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regulation of transcription, DNA-templated, Uncharacterized protein, Pyrococcus horikoshii OT3, nickel cation binding, protein binding, transcription regulatory region sequence-specific DNA binding, Transferred entry: 2.2.1.6., acetolactate synthase activity, negative regulation of transcription, DNA-templated, identical protein binding, Probable acetolactate synthase isozyme III (Small subunit), DNA binding, Escherichia coli K-12, Thermotoga maritima MSB8, Acetolactate synthase isozyme 3 small subunit, Nickel-responsive regulator, cytosol, Helicobacter pylori G27, Helicobacter pylori 26695, valine biosynthetic process, 2 pyruvate = 2-acetolactate + CO(2)., Acetolactate synthase small subunit, Nitrosomonas europaea ATCC 19718, isoleucine biosynthetic process, Putative nickel-responsive regulator, sequence-specific DNA binding

Transferred entry: 2.2.1.6., -!- The reaction shown is in the pathway of biosynthesis of valine. -!- The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine. -!- Formerly EC 4.1.3.18., Tyrosine 3-monooxygenase., cellular response to drug, cognition, response to activity, response to amphetamine, response to hypoxia, response to nutrient levels, response to pyrethroid, sphingolipid metabolic process, low-density lipoprotein particle receptor binding, Mycobacterium avium 104, ATPase activity, -!- The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 1.1.1.3. -!- This is also the case for two of the four isoenzymes in Arabidopsis thaliana. -!- The equilibrium constant strongly favors the reaction from right to left, i.e. the non-physiological direction of reaction., Homoserine dehydrogenase., Thiobacillus denitrificans ATCC 25259, Acetolactate synthase isozyme 1 small subunit, Amino acid-binding ACT:D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain:D-isomer specific 2-hydroxyacid dehydr, Mg2+ transport protein, Phospholipid-translocating ATPase., cellular response to magnesium starvation, Acetolactate synthase small subunit, Thermotoga maritima MSB8, cell wall, lysine biosynthetic process via diaminopimelate, D-ribose metabolic process, Aspartokinase 1, chloroplastic, 5-phosphoribose isomerase. D-ribose-5-phosphate ketol-isomerase. Phosphopentoseisomerase. Phosphopentosisomerase. Phosphoriboisomerase. Ribose 5-phosphate epimerase. Ribose phosphate isomerase., D-ribose 5-phosphate = D-ribulose 5-phosphate., Francisella tularensis subsp. tularensis SCHU S4, valine biosynthetic process, cellular response to glucose stimulus, cellular response to manganese ion, phytoalexin metabolic process, Pseudomonas putida KT2440, Helicobacter pylori 26695, endomembrane system, Unknown protein, D-methionine transmembrane transporter activity, pyridoxine biosynthetic process, response to corticosterone, response to isolation stress, response to lipopolysaccharide, terminal bouton, -!- The reaction involves an arene oxide which rearranges to give the phenolic hydroxy group. -!- This results in the hydrogen at C-4 migrating to C-3 and in part being retained, a process known as the NIH-shift. -!- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96. -!- The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin. -!- Formerly EC 1.14.3.1 and EC 1.99.1.2., L-phenylalanine + tetrahydrobiopterin + O(2) = L-tyrosine + 4a-hydroxytetrahydrobiopterin., PAH. Phenylalaninase. Phenylalanine 4-hydroxylase. Phenylalanine hydroxylase., Phenylalanine-4-hydroxylase, DNA binding, -!- A cytosolic peptidase that is active at neutral pH. -!- It has broad activity on peptides, although it is highly selective for Arg-Arg-2-naphthylamide, at pH 9.2. -!- Active in the hydrolysis of enkephalins. -!- Belongs to peptidase family M49., extracellular exosome, nuclear speck, proteolysis, -!- Catalyzes the first committed and rate-limiting step in the phosphoserine pathway of serine biosynthesis. -!- The reaction occurs predominantly in the direction of reduction. -!- The enzyme from the bacterium Escherichia coli also catalyzes the activity of EC 1.1.1.399., Aspartokinase., -!- Also acts on D-ribose 5-diphosphate and D-ribose 5-triphosphate., homoserine biosynthetic process, L-tyrosine + tetrahydrobiopterin + O(2) = L-dopa + 4a-hydroxytetrahydrobiopterin., Rattus norvegicus, aminergic neurotransmitter loading into synaptic vesicle, cytoplasmic vesicle membrane, dendrite, response to drug, response to electrical stimulus, response to light stimulus, response to metal ion, response to organic cyclic compound, Thermus thermophilus HB8, LDLR chaperone MESD, Probable dipeptidyl peptidase 3, Thermus thermophilus, Streptococcus mutans UA159, Archaeoglobus fulgidus DSM 4304, Mycobacterium tuberculosis CDC1551, pathogenesis, oogenesis, protein targeting to membrane, 2 pyruvate = 2-acetolactate + CO(2)., Acetohydroxy acid synthetase. Acetohydroxyacid synthase. Acetolactate pyruvate-lyase (carboxylating). Acetolactic synthetase. Alpha-acetohydroxy acid synthetase. Alpha-acetohydroxyacid synthase. Alpha-acetolactate synthase. Alpha-acetolactate synthetase., Acetolactate synthase., acetolactate synthase activity, -!- This enzyme in the enteric bacteria also possesses EC 5.4.99.5 activity and converts chorismate into prephenate., Prephenate dehydratase, Dipeptidyl aminopeptidase III. Dipeptidyl arylamidase III. DPP III. Enkephalinase B. Red cell angiotensinase., Dipeptidyl peptidase 3, Dipeptidyl-peptidase III., dipeptidyl-peptidase activity, cellular amino acid biosynthetic process, ATP binding, regulation of transcription, DNA-templated, Aspartokinase, Corynebacterium glutamicum ATCC 13032, Ribose-5-phosphate isomerase., Vibrio cholerae O1 biovar El Tor str. N16961, Escherichia coli K-12, Phosphoglycerate dehydrogenase., pentose-phosphate shunt, UPF0250 protein YbeD, Bifidobacterium adolescentis ATCC 15703, GTP pyrophosphokinase, Formyltetrahydrofolate deformylase., Plasmodium falciparum 3D7, Ribose-5-phosphate isomerase, magnesium ion binding, Acting on acid anhydrides; catalyzing transmembrane movement of substances., D-methionine transport, -!- Activated by phosphorylation, catalyzed by EC 2.7.11.27. -!- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96. -!- The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin., cellular response to growth factor stimulus, monooxygenase activity, neuron projection, response to ether, response to immobilization stress, response to peptide hormone, response to steroid hormone, social behavior, Methanocaldococcus jannaschii DSM 2661, [Pseudomonas syringae] pv. tomato str. DC3000, endoplasmic reticulum, Nitrosomonas europaea ATCC 19718, Corynebacterium crenatum, -!- GDP can also act as acceptor., GTP diphosphokinase., Brucella abortus 2308, Toxoplasma gondii ME49, -!- The enzyme from Saccharomyces cerevisiae acts most rapidly with NAD(+); the Neurospora enzyme with NADP(+). -!- The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 2.7.2.4., Phenylalanine 4-monooxygenase., phenylalanine 4-monooxygenase activity, Phosphoserine phosphatase, Similar to chorismate mutase, Staphylococcus aureus subsp. aureus Mu50, Prephenate = phenylpyruvate + H(2)O + CO(2)., Streptococcus pneumoniae TIGR4, Arabidopsis thaliana, -!- The enzyme catalyzes a reversible reaction. -!- The enzyme from the bacterium Peptoniphilus asaccharolyticus is specific for (R)-2-hydroxyglutarate. -!- The SerA enzyme from Escherichia coli can also accept (S)-2- hydroxyglutarate with a much higher Km, and also catalyzes the activity of EC 1.1.1.95., L-phenylalanine catabolic process, response to water deprivation, sensory perception of sound, Tyrosine 3-monooxygenase, amino acid binding, axon, dopamine binding, isoquinoline alkaloid metabolic process, perikaryon, Methionine import ATP-binding protein MetN 2, protein folding, phthalate metabolic process, Pyrococcus horikoshii OT3, Galdieria sulphuraria, aspartate kinase activity, 2-oxoglutarate reductase., serine binding, Aspartate kinase., Ribose-5-phosphate isomerase A, Vibrio vulnificus YJ016, 2-hydroxyglutarate dehydrogenase activity, Ribulose 5-phosphate isomerase, Enterococcus faecalis V583, -!- P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- The enzyme apparently has several activities, one of them being the movement of phospholipids from one membrane face to the other. -!- Formerly EC 3.6.3.13., Boca/MESD chaperone for YWTD beta-propeller-EGF, Caenorhabditis elegans, ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate., GTP pyrophosphokinase. Guanosine 3',5'-polyphosphate synthase. ppGpp synthetase I. Stringent factor., diaminopimelate biosynthetic process, Homo sapiens, plasma membrane, zinc ion binding, tetrahydrobiopterin binding, tyrosine 3-monooxygenase activity, Acetolactate synthase isozyme 3 small subunit, catecholamine biosynthetic process, cellular response to nicotine, cerebral cortex development, dopamine biosynthetic process from tyrosine, fatty acid metabolic process, ferric iron binding, ferrous iron binding, glycoside metabolic process, heart development, multicellular organism aging, protein domain specific binding, response to ethanol, response to herbicide, response to zinc ion, Modulator protein MzrA, cytoplasm, D-3-phosphoglycerate dehydrogenase, Homoserine dehydrogenase, Burkholderia thailandensis E264, acetolactate synthase complex, Porphyromonas gingivalis W83, ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)., Phosphoserine phosphatase., ribose-5-phosphate isomerase activity, chloroplast stroma, UPF0237 protein SP_0238, Transcriptional regulatory protein TyrR, negative regulation of transcription, DNA-templated, Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides., identical protein binding, protein localization to cell surface, Klebsiella pneumoniae subsp. pneumoniae MGH 78578, Pseudomonas aeruginosa PAO1, endoplasmic reticulum lumen, low-density lipoprotein receptor particle metabolic process, proboscis development, Wnt signaling pathway, apical part of cell, Aspartokinase LysC beta subunit, Uncharacterized protein HP_0495, Mycobacterium tuberculosis H37Rv, 10-formyltetrahydrofolate + H(2)O = formate + tetrahydrofolate., Formyltetrahydrofolate deformylase, L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H., Vibrio parahaemolyticus RIMD 2210633, Haemophilus influenzae Rd KW20, Lysine-sensitive aspartokinase 3, L-tyrosine hydroxylase. Tyrosine 3-hydroxylase. Tyrosine hydroxylase., circadian sleep/wake cycle, response to growth factor, response to insecticide, terpene metabolic process, isoleucine biosynthetic process, Mus musculus, Bartonella henselae str. Houston-1, Prephenate dehydratase., Lactobacillus salivarius UCC118, protein binding, ATP + L-aspartate = ADP + 4-phospho-L-aspartate., (R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH., 3-phosphoglycerate dehydrogenase. 3-phosphoglyceric acid dehydrogenase. 3PHP reductase. Alpha-KG reductase. Alpha-phosphoglycerate dehydrogenase. D-3-phosphoglycerate dehydrogenase. Glycerate 3-phosphate dehydrogenase. Glycerate-1,3-phosphate dehydrogenase. PGDH. Phosphoglycerate oxidoreductase. Phosphoglyceric acid dehydrogenase., cytosol, phosphoglycerate dehydrogenase activity, Probable chorismate mutase, Drosophila melanogaster, ER to Golgi vesicle-mediated transport, LDLR chaperone boca, Neisseria meningitidis MC58, growth, Formyl-FH(4) hydrolase. Formyltetrahydrofolate hydrolase., Rhodopseudomonas palustris CGA009, Saccharomyces cerevisiae S288C, pentose-phosphate shunt, non-oxidative branch, Chlorobium tepidum TLS, O-phospho-L(or D)-serine + H(2)O = L(or D)-serine + phosphate., Methionine import ATP-binding protein MetN, Burkholderia mallei ATCC 23344, Uncharacterized protein AF_1403, Francisella tularensis subsp. tularensis WY96-3418, Flippase. Magnesium-ATPase. Mg(2+)-ATPase. Phospholipid-transporting ATPase., response to nicotine, response to salt stress, synaptic vesicle, Paenarthrobacter aurescens TC1, cellular response to alkaloid, mitochondrion, neuronal cell body, oxygen binding, protein homotetramerization, response to estradiol