biosynthesis, i.e. the addition of two C atoms to the fatty-acid chain. -!- Escherichia coli mutants that lack this enzyme are deficient in unsaturated fatty acids. -!- Can use fatty acyl thioesters of ACP (C(2) to C(16)) as substrates, as well as fatty acyl thioesters of Co-A (C(4) to C(16)). -!- The substrate specificity is very similar to that of EC 2.3.1.179 with the exception that the latter enzyme is far more active with palmitoleoyl-ACP (C(16)-Delta(9)) as substrate, allowing the organism to regulate its fatty-acid composition with changes in temperature., BdcA (YjgI), [Acyl-carrier-protein] S-acetyltransferase., positive regulation of cellular metabolic process, -!- The enzyme catalyzes the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of thiamine. -!- The enzyme shows significant structural similarity to ubiquitin- activating enzyme. -!- In Escherichia coli, but not in Bacillus subtilis, the enzyme forms a cross link from Cys-184 to the ThiS carboxy terminus (the position that is also thiolated) via an acyldisulfide. -!- Formerly EC 2.7.7.n3., Pseudomonas sp. 101, NADH metabolic process, methanol oxidation, UDP-N-acetylglucosamine 4,6-dehydratase (inverting)., L-lactate dehydrogenase 1, Staphylococcus aureus subsp. aureus COL, oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor, leucine binding, mitochondrion organization, Aldehyde reductase I. NADPH-dependent carbonyl reductase. Prostaglandin 9-ketoreductase. Xenobiotic ketone reductase., carbonyl reductase (NADPH) activity, bacterial-type flagellum-dependent cell motility, NAD metabolic process, NADP(+) + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide., UDP-glucose 6-dehydrogenase activity, cellular nitrogen compound metabolic process, (S)-3-hydroxybutanoyl-CoA + NADP(+) = 3-acetoacetyl-CoA + NADPH., extrinsic component of pre-autophagosomal structure membrane, receptor binding, Meso-2,6-diaminoheptanedioate + H(2)O + NADP(+) = L-2-amino-6- oxoheptanedioate + NH(3) + NADPH., mRNA binding, saccharopine dehydrogenase (NAD+, L-lysine-forming) activity, long-chain fatty-acyl-CoA metabolic process, Uncharacterized protein, Plesiomonas shigelloides, Picrophilus torridus DSM 9790, GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase. GDP-fucose synthetase., GDP-L-fucose synthase., cobalt ion binding, lactate metabolic process, post-embryonic animal organ development, Acyl-ACP dehydrogenase. Enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific)., NAD(+) glycohydrolase., (1) A (2S,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 NADPH. (2) A (2S,3S)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 NADPH., NAD(P) transhydrogenase subunit alpha part 1, Rhodospirillum rubrum ATCC 11170, S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H., Acyl-ACP dehydrogenase. Enoyl acyl-carrier-protein reductase. Enoyl-ACP reductase. NADPH 2-enoyl Co A reductase., Trans-2-enoyl-CoA reductase (NADPH)., L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))., Sepiapterin reductase, Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)., Micromonospora echinospora, Vibrio cholerae O395, (S)-2-hydroxymethylglutarate + NAD(+) = 2-formylglutarate + NADH., 3-hydroxyisobutyrate dehydrogenase., Glyceraldehyde-3-phosphate dehydrogenase, testis-specific, [Candida] boidinii, copper ion binding, ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine., Xanthobacter autotrophicus Py2, Francisella tularensis subsp. tularensis SCHU S4, 3-oxoacyl-[acyl-carrier protein] reductase, -!- Acts on acetyl-D-mannosamine and glycolyl-D-mannosamine. -!- Highly specific., Phosphonate dehydrogenase., dTDP-glucose 4,6-dehydratase., FabG protein, -!- Also hydrolyzes several other phospho-beta-D-glucosides, but not their non-phosphorylated forms., 6-phospho-beta-glucosidase BglT, Phospho-beta-glucosidase. Phosphocellobiase., -!- Highly specific for 4-hydroxynon-2-enal and non-2-enal. -!- Alk-2-enals of shorter chain have lower affinities. -!- Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one. -!- Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid. -!- Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102)., 2-alkenal reductase (NAD(P)(+))., 2-alkenal reductase. NAD(P)H-dependent alkenal/one oxidoreductase. NADPH:2-alkenal alpha,beta-hydrogenase., Enoyl-ACP reductase, malate dehydrogenase (decarboxylating) (NAD+) activity, Lactobacillus helveticus, Thiomorpholine-carboxylate dehydrogenase., thyroid hormone binding, Podophyllum peltatum, GDP-mannose 3,5-epimerase., N-acetyl-gamma-glutamyl-phosphate reductase., L-aspartate + H(2)O + NAD(P)(+) = oxaloacetate + NH(3) + NAD(P)H., TruD, Putative 5-keto-D-gluconate 5-reductase, Alpha-glucosidase, Alpha-glucosidase., Jannaschia sp. CCS1, 3-oxoacyl-acyl carrier protein reductase, -!- This enzyme participates in the biosynthetic pathway for UDP-alpha-D- ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. -!- The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the the enzyme catalyzing the next step the pathway (EC 2.6.1.98). -!- The enzyme also possesses an EC 1.1.99.2 activity, and utilizes the 2-oxoglutarate produced by EC 2.6.1.98 to regenerate the tightly bound NAD(+). -!- The enzymes from Bordetella pertussis and Chromobacterium violaceum do not bind NAD(+) as tightly and do not require 2-oxoglutarate to function., UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase, UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase., female pregnancy, aspartate-semialdehyde dehydrogenase activity, CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H(2)O., Toxoplasma gondii, Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)., Transferring other nitrogenous groups., Streptomyces exfoliatus, Flavin reductase (NADPH)., heme catabolic process, Mannitol 2-dehydrogenase (NADP(+))., L-lactic acid dehydrogenase. L-lactic dehydrogenase., adenosylhomocysteinase activity, adenyl nucleotide binding, response to hypoxia, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, dTDP-4-dehydrorhamnose reductase activity, lipopolysaccharide biosynthetic process, Aldehyde reductase., -!- The enzyme from heart mitochondria is Re-specific with respect to NAD(+) and Si-specific with respect to NADP(+) (cf. EC 1.6.1.1.)., An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH., alanine metabolic process, serine binding, UDP-galactose 4-epimerase, mycolic acid biosynthetic process, UDP-alpha-D-glucuronate + NAD(+) = UDP-beta-L-threo-pentapyranos-4-ulose + CO(2) + NADH., UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating)., Glyoxylate reductase., Pseudomonas sp. CF600, Shikimate + NADP(+) = 3-dehydroshikimate + NADPH., Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating)., erythrose-4-phosphate dehydrogenase activity, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, Fatty acid synthase, L-threonine 3-dehydrogenase., -!- Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives. -!- The enzyme from placenta is specific for NAD(+)., glucose binding, Quinate 5-dehydrogenase. Quinate:NAD oxidoreductase. Quinate:NAD(+) 5-oxidoreductase. Quinic dehydrogenase., Quinate dehydrogenase., -!- Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA., 3-hydroxy-2-methylbutyryl-CoA dehydrogenase., cholate 7-alpha-dehydrogenase activity, lipid metabolic process, mitochondrial matrix, mitochondrial tRNA methylation, 4-phospho-D-erythronate + NAD(+) = (3R)-3-hydroxy-2-oxo-4- phosphonooxybutanoate + NADH., pentose-phosphate shunt, -!- The enzyme acts in the opposite direction. -!- The enzymes from the plants Ocimum basilicum (sweet basil), Clarkia breweri and Petunia hybrida only accept coniferyl acetate and form eugenol. -!- The enzyme from Pimpinella anisum (anise) forms anol (from 4-coumaryl acetate) in vivo, although the recombinant enzyme can form eugenol from coniferyl acetate. -!- The enzyme from Larrea tridentata (creosote bush) also forms chavicol from a coumaryl ester and can use NADH., Ocimum basilicum, flavonoid biosynthetic process, Probable oxidoreductase, morphine biosynthetic process, -!- Involved in the synthesis of a cell-wall peptide in bacteria., peptidoglycan biosynthetic process, Propan-2-ol + NADP(+) = acetone + NADPH., (R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH., -!- Formerly EC 1.1.1.109., 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity, 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase., Putative glucose 1-dehydrogenase, D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding, 3-hydroxyadipyl-CoA dehydrogenase, Carveol dehydrogenase (MythA.01326.c, A0R518 homolog), Eimeria tenella, -!- Also acts on 3-(3,4-dihydroxyphenyl)lactate. -!- Involved with EC 2.3.1.140 in the biosynthesis of rosmarinic acid., 3-alpha-hydroxysteroid 3-dehydrogenase (Si-specific)., L-gulonate 3-dehydrogenase., Lambda-crystallin homolog, 336aa long hypothetical dTDP-glucose 4,6-dehydratase, Phenylalanine dehydrogenase., -!- Also converts diacetyl into acetoin with NADH as reductant., Trk system potassium uptake protein TrkA homolog, ribose phosphate biosynthetic process, protease binding, negative regulation of transcription from RNA polymerase II promoter by histone modification, positive regulation of histone deacetylation, protein domain specific binding, Staphylococcus aureus subsp. aureus str. Newman, positive regulation of cellular response to hypoxia, seed development, pathogenesis, L-aspartate dehydrogenase, angiotensin-activated signaling pathway, -!- Catalyzes the reaction in the reverse direction. -!- This enzyme from Streptomyces collinus is specific for (E)-but-2- enoyl-CoA, and is proposed to provide butanoyl-CoA as a starter unit for straight-chain fatty acid biosynthesis., antibiotic biosynthetic process, Hypothetical oxidoreductase ydfI, -!- In chloroplasts and cyanobacteria the enzyme acts on plant-type [2Fe- 2S] ferredoxins, but in other bacteria it can also reduce bacterial 2[4Fe-4S] ferredoxins and flavodoxin. -!- Formerly EC 1.6.7.1 and EC 1.6.99.4., Sinapyl alcohol dehydrogenase, Aspergillus fumigatus Af293, 307aa long hypothetical phosphoglycerate dehydrogenase, Synechococcus sp., Ensifer adhaerens, (2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-hydroxy-2-methyl- 3-oxobutanoate + NADH., -!- The product, 10-deoxymethynolide, contains a 12-membered ring and is an intermediate in the biosynthesis of methymycin in the bacterium Streptomyces venezuelae. -!- The enzyme also produces narbonolide (see EC 2.3.1.240). -!- The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain. -!- Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP). -!- Not all active sites are used in the biosynthesis., Fatty acid synthase subunit alpha, fatty acid synthase complex, BH1974 protein, L-arabinitol + NAD(+) = L-xylulose + NADH., L-serine + NAD(+) = 2-aminoacetaldehyde + CO(2) + NADH., NADPH--quinone reductase, NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase, Medicago sativa, 3-dehydroquinate = 3-dehydroshikimate + H(2)O., Sporosarcina psychrophila, PtmO8, Methylobacillus flagellatus KT, Methyltransferase FkbM, Aspergillus terreus, Enoyl reductase LovC, Versicolorin reductase, USG-1 protein homolog, Ruminiclostridium thermocellum ATCC 27405, Chorismate mutase--prephenate dehydrogenase. Hydroxyphenylpyruvate synthase., D-amino-acid oxidase activity, Trimethylamine dehydrogenase, Desulfovibrio vulgaris str. Hildenborough, Formaldehyde dehydrogenase., NAD-binding phsophogluconase dehydrogenase-like protein, folic acid metabolic process, bile acid catabolic process, L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H., regulation of lipid metabolic process, Molybdopterin-synthase adenylyltransferase., NADP-retinol dehydrogenase activity, Acyl-ACP dehydrogenase. Enoyl-ACP reductase., Enoyl-[acyl-carrier-protein] reductase [NADPH] FabL, butanediol metabolic process, Mannose isomerase., Putative oxidoreductase GLYR1, proline biosynthetic process, Hydroxymethyl-, formyl- and related transferases., Alanine dehydrogenase/pyridine nucleotide transhydrogenase, (S)-imine reductase, Saccharopine dehydrogenase, Ligases., Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI, -!- Present in some but not all Rhizobium species. -!- Differs from hepatic 1,5-anhydro-D-fructose reductase, which yields 1,5-anhydro-D-glucitol as the product (see EC 1.1.1.263). -!- In Sinorhizobium morelense, the product of the reaction, 1,5-anhydro- D-mannitol, can be further metabolized to D-mannose. -!- Also reduces 1,5-anhydro-D-erythro-hexo-2,3-diulose and 2-ketoaldoses (called osones), such as D-glucosone (D-arabino-hexos-2-ulose) and 6-deoxy-D-glucosone. -!- Does not reduce common aldoses and ketoses, or non-sugar aldehydes and ketones., Sporolactobacillus inulinus CASD, Serratia marcescens, Sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)., amino acid catabolic process to alcohol via Ehrlich pathway, -!- The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. -!- Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form. -!- No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315). -!- Also active with 3-alpha-hydroxysteroids., tetrahydrofolate metabolic process, uronate dehydrogenase activity, amino acid binding, threonine metabolic process, 2 reduced adrenodoxin + NADP(+) = 2 oxidized adrenodoxin + NADPH., UDP-sulfoquinovose synthase, chloroplastic, 3-hydroxybutyryl-coA dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic, cofactor catabolic process, Glycerate dehydrogenase related protein, (S)-1-Phenylethanol dehydrogenase, Pseudomonas fluorescens, GDP-mannose 4,6 dehydratase 2, Achromobacter xylosoxidans, Alcohol dehydrogenase (NADP(+))., Polaromonas sp. JS666, bile acid binding, bile acid metabolic process, 3-hydroxy acid dehydrogenase., L-allo-threonine + NADP(+) = aminoacetone + CO(2) + NADPH., Hypothetical oxidoreductase yciK, L-dihydroanticapsin + NAD(+) = L-anticapsin + NADH., dTDP-glucose 4,6-dehydratase activity, ethanol metabolic process, SUMO activating enzyme complex, 6,7-dihydropteridine reductase activity, Dictyostelium discoideum, Glycerate dehydrogenase/glyoxylate reductase, C-terminal binding protein 1, Nicotiana tabacum, Bifunctional dTDP-4-dehydrorhamnose 3,5-epimerase/dTDP-4-dehydrorhamnose reductase, Staphylococcus epidermidis RP62A, Rhodotorula graminis, positive regulation of ion transmembrane transporter activity, Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044, UDP-N-acetylglucosamine 4,6-dehydratase, MccB protein, D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate., Plasmodium falciparum, GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H(2)O., O antigen biosynthetic process, -!- Not identical with EC 1.3.1.37 (cf. EC 1.3.1.8)., Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH., Gallus gallus, L-lactate dehydrogenase B chain, (1) 2 putrescine = sym-homospermidine + NH(3) + H(+). (2) Putrescine + spermidine = sym-homospermidine + propane-1,3-diamine., Ubiquitin-like modifier-activating enzyme 1, protein ubiquitination, Methylglyoxal reductase (NADPH)., ergosterol metabolic process, Aromatoleum aromaticum EbN1, Alcohol dehydrogenase 1, 2-dehydropantoate 2-reductase activity, Alcohol dehydrogenase 1A, shikimate 3-dehydrogenase (NAD+) activity, ADP binding, NADPH dehydrogenase (quinone) activity, Dihydrofolate reductase., Solanum lycopersicum, Medicago truncatula, 7-alpha-hydroxysteroid dehydrogenase., Ralstonia solanacearum Po82, Rhodopseudomonas palustris CGA009, Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase, Comamonas testosteroni, Streptomyces avermitilis MA-4680 = NBRC 14893, (+)-lariciresinol + NADP(+) = (+)-pinoresinol + NADPH., lignan biosynthetic process, neuron apoptotic process, signal transduction, Sirohydrochlorin ferrochelatase., UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase., Flavanone 4-reductase., -!- Acts on coniferyl alcohol, sinapyl alcohol, 4-coumaryl alcohol and cinnamyl alcohol (cf. EC 1.1.1.194)., -!- Catalyzes the reaction only in the opposite direction. -!- Involved in taurine degradation. -!- The bacterium Chromohalobacter salexigens strain DSM 3043 possesses two enzymes that catalyze this reaction, a constitutive enzyme (encoded by isfD2) and an inducible enzyme (encoded by isfD). -!- The latter is induced by taurine, and is responsible for most of the activity observed in taurine-grown cells., -!- NAD(+) cannot replace NADP(+) (cf. EC 1.1.1.387)., -!- The enzyme from Escherichia coli shows specificity for the B side of NADPH., Glycerol 3-phosphate dehydrogenase (NAD(P)). Glycerol 3-phosphate dehydrogenase (NADP). Glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)). L-glycerol-3-phosphate:NAD(P) oxidoreductase., (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH., Glycerol-3-phosphate dehydrogenase 1-like protein, negative regulation of protein kinase C signaling, regulation of ventricular cardiac muscle cell membrane depolarization, Halohydrin epoxidase B, Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl- [acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]., Beta-ketoacyl-[acyl-carrier-protein] synthase I., 3-hydroxyacyl-[acyl-carrier-protein] dehydratase., A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl- carrier protein] + H(2)O., Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier- protein]., (+)-cis-isopulegone + NADP(+) = (-)-isopiperitenone + NADPH., Formate--tetrahydrofolate ligase., (2S)-2-((1-(R)-carboxyethyl)amino)pentanoate + NAD(+) + H(2)O = L-2- aminopentanoic acid + pyruvate + NADH., -!- NAD(+) and NADP(+) can be used as cofactors with similar efficiency, unlike EC 1.2.1.12 and EC 1.2.1.13, which are NAD(+)- and NADP(+)- dependent, respectively., NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase. Triosephosphate dehydrogenase (NAD(P)(+)). Triosephosphate dehydrogenase (NAD(P))., (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)(+) + H(2)O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H., 4-hydroxy-tetrahydrodipicolinate reductase., cellular amino acid biosynthetic process, L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H., threonine biosynthetic process, -!- Does not catalyze the reduction of artificial dyes. -!- Does not by itself catalyze a H(2)/H(+) exchange reaction. -!- Does not contain nickel or iron-sulfur clusters. -!- Formerly EC 1.12.99.4., Methanothermobacter marburgensis str. Marburg, aldo-keto reductase (NADP) activity, tetrahydrobiopterin biosynthetic process, Bartonella henselae str. Houston-1, Candidatus Korarchaeum cryptofilum OPF8, Enoyl-[acyl-carrier-protein] reductase [NADPH, B-specific] 1, mitochondrial, Ketimine reductase., negative regulation of transcription from RNA polymerase II promoter, sensory perception of sound, Leishmania major, Secoisolariciresinol dehydrogenase, GDP-mannose 3,5-epimerase, -!- Catalyzes the first step in NAD biosynthesis from aspartate. -!- Strictly specific for L-aspartate as substrate. -!- Has a higher affinity for NAD(+) than NADP(+)., osteoblast differentiation, positive regulation of transcription from RNA polymerase II promoter, viral genome replication, 2-alkenal reductase [NAD(P)] activity, NADP-specific glutamate dehydrogenase, 3-hydroxyisobutyrate dehydrogenase, Streptococcus agalactiae, UFM1 activating enzyme activity, intracellular membrane-bounded organelle, protein ufmylation, Succinyl-CoA synthetase (GDP-forming)., Malic enzyme. NAD-malic enzyme. Pyruvic-malic carboxylase., Agrobacterium tumefaciens, -!- The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22. -!- Forms part of the pathway that detoxifies formaldehyde, since the product is hydrolyzed by EC 3.1.2.12. -!- Also specifically reduces S-nitrosylglutathione. -!- Formerly EC 1.2.1.1., S-(hydroxymethyl)glutathione dehydrogenase., formaldehyde dehydrogenase activity, GDP-mannose 6-dehydrogenase activity, GDP-mannose 6-dehydrogenase., single-species biofilm formation, Prosthecochloris vibrioformis, 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase., response to steroid hormone, Glucose-fructose oxidoreductase., C-terminal-binding protein 1, presynapse to nucleus signaling pathway, Pyrobaculum calidifontis JCM 11548, Aeromonas hydrophila subsp. hydrophila ATCC 7966, Cyclohexanol dehydrogenase, UDP-glucose 4-epimerase (Eurofung), intracellular, Escherichia coli O157:H7, Putative Acetoacetyl-CoA reductase, Bifunctional protein FolD, Methenyltetrahydrofolate cyclohydrolase., Scyllo-inositol 2-dehydrogenase (NADP(+))., scyllo-inositol 2-dehydrogenase (NADP(+)), GAIT complex, aspartic-type endopeptidase inhibitor activity, killing by host of symbiont cells, NEDD8 activating enzyme activity, Galactose/lactose metabolism regulatory protein GAL80, Precorrin-2 + NAD(+) = sirohydrochlorin + NADH., 1-deoxy-D-xylulose-5-phosphate reductoisomerase., 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH., 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase., negative regulation of transcription, DNA-templated, positive regulation of B cell proliferation, Bordetella bronchiseptica, L-lactate dehydrogenase activity, Mus musculus, cilium, Corynebacterium glutamicum ATCC 13032, quinate 3-dehydrogenase (NAD+) activity, RNA binding, Pseudomonas aeruginosa PAO1, 6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH., Haloarcula marismortui ATCC 43049, chloroplast stroma, Glyoxylate reductase/hydroxypyruvate reductase, glycerate dehydrogenase activity, peroxisomal matrix, Eugenol synthase 1, Zinc-containing alcohol dehydrogenase superfamily, 'de novo' GDP-L-fucose biosynthetic process, -!- Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent., peroxisomal membrane, Trypanosoma cruzi, Protein FdrA, D-chiro-inositol 1-dehydrogenase., Pteridine reductase, putative, Homoserine dehydrogenase, -!- The enzyme catalyzes a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone. -!- The animal, but not the plant, form of the enzyme is inhibited by dicoumarol. -!- Formerly EC 1.6.99.2., 3-hydroxybutyrate dehydrogenase., Glyceraldehyde-3-phosphate dehydrogenase, glycosomal, N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD(+) + H(2)O = L-lysine + 2-oxoglutarate + NADH., Saccharomyces cerevisiae S288C, lysine biosynthetic process, short-chain fatty acid metabolic process, Acyl-CoA + NAD(+) = trans-didehydroacyl-CoA + NADH., Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5- tetradehydroacyl-CoA + NADPH., fatty acid beta-oxidation using acyl-CoA oxidase, fatty acid metabolic process, Glycerol-3-phosphate dehydrogenase (NAD(+))., sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH., N-acyl-D-mannosamine + NAD(+) = N-acyl-D-mannosaminolactone + NADH., N-acylmannosamine 1-dehydrogenase, Octenoyl-CoA reductase/carboxylase, kinase binding, response to glucose, (1) (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2- methyl-3-oxobutanoate + NADPH. (2) (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2- ethyl-3-oxobutanoate + NADPH., 3-hydroxybutyryl-CoA dehydrogenase, Clostridium butyricum E4 str. BoNT E BL5262, Schizosaccharomyces pombe 972h-, Ubiquitin-activating enzyme E1 1, -!- Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates., 3-oxoacyl-[acyl-carrier-protein] reductase., UDP-galactopyranose mutase activity, L-malate dehydrogenase activity, internal protein amino acid acetylation, Probable shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase), (+)-trans-carveol dehydrogenase., Glutamate dehydrogenase (NADP(+))., vacuole, Lactate/malate dehydrogenase., glycolytic process, holo-[acyl-carrier-protein] synthase activity, Alcohol dehydrogenase superfamily, zinc-containing, Bartonella henselae, Alcohol dehydrogenase zinc-binding domain protein, Aneurinibacillus thermoaerophilus, GDP-4-dehydro-6-deoxy-D-mannose reductase activity, Putative short-chain oxidoreductase, galactose catabolic process via UDP-galactose, UDP-N-acetylmuramate--L-alanine ligase., circadian sleep/wake cycle, nucleus, 3-alpha(or 20-beta)-hydroxysteroid dehydrogenase., Androstan-3-alpha,17-beta-diol + NAD(+) = 17-beta-hydroxyandrostan-3-one + NADH., nucleoplasm, Flavin mononucleotide reductase. Flavine mononucleotide reductase. FMN reductase (NADPH). NADPH dehydrogenase (flavin). NADPH-dependent FMN reductase. NADPH-flavin reductase. NADPH-FMN reductase. NADPH-specific FMN reductase. NADPH:flavin oxidoreductase. NADPH:riboflavin oxidoreductase. Riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase. Riboflavin mononucleotide reductase. Riboflavine mononucleotide reductase., biliverdin reductase activity, Dehydrogenase/reductase SDR family member 1, endoplasmic reticulum, Estradiol 17-beta-dehydrogenase 1, estrogen metabolic process, Thermococcus litoralis DSM 5473, Lmo0794 protein, Mycobacterium thermoresistibile ATCC 19527, Moorea producens 3L, UDP-glucuronate decarboxylase activity, extracellular exosome, 5-dehydroshikimate reductase. 5-dehydroshikimic reductase. Dehydroshikimic reductase. DHS reductase. Shikimate 5-dehydrogenase. Shikimate oxidoreductase. Shikimate:NADP(+) 5-oxidoreductase. Shikimate:NADP(+) oxidoreductase., Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic, Spinacia oleracea, L-lactate dehydrogenase, (R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH., -!- Catalyzes the first committed and rate-limiting step in the phosphoserine pathway of serine biosynthesis. -!- The reaction occurs predominantly in the direction of reduction. -!- The enzyme from the bacterium Escherichia coli also catalyzes the activity of EC 1.1.1.399., 2-hydroxyglutarate dehydrogenase activity, ATP + succinate + CoA = ADP + phosphate + succinyl-CoA., Malic dehydrogenase., ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose., ADP-glyceromanno-heptose 6-epimerase., protein binding, membrane, -!- The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids. -!- The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270. -!- The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+)., 17-beta-estradiol dehydrogenase. 17-beta-HSD. 17-beta-hydroxysteroid dehydrogenase. 20-alpha-hydroxysteroid dehydrogenase. Estrogen 17-oxidoreductase., selenium compound metabolic process, NAD+ binding, (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O., 3-hydroxybutyryl-CoA epimerase., Glucose 1-dehydrogenase related protein, -!- Acts in concert with EC 2.3.1.29 in the degradation of threonine to glycine. -!- This threonine-degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex. -!- In aqueous solution, the product L-2-amino-3-oxobutanoate can spontaneously decarboxylate to form aminoacetone., Enoyl-[acyl-carrier-protein] reductase [NADH], 15-oxoprostaglandin 13-reductase., -!- Also acts on L-arabinose, 6-deoxy- and 2-deoxy-D-galactose., -!- This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose., D-galactose + NADP(+) = D-galactono-1,5-lactone + NADPH., Galactose 1-dehydrogenase (NADP(+))., Glucose 1-dehydrogenase, galactose 1-dehydrogenase (NADP+) activity, Succinate thiokinase. Succinyl-CoA synthetase (ADP-forming)., Quinone oxidoreductase. Zeta-crystallin., L-xylitol metabolic process, Acylating acetaldehyde dehydrogenase. Aldehyde dehydrogenase (acylating)., aromatic compound catabolic process, Corticosteroid 11-beta-dehydrogenase., 5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = biopterin + 2 NADPH., Pteridine reductase, Trypanosoma brucei brucei, chlorophyll biosynthetic process, D-mycarose 3-C-methyltransferase, Streptomyces argillaceus, D-sorbitol + acceptor = L-sorbose + reduced acceptor., -!- The product, narbonolide, contains a 14-membered ring and is an intermediate in the biosynthesis of narbonomycin and pikromycin in the bacterium Streptomyces venezuelae. -!- The enzyme also produces 10-deoxymethynolide (see EC 2.3.1.239). -!- The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain. -!- Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP). -!- Not all active sites are used in the biosynthesis., Malonyl-CoA + 5 (2S)-methylmalonyl-CoA + 5 NADPH = 10-deoxymethynolide + 6 CoA + 6 CO(2) + 5 NADP(+) + 2 H(2)O., transferase activity, transferring acyl groups other than amino-acyl groups, L-3-aldonate dehydrogenase., Clostridium sardiniense, NADP-dependent alcohol dehydrogenase, membrane raft, acetaldehyde metabolic process, behavioral response to ethanol, hydroxymethylfurfural reductase (NADPH) activity, hydroxyphenylpyruvate reductase activity, Probable quinone oxidoreductase protein, response to lead ion, Streptococcus pyogenes, Enoyl-CoA Hydratase, 2 reduced ferredoxin + NADP(+) + H(+) = 2 oxidized ferredoxin + NADPH., Formaldehyde dismutase, 6-phosphogluconate dehydrogenase NAD-binding, Monoterpenoid dehydrogenase., dihydrobiopterin metabolic process, Leishmania tarentolae, 3-hydroxyacyl CoA reductase. Butyryl-CoA dehydrogenase. Enoyl-coenzyme A reductase. Ethylene reductase. Short-chain acyl-coenzyme A dehydrogenase. Unsaturated acyl coenzyme A reductase., response to salt stress, fruit development, Haloferax volcanii DS2, Putative exported protein, ATP-dependent protein binding, Dihydropteridine reductase, hormone binding, L-arogenate + NAD(+) = L-tyrosine + NADH + CO(2)., morphogenesis of an epithelium, vulval development, uncultured bacterium Bio5, NAD-dependent malic enzyme, Vestitone reductase., Oenococcus oeni PSU-1, 6-phospho-beta-glucosidase, Lysinibacillus sphaericus, NADPH-dependent reductase BacG, Chorismate = prephenate., Prephenate + NAD(+) = 4-hydroxyphenylpyruvate + CO(2) + NADH., Malate dehydrogenase (NAD(P)(+))., Peroxisomal hydratase-dehydrogenase-epimerase, L-arabinitol 4-dehydrogenase, L-serine 3-dehydrogenase (NAD(+))., L-serine catabolic process, MupS, Bemisia argentifolii, Phospho-alpha-glucosidase., AmphI, Shewanella oneidensis MR-1, D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH., fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway, Cyprinus carpio, Acetyl-CoA + n malonyl-CoA + 2n NADPH = long-chain-acyl-CoA + n CoA + n CO(2) + 2n NADP(+)., Novosphingobium aromaticivorans DSM 12444, NAD dependent epimerase/dehydratase, Mo-molybdopterin cofactor biosynthetic process, Molybdopterin-synthase adenylyltransferase, tetrahydrobiopterin metabolic process, Adenosylmethionine-uroporphyrinogen III methyltransferase. S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase. SUMT. Urogen III methylase. Uroporphyrin-III C-methyltransferase. Uroporphyrinogen III methylase. Uroporphyrinogen methyltransferase. Uroporphyrinogen-III methylase. Uroporphyrinogen-III methyltransferase., Monooxygenase, Malate dehydrogenase (NADP(+))., (S)-acetoin dehydrogenase., Diacetyl reductase ((S)-acetoin forming)., L-xylulose reductase (NADP+) activity, Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic, phosphatidic acid biosynthetic process, Estradiol 17-beta-dehydrogenase 11, steroid dehydrogenase activity, sn-glycerol 3-phosphate + NAD(P)(+) = glycerone phosphate + NAD(P)H., regulation of calcium-mediated signaling, regulation of peptidyl-tyrosine phosphorylation, 2-deoxy-D-gluconate + NAD(+) = 3-dehydro-2-deoxy-D-gluconate + NADH., Adrenodoxin reductase. Nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase., Sulfite:UDP-glucose sulfotransferase., Fragaria vesca, 2-(R)-hydroxypropyl-CoM dehydrogenase., Mannitol dehydrogenase, Putative dehydrogenase, possibly 3-oxoacyl-[acyl-carrier protein] reductase, methylated histone binding, Digitalis lanata, 3-keto sterol reductase activity, Uronate dehydrogenase., (S)-2-chloropropanoate + NADP(+) = 2-chloroacrylate + NADPH., -!- The enzyme acts in the degradation pathway of unsaturated organohalogen compounds by the bacterium Burkholderia sp. WS., 2-haloacrylate reductase, nuclear import, L-phenylalanine dehydrogenase. PheDH., -!- The enzyme is involved in degradation of ethylbenzene., PED., Halohydrin epoxidase A, Putative 6-phospho-beta-glucosidase, Protein induced by osmotic stress, alditol:NADP+ 1-oxidoreductase activity, Bradyrhizobium elkanii, Coxiella burnetii RSA 493, anaerobic ethylbenzene catabolic process, Oxidoreductase HTATIP2, brain development, Glyceraldehyde-3-phosphate dehydrogenase B, chloroplastic, cellular amino acid metabolic process, Ovis aries, Cinnamaldehyde + CoA + NADP(+) = cinnamoyl-CoA + NADPH., Acinetobacter baumannii AB307-0294, 3-hydroxyisobutyrate dehydrogenase, mitochondrial, pantothenate biosynthetic process from valine, Nucleotidyltransferases., Polyketide synthase PksJ, GDP-alpha-D-mannose = GDP-beta-L-galactose., L-ascorbic acid biosynthetic process, N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5- glutamyl phosphate + NADPH., Oryza sativa Japonica Group, Entamoeba histolytica, Scytalone + NADP(+) = 1,3,6,8-tetrahydroxynaphthalene + NADPH., C-terminal-binding protein 2, Gadus morhua callarias, Lactobacillus paracasei, Burkholderia thailandensis E264, Blastochloris viridis, GTP binding, (-)-pinoresinol-(-)-lariciresinol reductase. Pinoresinol-lariciresinol reductases. Pinoresinol/lariciresinol reductase., lariciresinol reductase activity, mitotic DNA replication checkpoint, regulation of neuron apoptotic process, NEDD8-activating enzyme E1 catalytic subunit, Pecten maximus, adenosine metabolic process, Mycobacterium marinum M, Potassium uptake protein TrkA, oxidoreductase complex, 6-phosphogluconate dehydrogenase, NAD-binding protein, Gluconobacter oxydans 621H, H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338, Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase, Clostridium tetani E88, Formyltetrahydrofolate synthetase. Tetrahydrofolate formylase. Tetrahydrofolic formylase., -!- Acts on [acyl-carrier-protein] thioesters of fatty acids from C(12) to C(18), but the derivative of oleic acid is hydrolyzed much more rapidly than any other compound tested., Acyl carrier protein malonyltransferase. Malonyl coenzyme A-acyl carrier protein transacylase. Malonyl transacylase. Malonyl transferase. Malonyl-CoA-acyl carrier protein transacylase. Malonyl-CoA/dephospho-CoA acyltransferase. MCAT., Siroheme biosynthesis protein MET8, -!- The first enzyme in the biosynthetic pathway of pseudaminic acid, a sialic-acid-like sugar that is unique to bacteria and is used by Helicobacter pylori to modify its flagellin. -!- Plays a critical role in H.pylori's pathogenesis, being involved in the synthesis of both functional flagella and lipopolysaccharides. -!- Completely inhibited by UDP-alpha-D-galactose. -!- The reaction results in the chirality of the C-5 atom being inverted. -!- It is thought that Lys-133 acts sequentially as a catalytic acid, protonating the C-6 hydroxy group and as a catalytic base, abstracting the C-5 proton, resulting in the elimination of water., ketone body biosynthetic process, 3-oxoacyl-[acyl-carrier-protein] reductase FabG1, -!- This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)- dihydromyricetin, although some enzymes may act only on a subset of these compounds. -!- Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4- diol. -!- NAD(+) can act instead of NADP(+), but more slowly., Dihydroflavonol 4-reductase, Dihydroflavonol 4-reductase. Dihydrokaempferol 4-reductase. NADPH-dihydromyricetin reductase., Bacteroides thetaiotaomicron VPI-5482, -!- Catalyzes the second step in the biphenyl degradation pathway in bacteria., 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase. Biphenyl-2,3-dihydro-2,3-diol dehydrogenase., 3-methylbutanol:NAD(P) oxidoreductase activity, methionine adenosyltransferase complex, D 3 phosphoglycerate dehydrogenase putative, Short chain dehydrogenase, Alcohol dehydrogenase 4, Porphyromonas gingivalis ATCC 33277, sodium channel regulator activity, Acyl-[acyl-carrier-protein] hydrolase. S-acyl fatty acid synthase thioesterase., Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier- protein]., fatty acid synthase activity, sodium ion binding, -!- The enzyme catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate, cf. EC 1.1.1.38 and EC 1.1.1.39., NADP-dependent malic enzyme, neutrophil degranulation, positive regulation of cell proliferation, Iridoid synthase, Probable hydroxyacid dehydrogenase protein, C-1-tetrahydrofolate synthase, cytoplasmic, Lactobacillus plantarum WCFS1, Clavaldehyde dehydrogenase, protein self-association, gluconeogenesis, Plasmodium falciparum 3D7, Diketoreductase, -!- NADP(+) is a poor substitute for NAD(+) in the enzyme from Pseudomonas stutzeri WM88., Pseudomonas stutzeri, Lactobacillus casei BL23, Brucella suis 1330, Ketol-acid reductoisomerase (NADP(+))., Slackia exigua ATCC 700122, Streptomyces cyanogenus, Lactobacillus kefiri, Short chain alcohol dehydrogenase-related dehydrogenase, Mycobacterium avium subsp. paratuberculosis K-10, Reticulon-4-interacting protein 1, mitochondrial, response to cadmium ion, Putative dehydrogenase, uncultured bacterium, Opine dehydrogenase, testosterone 17-beta-dehydrogenase (NADP+) activity, -!- Itaconate can act instead of succinate and ITP instead of GTP., (R)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH., aging, Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821, membrane fusion, presynapse, fermentation, oxidoreductase activity, NAD(P)+ transhydrogenase (B-specific) activity, 1L-myo-inositol-1-phosphate lyase (isomerizing). D-glucose 6-phosphate cycloaldolase. Glucocycloaldolase. Glucose 6-phosphate cyclase. Inositol 1-phosphate synthetase. Myo-inositol-1-phosphate synthase., A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H., UDP-galactopyranose mutase., Galactitol 1-phosphate + NAD(+) = D-tagatose 6-phosphate + NADH., Galactitol 1-phosphate 5-dehydrogenase, galactitol catabolic process, 3-Hydroxyacyl-CoA dehydrogenase, 3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH., NADP oxidoreductase, coenzyme F420-dependent, ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl- gamma-D-glutamyl-meso-2,6-diaminoheptanedioate., Rickettsia prowazekii str. Madrid E, Prostaglandin reductase 2, Gluconobacter frateurii, NADPH-sorbose reductase, Thermus thermophilus HB27, nitrogen catabolite repression of transcription, thylakoid, enzyme binding, Galactitol dehydrogenase, extracellular matrix, negative regulation of translation, 2,4-dienoyl-CoA reductase, mitochondrial, Streptomyces venezuelae, GDP-mannose 4,6-dehydratase., -!- Also uses the corresponding deoxynucleoside diphosphate derivative as a substrate., GDP-mannose 6-dehydrogenase, -!- The product is the cyclic imine of the 2-oxoacid corresponding to S-(2-aminoethyl)cysteine. -!- In the reverse direction, a number of other cyclic unsaturated compounds can act as substrates, more slowly., Ketimine reductase mu-crystallin, thyroid hormone transport, Macaca fascicularis, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase., pentose-phosphate shunt, oxidative branch, Prephenate dehydrogenase, response to drug, NAD(P)(+) transhydrogenase (AB-specific). Pyridine nucleotide transhydrogenase. Transhydrogenase., NAD(P)+ transhydrogenase (AB-specific) activity, 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone., ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase, NADP-dependent isopropanol dehydrogenase, Ubiquitin-conjugating enzyme E2 variant 3, [Pseudomonas syringae] pv. tomato str. DC3000, Myo-inositol 2-dehydrogenase., Putative nucleotide sugar epimerase/ dehydratase, electron carrier activity, Arabidopsis thaliana, Uncharacterized protein At5g02240, D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H., D-glycerate dehydrogenase., excretion, glyoxylate reductase (NADP) activity, hydroxypyruvate reductase activity, protein oligomerization, A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a 6,7-dihydropteridine + NAD(P)H., D-erythrose 4-phosphate + NAD(+) + H(2)O = 4-phosphoerythronate + NADH., pyridoxine biosynthetic process, alanine catabolic process, Similar to surfactin synthetase, -!- The enzyme from Euglena gracilis acts on crotonoyl-CoA and, more slowly, on trans-hex-2-enoyl-CoA and trans-oct-2-enoyl-CoA., -!- Best substrates for reduction contain a 2,4-diene structure with chain length C(8) or C(10)., GDP-L-fucose synthase, GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + NADPH., Ureibacillus thermosphaericus, response to estrogen, Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)., nitric oxide biosynthetic process, sepiapterin reductase activity, ATP binding, 5,10-methenyltetrahydromethanopterin hydrogenase., Burkholderia multivorans ATCC 17616, TrkA domain protein, Pseudomonas savastanoi pv. phaseolicola 1448A, anthocyanidin reductase activity, Sugar 3-ketoreductase, (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH., Bordetella pertussis Tohama I, Brucella abortus 2308, -!- The enzyme, found in the bacterium Bacillus subtilis, also catalyzes the reaction of EC 1.1.1.18 and can also use D-glucose and D-xylose. -!- It shows trace activity with D-ribose and D-fructose. -!- It is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA. -!- Formerly EC 1.1.1.n6., Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase, -!- Catalyzes a step in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea. -!- The reaction is catalyzed in the opposite direction to that shown. -!- The enzyme from Sulfolobus tokodaii does not act on either NADH or crotonyl-CoA. -!- Different from EC 1.3.1.8, which acts only on enoyl-CoA derivatives of carbon chain length 4 to 16., -!- Catalyzes the reversible reduction of salutaridine to salutaridinol, which is a direct precursor of morphinan alkaloids in the poppy plant., Ubiquitin-like modifier-activating enzyme ATG7, autophagy, D-alanine catabolic process, dopamine biosynthetic process, (+)-trans-carveol + NAD(+) = (+)-(S)-carvone + NADH., Carveol dehydrogenase, Mycobacterium smegmatis str. MC2 155, Caulobacter crescentus CB15, -!- Acts on prostaglandins E(2), F(2-alpha) and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.196 and EC 1.1.1.197)., transforming growth factor beta receptor signaling pathway, L-threonine dehydrogenase, Oxidoreductase, short-chain dehydrogenase/reductase family protein, Bordetella bronchiseptica RB50, Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic, cytoplasm, estradiol 17-beta-dehydrogenase activity, steroid binding, steroid biosynthetic process, Adenosylhomocysteinase., S-adenosylhomocysteine catabolic process, Aldehyde reductase YahK, Thiobacillus denitrificans ATCC 25259, UDP-D-quinovosamine 4-dehydrogenase, 1,3,6,8-tetrahydroxynaphthalene reductase, 4 iron, 4 sulfur cluster binding, -!- The activity is part of a bifunctional enzyme also performing the reaction of EC 2.1.2.13. -!- Formerly EC 1.1.1.n1., UDP-4-amino-4-deoxy-L-arabinose formyltransferase., Alcohol dehydrogenase 1C, Glutamate dehydrogenase 1, mitochondrial, UDP-glucose 4-epimerase activity, UDP-glucose 4-epimerase., galactose catabolic process, NADP-dependent mannitol dehydrogenase., alcohol dehydrogenase activity, zinc-dependent, plasma membrane, riboflavin reductase (NADPH) activity, racemase and epimerase activity, acting on carbohydrates and derivatives, D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH., 3-phosphoglycerate dehydrogenase. 3-phosphoglyceric acid dehydrogenase. 3PHP reductase. Alpha-KG reductase. Alpha-phosphoglycerate dehydrogenase. D-3-phosphoglycerate dehydrogenase. Glycerate 3-phosphate dehydrogenase. Glycerate-1,3-phosphate dehydrogenase. PGDH. Phosphoglycerate oxidoreductase. Phosphoglyceric acid dehydrogenase., Glutamate dehydrogenase (NAD(P)(+))., Equus caballus, ADP-L-glycero-D-manno-heptose-6-epimerase, -!- The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety. -!- The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18. -!- The enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons., Enoyl-ACP reductase. NADH-enoyl acyl carrier protein reductase. NADH-specific enoyl-ACP reductase., Enoyl-[acyl-carrier-protein] reductase (NADH)., Thermus thermophilus HB8, 11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11- alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H., Prostaglandin reductase 3, D-galactose + NAD(+) = D-galactono-1,4-lactone + NADH., non-phosphorylated glucose catabolic process, Mycobacterium tuberculosis H37Rv, fatty acid binding, Streptococcus pneumoniae TIGR4, -!- Acts in the reverse direction. -!- With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74)., Beta-hydroxyacyl dehydrogenase. Beta-keto-reductase., Succinate--CoA ligase [ADP-forming] subunit alpha, fructose biosynthetic process, glucuronate catabolic process to xylulose 5-phosphate, NADP binding, acetaldehyde dehydrogenase (acetylating) activity, Shikimate dehydrogenase., Citrullus lanatus, cellular response to DNA damage stimulus, CDP-D-glucose-4,6-dehydratase, Thermoplasma acidophilum DSM 1728, flagellated sperm motility, 3-hydroxyacyl-CoA dehydrogenase activity, D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH., Elizabethkingia meningoseptica, Mannitol dehydrogenase., hydroxymethylfurfural reductase (NADH) activity, negative regulation of histone acetylation, Neisseria meningitidis FAM18, Alcohol dehydrogenase, zinc-containing, Mycobacterium thermoresistibile, Putative C-1-tetrahydrofolate synthase,cytoplasmic, (S)-malate + NAD(+) = pyruvate + CO(2) + NADH., Putative malic enzyme ((S)-malate:NAD+ oxidoreductase (Decarboxylating)), (1) L-threo-7,8-dihydrobiopterin + NADP(+) = sepiapterin + NADPH. (2) L-threo-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8- tetrahydropterin + 2 NADPH., 2-hydroxy-3-oxopropionate reductase, Plesiocystis pacifica SIR-1, small protein activating enzyme binding, SUMO binding, Vibrio vulnificus, Magnetospirillum magnetotacticum MS-1, Peroxisomal trans-2-enoyl-CoA reductase, phytol metabolic process, enterobactin biosynthetic process, Plasmodium berghei, Hydroxyphenylpyruvate reductase., L-gulonate + NAD(+) = 3-dehydro-L-gulonate + NADH., cytoplasmic side of plasma membrane, Voltage-gated potassium channel Kch, -!- Also reacts with other thiols and H(2)S, producing homocysteine or thioethers. -!- The name methionine synthase is more commonly applied to EC 2.1.1.13. -!- The enzyme from Saccharomyces cerevisiae also catalyzes the reaction of EC 2.5.1.47, but more slowly. -!- Formerly EC 4.2.99.10., O-acetyl-L-homoserine + methanethiol = L-methionine + acetate., O-acetylhomoserine aminocarboxypropyltransferase., Brucella suis ATCC 23445, Anabaena variabilis ATCC 29413, NAD-dependent L-serine dehydrogenase, Isoflavone reductase, Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic, spermatid development, Crotonyl CoA reductase, Beutenbergia cavernae DSM 12333, An n-alkanal + NADP(+) = an alk-2-enal + NADPH., NADPH-dependent alkenal/one oxidoreductase., -!- Occurs in a complex with EC 1.1.1.133., dTDP-4-dehydrorhamnose 3,5-epimerase., dTDP-4-keto-6-deoxyglucose 3,5-epimerase. dTDP-L-rhamnose synthetase. Thymidine diphospho-4-ketorhamnose 3,5-epimerase., response to aluminum ion, response to glucagon, 6-phosphogluconate dehydrogenase, decarboxylating 1, Aeromonas salmonicida subsp. salmonicida A449, Homoserine dehydrogenase related protein, Carbonyl reductase [NADPH] 3, Streptomyces sp. A7248, (+)-neomenthol dehydrogenase., -!- Acts on a number of other cyclohexanols and cyclohexenols. -!- Not identical with EC 1.1.1.207., Butanoyl-CoA + NADP(+) = (E)-but-2-enoyl-CoA + NADPH., Pimelobacter simplex, Catabolic NAD-specific glutamate dehydrogenase RocG, ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA., Acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating). Adenosine triphosphate citrate lyase. ATP citrate (pro-S)-lyase. ATP-citrate (pro-S-)-lyase. ATP-citric lyase. ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating). Citrate cleavage enzyme. Citrate-ATP lyase. Citric cleavage enzyme., acetyl-CoA biosynthetic process, citrate metabolic process, Glutathione-independent formaldehyde dehydrogenase, Tylactone synthase starter module and modules 1 & 2, Phenylcoumaran benzylic ether reductase PT1, Parabacteroides merdae ATCC 43184, TR-I. Tropine dehydrogenase. Tropinone reductase., histone binding, 3-oxo-Delta(4,5)-steroid 5-beta-reductase, Citrobacter sp. MY-5, Triphenylmethane reductase, NADP biosynthetic process, response to carbohydrate, CDP-paratose 2-epimerase., Secondary alcohol dehydrogenase, vitamin K metabolic process, benzaldehyde dehydrogenase activity, Lin1944 protein, Isethionate + NADP(+) = 2-sulfoacetaldehyde + NADPH., ion channel binding, positive regulation of sodium ion transport, Staphylococcus aureus M1064, Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1, Pseudomonas putida, 8-hydroxy-5-deazaflavin:NADPH oxidoreductase., F420-dependent NADP reductase, Bifunctional protein MdtA, 1,5-anhydro-D-fructose reductase, ElxO, Cinnamoyl-CoA reductase., Helicobacter pylori 51, Enoyl-[acyl-carrier-protein] reductase., Aspartate-semialdehyde dehydrogenase 1, Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases), 3-oxoacyl-(Acyl carrierprotein) reductase, Putative leucoanthocyanidin reductase 1, Carbonyl reductase, 2-deoxy-D-gluconate 3-dehydrogenase, methylenetetrahydrofolate dehydrogenase (NAD+) activity, Adrenodoxin-NADP(+) reductase., cellular response to phosphate starvation, Dihydroanticapsin 7-dehydrogenase., Methylenetetrahydrofolate dehydrogenase [NAD(+)], folic acid-containing compound biosynthetic process, Probable quinone oxidoreductase, MxaA, 17-beta-HSD. 17-ketoreductase., Testosterone + NAD(+) = androstenedione + NADH., D-isomer specific 2-hydroxyacid dehydrogenase family protein, Klebsiella pneumoniae 342, OCD. Ornithine cyclase. Ornithine cyclase (deaminating)., AU-rich element binding, vitamin B6 catabolic process, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Streptomyces chartreusis, Streptococcus agalactiae NEM316, Mycobacterium leprae TN, Streptomyces fradiae, Cinnamyl-alcohol dehydrogenase-like protein, N-acetyl-gamma-glutamyl-phosphate reductase, (2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (10-deoxymethynolide forming)., phosphopantetheine binding, 439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme], Alpha-N-acetylgalactosaminidase., N-acetyl-glutamate semialdehyde dehydrogenase. NAGSA dehydrogenase., nitrogen catabolite repression of transcription from RNA polymerase II promoter, negative regulation of cell proliferation, response to oxidative stress, extrinsic component of membrane, Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)., Brassica napus, ketol-acid reductoisomerase activity, Arthrobacter sp. AD2, 3-hydroxybutyrate dehydrogenase type 2, 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity, Xylitol + NADP(+) = L-xylulose + NADPH., Probable short-chain dehydrogenase, Oxidoreductase, enoyl-[acyl-carrier-protein] reductase activity, Alcohol dehydrogenase, -!- Also acts, in the reverse direction, on L-ornithine, L-lysine and L-histidine., N(2)-(D-1-carboxyethyl)-L-arginine + NAD(+) + H(2)O = L-arginine + pyruvate + NADH., Octopine dehydrogenase, Precorrin-2 dehydrogenase., 4-hydroxybutanoate + NADP(+) = succinate semialdehyde + NADPH., UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase, Thermoanaerobacter ethanolicus JW 200, Xanthine dehydrogenase, glutamate dehydrogenase (NADP+) activity, -!- The reaction of this enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: NAD(+)-dependent dehydrogenation of putrescine, transfer of the 4-aminobutylidene group from dehydroputrescine to a second molecule of putrescine and reduction of the imine intermediate to form homospermidine. -!- Hence the overall reaction is transfer of a 4-aminobutyl group. -!- Differs from EC 2.5.1.45, which cannot use putrescine as donor of the aminobutyl group., Homospermidine synthase., glutamate dehydrogenase (NAD+) activity, positive regulation of insulin secretion, 3-oxoacyl-(Acyl carrier protein) reductase, inositol-3-phosphate synthase activity, (+)-pinoresinol reductase., -!- The reaction is catalyzed in vivo in the opposite direction to that shown. -!- A multifunctional enzyme that usually further reduces the product to (+)-secoisolariciresinol (EC 1.23.1.4). -!- Isolated from the plants Thuja plicata (western red cedar), Linum perenne (perennial flax) and Arabidopsis thaliana (thale cress)., Thuja plicata, ubiquitin protein ligase binding, Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841, -!- Forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway, which is used in most eubacteria, and in all archaebacteria, algae and plants. -!- However, in the alpha-proteobacteria EC 2.3.1.37 is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine. -!- This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic alpha-proteobacterium. -!- Although higher plants do not possess EC 2.3.1.37, the protistan Euglena gracilis possesses both the C5 pathway and EC 2.3.1.37., Columba livia, regulation of cellular extravasation, uropod, Lyngbya majuscula, Rhizobium etli CFN 42, one-carbon metabolic process, Corynebacterium sp., pyrroline-5-carboxylate reductase activity, Glycerol-3-phosphate dehydrogenase (NAD(P)(+))., L-lactate dehydrogenase 2, 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NAD(+) = 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta-cholanate + NADH., Possible short chain dehydrogenase, 3-ketoacyl-acyl carrier protein synthase. 3-oxoacyl-[acyl-carrier-protein] synthase. Acyl-malonyl acyl carrier protein-condensing enzyme. Acyl-malonyl(acyl-carrier-protein)-condensing enzyme. Beta-ketoacyl acyl carrier protein synthase. Beta-ketoacyl synthetase. Beta-ketoacyl-[acyl carrier protein] synthase. Beta-ketoacyl-ACP synthase I. Beta-ketoacyl-ACP synthetase. Beta-ketoacyl-acyl carrier protein synthetase. Beta-ketoacylsynthase. Condensing enzyme. Fatty acid condensing enzyme. KAS I., (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase. Beta-hydroxyoctanoyl thioester dehydratase. Beta-hydroxyoctanoyl-ACP-dehydrase. Beta-hydroxyoctanoyl-acyl carrier protein dehydrase. D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase., -!- Essential, along with EC 2.3.1.39, for the initiation of fatty-acid biosynthesis in bacteria. -!- The substrate acetyl-CoA protects the enzyme against inhibition by N-ethylmaleimide or iodoacetamide. -!- This is one of the activities associated with EC 2.3.1.180., ACAT. Acetyl coenzyme A-acyl-carrier-protein transacylase. ACP acetyltransferase. Acyl-carrier-protein acetyltransferase., Sulfur carrier protein ThiS adenylyltransferase., Sorghum bicolor, Tryptophan dehydrogenase, Tryptophan dehydrogenase., sperm fibrous sheath, sperm principal piece, -!- This enzyme catalyzes a hydration step in peroxisomal beta-oxidation. -!- The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units. -!- The enzymes from Aeromonas caviae and Arabidopsis thaliana are monofunctional enzymes. -!- 2-enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2., -!- This enzyme catalyzes the final step in the de novo synthesis of tetrahydrobiopterin from GTP. -!- The enzyme, which is found in higher animals and some fungi and bacteria, produces the erythro form of tetrahydrobiopterin. -!- Cf. EC 1.1.1.325., G6PD. G6PDH. Glucose-6-phosphate 1-dehydrogenase. Glucose-6-phosphate dehydrogenase. GPD., Zingiber officinale double bond reductase, 3-hydroxyacyl-CoA dehydrogenase, putative, Acetohydroxy acid isomeroreductase. Alpha-keto-beta-hydroxylacyl reductoisomerase. Dihydroxyisovalerate dehydrogenase (isomerizing)., canonical glycolysis, apicoplast, C alpha-dehydrogenase, Atg12 activating enzyme activity, mitophagy, (R)-3-hydroxyacyl-CoA + NADP(+) = 3-oxoacyl-CoA + NADPH., Acetoacetyl-CoA reductase, Acetoacetyl-CoA reductase., cofactor binding, Enterococcus faecium, Trans-2-enoyl-CoA reductase (NAD(+))., Peroxisomal 2,4-dienoyl-CoA reductase, Glycerol-3-phosphate dehydrogenase [NAD(+)] 1, glycerol-3-phosphate dehydrogenase [NAD+] activity, protein import into peroxisome matrix, receptor antagonist activity, retinoid metabolic process, -!- Studies of the enzyme from the bacterium Escherichia coli have shown that the enzyme accepts (2S,4S)-4-hydroxy-2,3,4,5- tetrahydrodipicolinate and not (S)-2,3-dihydrodipicolinate as originally thought. -!- Formerly EC 1.3.1.26., N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP(+) + H(2)O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH., Saccharopine dehydrogenase (NADP(+), L-glutamate-forming)., GDP-mannose 4,6-dehydratase, alginic acid biosynthetic process, -!- One of the activities of EC 2.3.1.86, an enzyme found in yeasts (Ascomycota and the Basidiomycota). -!- Catalyzes the reduction of enoyl-acyl-[acyl-carrier protein] derivatives of carbon chain length from 4 to 16. -!- The yeast enzyme is Si-specific with respect to NADP(+). -!- Cf. EC 1.3.1.39 and EC 1.3.1.104 which describes enzymes whose stereo-specificity toward NADPH is not known. -!- See also EC 1.3.1.9., Enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)., GTP + succinate + CoA = GDP + phosphate + succinyl-CoA., Succinate--CoA ligase [GDP-forming] subunit alpha, NAD-dependent malic enzyme, mitochondrial, regulation of NADP metabolic process, Halohydrin dehalogenase, Putative quinone oxidoreductase YhfP, T4HN reductase., Tetrahydroxynaphthalene reductase., long-chain-enoyl-CoA hydratase activity, Putative quinone-oxidoreductase homolog, chloroplastic, Galactitol-1-phosphate 5-dehydrogenase., malate metabolic process, Lactobacillus pentosus, Burkholderia pseudomallei 1026b, WbbW, response to toxic substance, Gluconate 5-dehydrogenase., lipid particle, nuclear membrane, positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction, post-translational protein modification, Inositol-3-phosphate synthase., Myo-inositol-1-phosphate synthase (Ino1), Cavia porcellus, Prostaglandin reductase 1, Thiomorpholine 3-carboxylate + NAD(P)(+) = 3,4-dehydro-thiomorpholine-3- carboxylate + NAD(P)H., (-)-secoisolariciresinol + 2 NAD(+) = (-)-matairesinol + 2 NADH., GDP-mannose 3,5-epimerase activity, mitochondrion, Chalcone/stilbene synthase family protein, Eugenol synthase., Aspartate-semialdehyde dehydrogenase 2, Lactobacillus brevis, NAD(P)(+) transhydrogenase (Re/Si-specific)., Corticosteroid 11-beta-dehydrogenase isozyme 1, endoplasmic reticulum membrane, Chloroflexus aurantiacus J-10-fl, L-alanine + H(2)O + NAD(+) = pyruvate + NH(3) + NADH., protein autophosphorylation, 15-oxo-Delta(13)-prostaglandin reductase. Prostaglandin 13-reductase., Sulfolobus solfataricus, galactose catabolic process via D-galactonate, 3,2-trans-enoyl-CoA isomerase. Acetylene-allene isomerase. Delta(3),Delta(2)-enoyl-CoA isomerase. Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase. Dodecenoyl-CoA Delta-isomerase., 3-hydroxyacyl-CoA dehydrogenase., Trypanosoma brucei brucei TREU927, Oxidoreductases., Thermoanaerobacter brockii, Burkholderia pseudomallei 1710b, Myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + NADH., Actinomadura kijaniata, With a quinone or similar compound as acceptor., Salutaridinol + NADP(+) = salutaridine + NADPH., UDP-glucose metabolic process, response to abscisic acid, vacuolar membrane, -!- Also reduces hydroxypyruvate to glycerate. -!- Has some affinity for NAD(+)., ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate., D-glutamate ligase. D-glutamate-adding enzyme. MurD synthetase. UDP-Mur-NAC-L-Ala:D-Glu ligase. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase. UDP-N-acetylmuramoylalanine--D-glutamate ligase. Uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase., Azoreductase. Dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone). Diaphorase. DT-diaphorase. Flavoprotein NAD(P)H-quinone reductase. Menadione oxidoreductase. Menadione reductase. NAD(P)H dehydrogenase. NAD(P)H menadione reductase. NAD(P)H(2) dehydrogenase (quinone). NAD(P)H-quinone dehydrogenase. NAD(P)H-quinone oxidoreductase. NAD(P)H: menadione oxidoreductase. NAD(P)H:(quinone-acceptor)oxidoreductase. NADH-menadione reductase. Naphthoquinone reductase. p-benzoquinone reductase. Phylloquinone reductase. Quinone reductase. Reduced NAD(P)H dehydrogenase. Reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase. Viologen accepting pyridine nucleotide oxidoreductase. Vitamin K reductase. Vitamin-K reductase., (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH., D-beta-hydroxybutyrate dehydrogenase., Pteridine reductase 1. PTR1., extracellular region, Glyoxylate reductase, L-threonine 3-dehydrogenase, Flavobacterium sp. 141-8, Salmonella enterica subsp. enterica serovar Typhi, response to cAMP, Enoyl-[acyl-carrier-protein] reductase [NADPH], Staphylococcus aureus subsp. aureus N315, Epimerase family protein SDR39U1, Putative epimerase, -!- Catalyzes the ATP-dependent activation of ubiquitin through the formation of a thioester bond between the C-terminal glycine of ubiquitin and the sulfhydryl side group of a cysteine residue in the E1 protein. -!- The two-step reaction consists of the ATP-dependent formation of an E1-ubiquitin adenylate intermediate in which the C-terminal glycine of ubiquitin is bound to AMP via an acyl-phosphate linkage, then followed by the conversion to an E1-ubiquitin thioester bond via the cysteine residue on E1 in the second step. -!- Formerly EC 6.3.2.19 and EC 6.3.2.21., ubiquitin activating enzyme activity, ADP-ribosyl cyclase. Beta-NAD(+) glycohydrolase. Diphosphopyridine nucleosidase. DPN hydrolase. DPNase. NAD glycohydrolase. NAD nucleosidase. NAD(+) nucleosidase. NADase. Nicotinamide adenine dinucleotide glycohydrolase. Nicotinamide adenine dinucleotide nucleosidase., Short-chain type dehydrogenase/reductase, Sinorhizobium meliloti 1021, Saccharopine dehydrogenase (NAD(+), L-lysine-forming)., Short-chain dehydrogenase/reductase SDR, 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity, Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial, fatty acid beta-oxidation, chloroplast, GDP-L-fucose synthase activity, isomerase activity, Alclohol dehydrogenase/short-chain dehydrogenase, (R)-specific carbonyl reductase, 1-deoxyxylulose-5-phosphate reductoisomerase. DXP-reductoisomerase., isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway, Anthocyanidin reductase ((2S)-flavan-3-ol-forming)., NADH binding, (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl- CoA = (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl- CoA + H(2)O., -!- Differs from EC 1.1.1.187 in that the only product formed is GDP- alpha-D-rhamnose (GDP-6-deoxy-alpha-D-mannose). -!- D-rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria., GDP-4-keto-6-deoxy-D-mannose reductase. GDP-6-deoxy-D-lyxo-4-hexulose reductase., L-arabinitol 4-dehydrogenase activity, Vestitone + NADP(+) = 2'-hydroxyformononetin + NADPH., 3-dehydroquinate dehydratase., embryo development ending in seed dormancy, mRNA polyadenylation, regulation of ion transmembrane transporter activity, Tropinone reductase 1, Mycobacterium fortuitum subsp. fortuitum DSM 46621 = ATCC 6841, Aster yellows witches'-broom phytoplasma AYWB, Bilirubin + NAD(P)(+) = biliverdin + NAD(P)H., Biliverdin reductase., L-iditol 2-dehydrogenase, [Clostridium] scindens ATCC 35704, Hypothetical oxidoreductase, Mannitol-1-phosphate 5-dehydrogenase, L-glutamate + H(2)O + NAD(P)(+) = 2-oxoglutarate + NH(3) + NAD(P)H., pyruvate biosynthetic process, -!- The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi- functional protein complex composed of two subunits. -!- One subunit catalyzes the reactions EC 1.1.1.100 and EC 2.3.1.41, while the other subunit catalyzes the reactions of EC 2.3.1.38, EC 2.3.1.39, EC 4.2.1.59, EC 1.3.1.10 and EC 1.1.1.279. -!- The enzyme differs from the animal enzyme (EC 2.3.1.85) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid., long-chain fatty acid biosynthetic process, PaaA, Acinetobacter calcoaceticus, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, Salinibacter ruber DSM 13855, Pyrobaculum islandicum DSM 4184, Hypothetical 3-oxoacyl-(Acyl-carrier protein) reductase, CurK, -!- Group of enzymes whose specificity is directed mainly toward the exohydrolysis of 1,4-alpha-glucosidic linkages, and that hydrolyze oligosaccharides rapidly, relative to polysaccharides, which are hydrolyzed relatively slowly, or not at all. -!- The intestinal enzyme also hydrolyzes polysaccharides, catalyzing the reactions of EC 3.2.1.3, and, more slowly, hydrolyzes 1,6-alpha-D- glucose links., dTDP-4-dehydrorhamnose reductase, colanic acid biosynthetic process, cytosol, Trimethylamine + H(2)O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein., -!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4., S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine., homocysteine biosynthetic process, neuron projection, (R)-20-hydroxysteroid dehydrogenase. Cortisone reductase., ethanol oxidation, -!- The enzyme from Entamoeba histolytica reduces riboflavin and galactoflavin, and, more slowly, FMN and FAD. -!- NADH is oxidized more slowly than NADPH. -!- Formerly EC 1.6.8.2., UDP-D-xylose biosynthetic process, hydroxymethyl-, formyl- and related transferase activity, lipid A biosynthetic process, response to antibiotic, GAPDH. NAD-dependent glyceraldehyde-3-phosphate dehydrogenase. Triosephosphate dehydrogenase., D-lactic acid dehydrogenase. D-lactic dehydrogenase., Alanine-adding enzyme. L-Ala ligase. L-alanine-adding enzyme. MurC synthetase. UDP-acetylmuramyl-L-alanine synthetase. UDP-MurNAc:L-alanine ligase. UDP-N-acetylmuramoyl-L-alanine synthetase. UDP-N-acetylmuramoylalanine synthetase. UDP-N-acetylmuramyl:L-alanine ligase. UDPMurNAc-L-alanine synthetase. Uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase. Uridine diphosphate N-acetylmuramate:L-alanine ligase. Uridine diphospho-N-acetylmuramoylalanine synthetase. Uridine-diphosphate-N-acetylmuramate:L-alanine ligase., Acetaldehyde dehydrogenase, nucleotide binding, NADP-dependent glyceraldehyde-3-phosphate dehydrogenase. Triosephosphate dehydrogenase (NADP(+)). Triosephosphate dehydrogenase (NADP+)., With NAD(+) or NADP(+) as acceptor., Quinone oxidoreductase 1, Glucitol dehydrogenase. Polyol dehydrogenase. Sorbitol dehydrogenase., sorbitol catabolic process, Aspartate-semialdehyde dehydrogenase, UDP-glucose 4-epimerase, protein homodimerization activity, NADP-dependent mannitol dehydrogenase, lipopolysaccharide core region biosynthetic process, pyruvate metabolic process, Quinate + NAD(+) = 3-dehydroquinate + NADH., (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methylacetoacetyl-CoA + NADH., branched-chain amino acid catabolic process, 2-(hydroxymethyl)glutarate dehydrogenase, Kluyveromyces marxianus, 3-(4-hydroxyphenyl)lactate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + NADH., 3-alpha-HSD. 3-alpha-hydroxysteroid 3-dehydrogenase (B-specific). 3-alpha-hydroxysteroid dehydrogenase (B-specific). Hydroxyprostaglandin dehydrogenase., Pseudomonas sp. B-0831, cell surface, phosphorus-oxygen lyase activity, -!- Also oxidizes other L-3-hydroxyacids., Acting on the CH-OH group of donors., Dehydrogenase/reductase SDR family member 11, positive regulation of protein targeting to mitochondrion, SUMO activating enzyme activity, ubiquitin-like protein conjugating enzyme binding, -!- Arogenate dehydrogenases may utilize NAD(+) (EC 1.3.1.43), NADP(+) (EC 1.3.1.78), or both (EC 1.3.1.79). -!- NAD(+)-specific enzymes have been reported from some bacteria and plants. -!- Some enzymes also possess the activity of EC 1.3.1.12., Arogenate dehydrogenase., NADPH-dependent carbonyl reductase, Brucella melitensis ATCC 23457, uncultured archaeon GZfos26G2, Bacillus thuringiensis serovar kurstaki, dTDP-4-dehydrorhamnose reductase, rfbD ortholog, Populus tremuloides, -!- Enzyme-bound NADPH formed by oxidation of formaldehyde to formate is oxidized back to NADP(+) by reaction with a second formaldehyde, yielding methanol. -!- The enzyme from Mycobacterium sp. DSM 3803 also catalyzes the reactions of EC 1.1.99.36 and EC 1.1.99.37. -!- Formaldehyde and acetaldehyde can act as donors; formaldehyde, acetaldehyde and propanal can act as acceptors. -!- Formerly EC 1.2.99.4., 2,3-DHB dehydrogenase., 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, NADPH-ferredoxin reductase FprA, phagocytic vesicle, Putative blue fluorescent protein, unidimensional cell growth, Aldehyde reductase (NADPH)., NADP-dependent alcohol dehydrogenase 6, Burkholderia sp., Ketol-acid reductoisomerase (NAD(P)(+)), 7-alpha-hydroxysteroid deydrogenase, Amino acid-binding ACT:D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain:D-isomer specific 2-hydroxyacid dehydr, response to caffeine, response to estradiol, response to heat, Prephenate dehydrogenase., Histamine dehydrogenase, -!- The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 and EC 6.2.1.18. -!- Formerly EC 4.1.3.8., oxaloacetate metabolic process, thyroid hormone metabolic process, Glyceraldehyde-3-phosphate dehydrogenase 3, 6-deoxyerythronolide B synthase. DEBS. Deoxyerythronolide B synthase. Erythronolide synthase. Erythronolide-condensing enzyme., Saccharopolyspora erythraea, Nucleoside-diphosphate-sugar epimerase, UDP-4-keto-rhamnose-4-keto-reductase activity, dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose., dTDP-4-dehydrorhamnose 3,5-epimerase activity, dTDP-rhamnose biosynthetic process, Cryptococcus neoformans var. neoformans JEC21, Brucella abortus bv. 1 str. 9-941, liver development, D-2-hydroxyacid dehydrogensase protein, Ketogulonicigenium vulgare Y25, Bifunctional protein GAL10, Flavobacterium frigidimaris, mRNA 3'-UTR binding, visual perception, Intramolecular oxidoreductases., formate-tetrahydrofolate ligase activity, Methanopyrus kandleri AV19, (1) (S)-malate + NADP(+) = pyruvate + CO(2) + NADPH. (2) Oxaloacetate = pyruvate + CO(2)., -!- Does not decarboxylate added oxaloacetate., Micromonospora chalcea, Cladosporium herbarum, HL08057p, Glyceraldehyde-3-phosphate dehydrogenase A, UDP-alpha-D-sulfoquinovose + H(2)O = UDP-alpha-D-glucose + sulfite., sulfotransferase activity, Inositol dehydrogenase, ethanol biosynthetic process involved in glucose fermentation to ethanol, Probable phosphoglycerate oxidoreductase protein, -!- The enzyme acts on the hemiacetal form of the substrate., regulation of multicellular organism growth, CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose., CDP-paratose 2-epimerase, Leuconostoc mesenteroides, molybdopterin-synthase adenylyltransferase activity, Biliverdin reductase A, -!- This enzyme catalyzes the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol. -!- It can also catalyze the irreversible reduction of diacetyl to (S)- acetoin., Chromohalobacter salexigens DSM 3043, Short-chain dehydrogenase/reductase SDR:Glucose/ribitol dehydrogenase, Trichomonas vaginalis, -!- The enzyme, purified from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, shows activity with a range of 3- and 4-carbon 3-hydroxy acids. -!- The highest activity is seen with L-allo-threonine and D-threonine. -!- The enzyme from E.coli also shows high activity with L-serine, D-serine, (S)-3-hydroxy-2-methylpropanoate and (R)-3-hydroxy-2- methylpropanoate. -!- The enzyme has no activity with NAD(+) or L-threonine (cf. EC 1.1.1.103)., NADP-dependent 3-hydroxy acid dehydrogenase, -!- Also acts on other 17-beta-hydroxysteroids, on the 3-alpha-hydroxy group of pregnanes and bile acids. -!- Different from EC 1.1.1.50 or EC 1.1.1.213. -!- Formerly EC 1.1.1.63., Peroxisomal fatty acid beta-oxidation multifunctional protein MFP2, plasmodesma, LD36273p, Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase, Beta-D-hydroxybutyrate dehydrogenase, 2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase., Staphylococcus epidermidis, -!- Also acts on a number of substituted cinnamoyl esters of coenzyme A., Cinnamoyl-CoA reductase 1, Xanthomonas oryzae pv. oryzae MAFF 311018, Psychrobacter arcticus 273-4, 3-hydroxyisobutyrate dehydrogenase activity, L-phenylalanine catabolic process, Rhodococcus sp., phenylalanine dehydrogenase activity, cell aging, estrogen receptor binding, (R)-acetoin dehydrogenase., erythrocyte maturation, glucose 6-phosphate metabolic process, Granulicella mallensis MP5ACTX8, 3R-hydroxyacyl-CoA dehydratase activity, Uncharacterized NAD-dependent oxidoreductase MAP_4146, Lactococcus lactis subsp. lactis KF147, 10-deoxymethynolide syntase., Burkholderia vietnamiensis G4, alcohol catabolic process, [Clostridium] scindens, response to bile acid, Chloroflexus sp. Y-400-fl, protein phosphorylation, -!- The enzyme is a member of the mu-crystallin protein family. -!- The reaction is stimulated by the presence of ADP or ATP and is inhibited by O(2)., Ornithine cyclodeaminase., Putative alcohol dehydrogenase, Clostridium sp. ATCC BAA-442, 4-deoxy-L-erythro-5-hexoseulose uronate reductase A1-R', threonine catabolic process, Trichophyton rubrum BMU01672, regulation of macroautophagy, Escherichia coli, Deinococcus radiodurans R1, methionine catabolic process, 5-keto-D-gluconate 5-reductase. 5-ketogluconate 5-reductase. 5-ketogluconate reductase., Streptococcus suis 05ZYH33, Quinate/shikimate dehydrogenase., Burkholderia cepacia, UDP-glucose dehydrogenase, Cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) = biphenyl-2,3-diol + NADH., (2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + NADPH., A (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-dihydroflavonol + NADPH., Keto reductase, Lipopolysaccaride biosynthesis protein wbpB, Inositol-3-phosphate synthase, (-)-lariciresinol + NADP(+) = (-)-pinoresinol + NADPH., -!- The reaction is catalyzed in vivo in the opposite direction to that shown. -!- A multifunctional enzyme that further reduces the product to the lignan (-)-secoisolariciresinol (EC 1.23.1.2). -!- Isolated from the plants Forsythia intermedia, Thuja plicata (western red cedar), Linum perenne (perennial flax) and Linum corymbulosum. -!- The 4-pro-R hydrogen of NADH is transferred to the 7-pro-R position of lariciresinol., regulation of apoptotic process, Leifsonia aquatica, ferrochelatase activity, Serine 3-dehydrogenase (NADP(+))., positive regulation of protein localization to cell surface, ventricular cardiac muscle cell action potential, xylulose metabolic process, Vibrio parahaemolyticus AQ3810, Escherichia coli CFT073, NAD/NADP transhydrogenase alpha subunit 1, Vibrio vulnificus CMCP6, (-)-isopiperitenone reductase activity, cyclic threonylcarbamoyladenosine biosynthetic process, Pyrococcus furiosus DSM 3638, Pyrroline-5-carboxylate reductase, Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+)., Oleoyl-[acyl-carrier-protein] hydrolase., [Acyl-carrier-protein] S-malonyltransferase., regulation of cholesterol biosynthetic process, androgen catabolic process, cyclic ADP-ribose hydrolase, regulation of actin cytoskeleton organization, -!- The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. -!- The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3- one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates., Cinnamyl alcohol dehydrogenase 5, cell morphogenesis involved in neuron differentiation, norepinephrine metabolic process, UDP-glucuronate decarboxylase., (1) Beta-D-galacturonate + NAD(+) = D-galactaro-1,5-lactone + NADH. (2) Beta-D-glucuronate + NAD(+) = D-glucaro-1,5-lactone + NADH., Rhodococcus ruber, (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)- 11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH., extracellular vesicle, alcohol metabolic process, Methanosarcina mazei Go1, NADP-linked malate dehydrogenase., Firmicutes bacterium enrichment culture clone fosmid MGS-M2, -!- Catalyzes the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutyrate cycles, autotrophic CO(2) fixation pathways found in some green non-sulfur phototrophic bacteria and some thermoacidophilic archaea, respectively. -!- The enzyme from Sulfolobus tokodaii has been purified, and found to contain one RNA molecule per two subunits. -!- The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyzes the next reaction in the pathway, EC 1.1.1.298., Malonate semialdehyde + CoA + NADP(+) = malonyl-CoA + NADPH., Veillonella parvula DSM 2008, Brugia malayi, Glucose-fructose oxidoreductase, UDP-galactopyranose mutase, galactitol-1-phosphate 5-dehydrogenase activity, Malate dehydrogenase, mitochondrial, L-lactate dehydrogenase A chain, lactate dehydrogenase activity, response to hydrogen peroxide, -!- This enzyme completes each cycle of fatty acid elongation by catalyzing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to an acyl- carrier protein. -!- It is one of the activities of EC 2.3.1.85. -!- The mammalian enzyme is Re-specific with respect to NADP(+) (cf. EC 1.3.1.10 and and EC 1.3.1.104)., An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADPH., L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)), Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic, 333aa long hypothetical dehydrogenase, medium-chain fatty-acyl-CoA metabolic process, Ammonia-lyases., Pseudomonas putida KT2440, Putative ornithine cyclodeaminase, positive regulation of retinoic acid receptor signaling pathway, Yersinia enterocolitica, methylation, sulfur amino acid metabolic process, Mycobacterium avium 104, Collinsella aerofaciens ATCC 25986, 3-hydroxyacyl-CoA dehydratase activity, D-glucose + D-fructose = D-gluconolactone + D-glucitol., transcription corepressor activity, [Clostridium] symbiosum, Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic, Aminoadipate semialdehyde-glutamate reductase. Aminoadipic semialdehyde-glutamate reductase. Aminoadipic semialdehyde-glutamic reductase. Saccharopine reductase., Saccharopine dehydrogenase [NADP(+), L-glutamate-forming], -!- The enzyme from Saccharomyces cerevisiae acts most rapidly with NAD(+); the Neurospora enzyme with NADP(+). -!- The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 2.7.2.4., homoserine dehydrogenase activity, Lupinus luteus, Vibrio parahaemolyticus RIMD 2210633, Cryptosporidium parvum Iowa II, Succinic semialdehyde reductase., UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate ligase., Aspergillus nidulans FGSC A4, Glutathione-regulated potassium-efflux system protein KefC, glutathione-regulated potassium exporter activity, antimicrobial humoral immune response mediated by antimicrobial peptide, cellular response to interferon-gamma, response to osmotic stress, Malate dehydrogenase (oxaloacetate-decarboxylating)., methylamine metabolic process, valine biosynthetic process, Tetrahydrofolate dehydrogenase., Clostridioides difficile 630, Putative oxidoreductase with NAD(P)-binding Rossmann-fold domain, Redox-sensing transcriptional repressor Rex, (S)-lactaldehyde + NADP(+) = 2-oxopropanal + NADPH., -!- The enzyme from the yeast Saccharomyces cerevisiae catalyzes the reduction of a keto group in a number of compounds, forming enantiopure products. -!- Among the substrates are methylglyoxal (which is reduced to (S)- lactaldehyde), 3-methylbutanal, hexane-2,5-dione and 3-chloro-1- phenylpropan-1-one. -!- The enzyme differs from EC 1.1.1.78 which is found in mammals, by its coenzyme requirement, reaction direction, and enantiomeric preference., 3-methylbutanal reductase., filamentous growth, Streptococcus pneumoniae R6, Pyrobaculum aerophilum str. IM2, methionine adenosyltransferase regulator activity, -!- The activity is part of a bifunctional enzyme also performing the reaction of EC 1.1.1.305. -!- Formerly EC 2.1.2.n1., 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinose., NAD(P) transhydrogenase subunit alpha, NADPH + NAD(+) = NADP(+) + NADH., chloroplast envelope, Propanoyl-CoA + NADP(+) = acrylyl-CoA + NADPH., Salutaridine reductase (NADPH)., Glyceraldehyde-3-phosphate dehydrogenase 1, Hydroxysteroid dehydrogenase-like protein 2, Mycobacterium ulcerans Agy99, response to cold, response to light stimulus, response to sucrose, supramolecular complex, NAD(P)H dehydrogenase (quinone)., -!- Was originally thought to be an EC 1.2.1.12, but this has since been disproved, as glyceraldehyde 3-phosphate is not a substrate. -!- Forms part of the pyridoxal-5'-phosphate coenzyme biosynthesis pathway in Escherichia coli, along with EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5., D-erythrose-4-phosphate dehydrogenase, UDP-N-acetylmuramoylalanine-D-glutamate ligase activity, urea cycle, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity, 2-methyl-3-hydroxybutyryl-CoA dehydrogenase., -!- Also acts, more slowly, on L-arabinose and D-ribose., -!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343., 6-phosphogluconic carboxylase. 6-phosphogluconic dehydrogenase. 6PGD. Phosphogluconic acid dehydrogenase., Ubiquitin-activating enzyme E1., Ktr system potassium uptake protein A, 5,10-methenyltetrahydromethanopterin hydrogenase, H(2) + 5,10-methenyltetrahydromethanopterin = H(+) + 5,10- methylenetetrahydromethanopterin., Listeria monocytogenes EGD-e, D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH., Methanothermobacter thermautotrophicus str. Delta H, Ralstonia eutropha JMP134, 3-oxoacyl-[acyl-carrier-protein] reductase FabG, D-serine metabolic process, FAD binding, magnesium ion binding, terpenoid biosynthetic process, mevalonate-independent, Streptomyces sp. JS360, Rhodobacter sphaeroides 2.4.1, 3-oxoacyl-(Acyl-carrier-protein) reductase, Mycobacterium tuberculosis CDC1551, C-terminal protein lipidation, CVT pathway, pre-autophagosomal structure, protein modification by small protein conjugation, 2,4-dienoyl-CoA reductase (NADPH) activity, 2,4-dienoyl-CoA reductase (NADPH)., 4-enoyl-CoA reductase (NADPH)., -!- Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity)., Alpha-glycerol phosphate dehydrogenase (NAD). Alpha-glycerophosphate dehydrogenase (NAD). Glycerol 1-phosphate dehydrogenase. Glycerol phosphate dehydrogenase (NAD). Glycerol-3-phosphate dehydrogenase (NAD). Glycerophosphate dehydrogenase (NAD). Hydroglycerophosphate dehydrogenase. L-alpha-glycerol phosphate dehydrogenase. L-alpha-glycerophosphate dehydrogenase. L-glycerol phosphate dehydrogenase. L-glycerol-3-phosphate dehydrogenase. L-glycerophosphate dehydrogenase. NAD-alpha-glycerophosphate dehydrogenase. NAD-dependent glycerol phosphate dehydrogenase. NAD-dependent glycerol-3-phosphate dehydrogenase. NAD-L-glycerol-3-phosphate dehydrogenase. NAD-linked glycerol 3-phosphate dehydrogenase. NADH-dihydroxyacetone phosphate reductase., Anthocyanidin reductase ((2S)-flavan-3-ol-forming), Uncharacterized oxidoreductase YhhX, Isopropanol dehydrogenase (NADP(+))., Clostridium beijerinckii, Oxidoreductase, Gfo/Idh/MocA family, NmrA-like family domain-containing protein 1, Bacillus cereus ATCC 14579, Ketol-acid reductoisomerase (NADP(+)), Beta-hydroxybutyryl-CoA dehydrogenase. BHBD., Burkholderia cenocepacia J2315, CalS8, Sphingobium sp. SYK-6, ADP-glyceromanno-heptose 6-epimerase activity, Formaldehyde + NAD(+) + H(2)O = formate + NADH., Chromobacterium violaceum ATCC 12472, dTDP-4-keto-L-rhamnose reductase. dTDP-6-deoxy-L-mannose dehydrogenase., L-iditol 2-dehydrogenase activity, L-xylitol catabolic process, Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH., chorismate biosynthetic process, shikimate metabolic process, D-amino-acid oxidase., (R)-lactate + NAD(+) = pyruvate + NADH., D-lactate dehydrogenase, -!- Involved in the synthesis of a cell-wall peptide., ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine = ADP + phosphate + UDP- N-acetyl-alpha-D-muramoyl-L-alanine., Thermotoga maritima MSB8, Alcohol dehydrogenase 1B, Flavin reductase (NADPH), Reduced riboflavin + NADP(+) = riboflavin + NADPH., retinol dehydrogenase activity, UDP-GlcNAc 4-epimerase. Uridine diphosphoacetylglucosamine epimerase., UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine., TDH., apoplast, CDP-glucose 4,6-dehydratase., D-3-phosphoglycerate dehydrogenase, phosphoglycerate dehydrogenase activity, Succinate--CoA ligase (ADP-forming)., Malate dehydrogenase, glyoxysomal, extracellular space, ASA dehydrogenase. Aspartic semialdehyde dehydrogenase. L-aspartate-beta-semialdehyde dehydrogenase., Lactate dehydrogenase, -!- Specific for NADPH. -!- Catalyzes the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates. -!- Dicoumarol (cf. EC 1.6.5.2) and nitrofurantoin are competitive inhibitors with respect to the quinone substrate. -!- The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O(2). -!- Abundant in the lens of the eye of some mammalian species., NADPH + 2 quinone = NADP(+) + 2 semiquinone., NADPH regeneration, 11-beta-hydroxysteroid dehydrogenase., Alanine dehydrogenase, Archaeoglobus fulgidus DSM 4304, -!- This enzyme has similar activity with either NAD(+) or NADP(+). -!- Cf. EC 1.1.1.118 and EC 1.1.1.119., An aldopyranose + NAD(P)(+) = an aldono-1,5-lactone + NAD(P)H., glucose 1-dehydrogenase [NAD(P)] activity, protein tetramerization, Enoyl hydrase. Unsaturated acyl-CoA hydratase., Enoyl-CoA hydratase., -!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme., Adenosylhomocysteine hydrolase. AdoHcyase. S-adenosylhomocysteinase. S-adenosylhomocysteine hydrolase. S-adenosylhomocysteine synthase. SAHase., response to nutrient, Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)., lactate oxidation, motile cilium, -!- The enzyme from Leishmania (both amastigote and promastigote forms) catalyzes the NADPH-dependent reduction of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms. -!- It also catalyzes the reduction of 7,8-dihydropterins and 7,8- dihydrofolate to their tetrahydro forms. -!- In contrast to EC 1.5.1.3 and EC 1.5.1.34, pteridine reductase will not catalyze the reduction of the quinonoid form of dihydrobiopterin. -!- The enzyme is specific for NADPH; no activity has been detected with NADH. -!- It also differs from EC 1.5.1.3 in being specific for the B side of NADPH. -!- Formerly EC 1.1.1.253., 6,7-dihydropteridine:NAD(P)H oxidoreductase. DHPR. Dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase. Dihydropteridine reductase. Dihydropteridine reductase (NADH). NAD(P)H(2):6,7-dihydropteridine oxidoreductase. NADH-dihydropteridine reductase. NADPH-dihydropteridine reductase. NADPH-specific dihydropteridine reductase., pteridine reductase activity, EGS2., Vibrio cholerae O1 biovar El Tor str. N16961, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase., Diphosphopyridine nucleosidase., negative regulation of apoptotic process, positive regulation of transcription, DNA-templated, -!- Reduces glyoxylate to glycolate or hydroxypyruvate to D-glycerate., Plasmodium vivax, embryo development ending in birth or egg hatching, 2-alkenal reductase (NADP(+))., glutamyl-tRNA reductase activity, Putative hydroxylase/dehydratase, L-gulonate 3-dehydrogenase activity, Short-chain alcohol dehydrogenase, Thermococcus sibiricus MM 739, Paecilomyces sp. J18, Crotonyl-CoA carboxylase/reductase, 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase, Enoyl-[acyl-carrier-protein] reductase [NADPH, B-specific] 2, mitochondrial, Arogenic dehydrogenase. Cyclohexadienyl dehydrogenase. L-arogenate:NAD(+) oxidoreductase. Pretyrosine dehydrogenase., Homoserine dehydrogenase (Hom), Possible NADH oxidoreductase, Putative 3-oxoacyl-[acyl-carrier protein] reductase, Alpha-D-glucose = beta-D-glucose., negative regulation of cell cycle, Putative dTDP-d-glucose 4 6-dehydratase, Shikimate 5-dehydrogenase, 3-beta-hydroxysteroid dehydrogenase, (S)-malate + NAD(P)(+) = oxaloacetate + NAD(P)H., D-glycerate dehydrogenase. Hydroxypyruvate dehydrogenase., Glycerate dehydrogenase., Hydroxyphenylpyruvate synthase., T-protein, Sinorhizobium meliloti SM11, Alcohol dehydrogenase class-P, H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ0715, glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity, acrosomal vesicle, fatty acid alpha-oxidation, Formaldehyde dismutase., 2,3-dihydro-2,3-dihydroxybenzoate + NAD(+) = 2,3-dihydroxybenzoate + NADH., saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity, Cupriavidus necator N-1, Semialdehyde dehydrogenase NAD-binding protein, -!- Hydrolyzes a variety of 6-phospho-alpha-D-glucosides, including alpha-maltose 6-phosphate, alpha,alpha-trehalose 6-phosphate, sucrose 6-phosphate and p-nitrophenyl-alpha-D-glucopyranoside 6-phosphate (as a chromogenic substrate). -!- The enzyme is activated by Fe(2+), Mn(2+), Co(2+) and Ni(2+). -!- It is rapidly inactivated in air., Alpha-maltose 6'-phosphate + H(2)O = D-glucose + D-glucose 6-phosphate., Maltose-6'-phosphate glucosidase, -!- This plant enzyme catalyzes the penultimate step in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. -!- This activity was previously classified as part of EC 1.1.1.246, which is now known to be catalyzed by two enzymes, vestitone reductase and EC 4.2.1.139. -!- Formerly EC 1.1.1.246., Pectobacterium atrosepticum SCRI1043, Tropine + NADP(+) = tropinone + NADPH., GDP-6-deoxy-D-mannose reductase, GDP-alpha-D-rhamnose + NAD(P)(+) = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H., Uncharacterized oxidoreductase YciK, Burkholderia pseudomallei 305, Fatty-acyl-CoA synthase., Adenosylhomocysteinase 2, Putative 3-oxoacyl-[acyl-carrier-protein] reductase putative short-chain dehydrogenases/reductases (SDR) family protein, Geobacillus kaustophilus HTA426, (1) An alcohol + NAD(+) = an aldehyde or ketone + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH., Alcohol dehydrogenase E chain, Malate dehydrogenase [NADP], chloroplastic, Mannitol-1-phosphate 5-dehydrogenase., Sus scrofa, enoyl-[acyl-carrier-protein] reductase (NADH) activity, fatty acid elongation, identical protein binding, lipid biosynthetic process, Homo sapiens, estrogen biosynthetic process, glycolipid biosynthetic process, -!- The enzyme has an absolute requirement for both the 5-deazaflavin structure and the presence of an 8-hydroxy group in the substrate., 2-deoxygluconate dehydrogenase., Pectobacterium carotovorum subsp. carotovorum, All-trans-retinol-[cellular-retinol-binding-protein] + NAD(+) = all- trans-retinal-[cellular-retinol-binding-protein] + NADH., phagocytosis, -!- Adenylates the C-terminus of the small subunit of the molybdopterin synthase. -!- This activation is required to form the thiocarboxylated C-terminus of the active molybdopterin synthase small subunit. -!- The reaction occurs in prokaryotes and eukaryotes. -!- In the human, the reaction is catalyzed by the N-terminal domain of the protein MOCS3, which also includes a molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) C-terminal domain. -!- Formerly EC 2.7.7.n4., ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly- Gly-AMP., [LysW]-L-2-aminoadipate 6-phosphate reductase, Paraburkholderia phymatum STM815, Streptomyces sp. GF3546, protein C-terminus binding, Sulfur carrier protein ThiS adenylyltransferase, Chlorobaculum parvum NCIB 8327, 2-hydroxy-3-oxopropionate reductase., nucleotidyltransferase activity, Scheffersomyces stipitis CBS 6054, -!- The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin., quinone metabolic process, 3-oxoacyl-acyl-carrier-protein reductase FabG, 2-(R)-hydroxypropyl-CoM + NAD(+) = 2-oxopropyl-CoM + NADH., 1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + NADPH., Petunia x hybrida, Cryptic catabolic NAD-specific glutamate dehydrogenase GudB, Mesorhizobium loti MAFF303099, Eugenol synthase, Lactobacillus paracasei ATCC 334, Putative pteridine reductase 2, Acholeplasma laidlawii PG-8A, Methylobacterium extorquens PA1, Hydroxyphenylpyruvate reductase, Solenostemon scutellarioides, Inositol-1-phosphate synthase, 3-hydroxybutyryl-CoA dehydrogenase activity, Alpha-N-acetylgalactosaminidase, 418aa long hypothetical UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase, Brucella canis ATCC 23365, (R)-2,3-butanediol dehydrogenase. (R)-diacetyl reductase. 1-amino-2-propanol dehydrogenase. 1-amino-2-propanol oxidoreductase. 2,3-butanediol dehydrogenase. Aminopropanol oxidoreductase. Butylene glycol dehydrogenase. Butyleneglycol dehydrogenase. D-(-)-butanediol dehydrogenase. D-1-amino-2-propanol dehydrogenase. D-1-amino-2-propanol:NAD(2) oxidoreductase. D-aminopropanol dehydrogenase. D-butanediol dehydrogenase. Diacetyl (acetoin) reductase., (R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + NADH., (R,R)-butanediol dehydrogenase., D-sorbitol dehydrogenase (acceptor)., C-1-tetrahydrofolate synthase, cytoplasmic, putative, 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))., Putative UDP-glucose 4-epimerase, 3-alpha-hydroxybile acid CoA 3-dehydrogenase., Stigmatella aurantiaca, serine 3-dehydrogenase activity, Enterococcus mundtii QU 25, Porphyromonas gingivalis W83, (S)-1-phenylethanol + NAD(+) = acetophenone + NADH., Weissella confusa, RNA polymerase II transcription corepressor activity, fungal-type cell wall, heme transport, reactive oxygen species metabolic process, Putative oxidoreductase YfjR, protein sumoylation, Enoyl-acyl carrier protein reductase, 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2, pinoresinol reductase activity, GDP-mannose 4,6-dehydratase activity, -!- Involved in the biosynthesis of 3-deoxyanthocyanidins from flavanones such as naringenin or eriodictyol., NAD-dependent epimerase/dehydratase, UDP-glucose 4-epimerase (GalE-1), Metalloreductase STEAP3, endosome membrane, L-threonine 3-dehydrogenase, mitochondrial, Yersinia pestis, -!- This enzyme catalyzes the third of three steps leading to the formation of siroheme from uroporphyrinogen III. -!- The first step involves the donation of two S-adenosyl-L-methionine- derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107) and the second step involves an NAD(+)-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76). -!- In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. -!- In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirB being responsible for the above reaction., sulfate assimilation, Putative short-chain dehydrogenase/reductase, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity, serine family amino acid biosynthetic process, 2-hydroxyacid dehydrogenase, Escherichia coli P0299438.9, Golgi apparatus, ATP + [ThiS] = diphosphate + adenylyl-[ThiS]., Glycerol-3-phosphate dehydrogenase [NAD(+)], androstan-3-alpha,17-beta-diol dehydrogenase activity, Phormidium lapideum, Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase., Streptomyces griseoruber, NAD-dependent alcohol dehydrogenase, Sphingobium yanoikuyae, Alcohol dehydrogenase, propanol-preferring, Kribbella flavida DSM 17836, Vibrio vulnificus YJ016, Inner membrane protein YbaL, nucleosome, CAD., Cinnamyl-alcohol dehydrogenase., lignin biosynthetic process, dopamine metabolic process, voluntary musculoskeletal movement, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, Putative nucleoside-diphosphate-sugar epimerase, NDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, Prostaglandin-E(2) 9-reductase., cyclooxygenase pathway, prostaglandin-E2 9-reductase activity, Sulfoacetaldehyde reductase., 319aa long hypothetical homoserine dehydrogenase, (4R,6S)-carveol dehydrogenase. Carveol dehydrogenase. CDH., -!- Catalyzes the oxidation of carveol to carvone, with a strong stereoselectivity since it efficiently converts only the (6S)- stereoisomers, of which (-)-(4R,6S)-trans-carveol is the better substrate. -!- Displays a broad substrate specificity with a preference for substituted cyclohexanols, and does not catalyze the oxidation of primary or short chain aliphatic secondary alcohols. -!- Is also able, albeit more slowly, to oxidize limonene-1,2-diol into 1-hydroxy-2-oxolimonene., Glutamyl-tRNA reductase, regulation of inflammatory response, regulation of superoxide metabolic process, Bifidobacterium longum subsp. longum JCM 1217, JamJ, Paraburkholderia xenovorans LB400, Staphylococcus aureus subsp. aureus NCTC 8325, Methanosarcina barkeri str. Fusaro, Dehydrogenase/reductase SDR family member 4, cellular ketone metabolic process, Uronic acid dehydrogenase., (2S,3S)-butane-2,3-diol + NAD(+) = (S)-acetoin + NADH., (S,S)-butanediol dehydrogenase., L-2,3-butanediol dehydrogenase, phosphate ion binding, UDP-sulfoquinovose synthase., Arthrobacter sp. 1C, D-glyceraldehyde 3-phosphate + phosphate + NAD(P)(+) = 3-phospho-D- glyceroyl phosphate + NAD(P)H., aldehyde oxidase activity, GDP-D-mannose 4,6-dehydratase. GDP-D-mannose dehydratase. Guanosine 5'-diphosphate-D-mannose oxidoreductase. Guanosine diphosphomannose 4,6-dehydratase. Guanosine diphosphomannose oxidoreductase., Brucella ovis IntaBari-2002-82-58, 17-beta-hydroxysteroid dehydrogenase 14, Alcaligenes faecalis, Capsular polysaccharide synthesis enzyme Cap5F, Oxidoreductase, short-chain dehydrogenase/reductase family, ethanol binding, Dihydrodipicolinate reductase., Ubiquitin-like modifier-activating enzyme 5, NIK/NF-kappaB signaling, NAD(P)-dependent oxidoreductase, NDP-sugar epimerase, negative regulation of kinase activity, Precorrin-2 dehydrogenase, Precorrin-2 oxidase., response to methylglyoxal, FMN binding, Rhodobacter sphaeroides, Murein peptide ligase., Alcohol dehydrogenase (Zn containing) (Adh-4), Sulfolobus solfataricus P2, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity, androgen metabolic process, Pteridine reductase 1, pteridine metabolic process, thymidylate synthase activity, 3-oxoacyl-[acyl carrier protein] reductase, Enoyl-acyl carrier reductase, protein complex binding, protein kinase binding, Scaptodrosophila lebanonensis, Carbonyl reductase (NADPH)., Carbonyl reductase [NADPH] 2, D-2-hydroxyisocaproate dehydrogenase, NADH regeneration, UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L- arabino-hex-4-ulose + H(2)O., -!- This is the second shikimate dehydrogenase enzyme found in Escherichia coli and differs from EC 1.1.1.25, in that it can use both quinate and shikimate as substrate and either NAD(+) or NADP(+) as acceptor., glutamate biosynthetic process, glutamate catabolic process, Methionine adenosyltransferase 2 subunit beta, Carbonyl reductase family member 4, S-(hydroxymethyl)glutathione dehydrogenase, Putative zinc-binding dehydrogenase, Homospermidine synthase, L-threonine 3-dehydrogenase activity, Tropinone reductase homolog At1g07440, thiomorpholine-carboxylate dehydrogenase activity, Scyllo-inositol + NADP(+) = 2,4,6/3,5-pentahydroxycyclohexanone + NADPH., positive regulation of cytokine secretion, (-)-lariciresinol biosynthetic process, (-)-pinoresinol catabolic process, integral component of plasma membrane, manganese ion binding, ATP biosynthetic process, Eugenol + a carboxylate + NADP(+) = a coniferyl ester + NADPH., -!- This multiunctional enzyme catalyzes both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes. -!- In addition, the enzyme also catalyzes EC 2.4.99.20. -!- Cf. EC 3.2.2.5., B cell receptor signaling pathway, Glycolate + NADP(+) = glyoxylate + NADPH., Hydroxypyruvate reductase., NADPH binding, Synechococcus elongatus PCC 7942, -!- The enzyme from the archaeon Sulfolobus solfataricus shows broad specificity toward aldoses (D-glucose, D-galactose, D-xylose, L-arabinose, 6-deoxy-D-glucose, D-fucose) and can utilize NAD(+) and NADP(+) with similar catalytic efficiency. -!- It is involved in aldose catabolism via the branched variant of the Entner-Doudoroff pathway., D-galactose 1-dehydrogenase., D-glucose + NAD(P)(+) = D-glucono-1,5-lactone + NAD(P)H., Glycolate + NAD(+) = glyoxylate + NADH., Glycolate reductase. Glyoxylic acid reductase. NADH-dependent glyoxylate reductase., positive regulation of apoptotic process, late nucleophagy, piecemeal microautophagy of nucleus, D-serine catabolic process, proline catabolic process, Geobacter sulfurreducens PCA, regulation of nitric-oxide synthase activity, dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O., Staphylococcus aureus subsp. aureus MRSA252, racemase and epimerase activity, Aplysia californica, 2-dehydropantoate 2-reductase., Staphylococcus aureus subsp. aureus Mu50, Oxidoreductase, short chain dehydrogenase/reductase family, UDP-N-acetylglucosamine 4-epimerase, Cap5O, Salutaridine reductase, oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, -!- Also oxidizes other 3-hydroxymonocarboxylic acids., D(-)-3-hydroxybutyrate dehydrogenase, -!- The substrate is the quinonoid form of dihydropteridine. -!- Not identical with EC 1.5.1.3. -!- Formerly EC 1.6.99.7 and EC 1.6.99.10., 6,7-dihydropteridine reductase., Pteridine reductase., protein K69-linked ufmylation, Tetrahydroalstonine synthase, Treponema denticola ATCC 35405, fatty acid biosynthetic process, unsaturated fatty acid biosynthetic process, 3-oxoacyl-[acyl-carrier-protein] reductase, aerobic respiration, GDP-4-dehydro-D-rhamnose reductase activity, -!- The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382 and EC 1.1.1.383). -!- Formerly EC 1.1.1.89., Reductase homolog, NADH oxidation, 17beta-hydroxysteroid dehydrogenase, Curvularia lunata, disordered domain specific binding, stromule, N-acetyl-D-mannosamine dehydrogenase. N-acyl-D-mannosamine dehydrogenase. N-acylmannosamine dehydrogenase., Oxidoreductase, short chain dehydrogenase/reductase family protein, malic enzyme activity, Streptococcus mutans UA159, GDP-D-mannose + 2 NAD(+) + H(2)O = GDP-D-mannuronate + 2 NADH., cellular response to cell envelope stress, -!- D-mannose, D-xylose, D-galactose, 2-deoxy-D-glucose and L-arabinose will function as aldose substrates, but with low affinities. -!- The ketose substrate must be in the open-chain form. -!- The apparent affinity for fructose is low, because little of the fructose substrate is in the open-chain form. -!- Xylulose and glycerone (dihydroxyacetone) will replace fructose, but they are poor substrates. -!- The enzyme from Zymomonas mobilis contains tightly bound NADP(+)., -!- The enzyme from the archaeon Methanocaldococcus jannaschii catalyzes the reversible oxidation of (2R)-3-sulfolactate and (S)-malate to 3-sulfopyruvate and oxaloacetate, respectively (note that (2R)-3- sulfolactate has the same stereochemical configuration as (2S)-2- hydroxycarboxylates). -!- The enzyme can use both NADH and NADPH, although activity is higher with NADPH. -!- The oxidation of (2R)-3-sulfolactate was observed only in the presence of NADP(+). -!- The same organism also possesses an NAD(+)-specific enzyme with similar activity, cf. EC 1.1.1.337., A (2S)-2-hydroxycarboxylate + NAD(P)(+) = a 2-oxocarboxylate + NAD(P)H., response to calcium ion, ATP citrate synthase activity, ATP citrate synthase., azurophil granule lumen, Rhodococcus opacus B4, Propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH = 6-deoxyerythronolide B + 7 CoA + 6 CO(2) + H(2)O + 6 NADP(+)., uncultured Prochloron sp. 06037A, xenobiotic catabolic process, Malic enzyme, Polyketide synthase extender module 2, 3-oxoacyl-acyl-carrier protein reductase FabG4, Staphylococcus haemolyticus JCSC1435, Pantoea agglomerans, adenosylselenohomocysteinase activity, chronic inflammatory response to antigenic stimulus, Agaricus bisporus, -!- The 3-alpha-hydroxy group or 20-beta-hydroxy group of pregnane and androstane steroids can act as donor., alcohol dehydrogenase (NAD) activity, Bos taurus, UDP-alpha-D-glucose = UDP-alpha-D-galactose., (S)-malate + NAD(+) = oxaloacetate + NADH., Chlorobium tepidum TLS, Alcohol dehydrogenase zinc-containing, Flaveria bidentis, Cytophaga hutchinsonii ATCC 33406, oxidation-reduction process, Acid maltase. Glucoinvertase. Glucosidosucrase. Lysosomal alpha-glucosidase. Maltase. Maltase-glucoamylase., Geobacillus stearothermophilus, carbohydrate metabolic process, galactose metabolic process, glucose metabolic process, Aspartate-semialdehyde dehydrogenase., Haemophilus influenzae Rd KW20, Shikimate 5-dehydrogenase-like protein HI_0607, -!- Also acts, more slowly, on glycolaldehyde, propanal and butanal. -!- In several bacterial species this enzyme forms a bifunctional complex with EC 4.1.3.39. -!- The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.87. -!- Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols. -!- NADP(+) can replace NAD(+) but the rate of reaction is much slower., Acetaldehyde dehydrogenase (acetylating)., shikimate 3-dehydrogenase (NADP+) activity, An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH., Methylophilus methylotrophus, TMADh., Glyceraldehyde-3-phosphate dehydrogenase, D-lactate dehydrogenase., Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002, UDP-N-acetylmuramate--L-alanine ligase, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, L-threonine + NAD(+) = L-2-amino-3-oxobutanoate + NADH., Aquifex aeolicus VF5, Testosterone + NAD(P)(+) = androst-4-ene-3,17-dione + NAD(P)H., mitochondrial ribonuclease P complex, mitochondrial tRNA processing, 4-O-phosphoerythronate dehydrogenase. 4PE dehydrogenase. Erythronate-4-phosphate dehydrogenase., 4-phosphoerythronate dehydrogenase., 6-phosphogluconate dehydrogenase, decarboxylating, Lactococcus lactis subsp. cremoris MG1363, 3-phospho-D-glycerate + NAD(+) = 3-phosphonooxypyruvate + NADH., lysine biosynthetic process via diaminopimelate, Yersinia pseudotuberculosis, L-iditol + NAD(+) = L-sorbose + NADH., L-iditol 2-dehydrogenase., Alanine dehydrogenase., L-ornithine = L-proline + NH(3)., Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial, valine catabolic process, steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, Pyrococcus yayanosii CH1, Thermus caldophilus, Borrelia burgdorferi B31, Haloferax mediterranei ATCC 33500, CDP-glucose 4,6-dehydratase, 2-alkenal reductase (NADP(+)-dependent), Staphylococcus aureus subsp. aureus USA300, 2 formaldehyde + H(2)O = formate + methanol., nuclear envelope, A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H., Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids., protein complex, L-phenylalanine + H(2)O + NAD(+) = phenylpyruvate + NH(3) + NADH., Leydig cell differentiation, beta-amyloid binding, -!- The reaction is catalyzed in the reverse direction. -!- This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76). -!- While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. -!- This enzyme has been reported in the yeast Saccharomyces cerevisiae. -!- Different from EC 1.1.1.304. -!- Formerly EC 1.1.1.5., Diacetyl reductase ((R)-acetoin forming)., glutathione metabolic process, heme biosynthetic process, Cytosolic malate dehydrogenase, -!- The enzyme, characterized from the bacteria Thermacetogenium phaeum and Desulfococcus oleovorans and from the archaeon Archaeoglobus fulgidus, is specific for NADH (cf. EC 1.1.1.86 and EC 1.1.1.383)., Ketol-acid reductoisomerase (NAD(+))., Narbonolide synthase., (S)-1-phenylethanol dehydrogenase., alcohol dehydrogenase (NADP+) activity, 13-prostaglandin reductase activity, reproduction, Bacteroides fragilis NCTC 9343, Rhodotorula toruloides, Pseudomonas aeruginosa, SADH, D-glycerate + NAD(+) = hydroxypyruvate + NADH., Bacillus sp. SG-1, -!- This enzyme in the enteric bacteria also possesses EC 5.4.99.5 activity and converts chorismate into prephenate., Crotonyl-CoA reductase, crotonyl-CoA reductase activity, Moraxella sp., SUMO-activating enzyme subunit 1, acryloyl-CoA reductase (NADP+) activity, Pelophylax perezi, Candida albicans SC5314, aldose 1-epimerase activity, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 15-hydroxyprostaglandin dehydrogenase., (3R,4R)-4'-methoxyisoflavan-2',4,7-triol + NADP(+) = (3R)-vestitone + NADPH., Anaplasma phagocytophilum str. HZ, Ribitol 2-dehydrogenase, parturition, prostaglandin E receptor activity, Putative glutathione-regulated potassium-efflux system protein KefB, Cupriavidus taiwanensis LMG 19424, Cinnamoyl-CoA reductase-like protein, regulation of cardiac conduction, regulation of mRNA 3'-end processing, regulation of heart rate, regulation of sodium ion transmembrane transporter activity, Francisella tularensis subsp. tularensis, Phthiocerol synthesis polyketide synthase type I PpsC, Yersiniabactin biosynthetic protein YbtU, Oxidoreductase domain protein, L-glutamate 1-semialdehyde + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH., ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2, regulation of cell-matrix adhesion, regulation of integrin-mediated signaling pathway, Gluconobacter oxydans, Xylitol dehydrogenase, malate dehydrogenase (decarboxylating) (NADP+) activity, Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal, Leishmania mexicana, L-phenylalanine metabolic process, -!- CDP-paratose (CDP-3,6-dideoxy-D-glucose), is more systematically called CDP-alpha-3,6-dideoxy-D-ribo-hexose. -!- CDP-tyvelose (CDP-3,6-dideoxy-D-mannose) is systematically called CDP-3,6-dideoxy-D-arabino-hexose., Geobacter metallireducens GS-15, -!- The enzyme, characterized from the bacterium Agrobacterium fabrum, participates in oxidative degradation pathways for galacturonate and glucuronate. -!- The enzyme can only accept the beta anomeric form of the substrate. -!- The 1,5 lactone product is rather stable at cytosolic pH and does not hydrolyze spontaneously at a substantial rate. -!- Formerly EC 1.2.1.35., Uronate dehydrogenase, -!- Also acts on D-lyxose and D-rhamnose., 3-oxo-Delta(4)-steroid 5-beta-reductase. 5-beta-reductase. Androstenedione 5-beta-reductase. Cholestenone 5-beta-reductase. Cortisone 5-beta-reductase. Cortisone beta-reductase. Cortisone Delta(4)-5-beta-reductase. Delta(4)-3-ketosteroid 5-beta-reductase. Delta(4)-5-beta-reductase. Delta(4)-hydrogenase. Steroid 5-beta-reductase. Testosterone 5-beta-reductase., Delta(4)-3-oxosteroid 5-beta-reductase., cinnamyl-alcohol dehydrogenase activity, All-trans-retinol dehydrogenase (NAD(+))., Drosophila melanogaster, 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH., cellular response to cold, L-Trp-dehydrogenase. L-tryptophan dehydrogenase. TrpDH., L-tryptophan + NAD(P)(+) = (indol-3-yl)pyruvate + NH(3) + NAD(P)H., Micromonospora sp. TP-A0468, Malate dehydrogenase [NADP] 1, chloroplastic, metal ion binding, -!- This enzyme, isolated from the bacterium Chlorobium tepidum, catalyzes the final step in the de novo synthesis of tetrahydrobiopterin from GTP. -!- Cf. EC 1.1.1.153., 1,5-anhydro-D-fructose reductase. AFR., [Bacillus] selenitireducens MLS10, R-specific carbonyl reductase, Putative polyol dehydrogenase, -!- In the fruit-ripening process of strawberry (Fragaria x ananassa) the reaction is catalyzed in the reverse direction from that shown. -!- 4-hydroxy-2,5-dimethylfuran-3(2H)-one is one of the major aroma compounds in the fruits. -!- The enzyme has also been detected in tomato (Solanum lycopersicum) fruits. -!- NADPH is the preferred cofactor., 2-methylene-furan-3-one reductase., UDP-D-glucuronate carboxy-lyase. UDP-glucuronic acid decarboxylase., UDP-glucuronic acid decarboxylase 1, Oxygenase-reductase, D-lactate dehydrogenase (Fermentative), Clostridium acetobutylicum ATCC 824, 2-(R)-hydroxypropyl-CoM dehydrogenase, Conserved protein, Methylobacterium extorquens AM1, Putative D-beta-hydroxybutyrate dehydrogenase, DNA gyrase, subunit B:Short-chain dehydrogenase/reductase SDR:Glucose/ribitol dehydrogenase, Pyridoxal 4-dehydrogenase., 2-haloacrylate reductase., halogenated hydrocarbon catabolic process, -!- The enzyme, characterized from the bacteria Hydrogenobaculum sp. and Syntrophomonas wolfei subsp. wolfei and from the archaea Metallosphaera sedula and Ignisphaera aggregans, can use both NADH and NADPH with similar efficiency (cf. EC 1.1.1.86 and EC 1.1.1.382)., Ignisphaera aggregans DSM 17230, CurF, Sugar 3-C-methyl transferase, regulation of cell cycle, transcription factor binding, transcriptional repressor complex, quinone binding, L-xylulose reductase., methylglyoxal reductase (NADPH-dependent) activity, D-octopine synthase. Octopine dehydrogenase. ODH., Formate dehydrogenase, chloroplastic/mitochondrial, Trk system potassium uptake protein TrkA, Glutathione-regulated potassium-efflux system ancillary protein KefF, NAD(P)H dehydrogenase (quinone) activity, -!- The enzyme catalyzes the reincorporation into peptidoglycan of the tripeptide L-alanyl-gamma-D-glutamyl-2,6-meso-diaminoheptanedioate released during the maturation and constant remodeling of this bacterial cell wall polymer that occur during cell growth and division. -!- The enzyme can also use the tetrapeptide L-alanyl-gamma-D-glutamyl- meso-2,6-diaminoheptanedioyl-D-alanine or the pentapeptide L-alanyl- gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanyl-D-alanine in vivo and in vitro., Neisseria meningitidis MC58, 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate., AmphB, Plasmodium falciparum CDC/Honduras, formate catabolic process, formate dehydrogenase (NAD+) activity, UDP-N-acetylglucosamine 4,6-dehydratase (inverting), lung development, transferrin transport, Kluyveromyces lactis NRRL Y-1140, substantia nigra development, -!- Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol. -!- Si-specific with respect to NADPH (cf. EC 1.1.1.2)., NAD-dependent dehydrogenase, SKN-1 Dependent Zygotic transcript, epithelial cell differentiation, Bifunctional pinoresinol-lariciresinol reductase 1, NEDD8-activating enzyme E1 regulatory subunit, drug metabolic process, Quinate/shikimate dehydrogenase, Siroheme + 2 H(+) = sirohydrochlorin + Fe(2+)., precorrin-2 dehydrogenase activity, siroheme biosynthetic process, regulation of neutrophil chemotaxis, Iridoid synthase., (-)-isopiperitenone reductase, terpene metabolic process, -!- In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity., Pyrroline-5-carboxylate reductase 1, mitochondrial, negative regulation of hydrogen peroxide-induced cell death, Brucella melitensis bv. 1 str. 16M, Ralstonia solanacearum GMI1000, Ketopantoate reductase protein, Shigella flexneri, (1) (-)-(4R,6S)-trans-carveol + NAD(+) = (-)-(4R)-carvone + NADH. (2) (+)-(4S,6S)-cis-carveol + NAD(+) = (+)-(4S)-carvone + NADH., Carveol dehydrogenase ((+)-trans-carveol dehydrogenase), -!- The animal enzyme is a multifunctional protein catalyzing the reactions of EC 2.3.1.38, EC 2.3.1.39, EC 2.3.1.41, EC 1.1.1.100, EC 4.2.1.59, EC 1.3.1.39 and EC 3.1.2.14., Fatty-acid synthase., inositol biosynthetic process, (+)-secoisolariciresinol biosynthetic process, -!- The reaction is catalyzed in vivo in the opposite direction to that shown. -!- A multifunctional enzyme that also reduces (-)-pinoresinol (EC 1.23.1.3). -!- Isolated from the plants Thuja plicata (western red cedar) and Linum corymbulosum., Rhodotorula mucilaginosa, Polyketide synthase extender modules 3-4, Glycerol-3-phosphate dehydrogenase [NAD(P)+], Datura stramonium, Pseudotropine + NADP(+) = tropinone + NADPH., Yersinia pseudotuberculosis YPIII, all-trans retinal binding, Listeria innocua Clip11262, Lactococcus lactis subsp. lactis Il1403, Leishmania donovani, Serine 3-dehydrogenase., 1D-chiro-inositol + NAD(+) = 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH., Acrylyl-CoA reductase (NADPH)., Putative oxidoreductase, peroxisome, Saccharopine dehydrogenase [NAD(+), L-lysine-forming], lysine biosynthetic process via aminoadipic acid, -!- Unlike EC 1.1.1.39, this enzyme can also decarboxylate oxaloacetate, cf. EC 1.1.1.40., fatty acid omega-oxidation, 4-hydroxy-tetrahydrodipicolinate reductase, diaminopimelate biosynthetic process, Homoserine dehydrogenase., L-glutamate + H(2)O + NAD(+) = 2-oxoglutarate + NH(3) + NADH., -!- In the forward direction, the enzyme from Arthrobacter sp. acts also on secondary amine dicarboxylates such as N-(1-carboxyethyl)methionine and N-(1-carboxyethyl)phenylalanine. -!- Dehydrogenation forms an imine, which dissociates to the amino acid and pyruvate. -!- In the reverse direction, the enzyme acts also on neutral amino acids as an amino donor. -!- They include L-amino acids such as 2-aminopentanoic acid, 2-aminobutyric acid, 2-aminohexanoic acid, 3-chloroalanine, O-acetylserine, methionine, isoleucine, valine, phenylalanine, leucine and alanine. -!- The amino acceptors include 2-oxoacids such as pyruvate, oxaloacetate, glyoxylate and 2-oxobutyrate., Opine dehydrogenase., Streptococcus suis, ADH3. Chi-ADH. Class III alcohol dehydrogenase. FDH. Formaldehyde dehydrogenase. Formaldehyde dehydrogenase (glutathione). Formic dehydrogenase. GD-FALDH. Glutathione-dependent formaldehyde dehydrogenase. GS-FDH. NAD- and glutathione-dependent formaldehyde dehydrogenase. NAD-dependent formaldehyde dehydrogenase. NAD-linked formaldehyde dehydrogenase., Alcohol dehydrogenase class-3, response to redox state, E1 ubiquitin-activating enzyme., H(2)-dependent methylene-H(4)MPT dehydrogenase. H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase. Hydrogen:N(5),N(10)-methenyltetrahydromethanopterin oxidoreductase. N(5),N(10)-methenyltetrahydromethanopterin hydrogenase. Nonmetal hydrogenase., N5,N10-methenyltetrahydromethanopterin hydrogenase activity, 3-hydroxybutyryl-CoA dehydrogenase., Actinobacterium-type cell wall biogenesis, -!- Isolated from the plants Forsythia intermedia and Podophyllum peltatum. -!- An intermediate lactol is detected in vitro., Secoisolariciresinol dehydrogenase., 15-oxoprostaglandin 13-oxidase activity, regulation of nitrogen utilization, Helicobacter pylori 26695, Malate oxidoreductase, -!- The enzyme, found in the bacterium Bacillus subtilis, has no activity with NAD(+) (cf. EC 1.1.1.370)., defense response to fungus, intracellular ribonucleoprotein complex, NEDD8 transferase activity, protein heterodimerization activity, RNA polymerase II activating transcription factor binding, adhesion of symbiont to host cell, entry of bacterium into host cell, growth, Cryptosporidium parvum, -!- Catalyzes the second of three steps leading to the formation of siroheme from uroporphyrinogen III. -!- The first step involves the donation of two S-adenosyl-L-methionine- derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107) and the third step involves the chelation of ferrous iron to sirohydrochlorin to form siroheme (EC 4.99.1.4). -!- In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. -!- In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirC being responsible for the above reaction., Candida tropicalis, (3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O., (3R)-hydroxyacyl-CoA dehydrogenase., 2-enoyl-CoA hydratase 2. D-3-hydroxyacyl-CoA hydro-lyase. D-specific 2-trans-enoyl-CoA hydratase. ECH2., D-3-hydroxyacyl-CoA dehydratase., Glucose--fructose oxidoreductase, PDZ domain binding, transferase activity, transferring acyl groups, Methanocaldococcus jannaschii DSM 2661, Tetrahydroxynaphthalene reductase, bile acid biosynthetic process, -!- The NAD(+) dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1; finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form., 6-phospho-beta-D-glucosyl-(1,4)-D-glucose + H(2)O = D-glucose + D-glucose 6-phosphate., oxidoreductase activity, acting on NAD(P)H, D-gluconate + NAD(P)(+) = 5-dehydro-D-gluconate + NAD(P)H., Alcohol dehydrogenase (Zinc), -!- The enzyme from Pseudomonas acts equally well on NAD(+) or NADP(+), while those from Erwinia chrysanthemi and Escherichia coli are more specific for NAD(+)., 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase., daunorubicin metabolic process, protein heterotetramerization, -!- The enzyme catalyzes a reversible reaction. -!- The enzyme from the bacterium Peptoniphilus asaccharolyticus is specific for (R)-2-hydroxyglutarate. -!- The SerA enzyme from Escherichia coli can also accept (S)-2- hydroxyglutarate with a much higher Km, and also catalyzes the activity of EC 1.1.1.95., homoserine biosynthetic process, ArnADH. UDP-GlcUA decarboxylase., ArnAFT. UDP-L-Ara4N formyltransferase., protein dimerization activity, Putative ketoacyl reductase, Aldose 1-dehydrogenase (NAD(P)(+))., Glucose 1-dehydrogenase (NAD(P)(+))., Trypanosoma brucei, R-specific alcohol dehydrogenase, Putative uncharacterized protein, Thermus thermophilus, -!- This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. -!- It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. -!- Enzymes from different organisms or tissues display different substrate specificity. -!- The enzyme is specific to NAD(+) and can not use NADP(+)., L-aspartate 4-semialdehyde + phosphate + NADP(+) = L-4-aspartyl phosphate + NADPH., Erythrose-4-phosphate dehydrogenase., pyridoxal phosphate biosynthetic process, UDP-N-acetylmuramoylalanine--D-glutamate ligase, E4P dehydrogenase. E4PDH. Erythrose 4-phosphate dehydrogenase., (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA., -!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211)., Dodecenoyl-CoA isomerase., Pseudomonas fragi, -!- This multiunctional enzyme catalyzes both the removal of nicotinamide from NADP(+), forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP(+), a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes. -!- In addition, the enzyme also catalyzes EC 3.2.2.6., NAD hydrolase. NAD(+) nucleosidase. NADase. Nicotinamide adenine dinucleotide nucleosidase., NAD(+) + H(2)O = ADP-D-ribose + nicotinamide., apoptotic signaling pathway, L-lactate dehydrogenase C chain, -!- Also acts on other 3-beta- or 17-beta-hydroxysteroids (cf. EC 1.1.1.209)., 3-hydroxyacyl-CoA dehydrogenase type-2, D-xylose 1-dehydrogenase (NADP(+))., D-xylose-NADP dehydrogenase., Dipicolinate synthase subunit A, Hydro-lyases., Mycobacterium abscessus ATCC 19977, N-acylmannosamine 1-dehydrogenase., Inositol 2-dehydrogenase., Plasmodium falciparum HB3, Oxidoreductase, putative, -!- This enzyme catalyzes the hydrolysis of NAD(+), without associated ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC 3.2.2.6, bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase). -!- The enzyme from Group A streptococci has been implicated in the pathogenesis of diseases such as streptococcal toxic shock-like syndrome (STSS) and necrotizing fasciitis. -!- The enzyme from the venom of the snake Agkistrodon acutus also catalyzes EC 3.6.1.5., Vitis vinifera, Enterococcus faecalis V583, -!- Also acts on other short-chain secondary alcohols and, slowly, on primary alcohols., UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH., UDP-glucose 6-dehydrogenase., -!- NADP(+) cannot replace NAD(+). -!- Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. -!- Other enzymes involved in this pathway are EC 1.17.1.5, EC 1.3.7.1, EC 3.5.2.18, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32., 2-hydroxymethylglutarate dehydrogenase., 3-hydroxybutyrate dehydrogenase, Formate + NAD(+) = CO(2) + NADH., Formate dehydrogenase., Carveol dehydrogenase., Acyl-CoA synthetase (NDP forming), Ralstonia eutropha H16, Meso-diaminopimelate D-dehydrogenase, Meso-diaminopimelate D-dehydrogenase., Symbiobacterium thermophilum IAM 14863, Phosphonate dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate dehydrogenase (NADP(+))., Bacillus anthracis, Ralstonia sp. DSMZ 6428, Staphylococcus aureus, ficolin-1-rich granule lumen, NADH oxidoreductase, -!- Also oxidizes other tropan-3-alpha-ols, but not the corresponding beta-derivatives. -!- Represents, along with EC 1.1.1.236, a branch point in tropane alkaloid metabolism. -!- Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines. -!- Both enzymes are always found together in any given tropane-alkaloid- producing species, have a common substrate, tropinone, and are strictly stereospecific., SiaM, Dyadobacter fermentans DSM 18053, -!- The product, 6-deoxyerythronolide B, contains a 14-membered lactone ring and is an intermediate in the biosynthesis of erythromycin antibiotics. -!- Biosynthesis of 6-deoxyerythronolide B requires 28 active sites that are precisely arranged along three large polypeptides, denoted DEBS1, -2 and -3. -!- The polyketide product is synthesized by the processive action of a loading didomain, six extension modules and a terminal thioesterase domain. -!- Each extension module contains a minimum of a ketosynthase (KS), an acyltransferase (AT) and an acyl-carrier protein (ACP). -!- The KS domain both accepts the growing polyketide chain from the previous module and catalyzes the subsequent decarboxylative condensation between this substrate and an ACP-bound methylmalonyl extender unit, introduce by the AT domain. -!- This combined effort gives rise to a new polyketide intermediate that has been extended by two carbon atoms., 6-deoxyerythronolide-B synthase., erythronolide synthase activity, Probable dehydrogenase, Thermomonospora curvata DSM 43183, cognition, Trans-2-enoyl-CoA reductase, mitochondrial, Quinoid DihydroPteridine Reductase, Plasmodium berghei ANKA, Benzyl alcohol dehydrogenase, L-arabinitol 4-dehydrogenase., Neurospora crassa OR74A, -!- The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC 1.1.1.103). -!- The enzyme has only very low activity with NADP(+) (cf. EC 1.1.1.276)., Short-chain dehydrogenase/reductase, Gluconate dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase (Hbd-9), 2'-hydroxyisoflavone reductase., Aldose 1-epimerase., Aldose mutarotase. Mutarotase., 15-hydroxyprostaglandin dehydrogenase (NAD(+))., lipoxin metabolic process, lipoxygenase pathway, (+)-neomenthol + NADP(+) = (-)-menthone + NADPH., Aquaspirillum arcticum, Thermococcus profundus, -!- Wide specificity for D-amino acids. -!- Also acts on glycine., A D-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2)., Enoyl-[acyl-carrier-protein] reductase [NADH] FabI, Escherichia coli K-12, 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H., 17-beta-estradiol 17-dehydrogenase., estradiol binding, -!- A number of alkyl-substituted derivatives of trimethylamine can also act as electron donors. -!- Phenazine methosulfate and 2,6-dichloroindophenol can act as electron acceptors. -!- Formerly EC 1.5.99.7., Trimethylamine dehydrogenase., Pinus taeda, 3-beta hydroxysteroid dehydrogenase/isomerase family protein, Putative prephenate dehydrogenase, Magnaporthe grisea, 2,4-dienoyl-CoA reductase [NADPH], Megavirus chiliensis, Yeast fatty acid synthase., Probable 3-oxacyl-(Acyl-carrier-protein) reductase, Vestitone reductase, D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = 3-phospho-D- glyceroyl phosphate + NADPH., -!- NAD(+) cannot replace NADP(+). -!- In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10., alanine dehydrogenase activity, Adenosylhomocysteinase, NAD binding, 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase, zinc ion binding, -!- Also acts on UDP-2-deoxyglucose., Galactowaldenase. UDP-galactose 4-epimerase. Uridine diphosphate galactose 4-epimerase. Uridine diphospho-galactose-4-epimerase., UDP-N-acetylglucosamine 4-epimerase., Malate dehydrogenase., extracellular polysaccharide biosynthetic process, NADP(H)-dependent ketose reductase, serotonin metabolic process, Methyltransferase, Putative Oxidoreductase, alcohol dehydrogenase [NAD(P)+] activity, Agrobacterium fabrum str. C58, 3-oxoacyl-(Acyl-carrier-protein) reductase, putative, Metalloreductase STEAP4, -!- The reaction is catalyzed in the reverse direction. -!- This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76). -!- While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. -!- This enzyme has been reported in the bacteria Geobacillus stearothermophilus, Enterobacter aerogenes and Klebsiella pneumoniae. -!- Different from EC 1.1.1.303. -!- Formerly EC 1.1.1.5., Corynebacterium glutamicum, Probable sorbitol dehydrogenase (L-iditol 2-dehydrogenase), A 3-alpha-hydroxy bile acid CoA ester + NAD(+) = a 3-oxo bile acid CoA ester + NADH., 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic, Peroxisomal bifunctional enzyme, Wolinella succinogenes DSM 1740, repressing transcription factor binding, Mycobacterium tuberculosis H37Ra, hydrolase activity, acting on glycosyl bonds, L-2-hydroxyisocaproate dehydrogenase, Mannitol 2-dehydrogenase., furaldehyde metabolic process, regulation of angiogenesis, regulation of transcription from RNA polymerase II promoter, transcription coactivator activity, phosphogluconate dehydrogenase (decarboxylating) activity, Malate dehydrogenase (decarboxylating)., Estradiol 17-beta-dehydrogenase 8, D-glycerate + NAD(P)(+) = 2-hydroxy-3-oxopropanoate + NAD(P)H., Lysine dehydrogenase, Quinone oxidoreductase, Probable acrylyl-CoA reductase AcuI, Ketol-acid reductoisomerase (NAD(+)), Streptomyces antibioticus, Narbonolide/10-deoxymethynolide synthase PikA2, modules 3 and 4, Pikromycin PKS., macrolide biosynthetic process, Oxidoreductase, NAD binding, ferredoxin-NAD+ reductase activity, D-galactose-1-dehydrogenase protein, apoptotic process, Streptomyces aurantiacus JA 4570, -!- Shows highest activity with 1-nitrocyclohexene but also has significant activity with 2-methylpentenal and trans-cinnamaldehyde. -!- Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones. -!- Has very low activity with NAD as reductant (cf. EC 1.3.1.74)., cellular response to drug, (2R)-2,3-dihydroxy-3-methylbutanoate + NAD(P)(+) = (2S)-2-hydroxy-2- methyl-3-oxobutanoate + NAD(P)H., Ketol-acid reductoisomerase (NAD(P)(+))., Plm1, Streptomyces sp. HK803, Glutamyl-tRNA reductase 1, chloroplastic, Transferred entry: 1.1.1.303 and 1.1.1.304., enoyl-CoA hydratase activity, Fusobacterium nucleatum subsp. nucleatum ATCC 25586, Peptoniphilus asaccharolyticus, Aldehyde reductase 2, Sporidiobolus salmonicolor, -!- The enzymes from Bacillus badius and Sporosarcina ureae are highly specific for L-phenylalanine; that from Bacillus sphaericus also acts on L-tyrosine., Alcohol dehydrogenase S chain, chaperone binding, cholesterol biosynthetic process, glucose-6-phosphate dehydrogenase activity, response to water deprivation, mitochondrial envelope, Salmonella enterica, Leucine dehydrogenase, -!- Acts on prostaglandins E(2), F(2)-alpha and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.141 and EC 1.1.1.196). -!- May be identical with EC 1.1.1.189., -!- Reduces prostaglandin E(2) to prostaglandin F(2)-alpha. -!- A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds. -!- May be identical with EC 1.1.1.197., 15-hydroxyprostaglandin dehydrogenase (NADP(+))., Carbonyl reductase [NADPH] 1, Myo-inositol 2-dehydrogenase-like (Promiscuous), retinol metabolic process, NADPH-dependent 3-quinuclidinone reductase, Forming carbon-oxygen bonds., potassium ion binding, tRNA threonylcarbamoyladenosine dehydratase, 3-hydroxyacyl-CoA dehydrogenase, DIM/DIP cell wall layer assembly, -!- Essential, along with EC 2.3.1.38, for the initiation of fatty-acid biosynthesis in bacteria. -!- Also provides the malonyl groups for polyketide biosynthesis. -!- The product of the reaction, malonyl-ACP, is an elongation substrate in fatty-acid biosynthesis. -!- In Mycobacterium tuberculosis, holo-ACP (the product of EC 2.7.8.7) is the preferred substrate. -!- This enzyme also forms part of the multienzyme complexes EC 4.1.1.88 and EC 4.1.1.89. -!- Malonylation of ACP is immediately followed by decarboxylation within the malonate-decarboxylase complex to yield acetyl-ACP, the catalytically active species of the decarboxylase. -!- In the enzyme from Klebsiella pneumoniae, methylmalonyl-CoA can also act as a substrate but acetyl-CoA cannot whereas the enzyme from Pseudomonas putida can use both as substrates. -!- The ACP subunit found in fatty-acid biosynthesis contains a pantetheine-4'-phosphate prosthetic group; that from malonate decarboxylase also contains pantetheine-4'-phosphate but in the form of a 2'-(5-triphosphoribosyl)-3'-dephospho-CoA prosthetic group., -!- This enzyme is responsible for the dehydration step of the dissociated (type II) fatty-acid biosynthesis system that occurs in plants and bacteria. -!- The enzyme uses fatty acyl thioesters of ACP in vivo. -!- Different forms of the enzyme may have preferences for substrates with different chain length. -!- For example, the activity of FabZ, the ubiquitous enzyme in bacteria, decreases with increasing chain length. -!- Gram-negative bacteria that produce unsaturated fatty acids, such as Escherichia coli, have another form (FabA) that prefers intermediate chain length, and also catalyzes EC 5.3.3.14. -!- Despite the differences both forms can catalyze all steps leading to the synthesis of palmitate (C16:0). -!- FabZ, but not FabA, can also accept unsaturated substrates. -!- Formerly EC 4.2.1.58, EC 4.2.1.60 and EC 4.2.1.61., Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate., pantothenate metabolic process, acetaldehyde catabolic process, Glutamyl-tRNA reductase., Malic enzyme. NADP-malic enzyme. Pyruvic-malic carboxylase., ADP-ribosyl cyclase activity, specific granule membrane, steroid metabolic process, (-)-isopiperitenone reductase., Streptomyces clavuligerus, Quinone oxidoreductase PIG3, acetoin metabolic process, Carbonyl Reductase, Klebsiella pneumoniae subsp. pneumoniae MGH 78578, -!- The enzyme, which transfers electrons from NADPH to adrenodoxin molecules, is the first component in the mitochondrial cytochrome P450 electron transfer systems, and is involved in the biosynthesis of all steroid hormones., ferredoxin-NADP+ reductase activity, flavin adenine dinucleotide binding, Reduced coenzyme F420 + NADP(+) = oxidized coenzyme F420 + NADPH., Synechocystis sp. PCC 6803 substr. Kazusa, Synaptic vesicle membrane protein VAT-1 homolog-like, Sphingomonas elodea, Malonyl CoA reductase (NADP). NADP-dependent malonyl CoA reductase., Malonyl-CoA reductase, Zinc-type alcohol dehydrogenase-like protein, (1) S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L- homocysteine + precorrin-1. (2) S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2., -!- This enzyme catalyzes two sequential methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2. -!- It is the first of three steps leading to the formation of siroheme from uroporphyrinogen III. -!- The second step involves an NAD(+)-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76) and the third step involves the chelation of Fe(2+) to sirohydrochlorin to form siroheme (EC 4.99.1.4). -!- In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. -!- In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirA being responsible for the above reaction. -!- Also involved in the biosynthesis of cobalamin., Siroheme synthase, Uroporphyrinogen-III C-methyltransferase., (S)-malate + NADP(+) = oxaloacetate + NADPH., Thermus aquaticus, Nostoc punctiforme NIES-2108, nuclear speck, (1) 5-beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH. (2) 17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP(+) = cortisone + NADPH., Thermotoga sp. RQ2, Pseudotropine forming tropinone reductase. TR-II. Tropinone reductase., 2-hydroxymethylglutarate dehydrogenase activity, Dihydroanticapsin 7-dehydrogenase, Putative 2-hydroxyacid dehydrogenase, 4-hydroxy-2,5-dimethylfuran-3(2H)-one + NAD(P)(+) = 4-hydroxy-5-methyl-2- methylenefuran-3(2H)-one + NAD(P)H., Enone oxidoreductase., Clarkia breweri, Bacillus halodurans C-125, Moraxella catarrhalis BBH18, 2,4-dienoyl-CoA reductase, pyridoxal 4-dehydrogenase activity, Cinnamyl alcohol + NADP(+) = cinnamaldehyde + NADPH., Ascaris suum, NAD-dependent aspartate dehydrogenase. NADH(2)-dependent aspartate dehydrogenase. NADP(+)-dependent aspartate dehydrogenase., Probable L-aspartate dehydrogenase, Sulfolobus tokodaii str. 7, cellular response to oxidative stress, NADH-dependent quinuclidinone reductase, negative regulation of sequence-specific DNA binding transcription factor activity, mitochondrial outer membrane, Nitrogen metabolite repression protein nmrA, nucleolus, lysine catabolic process, NADP-dependent alkenal double bond reductase P1, killing of cells of other organism, negative regulation of endopeptidase activity, 17-beta-hydroxysteroid dehydrogenase (NAD+) activity, Peroxisomal multifunctional enzyme type 2, 3-oxoacyl-ACP reductase, Sulfolobus acidocaldarius DSM 639, 2-dehydro-3-deoxy-D-gluconate + NAD(+) = (4S)-4,6-dihydroxy-2,5- dioxohexanoate + NADH., 2-keto-3-deoxygluconate dehydrogenase., cadherin binding, Lactaldehyde dehydrogenase (NADP(+)). Methylglyoxal reductase (NADPH-dependent)., Shikimate dehydrogenase family protein, S-adenosylmethionine biosynthetic process, fatty-acyl-CoA biosynthetic process, -!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4., Nocardiopsis halophila, vesicle, Acid--amino-acid ligases (peptide synthases)., zymogen binding, prostaglandin metabolic process, potassium ion transport, regulation of pH, multivesicular body, protein secretion, Levodione reductase, R-CHOH-R' + NADP(+) = R-CO-R' + NADPH., acetoacetyl-CoA reductase activity, (1) L-quinate + NAD(P)(+) = 3-dehydroquinate + NAD(P)H. (2) Shikimate + NAD(P)(+) = 3-dehydroshikimate + NAD(P)H., glutamate dehydrogenase [NAD(P)+] activity, 7-alpha-hydroxysteroid dehydrogenase, Putative d-3-phosphoglycerate dehydrogenase oxidoreductase protein, Dihydroflavanol 4-reductase., Starvation sensing protein rspB, P5CR., Pyrroline-5-carboxylate reductase., (+)-lariciresinol biosynthetic process, (+)-pinoresinol catabolic process, (+)-pinoresinol-(+)-lariciresinol reductase. (+)-pinoresinol/(+)-lariciresinol. Pinoresinol-lariciresinol reductases. Pinoresinol/lariciresinol reductase., (+)-secoisolariciresinol + NADP(+) = (-)-lariciresinol + NADPH., (-)-lariciresinol catabolic process, (-)-pinoresinol reductase., protein neddylation, UDP-N-acetylmuramate-L-alanine ligase activity, choline catabolic process, Malate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase, Caenorhabditis elegans, Tropinone reductase II., Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase, isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process, response to organic cyclic compound, Atg8 activating enzyme activity, -!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction., Quinone oxidoreductase 2, Thermoplasma volcanium GSS1, 2-dehydropantoate 2-reductase, Ketopantoate reductase. Ketopantoic acid reductase. KPA reductase., -!- The enzyme, characterized from Vitis vinifera (grape), participates in the flavonoid biosynthesis pathway. -!- It catalyzes the double reduction of anthocyanidins, producing a mixture of (2S,3S)- and (2S,3R)-flavan-3-ols. -!- The enzyme catalyzes sequential hydride transfers to C-2 and C-4, respectively. -!- Epimerization at C-3 is achieved by tautomerization that occurs between the two hydride transfers. -!- Cf. EC 1.3.1.77., Inositol 2-dehydrogenase, Dehydrogenase, -!- Forms part of the rat peroxisomal multifunctional enzyme perMFE-2, which also exhibits a dehydrogenase activity. -!- Involved in the beta-oxidation of the cholesterol side chain in the cholic-acid biosynthesis pathway., (1) L-erythro-7,8-dihydrobiopterin + NADP(+) = sepiapterin + NADPH. (2) L-erythro-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8- tetrahydropterin + 2 NADPH., Trans-2-enoyl-CoA reductase [NADH], trans-2-enoyl-CoA reductase (NAD+) activity, trans-2-enoyl-CoA reductase (NADPH) activity, intracellular accumulation of glycerol, NADPH dependent R-specific alcohol dehydrogenase, macroautophagy, Capsular polysaccharide synthesis enzyme Cap8E, Diaminopimelate dehydrogenase., Candida parapsilosis, Acinetobacter baylyi, NAD-dependent phosphite dehydrogenas. NAD:phosphite oxidoreductase. Phosphite dehydrogenase., Phosphonate + NAD(+) + H(2)O = phosphate + NADH., -!- The enzyme catalyzes a step of the pentose phosphate pathway. -!- The enzyme is specific for NADP(+), cf. EC 1.1.1.363 and EC 1.1.1.388., dTDP-glucose 4,6-dehydratase, Calcium-gated potassium channel MthK, GDP-mannose metabolic process, Glutamate dehydrogenase., NAD-specific glutamate dehydrogenase, Methanothermus fervidus, Alcohol dehydrogenase class 4 mu/sigma chain, response to bacterium, L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH., -!- Forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-alpha-L-fucose. -!- In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalyzing the above reaction as well as the reaction catalyzed by EC 1.1.1.281., S-(hydroxymethyl)glutathione dehydrogenase activity, Succinate--CoA ligase (GDP-forming)., (1) (S)-malate + NAD(+) = pyruvate + CO(2) + NADH. (2) Oxaloacetate = pyruvate + CO(2)., Magnaporthe oryzae 70-15, -!- Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone. -!- Involved with EC 4.2.1.94 in the biosynthesis of melanin in pathogenic fungi. -!- Formerly EC 1.3.1.50., very long-chain fatty-acyl-CoA metabolic process, Brucella ovis ATCC 25840, UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose., D-3-phosphoglycerate dehydrogenase-related protein, -!- The enzyme from the bacterium Escherichia coli is involved in a galactitol degradation pathway., tricarboxylic acid cycle, Apicomplexa, regulation of intracellular estrogen receptor signaling pathway, -!- NADP(+) cannot replace NAD(+). -!- Forms part of the monoterpenoid biosynthesis pathway in Carum carvi (caraway) seeds., Catharanthus roseus, steroid catabolic process, Aeropyrum pernix K1, positive regulation of glycolytic process, -!- The enzyme from most aerobic organisms is devoid of redox-active centers but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centers, flavin and a molybdenum center. -!- Together with EC 1.12.1.2, forms a system previously known as formate hydrogenlyase., Formate dehydrogenase, methionine biosynthetic process, toxic substance binding, Streptomyces nodosus, 6-phospho-beta-glucosidase., Pyrobaculum islandicum, Aspartate dehydrogenase., Glutamic dehydrogenase., -!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols., Alcohol dehydrogenase., -!- Also oxidizes some other 2-hydroxydicarboxylic acids., Malate dehydrogenase, ADP-L-glycero-D-manno-heptose 6-epimerase., D-amino-acid oxidase, biotin biosynthetic process, protein homotetramerization, NADP+ binding, catalytic activity, Sorbitol dehydrogenase, Streptomyces coelicolor A3(2), glucocorticoid biosynthetic process, Rattus norvegicus, -!- In the reverse direction, reduction on the 4-position of the hexose moiety takes place only while the substrate is bound to another enzyme that catalyzes epimerization at C-3 and C-5; the complex has been referred to as dTDP-L-rhamnose synthase., dTDP-4-dehydrorhamnose reductase., dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + NADPH., -!- Also acts very slowly on D-glyceraldehyde and some other aldehydes. -!- Thiols can replace phosphate., Oryctolagus cuniculus, D-mannitol + NADP(+) = D-fructose + NADPH., Shikimate dehydrogenase (NADP(+)), Glutamate dehydrogenase, Bacillus subtilis subsp. subtilis str. 168, UDP-glucose 6-dehydrogenase, UDP-glucuronate biosynthetic process, glycosaminoglycan biosynthetic process, Glyoxylate reductase (NADP(+))., 2-oxoglutarate reductase., L-serine biosynthetic process, Phosphoglycerate dehydrogenase., succinate-CoA ligase complex (ADP-forming), Pyrococcus horikoshii OT3, cell wall, Bifunctional polymyxin resistance protein ArnA, (S)-lactate + NAD(+) = pyruvate + NADH., L-lactate dehydrogenase., NADPH:quinone reductase., CD38 molecule, UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase., galactose binding, xylose binding, (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA., (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH., -!- Also catalyzes the interconversion of 3-acetylenic fatty acyl thioesters and (+)-2,3-dienoyl fatty acyl thioesters, with fatty acid chain lengths C(6) to C(12)., Fatty acid oxidation complex subunit alpha, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, NAD+ nucleosidase activity, lactate biosynthetic process from pyruvate, -!- The enzyme is specific for quinate as substrate; phenylpyruvate, phenylalanine, cinnamate and shikimate will not act as substrates. -!- NAD(+) cannot be replaced by NADP(+)., Quinate/shikimate dehydrogenase (NAD(+)), 3(or 17)-beta-hydroxysteroid dehydrogenase., Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH., -!- This enzyme catalyzes a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate. -!- The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD(+). -!- In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyzes the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)- hydroxy acid. -!- Cf. EC 1.1.1.399., Erythronate-4-phosphate dehydrogenase, Malate dehydrogenase, cytoplasmic, Zingiber officinale, Lysine-2-oxoglutarate reductase., Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic, chloroplast thylakoid membrane, Helicobacter pylori G27, DCI 1-dehydrogenase., Papaver somniferum, salutaridine reductase (NADPH) activity