Search CATH

putamen development, Methionine aminopeptidase 2, 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase., CST complex, Protein STN1, telomere capping, Neck appendage protein, Transcriptional regulator, GntR family, HTH-type transcriptional regulator TsaR, endo-alpha-(2,8)-sialidase activity, Protein mlc, protein N-terminus binding, DNA-directed RNA polymerase III complex, DNA dealkylation involved in DNA repair, positive regulation of double-strand break repair, Possible MarR-transcriptional regulator, ATP-dependent DNA helicase activity, ATP-dependent helicase activity, Bloom syndrome protein, G-quadruplex DNA unwinding, four-way junction DNA binding, mitotic G2 DNA damage checkpoint, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Probable HTH-type transcriptional regulator YgaV, Mycobacterium tuberculosis CDC1551, amino acid binding, Z-DNA-binding protein 1, ORC1-type DNA replication protein 2, sequence-specific mRNA binding, HTH-type transcriptional repressor YvoA, Transcriptional regulator, AsnC family, Staphylococcus aureus subsp. aureus NCTC 8325, bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding, XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine., negative regulation of type I interferon production, cullin-RING ubiquitin ligase complex, ubiquitin-protein transferase activity, Chalcone OMT. CHMT., Licodione 2'-O-methyltransferase., licodione 2'-O-methyltransferase activity, cellular response to diamide, centrosome, chromatin DNA binding, mRNA transcription, positive regulation of cell proliferation, regulation of cellular response to heat, ribonucleoprotein complex, Kluyveromyces lactis NRRL Y-1140, DNA-dependent RNA polymerase. RNA nucleotidyltransferase (DNA-directed). RNA polymerase I. RNA polymerase II. RNA polymerase III., biotin binding, biotin metabolic process, Non-specific serine/threonine protein kinase., Protein phosphokinase. Protein serine kinase. Protein serine-threonine kinase. Protein-serine kinase. Serine kinase. Serine protein kinase. Serine(threonine) protein kinase. Serine-specific protein kinase. Serine/threonine protein kinase. Threonine-specific protein kinase., regulation of nitrate assimilation, adenosine to inosine editing, bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding, beta-catenin binding, canonical Wnt signaling pathway, General transcription factor IIF subunit 2, microtubule cytoskeleton, nucleoplasm, Escherichia coli K-12, sequence-specific DNA binding, cochlea morphogenesis, cytosol, dendrite morphogenesis, neurotransmitter secretion, positive regulation of protein phosphorylation, regulation of neurotransmitter levels, regulation of protein phosphorylation, skeletal muscle acetylcholine-gated channel clustering, cobalt ion binding, Response regulator SaeR, CviR transcriptional regulator, Methanosarcina mazei Go1, ERBB2 signaling pathway, DNA-binding response regulator, mitochondrion, positive regulation of cysteine-type endopeptidase activity, positive regulation of T-helper 1 cell differentiation, positive regulation of interleukin-12 biosynthetic process, regulation of adaptive immune response, anaphase-promoting complex, Plasmodium falciparum 3D7, Jannaschia sp. CCS1, Acetylserotonin O-methyltransferase., HTH-type transcriptional repressor PhnF, -!- Specifically methylates 2,4',7-trihydroxyisoflavanone on the 4'-position. -!- No activity with isoflavones. -!- The enzyme is involved in formononetin biosynthesis in legumes. -!- The protein from pea (Pisum sativum) also methylates (+)- 6a-hydroxymaackiain at the 3-position (cf. EC 2.1.1.270)., Isoflavone 4'-O-methyltransferase., S-adenosyl-L-methionine + 2,4',7-trihydroxyisoflavanone = S-adenosyl-L- homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone., transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding, ECF RNA polymerase sigma factor SigD, Yersinia pseudotuberculosis YPIII, channel regulator activity, -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49., leucine biosynthetic process, -!- Hydrolyzes the products of EC 2.1.1.77, EC 2.1.1.78, EC 2.1.1.80 and EC 2.1.1.100., Carminomycin 4-O-methyltransferase DnrK, daunorubicin biosynthetic process, Catalase HPII, anatomical structure morphogenesis, central nervous system development, peptidyl-lysine acetylation, positive regulation of transcription elongation from RNA polymerase II promoter, regulation of cell cycle, positive regulation of integrin activation, protein kinase C signaling, Possible two component system response transcriptional positive regulator PhoP, positive regulation of gene expression, protein secretion by the type VII secretion system, DNA repair, chromatin silencing at rDNA, Peroxin 14, tRNA modification, chromatin, error-prone translesion synthesis, nucleotide-excision repair, DNA incision, nucleotide-excision repair, preincision complex stabilization, protein phosphatase binding, telomere maintenance, Caffeate O-methyltransferase., Transcriptional activator HlyU, host cell cytoplasm, Klebsiella pneumoniae JM45, Lactococcus lactis subsp. cremoris MG1363, Bacteroides thetaiotaomicron VPI-5482, Putative curved DNA-binding protein, Burkholderia thailandensis E264, Cell division control protein 53, Heat shock factor protein, magnesium ion binding, double-stranded RNA adenosine deaminase activity, response to interferon-alpha, cellular glucose homeostasis, histone H4-K16 acetylation, regulation of autophagy, SAM pointed domain-containing Ets transcription factor, RecBCD enzyme subunit RecD, GDP binding, GTP binding, Lmo0741 protein, Probable transcription repressor NiaR, positive regulation of sporulation resulting in formation of a cellular spore, Clostridioides difficile 630, DNA-directed RNA polymerase III subunit RPC6, telomere maintenance via telomere lengthening, Transcriptional repressor PagR, DDRGK domain-containing protein 1, Endodeoxyribonucleases producing other than 5'-phosphomonoesters., response to intra-S DNA damage checkpoint signaling, Staphylococcus aureus USA300-ISMMS1, DNA-dependent ATPase activity, replisome, single-stranded DNA-dependent ATP-dependent DNA helicase complex, HTH-type transcriptional regulator MgrA, (1) S-adenosyl-L-methionine + 6-demethylmitomycin A = S-adenosyl-L- homocysteine + mitomycin A. (2) S-adenosyl-L-methionine + 6-demethylmitomycin B = S-adenosyl-L- homocysteine + mitomycin B., Nostoc sp. PCC 7120, UPF0502 protein PSPTO_2686, negative regulation of siderophore biosynthetic process, positive regulation of peroxidase activity, Transcriptional regulator BlaI, SsrB, cell morphogenesis, liver morphogenesis, trophectodermal cellular morphogenesis, Exiguobacterium sibiricum 255-15, Protein FEV, positive regulation of protein acetylation, protein kinase C binding, NEDD8-specific protease activity, nucleotide-excision repair, DNA damage recognition, OxyR, Histone H1, negative regulation of chromatin silencing, Probable [Fe-S]-dependent transcriptional repressor FeoC, carbon catabolite activation of transcription from RNA polymerase II promoter, chromosome segregation, Sensory transduction protein regX3, endosomal transport, endosome membrane, positive regulation of exosomal secretion, Ralstonia eutropha JMP134, Forkhead box protein P1, endothelial cell activation, negative regulation of androgen receptor signaling pathway, regulation of inflammatory response, regulation of interleukin-12 secretion, nucleosome, CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment, Forkhead box protein P3, NFAT protein binding, negative regulation of CREB transcription factor activity, Non-structural maintenance of chromosomes element 1 homolog, (RS)-norcoclaurine 6-O-methyltransferase., BH3703 protein, Ethanolamine utilization protein EutK, CalO1, nervous system development, response to G1 DNA damage checkpoint signaling, transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding, oxidoreductase activity, positive regulation of histone ubiquitination, positive regulation of sequence-specific DNA binding transcription factor activity, regulation of double-strand break repair via homologous recombination, Transcriptional regulator MntR, G1/S transition of mitotic cell cycle, SCF ubiquitin ligase complex, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, T cell receptor signaling pathway, cell cycle arrest, stimulatory C-type lectin receptor signaling pathway, LexA repressor, positive regulation of protein tyrosine kinase activity, protein self-association, segmentation, Neocarzinostatin O-methyltransferase., Streptomyces carzinostaticus, positive regulation of nitrogen compound metabolic process, positive regulation of oxidoreductase activity, response to nitric oxide, cellular response to hyperoxia, positive regulation of protein catabolic process, response to heat, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, plasmid recombination, GTPase activator activity, regulation of mRNA stability, negative regulation of protein phosphorylation, plasma membrane, protein localization to microtubule, receptor clustering, synapse, synapse organization, Iron-dependent repressor IdeR, cell wall, growth, -!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase)., 7-methylguanosine mRNA capping, transcriptional preinitiation complex, Methionyl aminopeptidase., Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides., aminopeptidase activity, Selenocysteine-specific elongation factor, carboxy-lyase activity, Archaeoglobus fulgidus DSM 4304, global genome nucleotide-excision repair, cellular response to interleukin-6, nucleotide-binding oligomerization domain containing 2 signaling pathway, positive regulation of NF-kappaB transcription factor activity, response to interleukin-1, regulation of Ras protein signal transduction, Klebsiella pneumoniae 342, HTH-type transcriptional regulator SarR, -!- This protein is involved in the repair of Sp diastereomers of DNA methylphosphotriester lesions. -!- This enzyme catalyzes only one turnover and therefore is not strictly catalytic. -!- The enzyme from the bacterium Escherichia coli also has the activity of EC 2.1.1.63 while the enzyme from Bacillus subtilis does not., DNA demethylation, Methylphosphotriester-DNA--[protein]-cysteine S-methyltransferase., SAM-dependent methyltransferase, Streptococcus pneumoniae D39, Protein distal antenna, antennal development, response to wounding, regulation of cell proliferation, regulation of nucleus size, Forkhead box protein Q1, H4 histone acetyltransferase activity, Histone acetyltransferase ESA1, positive regulation of macroautophagy, Mariner Mos1 transposase, Response regulator (Activator) in two-component regulatory system with RstB (OmpR family), Uncharacterized HTH-type transcriptional regulator Rv1985c, cellular response to antibiotic, Uncharacterized protein AF_1382, Leucine-responsive regulatory protein, Streptococcus pyogenes MGAS315, methyltransferase activity, -!- The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius are involved in the biosynthesis of the anthracycline daunorubicin. -!- In vitro the enzyme from Streptomyces sp. C5 also catalyzes the 4-O- methylation of 13-dihydrocarminomycin, rhodomycin D and 10-carboxy- 13-deoxycarminomycin., DNA-binding transcriptional activator EvgA, Shigella flexneri, Rhizobium leguminosarum bv. viciae, VIRF-1, Rhodopseudomonas palustris CGA009, Corynebacterium glutamicum ATCC 13032, regulation of glyoxylate cycle, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, Protein DsvD, Linum nodiflorum, 8-hydroxy-2'-deoxyguanosine DNA binding, DNA duplex unwinding, annealing helicase activity, cellular response to camptothecin, negative regulation of secondary metabolite biosynthetic process, Histone acetyltransferase KAT8, MLL1 complex, Endo-N-acetylneuraminidase. Endoneuraminidase. Poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase., Tail spike protein, Comamonas testosteroni, protein import into peroxisome matrix, tRNA 3'-end processing, DNA damage response, detection of DNA damage, DNA replication factor A complex, nuclear body, nucleotide-excision repair, DNA gap filling, nucleotide-excision repair, DNA incision, 3'-to lesion, regulation of exocytosis, Staphylococcus aureus subsp. aureus N315, Listeriolysin regulatory protein, SH3 domain binding, Xan phosphoribosyltransferase. Xanthine-guanine phosphoribosyltransferase. Xanthosine 5'-phosphate pyrophosphorylase. Xanthylate pyrophosphorylase. Xanthylic pyrophosphorylase. XMP pyrophosphorylase., Enterococcus faecalis V583, positive regulation of inflammatory response, pri-miRNA transcription from RNA polymerase II promoter, S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol., Double-stranded RNA adenosine deaminase. Double-stranded RNA-specific adenosine deaminase. DsRNA adenosine deaminase., cellular protein complex assembly, regulation of protein heterodimerization activity, Z-DNA binding protein kinase, Sulfolobus solfataricus P2, Transcriptional regulator, LysR family, Repressor protein, Glutamine receptor protein, Haloarcula marismortui ATCC 43049, Staphylococcus aureus subsp. aureus Mu50, Homologous-pairing protein 2 homolog, bacterial-type RNA polymerase regulatory region sequence-specific DNA binding, Repressor protein c, multicellular organism development, Transcriptional regulator, IclR family protein, Musca domestica, cell division, double-stranded DNA-dependent ATPase activity, Dehydrolipoate dehydrogenase. Diaphorase. Dihydrolipoamide dehydrogenase. Dihydrolipoic dehydrogenase. Dihydrothioctic dehydrogenase. E3 component of alpha-ketoacid dehydrogenase complexes. Glycine-cleavage system L-protein. L-protein. LDP-Glc. LDP-Val. Lipoamide dehydrogenase (NADH). Lipoamide oxidoreductase (NADH). Lipoamide reductase. Lipoamide reductase (NADH). Lipoate dehydrogenase. Lipoic acid dehydrogenase. Lipoyl dehydrogenase., Transposon Tn7 transposition protein TnsA, Transcription factor E, phosphate ion binding, KDP operon transcriptional regulatory protein KdpE, cytosolic small ribosomal subunit, KLLA0B06182p, N(4)-bis(aminopropyl)spermidine synthase., multivesicular body assembly, multivesicular body sorting pathway, macrophage activation, monocyte activation, response to lipopolysaccharide, somatic stem cell population maintenance, Pyrococcus abyssi GE5, Walker-Type ATPase, Radiation response metalloprotease IrrE, ETS-related transcription factor Elf-5, GTPase activity, double-strand break repair, Sorghum bicolor, Pseudomonas syringae, Regulatory protein AsnC, transcription factor TFIID complex, Bacillus licheniformis, Trypanosoma brucei brucei, protein heterooligomerization, Cullin-5, chromatin organization, negative regulation of T cell cytokine production, negative regulation of interleukin-4 production, positive regulation of histone acetylation, S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin., translation, Forkhead box protein O4, nuclear speck, stem cell differentiation, Putative transcriptional regulator (MarR/EmrR family), Apoptotic protease-activating factor 1, brain development, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, Schizosaccharomyces pombe 972h-, m7G(5')pppN diphosphatase activity, Protein-glutamate methylesterase., positive regulation of multi-organism process, Acting on ester bonds., Paired box protein Pax-8, cellular response to gonadotropin stimulus, regulation of thyroid-stimulating hormone secretion, thyroid gland development, vesicle docking involved in exocytosis, BH1 domain binding, activation of cysteine-type endopeptidase activity, caspase complex, cysteine-type endopeptidase activator activity involved in apoptotic process, embryo development ending in birth or egg hatching, peptidase activator activity involved in apoptotic process, positive regulation of synapse disassembly, regulation of cell adhesion, DNA-binding response regulator MtrA, positive regulation of type I interferon-mediated signaling pathway, Paired box protein Pax-5, intracellular membrane-bounded organelle, cytoplasmic vesicle, histone demethylase activity (H3-dimethyl-K4 specific), nuclear chromatin, protein demethylation, regulation of cellular protein localization, Redox-sensing transcriptional repressor Rex, Probable transcriptional regulator, Rhodococcus jostii RHA1, POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY ARSR-FAMILY), transition metal ion binding, Probable phenazine-specific methyltransferase, viral DNA genome packaging, Uncharacterized ATP-binding protein MJECL15, Cul4B-RING E3 ubiquitin ligase complex, R-SMAD binding, cytoskeleton organization, positive regulation of translation, NF-kappaB p50/p65 complex, inflammatory response, Probable transcriptional activator protein TraR, Tyrosine recombinase XerD, Transcriptional regulator, marR family, putative, Regulatory protein GntR, DNA endonuclease I-HmuI, interferon-alpha production, regulation of MyD88-independent toll-like receptor signaling pathway, Cyclic AMP receptor protein, Vibrio vulnificus YJ016, Werner syndrome ATP-dependent helicase, small ribosomal subunit, azurophil granule lumen, DNA recombination, Forkhead box protein K2, barrier septum assembly, Alkylmercury lyase, An alkylmercury + H(+) = an alkane + Hg(2+)., Anti-anti sigma factor/receiver protein PhyR, HTH-type transcriptional regulator Hpr, Transcriptional regulator, MarR family, putative, HTH-type transcriptional regulator MmpR5, endoplasmic reticulum, response to endoplasmic reticulum stress, Transcriptional regulatory protein PrrA, growth involved in symbiotic interaction, multicellular organism aging, Streptomyces lavendulae, Clostridium acetobutylicum ATCC 824, ETS domain-containing protein Elk-1, Deinococcus geothermalis DSM 11300, Yaba-like disease virus, protein retention in Golgi apparatus, Salmonella enterica subsp. enterica serovar Typhimurium, Lmo0815 protein, Cullin-3, peripheral nervous system neuron development, CTP + riboflavin = CDP + FMN., anatomical structure regression, erythrocyte differentiation, lymphoid progenitor cell differentiation, phospholipase C-inhibiting G-protein coupled receptor signaling pathway, ruffle membrane, protein deneddylation, protein kinase activity, (Iso)eugenol O-methyltransferase, Clarkia breweri, translation elongation factor binding, KLLA0B08173p, left-handed Z-DNA binding, -!- This protein is involved in the repair of alkylated DNA. -!- It acts only on the alkylated DNA (cf. EC 3.2.2.20 and EC 3.2.2.21). -!- This enzyme catalyzes only one turnover and therefore is not strictly catalytic., Acinetobacter sp. ADP1, cell proliferation, Phenylpyruvate C-beta-methyltransferase. Phenylpyruvate methyltransferase., RNA polymerase sigma factor RpoD, Staphylococcus aureus subsp. aureus MRSA252, Type II restriction enzyme., Type-2 restriction enzyme FokI, Penicillinase repressor, base conversion or substitution editing, negative regulation of protein kinase activity by regulation of protein phosphorylation, Arabinose metabolism transcriptional repressor, ATPase activity, forked DNA-dependent helicase activity, regulation of signal transduction by p53 class mediator, strand displacement, telomeric D-loop binding, -!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins., Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine., histone acetyltransferase complex, Cadmium resistance transcriptional regulatory protein CadC, RNA binding, extracellular space, transcription factor activity, sequence-specific DNA binding, Streptomyces purpurascens, Staphylococcus aureus, Uncharacterized protein, lateral plasma membrane, protein domain specific binding, single-stranded telomeric DNA binding, bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding, Thermoplasma volcanium GSS1, Transcriptional regulator, MarR family, Human gammaherpesvirus 8, Thermoanaerobacter ethanolicus JW 200, positive regulation of endothelial cell migration, positive regulation of erythrocyte differentiation, regulation of angiogenesis, RNA phosphodiester bond hydrolysis, endonucleolytic, endoribonuclease activity, single-stranded RNA binding, positive regulation of interferon-beta production, G2/M transition of mitotic cell cycle, Shewanella amazonensis SB2B, terminal bouton, Rac GTPase binding, cellular protein localization, frizzled binding, PefI protein, positive regulation of viral transcription, transcription from RNA polymerase II promoter, Transcriptional regulatory protein PcoR, cellular response to hypoxia, PCI domain-containing protein 2, ETS-related transcription factor Elf-3, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, Thermotoga maritima MSB8, Phosphotransferases with an alcohol group as acceptor., repressing transcription factor binding, Replication protein, ECF RNA polymerase sigma factor SigC, apoptosome, extracellular region, GTP-sensing transcriptional pleiotropic repressor CodY, positive regulation of lipid biosynthetic process, positive regulation of neuron apoptotic process, 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase., Deinococcus radiodurans R1, double-stranded DNA binding, Rhodobacter sphaeroides 2.4.1, cellular catabolic process, regulation of cellular amide catabolic process, Vacuolar protein-sorting-associated protein 25, GA-binding protein alpha chain, HTH-type transcriptional regulator CymR, Sinorhizobium fredii, Histone H5, negative regulation of cytokine secretion, negative regulation of histone deacetylation, Streptococcus agalactiae, 40S ribosomal protein S10, putative, PaaX-like protein, insulin receptor signaling pathway, Coxiella burnetii RSA 493, Hydroxyindole O-methyltransferase., SRP-dependent cotranslational protein targeting to membrane, focal adhesion, Staphylococcus aureus subsp. aureus MW2, Transcriptional regulator SarA, response to leucine, Protein L-glutamate O(5)-methyl ester + H(2)O = protein L-glutamate + methanol., Thermus aquaticus, hydrogen peroxide catabolic process, transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding, transcription factor complex, calcium channel activity, kidney development, positive regulation of thyroid hormone generation, thyroid-stimulating hormone receptor activity, Caenorhabditis elegans, Carboxydothermus hydrogenoformans Z-2901, DNA-templated transcription, elongation, Piccolo NuA4 histone acetyltransferase complex, Encephalitozoon cuniculi GB-M1, Endo-alpha-sialidase., Regulatory protein RecX, Response regulator protein VraR, negative regulation of protein homotetramerization, protein complex assembly, Listeria monocytogenes EGD-e, DNA translocase FtsK, Desulfitobacterium hafniense, DNA ligation, histone mRNA metabolic process, protein localization to cytoplasmic stress granule, tRNA export from nucleus, regulation of DNA damage checkpoint, translesion synthesis, Peroxide operon regulator, Rap guanine nucleotide exchange factor 4, Carminomycin 4-O-methyltransferase., Ferric uptake regulation protein, Eukaryotic translation initiation factor 3 subunit K, Transcriptional regulatory protein arsR family, Histone H1.11L, -!- The enzyme, characterized from the bacterium Streptomyces lavendulae, is involved in the biosynthesis of the quinone-containing antibiotics mitomycin A and mitomycin B., Mitomycin biosynthesis 6-O-methyltransferase, selenocysteine metabolic process, endonuclease activity, exodeoxyribonuclease V activity, exodeoxyribonuclease V complex, Stage 0 sporulation protein A, asymmetric cell division, Sulfolobus spindle-shaped virus 1, Corynebacterium glutamicum, Transcriptional regulator LdrP, CalO6, Selenocysteine-specific translation elongation factor SelB, protein acetylation, cadmium ion sensor activity, lead ion binding, Transcriptional activator, LuxR/UhpA family of regulators, Salmonella enterica subsp. enterica serovar Typhi, Transcriptional regulator ModE, RNA binding protein La-like protein, [Pseudomonas syringae] pv. tomato str. DC3000, CRP-like protein Clp, cyclic-di-GMP binding, CovR, Friend leukemia integration 1 transcription factor, hemostasis, gastrulation, actin cytoskeleton reorganization, phosphatidylinositol metabolic process, phosphatidylinositol-3,4-bisphosphate binding, Probable [Fe-S]-dependent transcriptional repressor, Dictyostelium discoideum, -!- This archaeal enzyme differs from EC 2.7.1.26 in using CTP as the donor nucleotide. -!- UTP, but not ATP or GTP, can also act as a phosphate donor but it is at least an order of magnitude less efficient than CTP. -!- Formerly EC 2.7.1.n2., Riboflavin kinase, lymphocyte differentiation, myeloid dendritic cell differentiation, negative regulation of MHC class II biosynthetic process, vasculature development, COP9 signalosome complex subunit 4, chromosome condensation, cell separation after cytokinesis, FNR type regulator, PadR-family transcriptional regulator, transposition, DNA-mediated, positive regulation of fatty acid biosynthetic process, 3'-flap-structured DNA binding, exonuclease activity, phosphorelay signal transduction system, Transcription factor FapR, 2 S-adenosyl 3-(methylthio)propylamine + spermidine = 2 S-methyl- 5'-thioadenosine + N(4)-bis(aminopropyl)spermidine., endocytic recycling, regulation of protein catabolic process, negative regulation of B cell apoptotic process, osteoclast differentiation, regulation of defense response to bacterium, regulation of macrophage colony-stimulating factor production, Interferon regulatory factor 1, defense response to virus, regulation of innate immune response, cellular response to estradiol stimulus, double-strand break repair via nonhomologous end joining, planar cell polarity pathway involved in neural tube closure, Mycobacterium tuberculosis H37Rv, Histone H1x, cadherin binding, DNA repair complex, Oxidoreductases., blood coagulation, histone H3-K9 demethylation, histone demethylase activity (H3-K4 specific), ligand-dependent nuclear receptor transcription coactivator activity, nuclear chromosome, telomeric region, regulation of transcription from RNA polymerase II promoter, cytoplasm, metalloexopeptidase activity, -!- The enzyme from the bacterium Streptomyces carzinostaticus is involved in the biosynthesis of 2-hydroxy-7-methoxy-5-methyl-1- naphthoate. -!- This compound is part of the enediyne chromophore of the antitumor antibiotic neocarzinostatin. -!- In vivo the enzyme catalyzes the regiospecific methylation at the 7-hydroxy group of its native substrate 2,7-dihydroxy-5-methyl-1- naphthoate. -!- In vitro it also recognizes other dihydroxynaphthoic acids and catalyzes their regiospecific O-methylation., O-methyltransferase activity, negative regulation of telomere maintenance via telomerase, Repressor LexA., Pseudomonas aeruginosa, positive regulation of apoptotic process, Uncharacterized HTH-type transcriptional regulator SAR2349, -!- Large group of enzymes which recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition site. -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/, Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates., Streptococcus pneumoniae R6, Type II site-specific deoxyribonuclease., Endoribonuclease LACTB2, mitochondrial matrix, Cullin-1, methylated-DNA-[protein]-cysteine S-methyltransferase activity, Homo sapiens, nucleus, chromosome, HTH-type sugar sensing transcriptional regulator TrmB, negative regulation of cysteine-type endopeptidase activity, Forkhead box protein K1, ECF RNA polymerase sigma factor SigK, ETS translocation variant 5, cellular response to oxidative stress, G-protein coupled receptor signaling pathway, Metallo-beta-lactamase family protein, RNA polymerase II regulatory region sequence-specific DNA binding, Segmentation protein paired, animal organ morphogenesis, humoral immune response, Agrobacterium tumefaciens, transcription regulatory region sequence-specific DNA binding, Holliday junction ATP-dependent DNA helicase RuvB, positive regulation of transcription, DNA-templated, Regulatory protein MarR, defense response to bacterium, Uncharacterized HTH-type transcriptional regulator YusO, Transcriptional regulator, ROK family, Helicobacter pylori 26695, Sinorhizobium meliloti 1021, Transcriptional regulatory protein FixJ, Anabaena variabilis ATCC 29413, P fimbrial regulatory protein KS71A, iris morphogenesis, visual perception, histone H2A monoubiquitination, cellular response to peptide hormone stimulus, cellular response to tumor necrosis factor, positive regulation of I-kappaB kinase/NF-kappaB signaling, transcription factor activity, RNA polymerase II core promoter sequence-specific, Interferon regulatory factor 4, positive regulation of interleukin-13 biosynthetic process, Nitrate/nitrite response regulator protein NarL, regulation of gene expression, protein import into nucleus, supraspliceosomal complex, Medicago sativa, CooA protein, entry into host via enzymatic degradation of host anatomical structure, virus tail, fiber, Vibrio cholerae O1 biovar El Tor str. N16961, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, peroxisome, protein import into peroxisome matrix, substrate release, protein import into peroxisome matrix, translocation, nuclear matrix, skeletal system development, quorum sensing, DNA replication, cellular response to ionizing radiation, Biofilm growth-associated repressor, MSL complex, methylated histone binding, Xanthomonas phaseoli pv. phaseoli, Aeropyrum pernix K1, IRES-dependent viral translational initiation, PML body organization, immune response, cellular response to DNA damage stimulus, macrophage apoptotic process, type I interferon signaling pathway, Catechol O-methyltransferase., Lolium perenne, low-density lipoprotein particle receptor binding, transport vesicle, apical part of cell, protein oligomerization, segment specification, Putative HTH-type transcriptional regulator TrmBL2, -!- Acts on eugenol and chavicol as well as isoeugenol., RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, protein homooligomerization, Danio rerio, 6-O-methylguanine-DNA methyltransferase. O-6-methylguanine-DNA-alkyltransferase., DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine., Eggerthella lenta DSM 2243, Staphylococcus epidermidis ATCC 12228, -!- The enzyme from the bacterium Streptomyces hygroscopicus NRRL3085 is involved in synthesis of the nonproteinogenic amino acid (2S,3S)- beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin., Phenylpyruvate C(3)-methyltransferase, Phenylpyruvate C(3)-methyltransferase., DNA-directed RNA polymerase., Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)., Transcriptional regulator LsrR, regulation of DNA-templated transcription, initiation, K9, protein phosphorylation, ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]., Bifunctional ligase/repressor BirA, biotin-[acetyl-CoA-carboxylase] ligase activity, Mus musculus, Segment polarity protein dishevelled homolog DVL-1, Wnt signaling pathway, planar cell polarity pathway, collateral sprouting, cytoplasmic microtubule organization, Thermus thermophilus HB27, Listeria innocua Clip11262, Desulfitobacterium dehalogenans, Putative regulator of mannose and mannoside utilization, ROK family, embryonic cleavage, integrin-mediated signaling pathway, activation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of apoptotic process involved in development, positive regulation of protein processing, Carbon monoxide oxidation system transcription regulator CooA-1, NuA4 histone acetyltransferase complex, peptide N-acetyltransferase activity, structural molecule activity, RRF2 family protein, 39 kDa initiator binding protein, Thermoplasmatales archaeon SCGC AB-539-N05, in utero embryonic development, regulation of cell-substrate adhesion, Multiple antibiotic resistance protein MarR, SOS response, NolR, nucleosomal DNA binding, negative regulation of T-helper 17 cell differentiation, negative regulation of immune response, negative regulation of interleukin-2 biosynthetic process, Smc5-Smc6 complex, negative regulation of regulatory T cell differentiation, regulation of MyD88-dependent toll-like receptor signaling pathway, exit from mitosis, metaphase/anaphase transition of mitotic cell cycle, Protein kinase containing Z-DNA binding domains, CheB methylesterase. Chemotaxis-specific methylesterase. Methyl-accepting chemotaxis protein methyl-esterase. Methylesterase CheB. PME. Protein carboxyl methylesterase. Protein methyl-esterase. Protein methylesterase., Putative TRANSCRIPTIONAL REGULATOR, -!- A manganese protein containing Mn(III) in the resting state, which also belongs here, is often called pseudocatalase. -!- The enzymes from some organisms, such as Penicillium simplicissimum, can also act as a peroxidase (EC 1.11.1.7) for which several organic substances, especially ethanol, can act as a hydrogen donor. -!- Enzymes that exhibit both catalase and peroxidase activity belong under EC 1.11.1.21., 2 H(2)O(2) = O(2) + 2 H(2)O., Two component transcriptional regulatoryprotein, bacterial-type RNA polymerase holo enzyme binding, negative regulation of inflammatory response, sequence-specific double-stranded DNA binding, SloR, glycolipid biosynthetic process, Sulfolobus sp. NOB8H2, negative regulation of phospholipid biosynthetic process, Streptococcus mutans UA159, Cul5-RING ubiquitin ligase complex, ATP-dependent breakage, passage and rejoining of double-stranded DNA., DNA topoisomerase (ATP-hydrolyzing)., damaged DNA binding, interstrand cross-link repair, mismatch repair, transcription-coupled nucleotide-excision repair, Caffeic acid 3-O-methyltransferase, cAMP-mediated signaling, Transcriptional repressor SmtB, Sulfolobus solfataricus, Diphtheria toxin repressor, DNA-binding transcriptional dual regulator of siderophore biosynthesis and transport(Fur family), Transcriptional regulatory protein BaeR, suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process, suppression by virus of host protein-protein interaction, Hydrolases., RNA 7-methylguanosine cap binding, DNA polymerase, Thermococcus kodakarensis KOD1, DNA binding, negative regulation of transcription, DNA-templated, response to oxidative stress, actinin binding, Bacillus cereus ATCC 10987, cell cycle, Putative metal uptake regulation protein, negative regulation of viral genome replication, positive regulation of mRNA catabolic process, Response regulatory protein, HTH-type transcriptional regulator CmtR, 3'-flap endonuclease activity, DNA replication protein DnaD, regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, Lactococcus lactis subsp. lactis Il1403, ORC1-type DNA replication protein 3, central nervous system formation, Paired box protein Pax-6, Vibrio cholerae, La-related protein 4, Transcription factor PU.1, cortical actin cytoskeleton organization, negative regulation of inositol phosphate biosynthetic process, platelet degranulation, positive regulation of inositol-polyphosphate 5-phosphatase activity, regulation of cell diameter, COP9 signalosome, positive regulation of cell motility, positive regulation of superoxide dismutase activity, regulation of response to reactive oxygen species, Moorella thermoacetica ATCC 39073, Bacillus anthracis, Bradyrhizobium japonicum, FixK2 protein, -!- Preference for double-stranded DNA. -!- Possesses DNA-dependent ATPase activity. -!- Acts endonucleolytically on single-stranded circular DNA. -!- Similar enzyme: Haemophilus influenzae ATP-dependent DNase., Bacteroides fragilis NCTC 9343, polytene chromosome, bacterial nucleoid, positive regulation of DNA-templated transcription, initiation, XylR protein, Sulfolobus islandicus, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, nuclear nucleosome, integral component of plasma membrane, positive regulation of catalytic activity, Viral IRF2-like protein, ORC1-type DNA replication protein, Trypanosoma brucei, Yop proteins translocation protein H, RNA polymerase II transcription factor binding, Ruegeria sp. TM1040, E.coli exonuclease V. Exonuclease V., -!- Acts on CH(3)Hg(+) and a number of other alkylmercury compounds, in the presence of cysteine or other thiols, liberating mercury as a mercaptide., Hermes transposase, negative regulation of angiogenesis, neuron apoptotic process, Uncharacterized HTH-type transcriptional regulator YydK, ficolin-1-rich granule lumen, phosphatase activator activity, transcription factor TFIIF complex, extracellular matrix, rRNA processing, Geobacillus kaustophilus HTA426, regulation of viral budding via host ESCRT complex, Parkin-FBXW7-Cul1 ubiquitin ligase complex, post-translational protein modification, protein polyubiquitination, stress-activated MAPK cascade, Conserved domain protein, Protein C-ets-1, RNA polymerase II core promoter proximal region sequence-specific DNA binding, regulation of apoptotic process, interferon-gamma-mediated signaling pathway, transcription cofactor activity, clathrin vesicle coat, signal sequence binding, synaptic vesicle budding from presynaptic endocytic zone membrane, Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3)., membrane, Isoliquiritigenin 2'-O-methyltransferase., isoliquiritigenin 2'-O-methyltransferase activity, Rhodospirillum rubrum, LysR-type regulatory protein, cellular response to copper ion, positive regulation of mitotic cell cycle, transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding, intracellular, Methicillin resistance regulatory protein MecI, Heat-inducible transcription repressor HrcA, Drosophila melanogaster, periodic partitioning by pair rule gene, Pyrococcus furiosus DSM 3638, Nucleotidyltransferases., flavin adenine dinucleotide binding, histone H3-K4 demethylation, histone demethylase activity, histone demethylase activity (H3-K9 specific), negative regulation of protein binding, negative regulation of transcription from RNA polymerase II promoter, protein complex, telomeric repeat-containing RNA binding, transcription factor binding, Pseudomonas aeruginosa PAO1, Carboxy-lyases., N-terminal protein amino acid modification, protein processing, regulation of response to stress, cerebral cortex development, protein homodimerization activity, positive regulation of JUN kinase activity, S-adenosyl-L-methionine + 2,7-dihydroxy-5-methyl-1-naphthoate = S-adenosyl-L-homocysteine + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate., -!- In the presence of single-stranded DNA, the RecA protein interacts with LexA causing an autocatalytic cleavage which disrupts the DNA- binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. -!- The activity was previously attributed to the RecA protein (formerly EC 3.4.99.37). -!- Belongs to peptidase family S24., Bacillus virus GA1, DNR protein, negative regulation of protein secretion, transcription regulatory region DNA binding, negative regulation of stress-activated MAPK cascade, positive regulation of autophagy, ubiquitin protein ligase binding, AttJ, positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, Putative polysaccharide biosynthesis protein with aminopeptidase-like domain, Regulator of G-protein signaling 9, Fusobacterium nucleatum subsp. nucleatum ATCC 25586, double-stranded DNA endodeoxyribonuclease activity, protein-DNA complex, Wnt signalosome, protein stabilization, RNA polymerase II core promoter sequence-specific DNA binding, mesenchymal to epithelial transition involved in metanephros morphogenesis, metanephric S-shaped body morphogenesis, Chlorobium tepidum TLS, Pleckstrin, platelet aggregation, positive regulation of actin filament depolymerization, positive regulation of platelet activation, protein secretion by platelet, thrombin-activated receptor signaling pathway, BH3 domain binding, Cell death protein 4, apoptotic process involved in development, caspase binding, protein homotetramerization, Catabolite expression activator, Coniferyl alcohol 9-O-methyltransferase, Ruegeria pomeroyi DSS-3, Putative GntR-family transcriptional regulator, Streptomyces avermitilis MA-4680 = NBRC 14893, Shewanella oneidensis MR-1, Global nitrogen regulator, Transcriptional regulator, PadR family, G-rich strand telomeric DNA binding, Replication protein A 32 kDa subunit, S-adenosyl-L-methionine + carminomycin = S-adenosyl-L-homocysteine + daunorubicin., Catalase., Magnetospirillum gryphiswaldense MSR-1 v2, Streptococcus mutans, transcription coactivator activity, transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding, Transcriptional repressor of nicotinamide riboside utilization NrtR, ECF RNA polymerase sigma-E factor, HTH-type transcriptional regulatory protein GabR, Fatty acid metabolism regulator protein, Segregation and condensation protein B, PI protein, biotin biosynthetic process, pre-miRNA processing, Desulfovibrio vulgaris str. Hildenborough, Protein C-ets-2, DNA double-strand break processing, lateral element, t-circle formation, acetyltransferase activity, histone H4-K5 acetylation, virion attachment to host cell, cAMP binding, Enterobacteria phage K1F, microtubule anchoring, DNA-directed 5'-3' RNA polymerase activity, PhiH1 repressor-like, protein localization to chromosome, calcium ion regulated exocytosis, guanyl-nucleotide exchange factor activity, Type-2 restriction enzyme NaeI, Uncharacterized HTH-type transcriptional regulator Rv0880, Zinc uptake regulation protein, MarR family regulatory protein, Chaetomium thermophilum var. thermophilum DSM 1495, signal transducer activity, Type-2 restriction enzyme DpnI, Xanthine phosphoribosyltransferase., Uncharacterized HTH-type transcriptional regulator YybR, Minichromosome maintenance protein MCM, Exodeoxyribonuclease V., Putative PadR-family transcriptional regulatory protein, defense response to fungus, single-stranded DNA-dependent ATP-dependent DNA helicase activity, S-adenosylmethionine-dependent methyltransferase activity, Terminase small subunit, Lin1550 protein, Putative iron uptake regulatory protein, stem cell division, Vibrio cholerae HC-21A1, Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446, cytoplasmic chromosome, Pyrobaculum aerophilum str. IM2, Putative sporulation transcription regulator WhiA, Thermincola potens JR, Molybdenum-binding transcriptional repressor, Transcription factor ETV6, mesenchymal cell apoptotic process, neurogenesis, regulation of phosphate metabolic process, cell aging, positive regulation of strand invasion, Yersinia pestis, Predicted transcriptional regulators, phosphorelay response regulator activity, Chromosome replication initiation protein, early endosome to late endosome transport, late endosome membrane, macroautophagy, recycling endosome, regulation of multivesicular body size involved in endosome transport, regulation of endothelial tube morphogenesis, regulation of tumor necrosis factor production, -!- The enzyme, characterized from the thermophilic archaeon Thermococcus kodakarensis, synthesizes the branched-chain polyamine N(4)- bis(aminopropyl)spermidine, which is required for cell growth at high-temperature. -!- When spermine is used as substrate, the enzyme forms N(4)- aminopropylspermine., N(4)-bis(aminopropyl)spermidine synthase, Deinococcus deserti VCD115, integral component of membrane, Putative DNA-binding protein, response to zinc ion, Erythrobacter litoralis HTCC2594, Uncharacterized HTH-type transcriptional regulator YbbH, CRISPR locus-related putative DNA-binding protein Csa3, tumor necrosis factor-mediated signaling pathway, Aliphatic amidase regulator, Escherichia coli O157:H7, DNA strand renaturation, negative regulation of NF-kappaB transcription factor activity, negative regulation of cytokine biosynthetic process, negative regulation of interleukin-10 production, negative regulation of interleukin-2 production, Thalictrum flavum subsp. glaucum, Streptococcus pneumoniae P1031, Iron-dependent transcription repressor related protein, negative regulation of G0 to G1 transition, positive regulation of cell cycle arrest, Crp/Fnr family transcriptional regulator, Methyltransferases., O-methyltransferase family protein, Chromosome partition protein MukF, O6-alkylguanine-DNA binding, P-body, mRNA decapping complex subunit 2, growth of symbiont in host, positive regulation of neuron projection development, Thermus thermophilus HB8, Moorella thermoacetica, -!- This membrane-bound enzyme, which is present in both prokaryotes and eukaryotes, releases the initiator methionine from nascent peptides. -!- The activity is dependent on the identity of the second, third and fourth amino acid residues of the target protein, but in general the enzyme acts only when the penultimate residue is small and uncharged (e.g. Gly, Ala, Cys, Ser, Thr, and Val). -!- Belongs to peptidase family M24A., peptidyl-methionine modification, dormancy process, host cell endosome lumen, Saccharomyces cerevisiae S288C, Escherichia virus Mu, Replication initiation protein, endocrine pancreas development, cellular response to UV, cellular response to gamma radiation, chromatin binding, enzyme binding, p53 binding, telomeric DNA binding, DEP domain-containing protein 1A, Pseudomonas syringae pv. syringae, interferon-beta production, negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, protein K11-linked ubiquitination, protein kinase binding, cadmium ion binding, nickel cation binding, regulation of transcription, DNA-templated, ATP + H(2)O = ADP + phosphate., mRNA splicing, via spliceosome, Forkhead box protein C2, lymphangiogenesis, Heterochromatin protein 1-binding protein 3, nucleosome binding, cAMP-activated global transcriptional regulator CRP, fibrillar center, Uncharacterized protein YjcQ, positive regulation of protein localization to endoplasmic reticulum, calcium ion binding, response to cadmium ion, Mycobacterium bovis AF2122/97, Vaccinia virus, eye development, Putative HTH-type transcriptional regulator YwnA, Putative uncharacterized protein aphA, Cullin-4B, UV-damage excision repair, Pex protein, cellular response to nicotine, negative regulation of NIK/NF-kappaB signaling, positive regulation of NIK/NF-kappaB signaling, response to UV-B, Interferon regulatory factor 7, regulation of reactive oxygen species metabolic process, mammary gland involution, Bifunctional transcriptional activator/DNA repair enzyme Ada, MutT/nudix family protein, RNA polymerase sigma factor, granulocyte differentiation, hematopoietic progenitor cell differentiation, AsnC family transcriptional regulator, SWI/SNF complex subunit SWI3, cellular alcohol catabolic process, sucrose catabolic process, DNA translocase activity, response to salt stress, tRNA 5'-leader removal, Lechevalieria aerocolonigenes, Escherichia coli CFT073, Phosphotransferases with a nitrogenous group as acceptor., Iron-dependent transcriptional regulator, DNA replication origin binding, Double-stranded RNA adenine deaminase., innate immune response, miRNA loading onto RISC involved in gene silencing by miRNA, protein export from nucleus, -!- Not identical to EC 2.1.1.65. -!- While EC 2.1.1.154 can use licodione as a substrate, EC 2.1.1.65 cannot use isoliquiritigenin as a substrate., S-adenosyl-L-methionine + isoliquiritigenin = S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin., S-adenosyl-L-methionine + licodione = S-adenosyl-L-homocysteine + 2'-O- methyllicodione., beta-tubulin binding, microtubule binding, DNA-directed RNA polymerase III subunit RPC3, protein biotinylation, Planomicrobium okeanokoites, Interferon regulatory factor 2, ATP + a protein = ADP + a phosphoprotein., RIO-type serine/threonine-protein kinase Rio2, actin cytoskeleton, Klebsiella pneumoniae subsp. pneumoniae MGH 78578, Bacillus megaterium QM B1551, DNA synthesis involved in DNA repair, G-quadruplex DNA binding, Y-form DNA binding, negative regulation of cell cycle, response to antibiotic, TRIF-dependent toll-like receptor signaling pathway, apoptotic process, SCF complex assembly, cellular iron ion homeostasis, positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition, proteasome-mediated ubiquitin-dependent protein catabolic process, Transcriptional regulator TcaR, Rattus norvegicus, Segment polarity protein dishevelled homolog DVL-2, protein binding, bridging, 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase, Multidrug resistance operon repressor, identical protein binding, Cupriavidus necator, negative regulation of double-strand break repair via nonhomologous end joining, nuclear stress granule, positive regulation of mRNA polyadenylation, protein homotrimerization, Methylated-DNA--[protein]-cysteine S-methyltransferase., S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol., PML body, cellular response to cadmium ion, cellular response to heat, intracellular ribonucleoprotein complex, signal transduction, Staphylococcus aureus subsp. aureus str. Newman, Putative HTH-type transcriptional regulator MJ1563, HTH-type transcriptional regulator LrpA, Wnt signaling pathway, axon, axon extension, axon guidance, clathrin-coated vesicle, convergent extension involved in neural plate elongation, positive regulation of canonical Wnt signaling pathway, positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, Ribonuclease II family protein, peroxisome organization, Streptococcus agalactiae NEM316, Uncharacterized HTH-type transcriptional regulator PF0864, General transcription factor IIF subunit 1, cell junction, response to xenobiotic stimulus, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, neutrophil degranulation, HTH-type transcriptional regulator mcbR, Transcriptional regulatory protein CpxR, Methanopyrus kandleri, Chromobacterium violaceum, Type 2 DNA topoisomerase 6 subunit A, Uncharacterized ATP-binding protein MJ1010, receptor activity, metanephric comma-shaped body morphogenesis, metanephric epithelium development, -!- Some other hydroxyindoles also act as acceptor, more slowly., Acetylserotonin O-methyltransferase, negative regulation of smooth muscle cell differentiation, protein deubiquitination, regulation of translation, Bacillus cereus ATCC 14579, Medicago truncatula, S-adenosyl-L-methionine + a 4'-hydroxyisoflavone = S-adenosyl-L- homocysteine + a 4'-methoxyisoflavone., negative regulation of megakaryocyte differentiation, extracellular exosome, protein C-terminus binding, DNA nucleotidyltransferase (DNA-directed). DNA-dependent DNA polymerase., positive regulation of interleukin-2 biosynthetic process, positive regulation of interleukin-4 biosynthetic process, Streptomyces peucetius, Mycobacterium tuberculosis CAS/NITR204, core promoter binding, histone H3 deacetylation, Heat shock factor protein 2, Interferon-inducible and double-stranded-dependent eIF-2kinase, response to nitrosative stress, Putative transcriptional regulator, histone displacement, HTH-type transcriptional regulator BenM, Dcp1-Dcp2 complex, mRNA cap binding complex, cellular response to hydroxyurea, four-way junction helicase activity, replication fork processing, Putative MarR-family transcriptional repressor, Streptomyces coelicolor A3(2), histone H4-K8 acetylation, CRP-like cAMP-activated global transcriptional regulator, -!- Although the name endo-N-acetylneuraminidase has also been used for this enzyme, this is misleading since its activity is not restricted to acetyl-substituted substrates. -!- An exo-alpha-sialidase activity is listed as EC 3.2.1.18. -!- See also 4.2.2.15., tRNA processing, error-free translesion synthesis, mitotic G1 DNA damage checkpoint, nucleotide-excision repair, nucleotide-excision repair, DNA incision, 5'-to lesion, Putative transcription regulatory protein, Synechococcus elongatus PCC 7942, UPF0122 protein SpyM3_0842, Methionine aminopeptidase, poly(U) RNA binding, Zinc finger CCCH-type antiviral protein 1, endodeoxyribonuclease activity, Planctopirus limnophila DSM 3776, Transcriptional regulator SaeR, endosome, Transcriptional regulatory protein RstA, nucleotide-excision repair, DNA duplex unwinding, regulation of immune response, RNA polymerase II transcription factor activity, sequence-specific DNA binding, blood vessel development, glucose homeostasis, pancreatic A cell development, eukaryotic translation initiation factor 3 complex, cellular response to hydrogen peroxide, cellular response to interleukin-1, membrane protein intracellular domain proteolysis, extracellular matrix organization, DDE-recombinase A, host, macrophage differentiation, positive regulation of pri-miRNA transcription from RNA polymerase II promoter, transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding, cell projection organization, histone binding, Putative transcriptional regulator MarR, DNA helicase RecQ, Aliivibrio fischeri, -!- A component of the multienzyme 2-oxo-acid dehydrogenase complexes. -!- In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12 and catalyzes oxidation of its dihydrolipoyl groups. -!- It plays a similar role in the oxoglutarate and 3-methyl-2- oxobutanoate dehydrogenase complexes. -!- Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system, in which it acts, together with EC 1.4.4.2 and EC 2.1.2.10 to break down glycine. -!- It can also use free dihydrolipoate, dihydrolipoamide or dihydrolipoyllysine as substrate. -!- Was first shown to catalyze the oxidation of NADH by methylene blue; this activity was called diaphorase. -!- The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein. -!- Formerly EC 1.6.4.3., Pyruvate dehydrogenase complex repressor, Putative ferric uptake regulator, selenocysteine insertion sequence binding, Proliferation-associated protein 2G4, Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides., single-stranded DNA-dependent ATPase activity, Alkylmercury lyase., Protein F-93, In phosphorus-containing anhydrides., negative regulation of lyase activity, siderophore biosynthetic process, Swr1 complex, Transcription initiation factor IIE subunit beta, Middle transcription regulatory protein motA, transposase activity, supercoiled DNA binding, Mitomycin 7-O-methyltransferase., quinone biosynthetic process, ORC1-type DNA replication protein 1, 3'-5' exonuclease activity, chromosome, telomeric region, nucleolus to nucleoplasm transport, protein complex binding, Xanthomonas campestris pv. campestris str. ATCC 33913, 34L protein, HTH-type transcriptional regulator MetR, Lin2960 protein, chemokine (C-C motif) ligand 2 secretion, regulation of interleukin-1 beta secretion, (S)-norcoclaurine 6-O-methyltransferase, S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine., negative regulation of T-helper 2 cell differentiation, regulation of CD8-positive, alpha-beta T cell proliferation, nucleosome assembly, histone acetyltransferase binding, negative regulation of T cell proliferation, neural tube closure, outflow tract morphogenesis, positive regulation of GTPase activity, -!- This eukaryotic enzyme is involved in RNA editing. -!- It destabilizes double-stranded RNA through conversion of adenosine to inosine. -!- Inositol hexakisphosphate is required for activity., positive regulation of viral genome replication, Hsp90 protein binding, MAPK cascade, cellular response to sodium arsenite, cellular response to unfolded protein, kinetochore, promoter-specific chromatin binding, protein heterodimerization activity, (Iso)eugenol O-methyltransferase., positive regulation of innate immune response, Peroxisomal membrane protein PEX14, receptor binding, CzrA protein, transcriptional repressor complex, positive regulation of transcription from RNA polymerase II promoter, carbon catabolite repression of transcription, Putative P4-specific DNA primase, demethylase activity, histone deacetylase activity, negative regulation of sequence-specific DNA binding transcription factor activity, Mycobacterium bovis, Methionine aminopeptidase. Peptidase M., regulation of rhodopsin mediated signaling pathway, pathogenesis, regulation of fatty acid metabolic process, response to hypoxia, Forkhead box protein P2, ATP export, ESCRT II complex, protein targeting to vacuole, Staphylococcus epidermidis RP62A, Arginine repressor, antibiotic biosynthetic process, negative regulation of transmembrane transport, negative regulation of apoptotic process, -!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48., Bacillus subtilis subsp. subtilis str. 168, Replication termination protein, neuromuscular junction development, prepulse inhibition, ferrous iron binding, iron ion binding, manganese ion binding, fibroblast growth factor receptor signaling pathway, protein binding, snRNA transcription from RNA polymerase II promoter, transcription elongation from RNA polymerase II promoter, heterochromatin organization, DNA-binding response regulator VicR, response to hormone, photoreceptor inner segment, RNA polymerase sigma-H factor, intermediate filament cytoskeleton, DNA replication initiator (Cdc21/Cdc54), MOZ/MORF histone acetyltransferase complex, histone H3 acetylation, negative regulation of extrinsic apoptotic signaling pathway, positive regulation of T cell receptor signaling pathway, establishment of viral latency, negative regulation of macrophage apoptotic process, Pex, actin filament depolymerization, embryonic morphogenesis, endopeptidase activator activity, regulation of cell size, regulation of cysteine-type endopeptidase activity involved in apoptotic process, branching involved in ureteric bud morphogenesis, forebrain development, positive regulation of apoptotic signaling pathway, Pyrobaculum spherical virus (isolate Yellowstone), Forkhead box protein O3, positive regulation of hydrolase activity, DNA processing chain A, Desulfitobacterium hafniense DCB-2, hyperosmotic response, Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)., Phosphate regulon transcriptional regulatory protein PhoB, ETS domain-containing protein Elk-4, Spore germination protein GerE, Human herpesvirus 8 strain GK18, host cell nucleus, Protein ORF112, response to temperature stimulus, Transcriptional regulator, PadR-like family, Drosophila mauritiana, DNA-binding transcriptional regulator BasR, Geobacillus sp. Y412MC52, DNA-binding protein Sto12a, ATP binding, Acetyl-CoA carboxylase biotin holoenzyme synthetase. Biotin--[acetyl-CoA carboxylase] synthetase. Biotin--protein ligase., Organic hydroperoxide resistance transcriptional regulator, -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70., response to virus, DNA helicase activity, helicase activity, negative regulation of DNA recombination, negative regulation of cell division, single-stranded DNA binding, Histone acetyltransferase., Lysine acetyltransferase. Protein lysine acetyltransferase., Lactobacillus salivarius UCC118, nuclear histone mRNA catabolic process, double-strand break repair via homologous recombination, nucleotide-excision repair, preincision complex assembly, telomere maintenance via recombination, S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L- homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate., Ras guanyl-nucleotide exchange factor activity, insulin secretion, DNA-binding protein, bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding, negative regulation of DNA replication, S-adenosyl-L-methionine + 3-phenylpyruvate = S-adenosyl-L-homocysteine + (3S)-2-oxo-3-phenylbutanoate., Streptomyces hygroscopicus, RNA polymerase sigma factor SigA, Endoribonucleases producing other than 5'-phosphomonoesters., Fc-epsilon receptor signaling pathway, intrinsic apoptotic signaling pathway, negative regulation of G2/M transition of mitotic cell cycle, protein ubiquitination, cell motility, positive regulation of leukocyte adhesion to vascular endothelial cell, MDA-5 signaling pathway, positive regulation of type I interferon production, vesicle-mediated transport, Caulobacter crescentus NA1000, ruffle organization, CTP-dependent riboflavin kinase., S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L- homocysteine + a 7-methoxyisoflavone., apoptotic process involved in blood vessel morphogenesis, synaptic vesicle, SWI/SNF complex, Clostridioides difficile R20291, Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH., Streptomyces phaeochromogenes, ATP-dependent chromatin remodeling, Transcriptional regulator, MarR/EmrR family, Histone acetyltransferase KAT6A, cellular senescence, ribosome, Transcriptional regulatory protein WalR, positive regulation of DNA binding, ETS translocation variant 1, Histone acetyltransferase KAT5, beta-catenin-TCF complex assembly, response to ionizing radiation, Metalloendopeptidases., UPF0122 protein SAV1236, Geobacillus stearothermophilus, Bacillus halodurans C-125, Micromonospora echinospora, Bacillus thuringiensis serovar israelensis, Kribbella flavida DSM 17836, DNA metabolic process, response to UV-C, Mitomycin 6-O-methyltransferase., Erwinia amylovora, Xanthomonas campestris pv. campestris str. B100, Streptococcus pyogenes, Streptococcus pneumoniae TIGR4, Probable transcriptional regulator, ArsR family protein, Transcription regulator RpiR family, Golgi apparatus, fibroblast apoptotic process, transcription antitermination, ATP-dependent DNA helicase Q1, HTH-type transcriptional regulator TtgV, Putative transcription regulator, regulation of monocyte differentiation, Anaphase-promoting complex subunit 2, histone deacetylase binding, negative regulation of interferon-gamma production, Acid--amino-acid ligases (peptide synthases)., melatonin biosynthetic process, HTH-type transcriptional regulator IscR, Transcriptional regulatory protein ComA, Transcriptional regulator, ArsR family, Rab family protein, Transcriptional regulatory protein OmpR, Ruminiclostridium thermocellum ATCC 27405, nucleotide binding, secretory granule lumen, 40S ribosomal protein S10, translational initiation, viral transcription, Putative MarR family transcriptional regulator, -!- Can introduce negative superhelical turns into double-stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.99.1.2)., DNA gyrase. DNA topoisomerase II. Type II DNA topoisomerase., Sulfolobus shibatae, positive regulation of mitotic cell cycle spindle assembly checkpoint, Transposable element Tc3 transposase, negative regulation of cell growth, negative regulation of transcription from RNA polymerase II promoter by glucose, Pur operon repressor, Enterobacteria phage P4, Methanocaldococcus jannaschii DSM 2661, transcription, DNA-templated, convergent extension involved in organogenesis, social behavior, siderophore biosynthetic process from catechol, Neisseria meningitidis MC58, MRF binding, androgen receptor binding, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, nucleolus, Transcriptional regulatory protein DevR (DosR), Aclacinomycin 10-hydroxylase RdmB, Vacuolar-sorting protein SNF8, Hydrolysis of Ala-|-Gly bond in repressor LexA., single-species submerged biofilm formation, regulation of cell morphogenesis, Sinorhizobium fredii NGR234, Cyclic nucleotide-binding domain protein, blastocyst development, Regulatory protein SdiA, positive regulation of cytokinesis, DNA (containing Sp-methylphosphotriester) + protein L-cysteine = DNA (without Sp-methylphosphotriester) + protein S-methyl-L-cysteine., Bacillus virus SPO1, Transcriptional activator protein TraR, axonogenesis, DNA helicase., RNA metabolic process, transcription initiation from RNA polymerase II promoter, Putative host cell surface-exposed lipoprotein, Streptococcus phage TP-J34, Transcription factor E2F4, Klebsiella pneumoniae, Transcription factor Dp-2, ATP-dependent DNA helicase RecQ, CST complex subunit STN1, hematopoietic stem cell proliferation, Transcriptional regulators, regulation of defense response to virus by host, Lmo2241 protein, Pseudomonas fluorescens, response to lead ion, Crossover junction endonuclease MUS81, DNA catabolic process, endonucleolytic, Chromobacterium violaceum ATCC 12472, ECF RNA polymerase sigma factor SigR, compound eye development, IS629 orfA, Transcription factor p65, activating transcription factor binding, cytokine-mediated signaling pathway, positive regulation of miRNA metabolic process, regulation of NIK/NF-kappaB signaling, Forkhead box protein M1, negative regulation of cell aging, regulation of cell cycle arrest, regulation of superoxide dismutase activity, CVT pathway, anion binding, Cyclic nucleotide-binding protein, Streptococcus gordonii, MarR family transcriptional regulator, Lupus La protein, mRNA binding, tRNA binding, base-excision repair, HTH-type transcriptional regulator LrpC, DNA-directed DNA polymerase., positive regulation of interleukin-10 biosynthetic process, Helicobacter pylori J99, Arsenical resistance operon repressor, putative, catalase activity, heme binding, Heat shock factor protein 1, heat shock protein binding, mitotic spindle pole, perinuclear region of cytoplasm, positive regulation of transcription from RNA polymerase II promoter in response to heat stress, Methylated-DNA--protein-cysteine methyltransferase, Escherichia coli, Uncharacterized HTH-type transcriptional regulator PH0061, Biotin--[acetyl-CoA-carboxylase] ligase., Sulfolobus tokodaii str. 7, Hepatocyte nuclear factor 3-gamma, Double-stranded RNA-specific adenosine deaminase, -!- As well as licodione (1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)- 1,3-propanedione), the 2''-hydroxy-derivative and isoliquiritigenin can act as acceptors, more slowly., Isoliquiritigenin 2'-O-methyltransferase, PhzR, Xylella fastidiosa 9a5c, histone acetylation, histone acetyltransferase activity, myeloid cell differentiation, Endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids., Transcriptional regulator, LuxR family, Transcriptional regulator SlyA, regulation of transcription from RNA polymerase III promoter, peroxisomal membrane, peroxisome transport along microtubule, transcription corepressor activity, -!- 3,4-dihydroxybenzaldehyde and catechol can act as acceptor, more slowly., Ras GTPase binding, DNA-methyltransferase activity, Forkhead box protein O1, cellular response to starvation, Pyrococcus horikoshii OT3, Uncharacterized HTH-type transcriptional regulator PH1519, Oenococcus oeni PSU-1, Transcriptional regulator, TcaR transcription regulator, sigma factor activity, Transcriptional regulator ERG, positive regulation of cellular component movement, transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding, Interferon regulatory factor 3, regulation of type I interferon production, NIK/NF-kappaB signaling, negative regulation of cell proliferation, -!- The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols., Caffeic acid O-methyltransferase, AP-2 adaptor complex, AP-2 complex subunit mu, heart development, heart morphogenesis, vitellogenesis, 40S ribosomal protein S25, ECF RNA polymerase sigma factor SigL, regulation of protein secretion, Pseudomonas putida DOT-T1E, regulation of protein complex stability, Lactobacillus reuteri 100-23, osteoclast development, positive regulation of smooth muscle cell proliferation, Bacteroides vulgatus ATCC 8482, anaphase-promoting complex-dependent catabolic process, Enterobacteria phage T4, Response regulator, Transcriptional regulatory protein EmbR, response to water, response to amino acid, 3'-5' DNA helicase activity, -!- The enzyme catalyzes the methylation of daidzein and genistein. -!- It does not methylate naringenin, apigenin, luteolin or kaempferol., Isoflavone 4'-O-methyltransferase, Forkhead box protein D3, Trichomonas vaginalis, carbon utilization, Escherichia coli UMEA 3718-1, Transcriptional regulator of ftsQAZ gene cluster, glycosome membrane, Gallus gallus, T cell activation, negative regulation of interleukin-17 production, Putative transcription factor, positive regulation of response to DNA damage stimulus, protein dimerization activity, -!- The enzyme will also catalyze the 6-O-methylation of (RS)- norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this alkaloid has not been found to occur in plants., CD8-positive, alpha-beta T cell differentiation, positive regulation of natural killer cell differentiation, Thermoplasma acidophilum DSM 1728, regulation of apoptotic DNA fragmentation, Halomicrobium mukohataei DSM 12286, S-methyltransferase activity, acetylserotonin O-methyltransferase activity, indolalkylamine biosynthetic process, Mycobacterium smegmatis str. MC2 155, Cyprinid herpesvirus 3, Carassius auratus, Putative regulator for galacturonate utilization, Transcriptional regulator, IclR family, response to osmotic stress, NUDIX family hydrolase, MHC class II regulatory factor RFX1, Alkyltransferase-like protein 1, Cyclic AMP receptor-like protein, cytoplasmic stress granule, deadenylation-dependent decapping of nuclear-transcribed mRNA, Possible transcriptional regulator, ArsR family protein, Topoisomerase V, otic vesicle development, HTH-type transcriptional regulator SarS, HTH-type transcriptional regulator YodB, Corynebacterium diphtheriae NCTC 13129, bubble DNA binding, nuclear chromosome, regulation of cyclin-dependent protein serine/threonine kinase activity, response to X-ray, telomeric D-loop disassembly, ATP-dependent DNA helicase Hel308, Double-stranded RNA-binding protein, regulation of transcription involved in G1/S transition of mitotic cell cycle, Clostridioides difficile, Blautia obeum ATCC 29174, Lin1836 protein, GrlA, negative regulation of DNA-templated transcription, initiation, photoreceptor outer segment, Forming phosphoric ester bonds., Uncharacterized HTH-type transcriptional regulator YtcD, Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841, IOMT 3, Transcriptional regulator AdcR, Cupriavidus metallidurans CH34, RNA polymerase sigma factor CnrH, NF-kappaB binding, response to organic substance, positive regulation of interferon-alpha production, regulation of cell growth, cornea development in camera-type eye, poly(A) binding, Probable transcriptional regulator, GntR family protein, Transcriptional regulator SdrP, immunoglobulin mediated immune response, type I interferon biosynthetic process, selenocysteine incorporation, multicellular pellicle formation, Organomercurial lyase. Organomercury lyase., Probable transcriptional regulatory protein pdtaR, Escherichia virus Lambda, Sulfolobus turreted icosahedral virus 1, DNA base-flipping protein, Vibrio parahaemolyticus AQ3810, ORF81, Pleckstrin-2, DNA packaging, Methanothermobacter thermautotrophicus str. Delta H, Lin2111 protein, Transcriptional regulatory protein RcsB, Light-activated DNA-binding protein EL222, Transcriptional regulator, Crp/Fnr family, cyclin binding, mitotic cell cycle, Vacuolar protein-sorting-associated protein 36, ubiquitin binding, negative regulation of G-protein coupled receptor protein signaling pathway, positive regulation of actin filament bundle assembly, Porphyromonas gingivalis W83, phagocytic vesicle, Probable transcriptional regulatory protein, -!- The enzyme from alfalfa can methylate daidzein, genistein and 6,7,4'-trihydroxyisoflavone but not flavones or flavanones., Isoflavone 7-O-methyltransferase., Isoflavone-7-O-methyltransferase 8, RNA polymerase II distal enhancer sequence-specific DNA binding, myeloid leukocyte differentiation, Transposase, TraR, positive regulation of mating type switching, Transcriptional regulator, BadM/Rrf2 family, ETS translocation variant 4, Dihydrolipoyl dehydrogenase., TVG0766549 protein, Agrobacterium fabrum str. C58, cell differentiation

histone deacetylase activity, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of transcription, DNA-templated, positive regulation of sequence-specific DNA binding transcription factor activity, positive regulation of transcription from RNA polymerase II promoter, transcription factor binding, Uncharacterized protein, ATPase activity, Paracoccus denitrificans PD1222, cellular response to gamma radiation, histone H3-K4 demethylation, negative regulation of sequence-specific DNA binding transcription factor activity, nucleus, Escherichia coli K-12, blood coagulation, histone demethylase activity (H3-dimethyl-K4 specific), ligand-dependent nuclear receptor transcription coactivator activity, p53 binding, protein complex, regulation of cellular protein localization, regulation of double-strand break repair via homologous recombination, telomeric repeat-containing RNA binding, ATP synthase subunit gamma, Corynebacterium diphtheriae NCTC 13129, Putative phage capsid protein, chromatin binding, enzyme binding, negative regulation of transcription from RNA polymerase II promoter, nuclear chromosome, telomeric region, mitochondrial proton-transporting ATP synthase complex, catalytic core F(1), ATP synthase subunit gamma, mitochondrial, Homo sapiens, cellular response to UV, demethylase activity, flavin adenine dinucleotide binding, histone H3-K9 demethylation, histone demethylase activity (H3-K4 specific), negative regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of histone ubiquitination, protein demethylation, regulation of transcription from RNA polymerase II promoter, membrane, proton-transporting ATPase activity, rotational mechanism, Yarrowia lipolytica CLIB122, ATP synthase. Chloroplast ATPase. F(0)F(1)-ATPase. F(1)-ATPase. F(o)F(1)-ATPase. H(+)-transporting ATP synthase. H(+)-transporting ATPase. Mitochondrial ATPase., ATP metabolic process, mitochondrial inner membrane, histone demethylase activity (H3-K9 specific), negative regulation of protein binding, oxidoreductase activity, telomeric DNA binding, proton-transporting ATP synthase complex, catalytic core F(1), DNA repair complex, Lysine-specific histone demethylase 1A, Oxidoreductases., MRF binding, mitochondrial proton-transporting ATP synthase, central stalk, androgen receptor binding, histone demethylase activity, nuclear chromatin, nucleoplasm, ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out)., Rattus norvegicus, Bacillus sp. TA2.A1, -!- A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. -!- Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (F(o), V(o), A(o)) and a cytoplasmic-compartment sector (F(1), V(1), A(1)). -!- The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. -!- All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 alpha- and 3 beta-subunits) is connected via the delta-subunit to the membrane sector by several smaller subunits. -!- Within this complex, the gamma- and epsilon-subunits, as well as the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. -!- This movement is driven by the H(+) electrochemical potential gradient. -!- The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archaeal) enzymes have a similar structure but, under physiological conditions, they pump H(+) rather than synthesize ATP. -!- Formerly EC 3.6.1.34., ATP synthase gamma chain, Geobacter sulfurreducens PCA, ATP synthesis coupled proton transport, Bos taurus

nucleus, transcriptional repressor complex, transcription regulatory region DNA binding, REST corepressor 3, Homo sapiens, negative regulation of transcription, DNA-templated, REST corepressor 1, transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding, protein binding