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Mycobacterium smegmatis str. MC2 155, alpha-linolenic acid metabolic process, extracellular exosome, outer membrane-bounded periplasmic space, long-chain-enoyl-CoA hydratase activity, Helicoverpa armigera, PSdsA, Pseudomonas sp. DSM 6611, Homo sapiens, lipid hydroperoxide transport, peroxisome, phospholipid transport, Archaeoglobus fulgidus DSM 4304, Mycobacterium tuberculosis H37Rv, modulation by symbiont of host programmed cell death, Aedes aegypti, (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl- CoA = (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl- CoA + H(2)O., (3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O., 17-beta-hydroxysteroid dehydrogenase (NAD+) activity, Mycobacterium tuberculosis CDC1551, Pseudomonas sp. S9, nucleoplasm, phosphatidylinositol transporter activity, protein localization to plasma membrane, cholesterol binding, fatty-acyl-CoA binding, Putative alkyl/aryl-sulfatase YjcS, Sulfuric ester hydrolases., alkyl sulfatase activity, Acetyltransferase, GNAT family, Enhanced intracellular survival protein, Enterococcus faecalis V583, (R)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH., 2-enoyl-CoA hydratase 2. D-3-hydroxyacyl-CoA hydro-lyase. D-specific 2-trans-enoyl-CoA hydratase. ECH2., 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity, D-3-hydroxyacyl-CoA dehydratase., medium-chain fatty-acyl-CoA metabolic process, propionyl-CoA C2-trimethyltridecanoyltransferase activity, protein binding, receptor binding, steroid biosynthetic process, aminoglycoside N-acetyltransferase activity, positive regulation by symbiont of host inflammatory response, Pseudomonas aeruginosa PAO1, SDS hydrolase SdsA1, Sterol carrier protein 2-like 2, Thermus thermophilus HB8, Yarrowia lipolytica CLIB122, Sec-alkylsulfatase, fatty acid beta-oxidation using acyl-CoA oxidase, membrane, positive regulation of intracellular cholesterol transport, positive regulation of steroid metabolic process, aminoglycoside antibiotic catabolic process, growth of symbiont in host cell, -!- Forms part of the rat peroxisomal multifunctional enzyme perMFE-2, which also exhibits a dehydrogenase activity. -!- Involved in the beta-oxidation of the cholesterol side chain in the cholic-acid biosynthesis pathway., Enoyl-CoA hydratase 2., estrogen metabolic process, fatty acid beta-oxidation, -!- This enzyme catalyzes a hydration step in peroxisomal beta-oxidation. -!- The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units. -!- The enzymes from Aeromonas caviae and Arabidopsis thaliana are monofunctional enzymes. -!- 2-enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2., 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase., peroxisomal membrane, protein homodimerization activity, Fatty acid-binding protein, inositol trisphosphate biosynthetic process, oleic acid binding, peroxisomal matrix, progesterone biosynthetic process, protein complex, Kribbella flavida DSM 17836, identical protein binding, (3R)-hydroxyacyl-CoA dehydrogenase., 3-hydroxyacyl-CoA dehydrogenase activity, Peroxisomal multifunctional enzyme type 2, 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl- CoA., Non-specific lipid-transfer protein, Sterol carrier protein 2/3-oxoacyl-CoA thiolase, androgen metabolic process, very long-chain fatty-acyl-CoA metabolic process, intracellular membrane-bounded organelle, long-chain fatty acyl-CoA binding, GCN5-related N-acetyltransferase, Transferring groups other than amino-acyl groups., growth of symbiont in host organelle, modulation by symbiont of defense-related host reactive oxygen species production, modulation by symbiont of host innate immune response, Sterol carrier protein 2, Uncharacterized protein, 3-oxopristanoyl-CoA hydrolase. 3-oxopristanoyl-CoA thiolase. Peroxisomal thiolase 2. Propionyl-CoA C(2)-trimethyltridecanoyltransferase. PTE-2. SCP(chi). SCP-X. Sterol carrier protein-chi. Sterol carrier protein-X., -!- Also acts on dihydroxy-5-beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. -!- Catalyzes the penultimate step in the formation of bile acids. -!- The bile acid moiety is transferred from the acyl-CoA thioester (RCO- SCoA) to either glycine or taurine (NH(2)R') by EC 2.3.1.65. -!- Formerly EC 2.3.1.154., Oryctolagus cuniculus, Propanoyl-CoA C-acyltransferase., osteoblast differentiation

basal protein localization, peroxisome fission, positive regulation of mitochondrial fission, vascular endothelial growth factor receptor signaling pathway, extracellular vesicle, post-translational protein modification, protein kinase inhibitor activity, intracellular transport of virus, nuclear membrane, Putative thioredoxin protein, Protein phosphokinase. Protein serine kinase. Protein serine-threonine kinase. Protein-serine kinase. Serine kinase. Serine protein kinase. Serine(threonine) protein kinase. Serine-specific protein kinase. Serine/threonine protein kinase. Threonine-specific protein kinase., modulation by symbiont of host signal transduction pathway, Encephalitozoon cuniculi GB-M1, oviposition, transcription corepressor activity, HAT1-interacting factor 1, response to pheromone, signal recognition particle, endoplasmic reticulum targeting, nuclear pore, regulation of gene silencing by miRNA, BAT3 complex binding, estrogen receptor binding, double-stranded RNA binding, membrane to membrane docking, maintenance of protein location, trisaccharide binding, Transcriptional regulator/TPR domain protein, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, Capnocytophaga ochracea DSM 7271, regulation of insulin receptor signaling pathway, Kinesin light chain 1, Histone-lysine N-methyltransferase SMYD3, Histone-lysine N-methyltransferase., -!- Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. -!- EC 2.4.1.255 transfers GlcNAc onto substrate proteins and EC 3.2.1.169 cleaves GlcNAc from the modified proteins., Protein O-GlcNAc transferase., UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, acetylglucosaminyltransferase activity, apoptotic process, histone H4-K8 acetylation, Dual-specificity kinase., protein serine/threonine kinase activity, NatA complex, Chlamydia pneumoniae, mRNA 3'-end-processing protein RNA14, Podospora anserina S mat+, Afadin, ER to Golgi vesicle-mediated transport, Uncharacterized protein YbbN, ruffle membrane, tRNA binding, chaperone binding, Heat shock protein STI1, Desulfovibrio magneticus RS-1, secretion, type IV pilus-dependent motility, protein adenylyltransferase activity, peroxisomal matrix, peroxisome targeting sequence binding, protein import into peroxisome matrix, docking, small GTPase binding, negative regulation of transcription from RNA polymerase II promoter, protein-lysine N-methyltransferase activity, procollagen-proline 4-dioxygenase activity, cadherin binding, cell junction, cell-cell signaling, positive regulation of spindle assembly, Arabidopsis thaliana, Peptidyl-prolyl cis-trans isomerase FKBP42, leaf development, COPII-coated vesicle budding, structural molecule activity, E3 SUMO-protein ligase RanBP2, Protein SMG7, ATP metabolic process, ATPase activity, blood microparticle, -!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1)., mitotic nuclear envelope disassembly, Secretory immunoglobulin A-binding protein EsiB, immunological synapse formation, regulation of cell size, Putative exported protein, cell wall, protein autophosphorylation, Non-specific serine/threonine protein kinase., Histone-lysine N-methyltransferase Smyd1, negative regulation of transcription, DNA-templated, TPR repeat-containing protein, Saimiri boliviensis boliviensis, GDP-dissociation inhibitor activity, Bacteroides vulgatus ATCC 8482, cellular response to type I interferon, negative regulation of helicase activity, cellular response to cold, misfolded protein binding, positive regulation of translation initiation in response to endoplasmic reticulum stress, mitochondrial inner membrane presequence translocase complex, Neisseria meningitidis MC58, Peptidyl-prolyl cis-trans isomerase D, Bacteroides fragilis YCH46, RNA binding, Hsp70 protein binding, heat shock protein binding, positive regulation of ubiquitin-protein transferase activity, ubiquitin protein ligase binding, histone methyltransferase activity (H3-K36 specific), Bacillus thuringiensis serovar thuringiensis str. IS5056, Nonsense-mediated mRNA decay protein, embryonic genitalia morphogenesis, Shigella flexneri, Ribonuclease P., chloroplast, xenobiotic metabolic process, histone acetyltransferase complex, phosphatidylinositol-3,4,5-trisphosphate binding, protein deubiquitination, positive regulation of pathway-restricted SMAD protein phosphorylation, protein tyrosine kinase activity, Aryl hydrocarbon receptor Interacting Protein (AIP) Related, acetyltransferase activator activity, adherens junction organization, cell adhesion, cell cortex region, establishment of mitotic spindle orientation, identical protein binding, Saccharomyces cerevisiae S288C, posttranslational protein targeting to endoplasmic reticulum membrane, Cyclophilin. Peptidyl-prolyl cis-trans isomerase. Peptidylprolyl cis-trans isomerase. PPIase. Rotamase., negative regulation of protein phosphorylation, Interferon-induced protein with tetratricopeptide repeats 5, poly(U) RNA binding, IRE1-mediated unfolded protein response, azurophil granule lumen, box C/D snoRNP assembly, C3HC4-type RING finger domain binding, negative regulation of cell proliferation, negative regulation of protein ubiquitination, positive regulation of interleukin-8 production, protein N-terminus binding, protein complex, TPR domain binding, pilus assembly, mitochondrial outer membrane translocase complex, mitochondrion targeting sequence binding, protein import into mitochondrial inner membrane, regulation of mitotic nuclear division, L-proline-[procollagen] + 2-oxoglutarate + O(2) = trans-4-hydroxy-L- proline-[procollagen] + succinate + CO(2)., Prolyl 4-hydroxylase subunit alpha-1, mitochondrial fragmentation involved in apoptotic process, cellular response to oxidative stress, respiratory burst, negative regulation of apoptotic process, Vibrio parahaemolyticus RIMD 2210633, chaperone-mediated protein complex assembly, Uncharacterized protein, histone acetylation, Beta-lactamase HcpB, MamA, protein oligomerization, apoptotic mitochondrial changes, negative regulation of ATPase activity, response to heat, Small glutamine-rich tetratricopeptide repeat-containing protein alpha, negative regulation of ER-associated ubiquitin-dependent protein catabolic process, negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process, avoidance of host defenses, Bacillus thuringiensis serovar israelensis ATCC 35646, locomotion, sarcomere organization, histone methylation, negative regulation of transforming growth factor beta receptor signaling pathway, ubiquitin-dependent SMAD protein catabolic process, Protein BCH1, Pentatricopeptide repeat-containing protein At3g46870, ubiquitin-dependent protein catabolic process, Regulatory protein PcrH, Golgi apparatus, Yersinia pestis, negative regulation of protein binding, Z disc, endoplasmic reticulum unfolded protein response, Outer membrane assembly lipoprotein YfiO, Hsc70 cochaperone (SGT), putative, negative regulation of neutrophil activation, Ran GTPase binding, protein sumoylation, Pseudomonas aeruginosa, cell division, Clathrin heavy chain 1, apical plasma membrane, filopodium, movement of cell or subcellular component, positive regulation of protein localization to early endosome, regulation of organelle assembly, protein maturation by protein folding, Bacteroides ovatus ATCC 8483, Bam protein complex, ciliary rootlet, mitotic spindle pole body, positive regulation of mitotic metaphase/anaphase transition, positive regulation of histone H3-K27 methylation, protein O-linked glycosylation, kinesin complex, Putaive YfrE protein, Protein FLUORESCENT IN BLUE LIGHT, chloroplastic, ATPase activity, coupled, ficolin-1-rich granule lumen, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of gene expression, Tetratricopeptide repeat protein, cell proliferation, protein phosphatase binding, negative regulation of GTPase activity, -!- Essential for tRNA processing; generates 5'-termini of mature tRNA molecules., tRNA processing, protein insertion into membrane, axo-dendritic transport, neuron projection, Adenosine monophosphate-protein transferase FICD homolog, peroxisomal membrane, peroxisome matrix targeting signal-1 binding, protein import into peroxisome membrane, Chlorobium tepidum TLS, intracellular, mitotic metaphase plate congression, establishment of endothelial intestinal barrier, nuclear speck, positive regulation of microtubule nucleation, vesicle, Response regulator aspartate phosphatase I, Mycobacterium tuberculosis H37Rv, growth of symbiont in host, type I interferon signaling pathway, reproduction, p53 binding, electron carrier activity, positive regulation of protein targeting to membrane, receptor binding, endosome, receptor-mediated endocytosis, 7S RNA binding, Cephalosporinase. Penicillinase., Magnetospirillum magnetotacticum, regulation of transcription, DNA-templated, histone dephosphorylation, positive regulation of glucocorticoid receptor signaling pathway, lung epithelial cell differentiation, asymmetric cell division, asymmetric neuroblast division, asymmetric protein localization, neuroblast proliferation, Peptidyl-prolyl cis-trans isomerase FKBP5, chromatin binding, protein dephosphorylation, -!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37., cell surface, nuclear pericentric heterochromatin, cellular response to testosterone stimulus, leukocyte cell-cell adhesion, regulation of cell shape, regulation of lymphocyte migration, Lipoprotein NlpI, HTH-type transcriptional regulator MalT, enzyme regulator activity, peptidoglycan biosynthetic process, ubiquitin-dependent ERAD pathway, response to stress, PEX5-related protein, embryo development ending in birth or egg hatching, Thermus thermophilus HB27, RING E3 ligase. Ubiquitin transferase RING E3., STIP1 homology and U box-containing protein 1, protein maturation, ubiquitin protein ligase activity, Chaperone SycD, starch metabolic process, Trypanosoma brucei brucei TREU927, S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]., histone-lysine N-methyltransferase activity, histone H4-K16 acetylation, protein adenylylation, type IV pilus biogenesis, Anaphase-promoting complex subunit 7, Xanthomonas campestris pv. campestris str. 8004, Procollagen-proline dioxygenase., NADPH oxidase complex, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, phagolysosome, protein homooligomerization, negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation, neutrophil degranulation, transcription coactivator activity, transcription factor binding, Cell division cycle protein 27 homolog, Proteinaceous RNase P 1, chloroplastic/mitochondrial, tRNA 5'-leader removal, mitotic spindle organization, Response regulator aspartate phosphatase H, Putative outer membrane protein, probably involved in nutrient binding, Drosophila melanogaster, Interferon-induced protein with tetratricopeptide repeats 1, positive regulation of viral genome replication, protein kinase binding, proteolysis involved in cellular protein catabolic process, Transcriptional activator CadC, defense response to virus, focal adhesion, histone deacetylase binding, intracellular ribonucleoprotein complex, negative regulation of cell death, skeletal muscle cell differentiation, RNA polymerase II core binding, AscG, E3 ubiquitin-protein ligase CHIP, ERBB2 signaling pathway, protein K63-linked ubiquitination, protein autoubiquitination, ubiquitin ligase complex, regulation of glucose transport, viral transcription, Zgc:110177, fungal-type cell wall chitin biosynthetic process, establishment of protein localization to plasma membrane, SRP-dependent cotranslational protein targeting to membrane, Putative beta-lactamase HcpC, Pan troglodytes, Methanococcus maripaludis S2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70., Phosphotransferases with an alcohol group as acceptor., glutamine catabolic process, cell periphery, negative regulation of neuron death, phosphoprotein phosphatase activity, T cell migration, cell adhesion molecule binding, cytoskeleton, Escherichia coli CFT073, gland morphogenesis, positive regulation of cellular protein catabolic process, pseudopodium, structural constituent of cytoskeleton, positive regulation of cell proliferation, spindle, positive regulation of transcription from RNA polymerase II promoter, response to insulin, mitotic spindle assembly checkpoint, Golgi to ER traffic protein 4, positive regulation of N-terminal peptidyl-serine acetylation, peptidyl-prolyl cis-trans isomerase activity, positive regulation of GTPase activity, cell cortex, regulation of mitotic spindle organization, regulation of membrane potential, Mitochondrial import receptor subunit TOM20-3, mitochondrial inner membrane, protein self-association, Stress-induced-phosphoprotein 1, Mus musculus, RING-type E3 ubiquitin transferase., protein binding, bridging, Yersinia enterocolitica, Bacteroides thetaiotaomicron VPI-5482, calcium ion binding, antigen processing and presentation of exogenous peptide antigen via MHC class II, ATPase inhibitor activity, autophagy, ESX-1 secretion system protein EccA1, Kinesin light chain 2, NprR, Adenosine monophosphate-protein transferase FICD, Outer membrane protein assembly factor BamD, Bacillus subtilis subsp. subtilis str. 168, TPR repeat-containing protein YrrB, Peroxisomal targeting signal 1 receptor, enzyme binding, peroxisome, protein import into peroxisome matrix, Cell division cycle protein 16 homolog, Low Calcium Response Protein H, negative regulation of defense response to virus by host, histone binding, transcription, DNA-templated, Golgi to plasma membrane transport, Magnetospirillum gryphiswaldense, Danio rerio, TPR repeat-containing protein associated with Hsp90, ATP binding, centriole, positive regulation of tumor necrosis factor-mediated signaling pathway, Rattus norvegicus, ATPase activator activity, SNARE complex, SNARE complex disassembly, vacuole fusion, non-autophagic, Response regulator aspartate phosphatase F, G-protein alpha-subunit binding, Serine/threonine-protein phosphatase 5, [a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate., perikaryon, SMAD binding, regulation of protein stability, ubiquitin protein ligase activity involved in ERAD pathway, Peroxisome targeting signal 1 receptor PEX5, Bacillus halodurans C-125, intermediate filament cytoskeleton, Transcriptional regulatory protein EmbR, Cleavage stimulation factor subunit 3, Proteinaceous RNase P 2, apical cortex, asymmetric protein localization involved in cell fate determination, neuroblast fate determination, motor activity, retrograde vesicle-mediated transport, Golgi to ER, ncRNA metabolic process, nuclear pore cytoplasmic filaments, nuclear pore nuclear basket, tRNA export from nucleus, Bacteroides fragilis NCTC 9343, T cell aggregation, viral process, positive regulation of ER-associated ubiquitin-dependent protein catabolic process, T cell proliferation, establishment of endothelial barrier, microvillus, periplasmic side of cell outer membrane, Putative fimbrial biogenesis and twitching motility protein, cytosol, protein binding, TRC complex, protein insertion into ER membrane, Ras GTPase binding, dynein complex binding, positive regulation of protein localization to cell cortex, FK506 binding, Peptidyl-prolyl cis-trans isomerase FKBP4, regulation of cellular response to heat, metaphase/anaphase transition of mitotic cell cycle, positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition, regulation of exit from mitosis, regulation of mitotic metaphase/anaphase transition, -!- The RING domain of E3 ubiquitin transferase serves as a mediator bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin an the epsilon-amino group of an L-lysine residue of the acceptor protein. -!- The RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin (unlike the HECT domain, EC 2.3.2.26). -!- RING-type ubiquitin transferases may occur as single-chain enzymes but also in dimeric forms or in multi-subunit assemblies. -!- Formerly EC 6.3.2.19 and EC 6.3.2.21., cellular response to misfolded protein, positive regulation of protein ubiquitination, proteasome-mediated ubiquitin-dependent protein catabolic process, protein homodimerization activity, protein ubiquitination, Peroxisome targeting signal 1 receptor, Anaphase-promoting complex subunit 8, mitochondrial outer membrane, regulation of signal transduction by p53 class mediator, integral component of peroxisomal membrane, mitochondrion morphogenesis, positive regulation of intrinsic apoptotic signaling pathway, protein dimerization activity, Neutrophil cytosol factor 2, innate immune response, superoxide metabolic process, apical part of cell, negative regulation of viral genome replication, positive regulation of I-kappaB kinase/NF-kappaB signaling, single-stranded RNA binding, RNA cap binding, Coatomer subunit epsilon, promoter-specific chromatin binding, DnaJ homolog subfamily C member 3, actin cytoskeleton, Protein TOM71, peroxisome organization, SMG-7, growth, positive regulation by symbiont of defense-related host reactive oxygen species production, UNC-45, snoRNA processing, Interferon-induced protein with tetratricopeptide repeats 2, positive regulation of transcription, DNA-templated, establishment of spindle orientation, cellular response to exogenous dsRNA, G-protein coupled receptor binding, Heat shock 70 kDa protein 1B, cellular response to heat, inclusion body, mRNA catabolic process, negative regulation of cell growth, perinuclear region of cytoplasm, positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, protein binding involved in protein folding, protein refolding, Alpha-soluble NSF attachment protein, Protein-serine/threonine phosphatase., cellular response to hydrogen peroxide, -!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8., A beta-lactam + H(2)O = a substituted beta-amino acid., Klebsiella pneumoniae subsp. pneumoniae MGH 78578, protein phosphatase 2A binding, regulation of dephosphorylation, telomeric DNA binding, TPR repeat, Thermococcus onnurineus NA1, Brachypodium distachyon, Schizosaccharomyces pombe 972h-, histone H3-K4 trimethylation, phosphatidylinositol-mediated signaling, regulation of glycolytic process, response to nutrient, microtubule-based movement, N-terminal acetyltransferase A complex subunit nat1, intra-Golgi vesicle-mediated transport, RNA interference, NLS-bearing protein import into nucleus, annulate lamellae, Homo sapiens, nucleus, S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine., ubiquitin-protein transferase activity, outer membrane, starch binding, peptidyl-lysine dimethylation, nuclear inclusion body, Aeromonas hydrophila, centrosome localization, Rhodothermus marinus DSM 4252, IgA binding, negative regulation of immune response, Anaphase-promoting complex subunit cut9, Escherichia coli O157:H7, Escherichia coli K-12, kinesin binding, Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor., ATP + [protein] = diphosphate + [protein]-AMP., Type 4 fimbrial biogenesis protein PilF, Mitochondrial import receptor subunit TOM70, Caenorhabditis elegans, Protein methylase 3. Protein methylase III. Protein methyltransferase II. Protein-lysine N-methyltransferase., O-linked N-acetylglucosaminyltransferase. OGTase., positive regulation of proteolysis, protein O-GlcNAc transferase activity, cytoplasm, anaphase-promoting complex, cell-cell junction, protein C-terminus binding, G-protein coupled receptor signaling pathway, Kluyveromyces lactis NRRL Y-1140, anaphase-promoting complex-dependent catabolic process, negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, calmodulin binding, COPII vesicle coat, proximal dendrite, Methyltransferases., N-lysine methyltransferase SMYD2, calcium-mediated signaling using intracellular calcium source, mitochondrial fission, mitophagy, cellular protein metabolic process, cellular defense response, vesicle coating, R2TP complex, chronological cell aging, Agrobacterium fabrum str. C58, aggresome, cellular heat acclimation, protein stabilization, regulation of mitotic spindle assembly, Hsc70-interacting protein, protein complex binding, protein localization, vesicle fusion with Golgi apparatus, endoplasmic reticulum lumen, intracellular membrane-bounded organelle, Acting on ester bonds., lysine N-methyltransferase activity, peptidyl-lysine monomethylation, regulation of DNA damage response, signal transduction by p53 class mediator, Mitochondrial fission 1 protein, negative regulation of endoplasmic reticulum calcium ion concentration, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, zinc ion binding, actin cortical patch, response to drug, signal recognition particle binding, Beta-lactamase., beta-lactamase activity, mRNA export from nucleus, ADP binding, determination of adult lifespan, response to lead ion, LD33695p, establishment of mitotic spindle localization, Cytophaga hutchinsonii ATCC 33406, Tetratricopeptide repeat domain protein, DNA binding, intracellular transport of viral protein in host cell, establishment of epithelial cell apical/basal polarity, leukocyte migration, MAPK cascade, protein serine/threonine phosphatase activity, GTPase activity, modulation by symbiont of host phagocytosis, Similarity to SUPPRESSOR OF FORKED PROTEIN(MRNA stability), cleavage furrow, chromatin remodeling, heart development, chromatin silencing at telomere, nucleosome assembly, Protein unc-45 homolog A, kinase binding, positive regulation of chaperone-mediated protein complex assembly, regulation of glucocorticoid metabolic process, Bos taurus, Aspergillus fumigatus Af293, DEAD/H-box RNA helicase binding, sister chromatid cohesion, Pseudomonas aeruginosa PAO1, protein secretion by the type III secretion system, Xanthomonas campestris pv. campestris str. ATCC 33913, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, protein targeting to mitochondrion, signal transducer activity, misfolded or incompletely synthesized protein catabolic process, ubiquitin-ubiquitin ligase activity, Starch-binding protein SusD, nucleoplasm, regulation of Rac protein signal transduction, signal transduction, ATP + a protein = ADP + a phosphoprotein., Dual specificity protein kinase TTK, spindle organization, extracellular space, release of cytochrome c from mitochondria, nucleolus, Moesin, double-stranded DNA binding, COPI vesicle coat, late endosome to vacuole transport via multivesicular body sorting pathway, centrosome, Gram-negative-bacterium-type cell outer membrane assembly, mitochondrion, negative regulation of protein homotetramerization, defense response to Gram-negative bacterium, endoplasmic reticulum, protein tetramerization, integral component of mitochondrial outer membrane, protein import into mitochondrial matrix, Cell division cycle protein 23 homolog, mitotic cell cycle, maintenance of centrosome location, -!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively., Peptidylprolyl isomerase., chaperone-mediated protein folding, Hypothetical conserved protein, mitochondrial fusion, positive regulation of cytosolic calcium ion concentration, positive regulation of mitochondrial calcium ion concentration, regulation of mitochondrion organization, extracellular region, Peptidylprolyl isomerase, Plasmodium falciparum 3D7, Spodoptera frugiperda, cell redox homeostasis, superoxide anion generation, Cargo-transport protein YPP1, protein targeting to vacuole, BH0479 protein, Helicobacter pylori 26695, Type III export protein PscG, Acid--amino-acid ligases (peptide synthases)., mRNA processing, RNA polymerase II-associated protein 3, response to virus, cellular response to cadmium ion, microtubule binding, protein heterooligomerization, Deinococcus radiodurans R1, Tetratricopeptide repeat protein 5, Formate-dependent nitrite reductase complex subunit NrfG, arrestin family protein binding, clathrin coat assembly, disordered domain specific binding, Serine/threonine-protein kinase PknG, glutamate catabolic process, negative regulation of cytolysis by symbiont of host cells, pathogenesis, POSSIBLE PROTEIN OF NUCLEAR SCAFFOLD, Transcriptional activator plcR, Salinibacter ruber DSM 13855, Trypanosoma brucei, exomer complex, Signal recognition particle subunit SRP72, signal recognition particle, positive regulation of early endosome to late endosome transport, P-P-bond-hydrolysis-driven protein transmembrane transporter activity, Penicillin-binding protein activator LpoA, cell outer membrane, Hexosyltransferases., dendrite, protein folding, protein polyubiquitination, ubiquitin conjugating enzyme complex, Putative type III secretion protein, protein disulfide oxidoreductase activity, Protein transport protein SEC31, Chaperone protein IpgC, ribonuclease P activity, Bacillus thuringiensis serovar thuringiensis, AH receptor-interacting protein, GAF domain binding, unfolded protein binding, (1) UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine. (2) UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine., histone H4-K5 acetylation, plasma membrane, protein N-acetylglucosaminyltransferase activity, membrane, mitotic spindle pole, Peptidylproline (omega=180) = peptidylproline (omega=0)., protein K11-linked ubiquitination, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, Putative Kinesin light chain, G-protein-signaling modulator 2, Ran protein signal transduction, extracellular exosome, Bordetella parapertussis 12822, mRNA binding, Mitochondria fission 1 protein, negative regulation of inclusion body assembly, regulation of protein ubiquitination, chaperone cofactor-dependent protein refolding, dATP binding, negative regulation of protein refolding, Hsp90 protein binding, extrinsic component of membrane, soluble NSF attachment protein activity, Candidatus Magnetobacterium bavaricum, Adenosine monophosphate-protein transferase., Magnetosome protein MamA, protein import into peroxisome matrix, translocation, protein targeting to peroxisome, nuclear envelope, cristae formation, Procollagen-proline 4-dioxygenase. Procollagen-proline,2-oxoglutarate-4-dioxygenase. Proline hydroxylase. Proline,2-oxoglutarate 4-dioxygenase. Prolyl 4-hydroxylase. Prolyl hydroxylase. Protocollagen hydroxylase., Response regulator aspartate phosphatase J