Search CATH

platelet aggregation, Magnesium chelatase., positive regulation of DNA ligation, negative regulation of establishment of protein localization to plasma membrane, locomotor rhythm, mating behavior, regulation of JAK-STAT cascade, regulation of border follicle cell delamination, smooth septate junction, tricellular tight junction, Nanoarchaeum equitans Kin4-M, dGDP phosphorylation, secretory vesicle, Methanopyrus kandleri AV19, Borrelia burgdorferi B31, GTP-binding protein SAR1a, AP-1 adaptor complex binding, AP-3 adaptor complex binding, Acinetobacter baumannii AB307-0294, mating projection base, prospore membrane, profilin binding, Ras-related protein Rab-28, epidermal growth factor receptor binding, exocrine system development, signal transducer activity, Plasmodium yoelii yoelii, Debaryomyces hansenii CBS767, ADP-ribosylation factor-like protein 6, protein localization to cilium, Voltage-dependent L-type calcium channel subunit beta-4, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, cellular response to insulin stimulus, Probable bifunctional SAT/APS kinase, G protein alpha subunit putative, ORC1-type DNA replication protein 1, ATPase, ParA family, cell-cell adherens junction, Ras-related protein Rab-35, Teg14, ORC1-type DNA replication protein, activation of MAPKK activity, exocytic vesicle, chloroplast envelope, ParA family chromosome partitioning protein, Ras-related protein Rab-3B, hemocyte migration, negative regulation of neuromuscular synaptic transmission, negative regulation of synaptic growth at neuromuscular junction, neuromuscular junction, regulation of post-lysosomal vacuole size, Cryptosporidium parvum, -!- A bacterial enzyme that imports ferric cations., Atlastin, endoplasmic reticulum membrane fusion, Rac-like GTP-binding protein ARAC6, Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3, Leucine-rich repeat serine/threonine-protein kinase 2, Wnt signalosome, Wnt signalosome assembly, co-receptor binding, extracellular space, glycoprotein binding, mitochondrial membrane, multivesicular body, internal vesicle, negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation, neuron death, peroxidase inhibitor activity, regulation of branching morphogenesis of a nerve, regulation of mitochondrial fission, ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)., Nicotinamide-nucleotide adenylyltransferase., Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1, heparan sulfate proteoglycan biosynthetic process, 3'-phosphoadenylyl sulfate + alpha,alpha-trehalose = adenosine 3',5'-bisphosphate + 2-O-sulfo-alpha,alpha-trehalose., Uncharacterized protein YqeN, Staphylococcus aureus subsp. aureus Mu3, mitotic sister chromatid cohesion, response to isolation stress, nucleosome-dependent ATPase activity, post-embryonic development, regulation of melanocyte differentiation, positive regulation of mitotic cell cycle, -!- ATP hydrolysis is linked with peptide bond hydrolysis. -!- Vanadate inhibits both reactions. -!- A similar enzyme occurs in animal mitochondria. -!- Belongs to peptidase family S16., ATP-dependent protease La. ATP-dependent serine proteinase., Ras-related protein Rab-4B, Septin-6, Geobacillus kaustophilus HTA426, leading strand elongation, ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway, Thermococcus litoralis DSM 5473, axon, positive regulation of smooth muscle contraction, regulation of postsynaptic membrane potential, Ras-related protein Rab-6A, purine nucleobase metabolic process, Anabaena variabilis ATCC 29413, cerebral cortex cell migration, forebrain radial glial cell differentiation, telomere maintenance via recombination, 3'-dephospho-CoA pyrophosphorylase. Dephospho-CoA diphosphorylase. Dephospho-CoA pyrophosphorylase. Dephospho-coenzyme A pyrophosphorylase. Phosphopantetheine adenylyltransferase. PPAT., pantetheine-phosphate adenylyltransferase activity, (1) ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide. (2) ATP + cobinamide = triphosphate + adenosylcobinamide., blue light signaling pathway, channel regulator activity, gibberellic acid mediated signaling pathway, reactive oxygen species metabolic process, Tyrosine-protein kinase etk, 5'-3' DNA helicase activity, Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3, apoptosome, response to G1 DNA damage checkpoint signaling, Cancer-related nucleoside-triphosphatase, dendrite cytoplasm, glutamate receptor binding, neuronal ion channel clustering, postsynaptic neurotransmitter receptor diffusion trapping, receptor localization to synapse, nucleotide-excision repair, preincision complex assembly, transcription initiation from RNA polymerase II promoter, plastid, embryo development ending in seed dormancy, plasmodesma, vacuolar membrane, dorsal/ventral neural tube patterning, ribosome assembly, Probable ATP-dependent RNA helicase MJ0669, symbiont-containing vacuole membrane, outer membrane-bounded periplasmic space, positive regulation of synaptic growth at neuromuscular junction, Interferon-induced GTP-binding protein Mx1, NMDA selective glutamate receptor signaling pathway, GTP-binding protein Di-Ras1, Division plane positioning ATPase MipZ, Deoxynucleotide monophosphate kinase, Ras-related protein Ral-A, Yarrowia lipolytica CLIB122, synaptic vesicle exocytosis, meiotic chromosome segregation, Burkholderia vietnamiensis G4, Fructokinase., ATPase get3, Small ribosomal subunit biogenesis GTPase RsgA, (1) ATP + uridine = ADP + UMP. (2) ATP + cytidine = ADP + CMP., androgen receptor binding, positive regulation of DNA damage response, signal transduction by p53 class mediator, fungal-type vacuole membrane, Streptococcus pyogenes, UNAG kinase., chromatin silencing complex, heterochromatin assembly, nuclear-transcribed mRNA catabolic process, non-stop decay, Mycobacterium tuberculosis H37Ra, Mycoplasma mycoides subsp. mycoides SC str. PG1, Spinacia oleracea, protein to membrane docking, activation of phospholipase D activity, Voltage-dependent L-type calcium channel subunit beta-3, Twitching mobility protein, forebrain neuron development, Staphylococcus epidermidis ATCC 12228, Vacuolar protein sorting-associated protein 4, Plasmid partition protein A, Vaccinia virus Copenhagen, 3'-UTR-mediated mRNA destabilization, Regulator of nonsense transcripts 1, positive regulation of mRNA catabolic process, regulation of telomere maintenance, supraspliceosomal complex, telomere maintenance via semi-conservative replication, Dynein heavy chain, cytoplasmic, phagolysosome membrane, tubulin binding, Polynucleotide 3'-phosphatase., Ribosome-interacting GTPase 1, cytoplasmic translation, Physcomitrella patens, nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', Ehrlichia chaffeensis str. Arkansas, Teg12, uncultured soil bacterium, Shikimate kinase 2, chloroplastic, Bacillus phage SPP1, Cricetulus griseus, regulation of osteoblast proliferation, regulation of systemic arterial blood pressure by endothelin, short-chain fatty acid catabolic process, Dimethylallyl diphosphate + AMP = diphosphate + N(6)- (dimethylallyl)adenosine 5'-phosphate., ATPase activity, coupled to transmembrane movement of substances, D-methionine transmembrane transporter activity, D-methionine transport, negative regulation of strand invasion, SRP-dependent cotranslational protein targeting to membrane, response to nematicide, viral procapsid maturation, Guanine nucleotide-binding protein subunit alpha-13, UTP metabolic process, Ras-related protein Rab-21, cytoplasmic side of plasma membrane, positive regulation of receptor-mediated endocytosis, Golgi to transport vesicle transport, very-low-density lipoprotein particle assembly, NDK. Nucleoside 5'-diphosphate phosphotransferase. Nucleoside diphosphokinase., Nucleoside-diphosphate kinase., ATP-dependent RNA helicase DDX3X, mature ribosome assembly, negative regulation of translation, positive regulation of translation, mRNA branch site recognition, cell-cell junction, positive regulation of RNA polymerase II transcriptional preinitiation complex assembly, cellular response to drug, establishment or maintenance of apical/basal cell polarity, keratinization, leading edge membrane, regulation of protein metabolic process, storage vacuole, Uncharacterized GTP-binding protein YjiA, negative regulation of cell adhesion, chromosome organization, cellular response to antibiotic, Shikimate kinase, Ras-related and estrogen-regulated growth inhibitor, Ras-related protein R-Ras2, osteoblast differentiation, rhoptry, Ribosome biogenesis GTPase A, endomembrane system, ATPase-coupled anion transmembrane transporter activity, bicarbonate transport, positive regulation of voltage-gated chloride channel activity, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal large subunit biogenesis, Thermosynechococcus elongatus BP-1, ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA., DNA binding, bending, estrone sulfotransferase activity, cytoplasmic viral factory, keratin filament binding, modulation by virus of host transcription, negative regulation by symbiont of host protein levels, negative regulation of B cell proliferation, mitotic spindle disassembly, Putative ABC transporter, ATP-binding protein ComA, TAP2 binding, peptide antigen transport, DNA double-strand break repair Rad50 ATPase, recombinase activity, Obg-like ATPase 1, Oryza sativa Japonica Group, guanosine metabolic process, metalloendopeptidase activity, colanic acid biosynthetic process, peptidyl-tyrosine autophosphorylation, ATP synthase subunit alpha, cholesterol biosynthetic process, positive regulation of insulin secretion involved in cellular response to glucose stimulus, Macaca mulatta polyomavirus 1, Probable GTP-binding protein EngB, cilium assembly, trans-Golgi network membrane, Group II intron splicing, Type IV pilus assembly protein PilF, endoplasmic reticulum organization, ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate., ribonucleoprotein complex binding, Ruminiclostridium thermocellum ATCC 27405, Probable ATP-dependent RNA helicase DDX6, RISC complex, ATP + H(2)O + vitamin B12(Out) = ADP + phosphate + vitamin B12(In)., activation of cysteine-type endopeptidase activity, apoptotic process, Formyltetrahydrofolate synthetase. Tetrahydrofolate formylase. Tetrahydrofolic formylase., BAT3 complex binding, nucleoside triphosphate adenylate kinase activity, 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate., dephospho-CoA kinase activity, face morphogenesis, positive regulation of angiogenesis, Type IV secretion system protein VirB11, Probable hydrogenase nickel incorporation protein HypB, SNARE binding, SNARE complex assembly, Ino80 complex, R2TP complex, Swr1 complex, protein heterotrimerization, DNA repair, pyrimidine nucleobase salvage, 3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate., female pregnancy, G-protein coupled serotonin receptor binding, Zika virus, ATP-dependent DNA helicase Q1, first spliceosomal transesterification activity, positive regulation of protein serine/threonine kinase activity, positive regulation of protein ubiquitination, protein polyubiquitination, ubiquitin-protein transferase activity, Elongator holoenzyme complex, postreplication repair, pseudopodium, Histidine permease., Light-independent protochlorophyllide reductase., nuclease activity, -!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase)., NTPase. Nucleoside 5-triphosphatase. Nucleoside triphosphate hydrolase. Nucleoside triphosphate phosphohydrolase. Nucleoside-5-triphosphate phosphohydrolase. Nucleoside-triphosphatase., evasion or tolerance by virus of host immune response, mRNA (guanine-N(7)-)-methyltransferase., Circadian clock protein kinase KaiC, Protein phosphokinase. Protein serine kinase. Protein serine-threonine kinase. Protein-serine kinase. Serine kinase. Serine protein kinase. Serine(threonine) protein kinase. Serine-specific protein kinase. Serine/threonine protein kinase. Threonine-specific protein kinase., negative regulation of circadian rhythm, coenzyme A biosynthetic process, pantothenate kinase activity, centrosome, positive regulation of protein localization to cell cortex, Translation initiation factor 2 subunit gamma, cellular response to DNA damage stimulus, -!- Formerly known as tRNA isopentenyltransferase (EC 2.5.1.8), but it is now known that dimethylallyl diphosphate, rather than isopentenyl diphosphate, is the substrate. -!- Formerly EC 1.8.6.1 and EC 2.5.1.8., Dimethylallyl diphosphate + adenine(37) in tRNA = diphosphate + N(6)- dimethylallyladenine(37) in tRNA., extrinsic component of cytoplasmic side of plasma membrane, maltodextrin transport, ATP-dependent RNA helicase SUPV3L1, mitochondrial, negative regulation of apoptotic process, CTP synthase (glutamine hydrolyzing)., cytoplasmic side of early endosome membrane, ATPase GET3, guanyl-nucleotide exchange factor activity, Lipid A export ATP-binding/permease protein MsbA, cytotoxic T cell degranulation, melanosome transport, pigmentation, eukaryotic translation initiation factor 4F complex, -!- The enzyme from yeast and human also has the activity of EC 2.7.1.22. -!- Formerly EC 2.7.1.n4., ERAD pathway, autophagosome maturation, deubiquitinase activator activity, double-strand break repair, ficolin-1-rich granule lumen, protein N-linked glycosylation via asparagine, Multidrug resistance protein 1A, G2/M transition of mitotic cell cycle, early endosome membrane, execution phase of apoptosis, intracellular membrane-bounded organelle, peroxisome, peroxisome fission, Enterobacteria phage T4, Acting on ester bonds., Geobacillus stearothermophilus, -!- Large group of enzymes that have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. -!- They recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. -!- Multifunctional proteins which also catalyze the reactions of EC 2.1.1.72 and EC 2.1.1.73, with similar site specificity. -!- Formerly EC 3.1.24.1 and EC 3.1.24.2. -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/, DNA double-strand break processing, G-quadruplex DNA binding, positive regulation of transcription, DNA-templated, regulation of cyclin-dependent protein serine/threonine kinase activity, telomeric D-loop binding, Dynamin-1, protein complex binding, synaptic vesicle, Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial, DTB synthetase., adenosylmethionine-8-amino-7-oxononanoate transaminase activity, heme-transporting ATPase activity, mitochondrial envelope, RNA-directed 5'-3' RNA polymerase activity, virion assembly, positive regulation of mitochondrial membrane potential, ubiquitin-specific protease binding, RNA nuclear export complex, extracellular exosome, extracellular matrix, membrane, recycling endosome, Adenylate kinase., positive regulation of actin cytoskeleton reorganization, positive regulation of miRNA metabolic process, stimulatory C-type lectin receptor signaling pathway, Neisseria meningitidis MC58, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane organization, mitotic metaphase plate congression, spindle pole, Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)., DNA-dependent DNA replication, ATP + 3'-dephospho-CoA = ADP + CoA., Ras-related protein Rab-7a, Guanylate kinase., drug binding, RNase l inhibitor, TMP metabolic process, Thymidylate kinase. Thymidylic acid kinase. TMPK., nucleobase-containing compound metabolic process, Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB), ATPase-coupled protein transmembrane transporter activity, cell envelope Sec protein transport complex, enzyme binding, negative regulation of protein localization to plasma membrane, Ras-related protein Rab-11A, ciliary basal body docking, ER-mitochondrion membrane contact site, mitochondrial membrane organization, endocytosis, protein targeting to vacuole, -!- Enzymes of Gram-positive bacteria and eukaryotic cells that export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally. -!- Several distinct enzymes may be present in a single eukaryotic cell. -!- Many of them transport glutathione conjugates with drugs. -!- Some also show some 'flippase' (EC 3.6.3.1) activity. -!- Formerly EC 3.6.3.45., positive regulation of lamellipodium assembly, positive regulation of pseudopodium assembly, ATP-dependent RNA helicase DOB1, nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription, ATP + shikimate = ADP + shikimate 3-phosphate., anatomical structure morphogenesis, inflammatory response, movement of cell or subcellular component, negative regulation of interleukin-23 production, negative regulation of receptor-mediated endocytosis, regulation of hydrogen peroxide metabolic process, actin filament organization, signal transduction, NAD metabolic process, Nicotinate riboside kinase., Arabidopsis thaliana, Ras-related protein RABF2b, Ureaplasma parvum serovar 3 str. ATCC 700970, Metalloendopeptidases., Ras-related protein SEC4, ascospore-type prospore assembly, exocytosis, DNA helicase activity, Nostoc sp. PCC 7120, Anaplasma phagocytophilum str. HZ, establishment of epithelial cell polarity, hepatocyte apoptotic process, liver development, regulation of membrane potential, syntaxin-1 binding, response to cholesterol, Peptidase S16, Moorea producens 3L, phagocytosis, pinocytosis, protein processing in phagocytic vesicle, Methanosarcina acetivorans C2A, Replication factor C subunit 5, Eukaryotic translation initiation factor 2 subunit gamma, formation of translation preinitiation complex, -!- The enzyme also catalyzes the sulfation of chondroitin 4-sulfate and dermatan sulfate, but to a much more limited extent. -!- Formerly EC 2.8.2.12., 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine., 3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase. 3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase. 3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase. Desulfoheparin sulfotransferase. Glucosaminyl N-deacetylase/N-sulfotransferase. Heparan sulfate 2-N-sulfotransferase. Heparan sulfate N-deacetylase/N-sulfotransferase. Heparan sulfate N-sulfotransferase. Heparan sulfate sulfotransferase. Heparin N-sulfotransferase. Heparitin sulfotransferase. N-desulfoheparin sulfotransferase. N-heparan sulfate sulfotransferase. N-HSST. PAPS:DSH sulfotransferase. PAPS:N-desulfoheparin sulfotransferase., Guanylate kinase, putative, Gluconokinase, Ras-related protein Rab-2B, DNA double-strand break repair helicase HerA, DNA secondary structure binding, mitotic sister chromatid segregation, Caulobacter crescentus CB15, negative regulation of keratinocyte proliferation, negative regulation of wound healing, neurotransmitter secretion, SLIK (SAGA-like) complex, negative regulation of histone H3-K9 acetylation, nucleosome organization, regulation of nucleosome density, Golgi apparatus, positive regulation of DNA replication, mitochondrial translational elongation, Nucleotidyltransferases., ATP-dependent RNA helicase DDX18, cellular response to glucagon stimulus, developmental growth, Magnesium-chelatase 38 kDa subunit, phosphoprotein binding, late endosomal microautophagy, [Eubacterium] rectale, Disks large 1 tumor suppressor protein, apical cortex, asymmetric protein localization involved in cell fate determination, gravitaxis, RNA polymerase II regulatory region sequence-specific DNA binding, ribosome biogenesis, Cell division control protein 11, cytoplasmic microtubule, signal recognition particle, endoplasmic reticulum targeting, Ras-related protein Rab-22A, brassinosteroid metabolic process, response to salicylic acid, Rho GTPase binding, negative regulation of hydrogen peroxide-induced cell death, positive regulation of dopamine receptor signaling pathway, cytokine-mediated signaling pathway, ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing, Gallus gallus, regulation of actin polymerization or depolymerization, stress-activated protein kinase signaling cascade, structural molecule activity, T-tubule, GTPase ObgE/CgtA, Clostridium pasteurianum, GDP biosynthetic process, Equine herpesvirus type 4 (strain 1942), Mitochondrial Rho GTPase, mitochondrion localization, Protein tyrosine kinase, Caulobacter crescentus NA1000, phospholipase activator activity, D-fructokinase., Adenylate kinase isoenzyme 6 homolog, negative regulation of neuron death, JC polyomavirus, response to oxidative stress, transcription initiation from RNA polymerase I promoter, cell plate, root hair initiation, basal plasma membrane, MoxR-like ATPase, abscisic acid-activated signaling pathway, cellular response to abscisic acid stimulus, ATP-dependent DNA helicase Saci_0192, Elongation factor G (EF-G-2), Putative signal recognition particle protein, Thermoplasma acidophilum DSM 1728, Plasmid partitioning protein ParF, Synechocystis sp. PCC 6803 substr. Kazusa, MipZ, transmission of nerve impulse, negative regulation of viral genome replication, regulation of cell wall (1->3)-beta-D-glucan biosynthetic process, ATP-dependent RNA helicase dbp5, Paenarthrobacter aurescens TC1, DNA replication checkpoint, GTP-binding protein YqeH required for biosis of 30S ribosome subunit, multicellular organism development, piecemeal microautophagy of nucleus, vacuole-mitochondrion membrane contact site, RNA processing, spliceosomal snRNP assembly, Murray valley encephalitis virus (strain MVE-1-51), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, ARF guanyl-nucleotide exchange factor activity, Probable ATP-dependent RNA helicase DDX53, cellular response to starvation, regulation of dendrite morphogenesis, cellular bud neck septin ring organization, Burkholderia cenocepacia J2315, Photobacterium angustum S14, Putative repressor protein luxO, endoplasmic reticulum tubular network organization, establishment of protein localization to endoplasmic reticulum membrane, Paraburkholderia phymatum STM815, CTP synthase activity, Staphylococcus xylosus, Chloramphenicol 3-O phosphotransferase, cellular response to amino acid starvation, Agrobacterium fabrum str. C58, Elongation factor 4., ribosomal large subunit binding, Kokobera virus, -!- Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome., microtubule-severing ATPase activity, intrinsic component of plasma membrane, Aryl sulfotransferase., Regulatory protein SIR3, Elongation factor Tu 2, positive regulation of TOR signaling, Probable adenylyl-sulfate kinase, SPBc2 prophage-derived uncharacterized protein YorR, ATP-dependent RNA helicase A, UPF0200 protein SSO1041, peptide binding, GTP-binding protein GTR1, GTP + adenosylcobinamide phosphate = diphosphate + adenosylcobinamide- GDP., Probable translation initiation factor IF-2, -!- Also hydrolyzes nucleoside 2'-, 3'- and 5'-monophosphates, but only 2'- and 3'-phosphopolynucleotides., Hepatitis C virus (isolate Taiwan), endosome to plasma membrane transport vesicle, minus-end-directed organelle transport along microtubule, Guanine nucleotide-binding protein G(o) subunit alpha, alpha-beta T cell lineage commitment, cell-matrix adhesion, odontogenesis, trabecula morphogenesis, Energy-dependent translational throttle protein EttA, Sulfolobus acidocaldarius DSM 639, Iron-sulfur clusters transporter ATM1, mitochondrial, antigen processing and presentation, cytoplasmic translational termination, -!- The corrinoid adenosylation pathway comprises three steps: (1) Reduction of Co(III) to Co(II) by a one-electron transfer; this can be carried out by EC 1.16.1.3, or non-enzymically in the presence of dihydroflavin nucleotides. (2) Co(II) is reduced to Co(I) in a second single-electron transfer by EC 1.16.1.4. (3) The Co(I) conducts a nucleophilic attack on the adenosyl moiety of ATP to leave the cobalt atom in a Co(III) state (EC 2.5.1.17). -!- The enzyme responsible for the adenosylation reaction is the product of the gene cobO in the aerobic bacterium Pseudomonas denitrificans and of the gene cobA in the anaerobic bacterium Salmonella typhimurium. -!- In P.denitrificans, the enzyme shows specificity for cobyrinic acid a,c-diamide and the corrinoids that occur later in the biosynthetic pathway whereas CobA seems to have broader specificity. -!- While CobA has a preference for ATP and Mn(2+), it is able to transfer a variety of nucleosides to the cobalt, including CTP, UTP and GTP, in decreasing order of preference and to use Mg(2+) instead of Mn(2+)., Predicted protein, Methylobacterium extorquens, amine biosynthetic process, Sulfotransferase 4A1, Mycobacterium tuberculosis CDC1551, Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs)., Sporosarcina globispora, Bacillus sp. PS3, Caldanaerobacter subterraneus subsp. tengcongensis MB4, postsynaptic membrane, cyclic-di-GMP binding, negative regulation of extracellular matrix assembly, ATP-dependent 5'-3' RNA helicase activity, DNA-binding protein SMUBP-2, Trypanosoma brucei gambiense DAL972, global genome nucleotide-excision repair, negative regulation of SMAD protein complex assembly, positive regulation of viral life cycle, positive regulation of viral release from host cell, U5 small nuclear ribonucleoprotein 200 kDa helicase, Fidgetin-like protein 1, mRNA cleavage factor complex, Oryctolagus cuniculus, cardiac conduction system development, filopodium assembly, positive regulation of phosphatidylinositol 3-kinase activity, single organismal cell-cell adhesion, cell surface, small ribosomal subunit rRNA binding, Eukaryotic initiation factor 4A-III, exon-exon junction complex, female gamete generation, meiotic cell cycle, R-SMAD binding, androgen receptor signaling pathway, primary miRNA binding, protein urmylation, Gtr1-Gtr2 GTPase complex, Sliding-clamp-loader gp44 subunit, positive regulation of ER to Golgi vesicle-mediated transport, positive regulation of calcium ion-dependent exocytosis, Phosphotransferases with a phosphate group as acceptor., DNA translocase FtsK, double-stranded DNA-dependent ATPase activity, Adenylate kinase isoenzyme 5, Replication factor C small subunit, positive regulation of late endosome to lysosome transport, regulation of phospholipid metabolic process, translation release factor activity, codon nonspecific, Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, Ras-related protein Rab-6B, cellular response to hydrogen peroxide, phagosome-lysosome fusion, L-type voltage-gated calcium channel complex, voltage-gated calcium channel complex, Spodoptera frugiperda, DNA polymerase III subunit delta, type IV pilus, Tyrosylprotein sulfotransferase., protection from natural killer cell mediated cytotoxicity, regulation of protein localization, cellular homeostasis, mitochondrial outer membrane permeabilization, sulfur amino acid metabolic process, Antiviral helicase SKI2, Transcription termination factor Rho, Thermoresistant gluconokinase, V-type sodium ATPase catalytic subunit A, 26S protease regulatory subunit 6A, cellular response to organic cyclic compound, Moorella thermoacetica, DNA mismatch repair protein Msh2, positive regulation of axonogenesis, positive regulation of lipase activity, ubiquitin ligase complex, regulation of cell junction assembly, circadian rhythm, Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein, ATP-dependent RecD-like DNA helicase, response to ionizing radiation, viral terminase, large subunit, dTTP biosynthetic process, apical junction assembly, cellular response to chemokine, endothelial tube lumen extension, response to light stimulus, rhodopsin mediated signaling pathway, Replication protein E1, Channel-conductance-controlling ATPase., chloride transmembrane transporter activity, sperm capacitation, Sulfotransferase family cytosolic 1B member 1, cellular biogenic amine metabolic process, phenol-containing compound metabolic process, thyroid hormone metabolic process, calcium-dependent protein binding, filamentous actin, positive regulation of cell adhesion mediated by integrin, mRNA cleavage and polyadenylation factor CLP1, intraciliary transport, lipopolysaccharide transport, RNA stem-loop binding, Wnt signaling pathway, chromosome segregation, negative regulation of cell growth, negative regulation of intrinsic apoptotic signaling pathway, Hepatitis C virus (isolate H), STAT family protein binding, host intracellular organelle, negative regulation of cell death, negative regulation of endoribonuclease activity, negative regulation of protein autophosphorylation, negative regulation of tumor necrosis factor-mediated signaling pathway, peptidase activity, positive regulation of viral process, suppression by virus of host NF-kappaB transcription factor activity, Saccharomyces cerevisiae YJM789, Probable thymidylate kinase, 'de novo' pyrimidine nucleobase biosynthetic process, Uridylate kinase, Sulfotransferases., mitotic cleavage furrow formation, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of cell size, positive regulation of T cell migration, annealing helicase activity, cellular response to ionizing radiation, four-way junction DNA binding, single-stranded DNA binding, cobalamin transport, cobalamin-transporting ATPase activity, dethiobiotin synthase activity, Golgi vesicle fusion to target membrane, Cysteine endopeptidases., actin-dependent intracellular transport of virus, positive regulation of glycoprotein metabolic process, ATP-dependent helicase/deoxyribonuclease subunit B, RNA catabolic process, mitochondrial degradosome, mitochondrial mRNA surveillance, mitochondrion morphogenesis, protease binding, antigen processing and presentation of exogenous peptide antigen via MHC class II, viral DNA genome replication, RNA-dependent ATPase activity, mRNA 3'-end processing, positive regulation of DNA-templated transcription, elongation, transcription export complex, acyl binding, ATP-dependent RNA helicase MSS116, mitochondrial, Group I intron splicing, CMP kinase. Cytidine monophosphate kinase. Cytidylate kinase. dCMP kinase. Deoxycytidine kinase. Deoxycytidylate kinase. UMP-CMP kinase. Uridine monophosphate-cytidine monophosphate phosphotransferase., Dictyostelium discoideum, UMP/CMP kinase., nucleotide salvage, viral envelope, Schistosoma mansoni, Estrone sulfotransferase., GTPase (Rab6), ATP-dependent peptidase activity, disordered domain specific binding, caspase complex, positive regulation of cysteine-type endopeptidase activity, Novosphingobium aromaticivorans DSM 12444, ruffle membrane, endoplasmic reticulum unfolded protein response, positive regulation of Lys63-specific deubiquitinase activity, positive regulation of oxidative phosphorylation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, proteasome complex, proteasome-mediated ubiquitin-dependent protein catabolic process, protein phosphatase binding, Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate., Elongation factor 3A, Adenosinetriphosphatase., Adenylpyrophosphatase. ATP monophosphatase. ATPase. Triphosphatase., Nucleoside-triphosphate--adenylate kinase., positive regulation of actin filament polymerization, -!- Comprises bacterial enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine, octopine and nopaline., Polar-amino-acid-transporting ATPase., cellular response to acidic pH, chloroplast, negative regulation of transcription elongation from RNA polymerase II promoter, bone resorption, Methanococcus voltae, Dephosphocoenzyme A kinase., Thermus thermophilus HB8, -!- A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. -!- They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. -!- They include peroxin, which apparently is involved in Zellweger's syndrome., Derlin-1 retrotranslocation complex, Mus musculus, Transitional endoplasmic reticulum ATPase, VCP-NSFL1C complex, myelin sheath, ubiquitin-dependent protein catabolic process, DNA polymerase III subunit tau, DNA polymerase processivity factor activity, -!- The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases (EC 2.7.1.76 and EC 2.7.1.113) in its broad specificity for all four common 2'-deoxyribonucleosides., actin filament polymerization, ficolin-1-rich granule membrane, lamellipodium, positive regulation of Rho protein signal transduction, regulation of cell migration, regulation of defense response to virus by virus, Ras-related C3 botulinum toxin substrate 2, regulation of cell-substrate adhesion, posttranslational protein targeting to endoplasmic reticulum membrane, retrograde vesicle-mediated transport, Golgi to ER, unfolded protein binding, transport vesicle, DNA duplex unwinding, ribosome binding, Shikimate kinase 2, Azotobacter vinelandii, nitrogenase activity, serine-type peptidase activity, ATP-binding cassette (ABC) transporter complex, Type I restriction enzyme., GTP + H(2)O = GDP + phosphate., membrane fusion, microtubule, mitochondrion organization, Translocase of chloroplast 34, melanocyte differentiation, natural killer cell degranulation, secretory granule, purine ribonucleotide interconversion, IPP transferase. tRNA prenyltransferase., tRNA binding, transfer RNA gene-mediated silencing, tRNA modification GTPase MnmE, CTP synthetase. UTP--ammonia ligase., proton-transporting ATPase activity, rotational mechanism, Non-specific protein-tyrosine kinase., early endosome to late endosome transport, positive regulation of exocytosis, regulation of autophagosome assembly, synaptic vesicle recycling, nuclear-transcribed mRNA poly(A) tail shortening, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), nuclear polyadenylation-dependent mRNA catabolic process, polyadenylation-dependent snoRNA 3'-end processing, Methyltransferases., G-protein coupled receptor internalization, positive regulation of synaptic vesicle recycling, response to virus, ATP-dependent DNA helicase activity, endosome to melanosome transport, Yersinia pseudotuberculosis YPIII, Golgi transport complex, actin cytoskeleton organization, blood coagulation, focal adhesion, identical protein binding, neuronal cell body, regulation of attachment of spindle microtubules to kinetochore, regulation of lamellipodium assembly, thioesterase binding, Rho GTPase-activating protein 35, preribosome binding, Fc-epsilon receptor signaling pathway, GTPase HRas, cell cycle arrest, epidermal growth factor receptor signaling pathway, mitotic cell cycle checkpoint, positive regulation of cell migration, -!- A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. -!- Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (F(o), V(o), A(o)) and a cytoplasmic-compartment sector (F(1), V(1), A(1)). -!- The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. -!- All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 alpha- and 3 beta-subunits) is connected via the delta-subunit to the membrane sector by several smaller subunits. -!- Within this complex, the gamma- and epsilon-subunits, as well as the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. -!- This movement is driven by the H(+) electrochemical potential gradient. -!- The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archaeal) enzymes have a similar structure but, under physiological conditions, they pump H(+) rather than synthesize ATP. -!- Formerly EC 3.6.1.34., ATP synthase subunit beta, mitochondrial, H(+)-transporting two-sector ATPase., mitochondrial matrix, translation elongation factor activity, translational elongation, establishment of protein localization to Golgi, anterior/posterior axis specification, follicular epithelium, male courtship behavior, morphogenesis of a polarized epithelium, morphogenesis of larval imaginal disc epithelium, type I terminal bouton, type Ib terminal bouton, Predicted ATPase involved in replication control, Cdc46/Mcm family, Heparan sulfate glucosamine 3-O-sulfotransferase 5, regulation of viral entry into host cell, nucleoside-triphosphatase activity, Thymidylate kinase, Pseudomonas phage phi12, establishment of vesicle localization, microtubule binding, multivesicular body, multivesicular body assembly, regulation of multivesicular body size, cellular protein complex localization, response to endoplasmic reticulum stress, maintenance of translational fidelity, ATP + GMP = ADP + GDP., -!- Inorganic triphosphate can also act as donor., -!- A bacterial enzyme that imports phosphate anions., intracellular protein transport, Dengue virus 2, Zea mays, RNA helicase., S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA., regulation of phosphorelay signal transduction system, Pantothenate kinase., Signal recognition particle protein, protein transport, DNA repair and recombination protein RadA, Pyrococcus furiosus DSM 3638, ADP-ribosylation factor-like protein 13B, GTPase RhebL1, TOR signaling, Thermotoga neapolitana DSM 4359, Shu complex, maintenance of rDNA, Fructokinase, [heparan sulfate]-glucosamine N-sulfotransferase activity, Streptococcus pneumoniae TIGR4, Plasmodium vivax Sal-1, intrinsic component of endoplasmic reticulum membrane, microtubule depolymerization, Janibacter sp. HTCC2649, enzyme regulator activity, Probable secretion system apparatus ATP synthase SsaN, cellular bud neck septin ring, meiotic spindle, phosphatidylinositol-4-phosphate binding, spindle microtubule, endoplasmic reticulum signal peptide binding, Branched chain amino acid ABC transporter, ATP-binding protein, brassinosteroid sulfotransferase activity, regulation of fungal-type cell wall organization, regulation of secondary cell septum biogenesis, Desulfovibrio gigas, cell pole, plasma membrane tubulation, GTPase IMAP family member 4, Ras-related protein Rab-3, cytoskeletal matrix organization at active zone, apicoplast, Nucleoside-triphosphatase THEP1, GTPase, Flagella-related protein H, Humulus lupulus, histone H2B conserved C-terminal lysine ubiquitination, regulation of transcriptional start site selection at RNA polymerase II promoter, transcription regulatory region DNA binding, Geobacillus kaustophilus GBlys, DNA polymerase III, gamma subunit-related protein, MAP kinase kinase activity, regulation of locomotion, regulation of lysosomal lumen pH, regulation of synaptic vesicle transport, tangential migration from the subventricular zone to the olfactory bulb, Phosphomevalonate kinase, Rho-related GTP-binding protein RhoQ, phospholipid binding, multivesicular body membrane, positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, Danio rerio, multi-eIF complex, positive regulation of translational fidelity, phosphatase binding, Urease accessory protein UreG, bone development, Magnesium-chelatase. Magnesium-protoporphyrin chelatase. Magnesium-protoporphyrin IX chelatase. Mg-chelatase. Mg-protoporphyrin IX chelatase. Mg-protoporphyrin IX magnesio-lyase. Protoporphyrin IX magnesium-chelatase. Protoporphyrin IX Mg-chelatase., insulin-responsive compartment, ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)., L-seryl-tRNA(Sec) kinase, GTP-binding protein Di-Ras2, ATP or GTP + adenosylcobinamide = adenosylcobinamide phosphate + ADP or GDP., nucleic acid binding, peptidyl-cysteine methylation, negative regulation of protein binding, T cell proliferation, R7 cell development, nucleoside diphosphate metabolic process, nuclear import, Binfunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein, Site-determining protein, Herbaspirillum seropedicae SmR1, Shikimate kinase 1, ADP-ribosylation factor-like protein 2, Francisella tularensis subsp. tularensis SCHU S4, regulation of type B pancreatic cell development, chloroplast thylakoid membrane, vacuole, xylem and phloem pattern formation, DNA mismatch repair protein Msh3, Disks large homolog 1, protein localization to cell surface, regulation of dendritic spine development, ATP-dependent DNA helicase uvsW, G-protein coupled receptor signaling pathway, coupled to S1P second messenger, response to low fluence blue light stimulus by blue low-fluence system, seed germination, Bacillus cereus, -!- dATP can substitute for ATP., ATP-dependent protease Lon, acetylcholine receptor binding, beta-1 adrenergic receptor binding, positive regulation of synaptic transmission, regulation of NMDA receptor activity, Transcriptional regulator FleQ, bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding, Endopeptidase La., eukaryotic 48S preinitiation complex, formation of cytoplasmic translation initiation complex, ADP-ribosylation factor, putative, DNA topological change, hair cell differentiation, regulation of mitotic cell cycle phase transition, termination of RNA polymerase I transcription, Probable ATP-dependent RNA helicase DDX52, ATP-dependent RNA helicase DbpA, dendritic spine development, regulation of reactive oxygen species metabolic process, positive regulation of microtubule depolymerization, regulation of synaptic plasticity, Structural maintenance of chromosomes protein 1, Clostridium acetobutylicum ATCC 824, 373aa long hypothetical sugar-binding transport ATP-binding protein, membrane raft localization, Metallosphaera sedula DSM 5348, GTP-binding protein TypA/BipA, negative regulation of innate immune response, Aeropyrum pernix K1, response to amino acid, Staphylococcus aureus subsp. aureus MRSA252, 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate., nucleosomal histone binding, Spastin, cytoskeleton-dependent cytokinesis, exit from mitosis, nuclear envelope organization, Sphingomonas sp., riboflavin transporter activity, Cell division protein CdvC, Vps4, viral release from host cell, regulation of membrane repolarization during action potential, Retinol dehydratase, MobB protein homolog, Golgi lumen, [Heparan sulfate]-glucosamine 3-sulfotransferase 1., ATP-dependent dethiobiotin synthetase BioD 1, phospholipase C-activating dopamine receptor signaling pathway, -!- The tyrosine residues of some specific proteins of rat pheochromocytoma cells act as acceptors. -!- Formerly EC 2.8.2.n1., DNA repair protein RAD51, heteroduplex formation, AAA family ATPase, p60 katanin, Vaccinia virus Ankara, Uridine-cytidine kinase 2, Ras-related protein Rab-9A, Methylmalonyl-CoA mutase accessory protein, phosphate ion transport, GTP-binding protein YPT32/YPT11, A 3'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate., DNA repair protein RecN, Elongation factor 4, GTPase ArgK, ATP-dependent DNA helicase Rep, bacterial-type DNA replication, Type IV secretory pathway VirB4 components-like protein, ATP + H(2)O + heme(In) = ADP + phosphate + heme(Out)., Intraflagellar transport protein 27, Ras-related protein Rab-23, negative regulation of proteolysis, bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding, positive regulation of cilium-dependent cell motility, protein-DNA complex, Staphylococcus aureus subsp. aureus NCTC 8325, signal recognition particle receptor complex, U4/U6 x U5 tri-snRNP complex, Interferon-inducible GTPase 1, cellular response to interferon-beta, maltose binding, negative regulation of I-kappaB kinase/NF-kappaB signaling, regulation of modification of synaptic structure, DNA replication protein DnaC, mitochondrial proton-transporting ATP synthase complex, catalytic core F(1), pre-mRNA cleavage required for polyadenylation, response to carbohydrate, kidney development, smoothened signaling pathway, Ras-related protein Rab-11B, regulation of protein localization to cell surface, retrograde transport, endosome to plasma membrane, Terminase, large subunit, Uridine kinase, canonical Wnt signaling pathway, dendritic spine morphogenesis, epidermis morphogenesis, hair follicle morphogenesis, hair follicle placode formation, keratinocyte development, positive regulation of epithelial cell proliferation involved in lung morphogenesis, positive regulation of hair follicle cell proliferation, modulation by virus of host protein transport, metaphase plate congression, response to osmotic stress, positive regulation of early endosome to late endosome transport, regulation of neuron death, Alpha-hemolysin translocation ATP-binding protein HlyB, flavonoid metabolic process, Putative ABC transporter ATP-binding protein, ATP-dependent RNA helicase DBP5, negative regulation of acute inflammatory response, protein localization to lipid particle, serine-type endopeptidase activity, suppression by virus of host IRF9 activity, suppression by virus of host MAVS activity by MAVS proteolysis, sterol metabolic process, telomeric DNA binding, Ras and EF-hand domain-containing protein, Multidrug resistance protein pgp-1, endodeoxyribonuclease activity, strand invasion, ATP-dependent DNA helicase RecG, Mitochondrial Rho GTPase 1, positive regulation of endothelial cell migration, potassium ion binding, response to pH, tRNA methylation, negative regulation of exosomal secretion, Rho-related GTP-binding protein Rho6, adherens junction, exodeoxyribonuclease V activity, PF-32 protein, ATP-dependent RNA helicase DDX19B, nuclear pore, GTPase Era, protein phosphorylation, reciprocal meiotic recombination, TAP complex, nucleotide binding, Probable ATP-dependent RNA helicase DDX5, SMAD binding, intrinsic apoptotic signaling pathway by p53 class mediator, EGO complex, tertiary granule membrane, Klebsiella pneumoniae 342, Rab GTPase binding, regulation of mitophagy, Coxiella burnetii RSA 493, 3'-5' RNA helicase activity, negative regulation of protein kinase activity, ribosome, chloroplast stroma, ATP-dependent DNA helicase Q5, DNA-directed RNA polymerase II, holoenzyme, -!- This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency. -!- dCMP can also act as acceptor. -!- Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase. -!- This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency. -!- dCMP can also act as acceptor. -!- Different from the monofunctional prokaryotic enzymes EC 2.7.4.25 and EC 2.7.4.22. -!- Formerly EC 2.7.4.5., CDP biosynthetic process, bacterial nucleoid, Acting on ATP; involved in cellular and subcellular movement., cell cycle, nucleobase-containing small molecule interconversion, Adenylyl-sulfate kinase., cis-Golgi network, regulation of endoplasmic reticulum unfolded protein response, Protein RecA, RNA strand annealing activity, Hepatitis C virus, RIG-I signaling pathway, actin cytoskeleton, protein heterooligomerization, adenylate cyclase-activating G-protein coupled receptor signaling pathway, dUDP biosynthetic process, myosin binding, regulation of cell motility, F-box only protein 4, proton-transporting ATP synthase complex, catalytic core F(1), -!- Occurs in photosynthetic bacteria, cyanobacteria, green algae and gymnosperms. -!- The enzyme catalyzes trans-reduction of the D-ring of protochlorophyllide; the product has the (7S,8S)-configuration. -!- Unlike EC 1.3.1.33 light is not required. -!- The enzyme contains a [4Fe-4S] cluster, and structurally resembles the Fe protein/MoFe protein complex of EC 1.18.6.1, which catalyzes an ATP-driven reduction., [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity, photoreceptor disc membrane, Chromosomal replication initiator protein DnaA, CTPase activity, cell wall, evasion or tolerance by symbiont of host-produced reactive oxygen species, Bovine papillomavirus type 1, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, Fructose-2,6-bisphosphate 2-phosphatase., Psp operon transcriptional activator, -!- Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39. -!- The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA. -!- Formerly EC 3.6.1.4., ATP + H(2)O + polar amino acid(Out) = ADP + phosphate + polar amino acid(In)., regulation of macroautophagy, tRNA dimethylallyltransferase, suppression by virus of host STAT1 activity by positive regulation of STAT1 catabolic process, suppression by virus of host translation initiation factor activity by induction of host protein dephosphorylation, DNA replication initiation, Sulfolobus tokodaii str. 7, adenine/cytosine mispair binding, mismatch repair complex, (1) 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate. (2) 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate., regulation of cytoplasmic mRNA processing body assembly, Chaetomium thermophilum, SOS response, Retinoic acid inducible protein I, guanine/thymine mispair binding, Nitrogenase., GTP-dependent protein binding, RNA cap binding, translational initiation, Acting on acid anhydrides., protein insertion into ER membrane, U4 snRNA 3'-end processing, poly(A) binding, rRNA catabolic process, Ras-related protein Rab-5A, regulation of synaptic vesicle exocytosis, Ras-related protein M-Ras, incipient cellular bud site, lymphocyte aggregation, positive regulation of protein targeting to mitochondrion, Deoxynucleoside kinase, Drosophila melanogaster, deoxynucleoside kinase activity, p4, 8-hydroxy-2'-deoxyguanosine DNA binding, cellular response to camptothecin, cellular response to hydroxyurea, forked DNA-dependent helicase activity, nuclear matrix, regulation of signal transduction by p53 class mediator, Tobacco mosaic virus strain tomato/L, D2 dopamine receptor binding, nitric-oxide synthase binding, regulation of autophagy, Moorella thermoacetica ATCC 39073, protein sumoylation, Hepacivirin., host cell perinuclear region of cytoplasm, chromatin maintenance, mitochondrial RNA 3'-end processing, mitochondrial mRNA catabolic process, Probable GTPase Rv1496, Corynebacterium diphtheriae NCTC 13129, maltose transport, heme transport, ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate., Hepatitis C virus subtype 1b, ER to Golgi vesicle-mediated transport, cell migration, Tyrosine-protein kinase wzc, Yellow fever virus 17D, regulation of type I interferon production, pre-autophagosomal structure membrane, cytoplasmic stress granule, protein domain specific binding, -!- A bacterial enzyme that imports cobalamin derivatives., GTPase KRas, caspase binding, Probable ATP-dependent RNA helicase DDX23, RNA splicing, mRNA splicing, via spliceosome, azurophil granule lumen, establishment of protein localization, extracellular region, lipid particle, apical plasma membrane, ceramide-translocating ATPase activity, phosphatidylcholine-translocating ATPase activity, embryonic digit morphogenesis, regulation of COPII vesicle coating, single-organism membrane organization, GBD domain binding, dendritic spine, macrophage differentiation, mitotic spindle, positive regulation of muscle cell differentiation, positive regulation of stress fiber assembly, ATP synthase subunit alpha, mitochondrial, GDP binding, animal organ morphogenesis, cellular senescence, plasma membrane, positive regulation of JNK cascade, positive regulation of MAP kinase activity, positive regulation of epithelial cell proliferation, positive regulation of wound healing, ATP + H(2)O = ADP + phosphate., ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out)., DNA replication, DNA polymerase III complex, Rac GTPase binding, vacuole organization, Staphylococcus aureus subsp. aureus MW2, cytokine binding, negative regulation of T cell receptor signaling pathway, negative regulation of interleukin-2 secretion, negative regulation of substrate adhesion-dependent cell spreading, cytokinesis, establishment of protein localization to membrane, exosomal secretion, Small COPII coat GTPase SAR1, dTMP kinase., NTPase P4, protein homotetramerization, protein hexamerization, retrograde protein transport, ER to cytosol, cell adhesion, neutrophil degranulation, positive regulation of apoptotic process, positive regulation of neutrophil chemotaxis, Ribosylnicotinic acid kinase., Cap1-MTase. mRNA (nucleoside-2'-O)-methyltransferase., Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)., ATP synthesis coupled proton transport, mitochondrial proton-transporting ATP synthase, catalytic core, replication fork processing, focal adhesion assembly, lamellipodium assembly, Elongation factor G, Thermus thermophilus, Deoxyguanosine kinase, ATP + a protein = ADP + a phosphoprotein., protein folding, intracellular signal transduction, regulation of proteasomal ubiquitin-dependent protein catabolic process, ADP-ribosylation factor-like protein 5A, potassium ion transport, asymmetric protein localization, basal protein localization, chemical synaptic transmission, establishment or maintenance of epithelial cell apical/basal polarity, establishment or maintenance of neuroblast polarity, ovarian follicle cell development, pole plasm protein localization, positive phototaxis, septate junction, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2, Adenosine triphosphate-nicotinamide mononucleotide transadenylase. Diphosphopyridine nucleotide pyrophosphorylase. NAD(+) diphosphorylase. NAD(+) pyrophosphorylase. Nicotinamide adenine dinucleotide pyrophosphorylase. Nicotinamide mononucleotide adenylyltransferase. NMN adenylyltransferase. NMNAT., Hydrolases., centrosome cycle, ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate., Phosphomevalonate kinase., phosphomevalonate kinase activity, Legionella pneumophila, All4481 protein, Ras-related protein Rab-32, melanosome assembly, pathogenesis, Putative sulfotransferase, cytoplasmic side of mitochondrial outer membrane, exploration behavior, ABC-type bacteriocin transporter, sorocarp morphogenesis, Neisseria gonorrhoeae FA 1090, Burkholderia pseudomallei 1710b, response to type I interferon, Superkiller protein 7, protein binding, bridging, RNA polymerase II complex import to nucleus, regulation of chromatin silencing at telomere, forebrain development, mitotic cell cycle, ribosomal large subunit export from nucleus, viral process, ATP-dependent RNA helicase SrmB, ribosomal large subunit assembly, transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding, stromule, thylakoid, negative regulation of coagulation, positive regulation of Ras protein signal transduction, nuclear lamina, nucleosome positioning, regulation of chromatin organization, AMP dimethylallyltransferase activity, Sus scrofa, morphogenesis of an epithelial sheet, Probable ATP-dependent kinase TDA10, Escherichia coli ETEC H10407, DNA repair protein RAD51 homolog 1, mitotic recombination, calcium channel regulator activity, Fe(3+) ions import ATP-binding protein FbpC, Saccharomyces cerevisiae AWRI796, food vacuole, endothelial cell proliferation, immunological synapse, ligand-gated ion channel activity, growth, positive regulation of cytosolic calcium ion concentration, Holliday junction ATP-dependent DNA helicase RuvB, 3'-5' DNA helicase activity, nucleotide-excision repair, DNA incision, 3'-to lesion, protein N-terminus binding, transcription elongation from RNA polymerase I promoter, transcription elongation from RNA polymerase II promoter, GTPase HflX, Dynamin-related protein 1A, clathrin-dependent endocytosis, protein histidine kinase binding, presynaptic membrane, Cytophaga hutchinsonii ATCC 33406, nucleus organization, regulation of centrosome duplication, response to lipid, AMP salvage, microtubule cytoskeleton organization, Chromosome segregation in meiosis protein 2, DNA recombinase assembly, fungal-type vacuole, positive regulation of NF-kappaB transcription factor activity, ATPase activator activity, anchored component of synaptic vesicle membrane, Chloroflexus aurantiacus J-10-fl, Tight junction protein ZO-3, hippo signaling, clathrin-coated endocytic vesicle, ciliary basal body, Sensor protein KdpD, Adenylate kinase 2, mitochondrial, RNA polymerase binding, regulation of stomatal movement, Sulfotransferase 1C2, platelet alpha granule lumen, (Deoxy)nucleoside-phosphate kinase., sulfate binding, Ras-related protein Ral-a, regulation of Notch signaling pathway, neuron apoptotic process, Chaperone protein ClpB1, positive regulation of neuromuscular synaptic transmission, regulation of terminal button organization, Cell division protein FtsY homolog, chloroplastic, Lactobacillus plantarum WCFS1, negative regulation of autophagosome assembly, olfactory bulb development, protein kinase A binding, protein kinase activity, protein localization to mitochondrion, regulation of canonical Wnt signaling pathway, regulation of dendritic spine morphogenesis, 55 kDa erythrocyte membrane protein, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex, Rho-related GTP-binding protein RhoU, Primosome component (Helicase loader), Pyrobaculum aerophilum str. IM2, establishment of mitochondrion localization, microtubule-mediated, potassium channel regulator activity, activation of adenylate cyclase activity, Twitching motility protein PilT, Bifunctional coenzyme A synthase, Pantetheine-phosphate adenylyltransferase., antigen processing and presentation of peptide antigen via MHC class I, intracellular transport of viral protein in host cell, cytoplasmic microtubule organization, early phagosome membrane, minus-end-directed vesicle transport along microtubule, 2'(3')-polynucleotidase., Methanosarcina mazei Go1, Thermoanaerobacter pseudethanolicus ATCC 33223, Translation initiation factor IF-2, Ras-like protein family member 12, Schizosaccharomyces pombe 972h-, Aquacob(I)alamin adenosyltransferase. Aquocob(I)alamin vitamin B12s adenosyltransferase. ATP:cob(I)alamin Co-beta-adenosyltransferase. ATP:corrinoid adenosyltransferase. Cob(I)alamin adenosyltransferase., developmental pigmentation, Maltose-binding periplasmic protein, periplasmic space, Hydrolysis of proteins in presence of ATP., Lon protease 1, RNA polymerase II transcription factor binding, ribosome disassembly, Adenosylcobinamide-phosphate guanylyltransferase., BmVLG protein, negative regulation of neuron differentiation, defense response to fungus, germarium-derived egg chamber formation, phototransduction, Streptococcus pneumoniae D39, angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure, regulation of microtubule cytoskeleton organization, regulation of neural precursor cell proliferation, Synechococcus sp. PCC 7002, -!- In archaea and eukarya selenocysteine formation is achieved by a two- step process: O-phosphoseryl-tRNA(Sec) kinase (PSTK) phosphorylates the endogenous L-seryl-tRNA(Sec) to O-phospho-L-seryl-tRNA(Sec), and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNA(Sec) by EC 2.9.1.2. -!- Formerly EC 2.7.1.n3., Ras-related protein Rab-12, cellular bud tip, Nicotiana tabacum, Ribulose bisphosphate carboxylase/oxygenase activase 1, chloroplastic, ATP-dependent helicase/nuclease subunit A, positive regulation of establishment of protein localization to plasma membrane, AAA ATPase, central domain protein, DNA replication factor C complex, Replication factor C subunit 1, Multidrug resistance-associated protein 1, basolateral plasma membrane, -!- Belongs to peptidase family S14., Endopeptidase Clp., Elg1 RFC-like complex, Rac-like GTP-binding protein 1, Mycobacterium smegmatis, immune response, ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + UDP-N-acetyl-alpha-D- glucosamine 3'-phosphate., UDP-N-acetylglucosamine kinase., E.coli exonuclease V. Exonuclease V., Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides., single-stranded DNA-dependent ATPase activity, CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC, Carboxydothermus hydrogenoformans Z-2901, Chlamydomonas reinhardtii, Probable DNA double-strand break repair Rad50 ATPase, photoreceptor cell development, Bile-salt sulfotransferase., ATP-dependent DNA helicase PcrA, lysosomal membrane organization, UvrABC system protein A, Estrogen sulfotransferase, sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin), tRNA threonylcarbamoyladenosine biosynthesis protein TsaE, mitochondrion transport along microtubule, nervous system development, Hydroxysteroid sulfotransferase., Signal recognition particle receptor FtsY, negative regulation of intralumenal vesicle formation, protein targeting to lysosome, retromer complex binding, Ras-related protein Rab-33B, 3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase. 3-OST-1. Glucosaminyl 3-O-sulfotransferase. Heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Heparin-glucosamine 3-O-sulfotransferase., Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, BMP signaling pathway, alternative mRNA splicing, via spliceosome, intracellular estrogen receptor signaling pathway, regulation of alternative mRNA splicing, via spliceosome, regulation of androgen receptor signaling pathway, dTDP biosynthetic process, Phosphoric monoester hydrolases., Phosphotransferases with an alcohol group as acceptor., cell projection, neuron fate determination, endosome organization, Flagellar regulatory protein C, glutamate receptor signaling pathway, Sulfotransferase 1A1, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, AlgS, calmodulin binding, GTP-binding protein SAR1b, retrograde transport, plasma membrane to Golgi, Vesicle-fusing ATPase, Probable gliding protein mglA, intralumenal vesicle formation, protein retention in Golgi apparatus, cell cycle phase transition, cellular response to lipopolysaccharide, chromatin, deoxyguanosine kinase activity, Lactobacillus casei, sulfate adenylyltransferase complex (ATP), sulfate assimilation via adenylyl sulfate reduction, spindle disassembly, 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process, Adenosine 5'-phosphosulfate kinase. Adenylylsulfate kinase. APS kinase., Golgi vesicle budding, SNARE complex disassembly, negative regulation of transcription, DNA-templated, MLL1 complex, NuA4 histone acetyltransferase complex, histone H2A acetylation, P granule, Amino acid ABC transporter, lysosome, Bacillus halodurans C-125, Guanine nucleotide-binding protein G(k) subunit alpha, polysomal ribosome, GTPase activating protein binding, ATP + H(2)O + arsenite(In) = ADP + phosphate + arsenite(Out)., 3'-deoxynucleotidase., cytoskeleton organization, negative regulation by symbiont of host defense-related protein level, negative regulation of endoplasmic reticulum unfolded protein response, negative regulation of kinase activity, negative regulation of transcription from RNA polymerase II promoter, response to salt stress, chorismate biosynthetic process, shikimate metabolic process, Golgi cisterna membrane, Adenylate kinase isoenzyme 1, ATP-binding cassette sub-family B member 10, mitochondrial, integral component of mitochondrial membrane, Membrane ATPase/protein kinase, Mycobacterium thermoresistibile ATCC 19527, Desulfovibrio vulgaris str. 'Miyazaki F', DNA helicase RecQ, -!- This enzyme comprises a family of proteins involved in prokaryotic as well as eukaryotic protein synthesis. -!- In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. -!- In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. -!- In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1-alpha (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). -!- EF-Tu and EF-1-alpha catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. -!- GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs. -!- Formerly EC 3.6.1.48., Elongation factor (EF). Initiation factor (IF). Peptide-release factor (RF). Peptide-release or termination factor., regulation of establishment of cell polarity, lipopolysaccharide-transporting ATPase activity, cellular response to arsenic-containing substance, eukaryotic initiation factor 4E binding, transcription factor binding, positive regulation of alkaline phosphatase activity, suppression by virus of host PKR activity, suppression by virus of host intracellular interferon activity, suppression by virus of host protein phosphorylation, Paracoccus denitrificans PD1222, Penicillium chrysogenum, branching involved in blood vessel morphogenesis, ATP-dependent dethiobiotin synthetase BioD, Transforming protein RhoA, apical junction complex, endothelial cell migration, SCF ubiquitin ligase complex, peptide transport, tapasin binding, Vibrio cholerae O1 biovar El Tor str. N16961, ATP + nucleoside diphosphate = ADP + nucleoside triphosphate., -!- A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of EC 3.6.1.46. -!- Involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies). -!- Formerly EC 3.6.1.47., epithelial cell differentiation, transcriptional activation by promoter-enhancer looping, ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin., Ferrous iron transport protein B, ATP-independent chaperone mediated protein folding, pigment granule localization, DNA mismatch repair protein MutS, cellular copper ion homeostasis, Metallophosphoesterase, Ras-related protein Rab-1B, endoplasmic reticulum-Golgi intermediate compartment membrane, multi-organism process, Cobyrinic Acid a,c-diamide synthase, ATM1-type heavy metal exporter, ER-associated misfolded protein catabolic process, regulation of apoptotic process, ubiquitin-like protein ligase binding, drug transmembrane transport, drug transport, NLR family CARD domain-containing protein 4, regulation of cysteine-type endopeptidase activity involved in apoptotic process, azurophil granule membrane, plasma membrane to endosome transport, Caldalkalibacillus thermarum TA2.A1, positive regulation of non-motile cilium assembly, Dynamin GTPase., intracellular distribution of mitochondria, positive regulation of intrinsic apoptotic signaling pathway, protein oligomerization, regulation of peroxisome organization, Large T antigen, RNA secondary structure unwinding, DNA-dependent ATPase activity, DNA-templated transcription, termination, Alicyclobacillus acidocaldarius subsp. acidocaldarius, GTP metabolic process, ITP metabolic process, cortical actin cytoskeleton organization, endocytic vesicle, filopodium membrane, protein localization to endosome, ruffle, bicellular tight junction, positive regulation of transcription factor import into nucleus, chromosome separation, UMP kinase activity, cytidylate kinase activity, Thymidine kinase, putative, cell proliferation, Uncharacterized ABC transporter ATP-binding protein MJ0796, positive regulation of telomere maintenance via telomerase, Reverse gyrase, gene looping, Elongation factor 1-alpha 2, Heparan sulfate glucosamine 3-O-sulfotransferase 3A1, photoreceptor outer segment membrane, -!- An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. -!- It is also involved in the functioning of other transmembrane channels., Cystic-fibrosis membrane-conductance-regulating protein., -!- The enzyme copurifies with EC 2.7.1.105 (cf. EC 3.1.3.54)., Fructose-2,6-bisphosphatase., -!- The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate and the second step is catalyzed by the APS kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme bound APS and ATP. -!- This is in contrast to what is found in bacteria, yeasts, fungi and plants, where the formation of PAPS is carried out by two individual polypeptides, EC 2.7.7.4 and EC 2.7.1.25., ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide., Nicotinamide riboside kinase 1, DNA helicase II, single-stranded DNA-dependent ATP-dependent DNA helicase activity, -!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6., Flavivirin., S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)- (purine-ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)- methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)- [mRNA]., regulation of mitotic spindle organization, (d)CMP kinase., Cytidylate kinase, platelet activation, secretory granule membrane, substrate adhesion-dependent cell spreading, Sulfolobus solfataricus P2, Guanine nucleotide-binding protein subunit alpha-12, regulation of cell shape, regulation of fibroblast migration, Nitrogenase iron protein 1, DNA polymerase III, clamp loader complex, alveolar lamellar body, thymidylate kinase activity, pyrimidine nucleoside salvage, ADP biosynthetic process, AMP binding, tRNA modification, Entamoeba histolytica, ATP-binding cassette sub-family B member 6, mitochondrial, efflux transmembrane transporter activity, -!- The enzyme contains three functionally distinct sites: an allosteric GTP-binding site, a glutaminase site where glutamine hydrolysis occurs (cf. EC 3.5.1.2), and the active site where CTP synthesis takes place. -!- The reaction proceeds via phosphorylation of UTP by ATP to give an activated intermediate 4-phosphoryl UTP and ADP. -!- Ammonia then reacts with this intermediate generating CTP and a phosphate. -!- The enzyme can also use ammonia from the surrounding solution., mitochondrial inner membrane, somatodendritic compartment, mRNA binding, phagocytic vesicle membrane, regulation of neutrophil migration, ATP-dependent 3'-5' RNA helicase activity, ncRNA polyadenylation, Dengue virus 4, intracellular protein transmembrane transport, Guanylate-binding protein 1, negative regulation of DNA recombination, t-circle formation, cilium, non-motile cilium, peptidase activator activity involved in apoptotic process, positive regulation of protein processing, positive regulation of synapse disassembly, microtubule-dependent intracellular transport of viral material, growth hormone secretion, vesicle transport along microtubule, Protein-tyrosine kinases., protein tyrosine kinase activity, Peptide chain release factor 3, ATP-dependent DNA helicase dda, ATP + H(2)O + maltose(Out) = ADP + phosphate + maltose(In)., Maltose/maltodextrin import ATP-binding protein MalK, synapse, -!- CTP has half the activity of ATP., -!- S-adenosylhomocysteine can also act as donor., Elongation factor G 1, Vibrio vulnificus CMCP6, Ras-related protein Rab-30, Adenylate dimethylallyltransferase (ADP/ATP-dependent)., DNA replication and repair protein RecF, Sulfotransferase, GTP binding, negative regulation of gene expression, positive regulation of cell proliferation, protein binding, Walker-Type ATPase, eukaryotic 43S preinitiation complex, cytoskeletal protein binding, mitogen-activated protein kinase kinase binding, intrinsic component of membrane, sensory perception of smell, DNA polymerase binding, RAD54-like (S. cerevisiae), Vacuolar protein sorting-associated protein 21, ATP-dependent RNA helicase DDX25, cell fate specification, establishment or maintenance of polarity of follicular epithelium, establishment or maintenance of polarity of larval imaginal disc epithelium, ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out)., ATP phosphohydrolase (steroid-exporting). MDR protein. Multidrug-resistance protein. P-glycoprotein. PDR protein. Pleiotropic-drug-resistance protein. Steroid-transporting ATPase., Multidrug resistance ABC transporter ATP-binding and permease protein, centriole, nucleolus, positive regulation of protein binding, ribosomal small subunit export from nucleus, tRNA export from nucleus, ATP + thymidine = ADP + thymidine 5'-phosphate., Cell division control protein 42 homolog, establishment or maintenance of cell polarity, regulation of stress fiber assembly, Peripheral plasma membrane protein CASK, basement membrane, negative regulation of cell-matrix adhesion, Haemophilus influenzae Rd KW20, -!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase)., DNA primase/helicase, ATP synthase. Chloroplast ATPase. F(0)F(1)-ATPase. F(1)-ATPase. F(o)F(1)-ATPase. H(+)-transporting ATP synthase. H(+)-transporting ATPase. Mitochondrial ATPase., ATPase activity, ABC phosphate transporter., Deoxycytidine kinase, NTP + deoxycytidine = NDP + dCMP., deoxycytidine kinase activity, mitochondrial intermembrane space, Protein translocase subunit SecA, Transcriptional regulator (NtrC family), astral microtubule organization, neuron projection development, vesicle, ATPase complex, GMP binding, CVT pathway, Ras-related protein Rab-5B, Caseinolytic protease. Endopeptidase Ti. Protease Ti., Replication factor C subunit 3, cellular response to manganese ion, negative regulation of protein targeting to mitochondrion, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, regulation of neuroblast proliferation, Translocase of chloroplast 33, chloroplastic, positive regulation of dopamine uptake involved in synaptic transmission, Ras-related protein Rab-31, Shewanella amazonensis SB2B, type I interferon signaling pathway, GPN-loop GTPase 1, nucleocytoplasmic transport, positive regulation of protein autophosphorylation, regulation of JNK cascade, regulation of exocyst localization, Ras-related protein Rap-1A, EH domain-containing protein 2, caveola, presynaptic active zone, positive regulation of dendrite morphogenesis, Ras-related protein Rab-3A, intracellular organelle, Sulfotransferase 1 family member D1, Probable ATP-dependent RNA helicase DDX20, SMN complex, nuclear body, spliceosomal tri-snRNP complex assembly, fructose 2,6-bisphosphate metabolic process, Energy-coupling factor transporter ATP-binding protein EcfA3, regulation of neuron maturation, Recombination and repair protein, BLOC-2 complex binding, Helicase of the snf2/rad54 family (Amino end), hypothetical, neuromuscular junction development, Dynamin-A, ciliary membrane, protein polymerization, protein self-association, positive regulation of protein kinase activity, Golgi-associated vesicle, activation of MAPK activity, ParA protein, Type I site-specific restriction-modification system, R (Restriction) subunit, Dynamin-3, ADP-ribosylation factor-like protein 5B, N-acetylglucosamine deacetylase activity, -!- The sulfation of trehalose in the bacterium Mycobacterium tuberculosis is required for the biosynthesis of sulfolipid-1., SufC protein (ATP-binding protein), maintenance of protein location in nucleus, tubulin complex assembly, response to unfolded protein, amphisome, CapA, plastoglobule, response to jasmonic acid, Chromo domain-containing protein 1, nucleolar chromatin, nucleosome mobilization, cell chemotaxis, transporter activity, negative regulation of neuron projection development, neuron projection morphogenesis, response to mechanical stimulus, Transport activator, DNA repair helicase XPD, CTP synthase 1, Ras-related protein Rab6, Apoptotic protease-activating factor 1, activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, GTP-binding protein REM 1, Ras-related protein Rab-4A, -!- In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyze reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). -!- CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole. -!- The second branch of the nucleotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by CobU. -!- The final step in adenosylcobalamin biosynthesis is the condensation of AdoCbi-GDP with alpha-ribazole, which is catalyzed by CobS (EC 2.7.8.26), to yield adenosylcobalamin. -!- CobU is a bifunctional enzyme that has both kinase (EC 2.7.1.156) and guanylyltransferase (EC 2.7.7.62) activities. -!- However, both activities are not required at all times. -!- The kinase activity has been proposed to function only when S.typhimurium is assimilating cobinamide whereas the guanylyltransferase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin., Adenosylcobinamide kinase., response to exogenous dsRNA, ATP-dependent microtubule motor activity, minus-end-directed, cytoplasmic dynein complex, Putative arsenical pump-driving ATPase, Bifunctional polynucleotide phosphatase/kinase, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, photoreceptor cell maintenance, Hepatitis C virus isolate HC-J4, photoreceptor connecting cilium, sperm annulus, Transcriptional regulatory protein ZraR, cotranslational protein targeting to membrane, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, clathrin binding, nuclear pore cytoplasmic filaments, DNA mismatch repair protein Msh6, Voltage-dependent L-type calcium channel subunit beta-1, dormancy process, hydrolase activity, defense response to protozoan, Tepidanaerobacter acetatoxydans Re1, Disks large homolog 4, excitatory synapse, juxtaparanode region of axon, negative regulation of receptor internalization, positive regulation of excitatory postsynaptic potential, postsynaptic density, nucleotide-excision repair, DNA incision, transcription from RNA polymerase II promoter, mitotic cleavage furrow ingression, sarcomere, Rac-like GTP-binding protein ARAC2, Saguinus oedipus, cell-cell junction assembly, intercellular bridge, GTPase inhibitor activity, cell death, Eukaryotic initiation factor 4A-II, Sulfate adenylyltransferase subunit 1, Uridine-cytidine kinase 1, ADP-ribosylation factor 1, putative, regulation of cell morphogenesis, ABC transporter related, positive regulation of production of miRNAs involved in gene silencing by miRNA, pre-mRNA binding, transcription coactivator activity, Putative multidrug export ATP-binding/permease protein SAV1866, Vibrio cholerae O395, -!- This enzyme differs from EC 2.8.2.29 and EC 2.8.2.30 by being the most selective for a precursor of the antithrombin-binding site. -!- It has a minimal acceptor sequence of: -> GlcNAc6S->GlcA-> GlcN2S*+-6S->IdoA2S->GlcN2S->. -!- It can also modify other precursor sequences within heparan sulfate but this action does not create functional antithrombin-binding sites. -!- These precursors are variants of the consensus sequence: -> Glc(N2S>NAc)+-6S->GlcA->GlcN2S*+-6S->GlcA>IdoA+-2S-> Glc(N2S/NAc)+-6S->. -!- If the heparan sulfate substrate lacks 2-O-sulfation of GlcA residues, then enzyme specificity is expanded to modify selected glucosamine residues preceded by IdoA as well as GlcA., Heparan sulfate glucosamine 3-O-sulfotransferase 1, phospholipase D activator activity, regulation of receptor internalization, translation regulator activity, nucleic acid binding, RNA polymerase core enzyme binding, Transcription-repair-coupling factor, regulation of transcription, DNA-templated, transcription-coupled nucleotide-excision repair, DNA damage recognition, Sulfolobus turreted icosahedral virus 2, -!- A number of aromatic compounds can act as acceptors. -!- Organic hydroxylamines are not substrates (cf. EC 2.8.2.9)., Phenol sulfotransferase. Sulfokinase., amine metabolic process, Protein-tyrosine sulfotransferase 2, peptidyl-tyrosine sulfation, Sulfotransferase 1C3, Bacillus subtilis subsp. spizizenii str. W23, Molybdopterin-guanine dinucleotide biosynthesis protein B, positive regulation of oligodendrocyte differentiation, cellular response to oxidative stress, Energy-coupling factor transporter ATP-binding protein EcfA1, alpha-tubulin binding, cytokinetic process, membrane fission, epithelial cell-cell adhesion, multicellular organism growth, nuclear migration, nucleus localization, regulation of protein catabolic process, regulation of protein kinase activity, endosome to lysosome transport via multivesicular body sorting pathway, positive regulation of centriole elongation, -!- Involved in the biosynthesis of cytokinins in plants. -!- Some isoforms from the plant Arabidopsis thaliana are specific for AMP while others also have the activity of EC 2.5.1.112., Adenylate isopentenyltransferase. Cytokinin synthase. Isopentenyltransferase., ATP-dependent RNA helicase, putative, Cob(I)yrinic acid a,c-diamide adenosyltransferase., peptide transporter activity, vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane, cell morphogenesis, negative regulation of intracellular steroid hormone receptor signaling pathway, negative regulation of oxidative phosphorylation, negative regulation of reactive oxygen species biosynthetic process, positive regulation of alpha-beta T cell differentiation, coenzyme binding, Type II secretion system protein E, nucleoside triphosphate metabolic process, 375aa long hypothetical multiple sugar-binding transport ATP-binding protein, Ras-related protein Rap-1b, extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, ribosomal small subunit binding, suppression by virus of host apoptotic process, suppression by virus of host transcription, translocation of peptides or proteins into host cell cytoplasm, viral protein processing, Chaetomium thermophilum var. thermophilum DSM 1495, DNA strand renaturation, -!- Many nucleoside diphosphates can act as acceptors. -!- Many ribo- and deoxyribonucleoside triphosphates can act as donors., nucleoside diphosphate kinase activity, pyrimidine ribonucleotide biosynthetic process, small GTPase mediated signal transduction, intracellular ATPase-gated chloride channel activity, rRNA processing, spliceosomal complex disassembly, Aspergillus fumigatus Af293, Exodeoxyribonuclease V., exodeoxyribonuclease V complex, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, A deoxyribonucleoside 3'-phosphate + H(2)O = a deoxyribonucleoside + phosphate., Deoxynucleotide 3'-phosphatase., 3'-phosphoadenosine 5'-phosphosulfate metabolic process, aryl sulfotransferase activity, steroid metabolic process, sulfation, nucleoside phosphate kinase activity, nucleotide metabolic process, Regulatory protein RepA, Arsenical pump-driving ATPase, Arsenite-transporting ATPase., Mycoplasma pneumoniae M129, Protein-serine/threonine kinases., Toll-like receptor 2 binding, host cell lipid particle, negative regulation of ATPase activity, negative regulation of defense response to virus by host, regulation of translational termination, negative regulation of protein catabolic process, endosome to lysosome transport, epidermal growth factor catabolic process, retrograde transport, endosome to Golgi, enzyme activator activity, protein localization to Golgi apparatus, toxin metabolic process, calcium ion transmembrane transport, RecBCD enzyme subunit RecB, DNA helicase, Guanine nucleotide-binding protein G(q) subunit alpha, cell body, heart development, RNA polymerase II distal enhancer sequence-specific DNA binding, nuclear euchromatin, Pseudomonas putida KT2440, peptide antigen-transporting ATPase activity, MH2 domain binding, epithelial to mesenchymal transition, estrogen receptor binding, nuclear-transcribed mRNA catabolic process, negative regulation of protein phosphorylation, Canis lupus familiaris, Probable ATP-dependent RNA helicase DDX41, axoneme, stress fiber, post-Golgi vesicle-mediated transport, signal transducer activity, downstream of receptor, cellular response to forskolin, Plasmodium falciparum, -!- Can introduce negative superhelical turns into double-stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.99.1.2)., regulation of anion transport, -!- Not identical with EC 2.7.1.11. -!- The enzyme copurifies with EC 3.1.3.46., ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate., ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate., ATP-sulfurylase. Sulfate adenylate transferase. Sulfurylase., Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2, adenylylsulfate kinase activity, skeletal system development, Golgi stack, pre-mRNA catabolic process, beta-catenin-TCF complex assembly, GTPase binding, cellular response to leucine, Uncharacterized ABC transporter ATP-binding protein HI_1470, actin cytoskeleton reorganization, cell junction, negative regulation of axonogenesis, phosphatidylinositol-mediated signaling, stress fiber assembly, Protochlorophyllide a + reduced ferredoxin + 2 ATP + 2 H(2)O = chlorophyllide a + oxidized ferredoxin + 2 ADP + 2 phosphate., double-stranded DNA binding, negative regulation of DNA damage checkpoint, spliceosomal complex, spliceosomal complex assembly, viral mRNA export from host cell nucleus, sulfotransferase activity, Guanine nucleotide-binding protein G(t) subunit alpha-1, transition metal ion binding, transcription, DNA-templated, negative regulation of interleukin-6 production, negative regulation of toll-like receptor 4 signaling pathway, negative regulation of toll-like receptor 9 signaling pathway, negative regulation of tyrosine phosphorylation of STAT protein, positive regulation by symbiont of host transcription, positive regulation of proteolysis, vesicle membrane, long term synaptic depression, -!- A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. -!- An enzyme found in alkaliphilic bacteria that is similar to EC 3.6.3.14., Sodium-transporting two-sector ATPase., positive regulation of mitochondrial RNA catabolic process, TRAMP complex, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, Deoxynucleoside kinase., Escherichia coli O157:H7, melanosome localization, Iron-sulfur cluster carrier protein, embryonic morphogenesis, single-stranded RNA binding, ADP-ribosylation factor 1, positive regulation of apoptotic process involved in development, regulation of cell adhesion, RNA splicing, via transesterification reactions, U5 snRNP, -!- Comprises bacterial enzymes that import maltose and maltose oligosaccharides., Negative regulator of genetic competence ClpC/MecB, mitochondrial fragmentation involved in apoptotic process, release of cytochrome c from mitochondria, Elongation factor 1-alpha, Staphylococcus aureus, Adenosylmethionine--8-amino-7-oxononanoate transaminase., positive regulation by symbiont of host protein levels, cholesterol transport, intracellular pH elevation, membrane hyperpolarization, positive regulation of protein K63-linked deubiquitination, proteasomal protein catabolic process, site of double-strand break, translesion synthesis, viral genome replication, interleukin-1 beta secretion, Neuronal-specific septin-3, Amino acid ABC transporter, ATP-binding protein, CENP-A containing nucleosome assembly, Centromere protein M, sister chromatid cohesion, Mycobacterium smegmatis str. MC2 155, ATP-dependent helicase activity, DNA synthesis involved in DNA repair, G-quadruplex DNA unwinding, PML body, Y-form DNA binding, bubble DNA binding, negative regulation of cell division, nuclear chromosome, p53 binding, Mycobacterium abscessus ATCC 19977, actin filament depolymerization, cysteine-type endopeptidase activator activity involved in apoptotic process, embryo development ending in birth or egg hatching, Gluconokinase., gluconokinase activity, histone H4 acetylation, ATP-dependent RNA helicase vasa, isoform A, Putative ABC-transporter ATP-binding protein, Cystic fibrosis transmembrane conductance regulator, cellular response to cAMP, chloride channel activity, Escherichia coli O127:H6 str. E2348/69, pseudopodium organization, ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate., chromatin binding, miRNA metabolic process, protein export from nucleus, protein import into nucleus, translocation, regulation of cholesterol biosynthetic process, filopodium, negative regulation of protein complex assembly, Aquifex aeolicus VF5, positive regulation of epithelial cell migration, post-translational protein modification, renal water homeostasis, ADP-ribosylation factor-like protein 1, protein localization to pre-autophagosomal structure, protein targeting to Golgi, peptidyl-diphthamide biosynthetic process from peptidyl-histidine, ADP-ribosylation factor-like protein 8A, protein targeting, Non-specific serine/threonine protein kinase., Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, endosome, Kunjin virus (STRAIN MRM61C), ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide., guanylate kinase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, aggresome assembly, polyubiquitin binding, -!- Composed of two proteins that can be separated but are both required for nitrogenase activity. -!- Dinitrogen reductase is a [4Fe-4S] protein, which, with two molecules of ATP and ferredoxin, generates an electron. -!- The electron is transferred to the other protein, dinitrogenase (molybdoferredoxin). -!- Dinitrogenase is a molybdenum-iron protein that reduces dinitrogen in three succesive two-electron reductions from nitrogen to diimine to hydrazine to two molecules of ammonia; the molybdenum may be replaced by vanadium or iron. -!- The reduction is initiated by formation of hydrogen in stoichiometric amounts. -!- Acetylene is reduced to ethylene (but only very slowly to ethane), azide to nitrogen and ammonia, and cyanide to methane and ammonia. -!- In the absence of a suitable substrate, hydrogen is slowly formed. -!- Ferredoxin may be replaced by flavodoxin (see EC 1.19.6.1). -!- Formerly EC 1.18.2.1., -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49., DNA polymerase III subunit delta', Thymidine kinase, cytosolic, thymidine kinase activity, Pyrococcus horikoshii OT3, ATP + H(2)O + phosphate(Out) = ADP + phosphate + phosphate(In)., Phosphate-transporting ATPase., cadherin binding, endosome membrane, ATP + deoxyguanosine = ADP + dGMP., Dengue virus 4 Thailand/0348/1991, NS2B-3 proteinase. Yellow fever virus protease., RNA nucleotidyltransferase (RNA-directed)., Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala., Ms-dNK. Multifunctional deoxynucleoside kinase. Multispecific deoxynucleoside kinase. Multisubstrate deoxyribonucleoside kinase., nucleotide phosphorylation, Ras-related C3 botulinum toxin substrate 1, Wnt signaling pathway, planar cell polarity pathway, cell motility, ruffle organization, Flagellar biosynthesis protein FlhF, iron-sulfur cluster assembly, regulation of calcium-mediated signaling, regulation of TOR signaling, pyrimidine nucleotide metabolic process, dCMP kinase. Deoxycytidine monophosphokinase. Deoxycytidylate kinase., protein targeting to mitochondrion, clathrin-coated vesicle membrane, mitochondrial outer membrane, skin development, transport, mitochondrial RNA surveillance, regulation of vesicle size, nuclear mitotic cohesin complex, microtubule cytoskeleton, Geobacillus stearothermophilus 10, cellular response to exogenous dsRNA, budding cell bud growth, Replication factor C subunit 2, positive regulation of lipid metabolic process, Protein CbbX, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component, lysosome localization, Rac-like GTP-binding protein ARAC7, Phosphoribulokinase., fructose metabolic process, DnaA-related protein, leaf senescence, ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity, lipid particle organization, flavonoid sulfotransferase activity, Prochlorococcus marinus subsp. marinus str. CCMP1375, GTP-dependent protein kinase activity, inclusion body, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of macroautophagy, protein serine/threonine kinase activity, regulation of CAMKK-AMPK signaling cascade, regulation of mitochondrial depolarization, regulation of retrograde transport, endosome to Golgi, ATP-binding cassette, sub-family B, member 1, Cyanidioschyzon merolae strain 10D, multivesicular body sorting pathway, Small GTP binding protein rab1a, probable, eukaryotic translation initiation factor 2 complex, ATP synthase subunit beta 1, Histidine transport ATP-binding protein HisP, -!- This is the first committed step of chlorophyll biosynthesis and is a branchpoint of two major routes in the tetrapyrrole pathway., Rhodobacter capsulatus SB 1003, CTP synthase 2, Putative polyphosphate kinase 2 family protein, -!- Nicotinate nucleotide can also act as acceptor. -!- See also EC 2.7.7.18., [Heparan sulfate]-glucosamine N-sulfotransferase., Nuclear valosin-containing protein-like, heparan sulfate proteoglycan biosynthetic process, enzymatic modification, ATP-dependent chromatin remodeling, negative regulation of DNA-dependent DNA replication, ERBB2 signaling pathway, GTPase activity, cellular response to gamma radiation, leukocyte migration, negative regulation of GTPase activity, protein C-terminus binding, -!- Involved in the biosynthesis of cytokinins in plants. -!- The IPT4 isoform from the plant Arabidopsis thaliana is specific for ADP and ATP. -!- Other isoforms, such as IPT1 from Arabidopsis thaliana and the enzyme from the common hop, Humulus lupulus, also have a lower activity with AMP (cf. EC 2.5.1.27). -!- Formerly EC 2.5.1.n4., TrwB, interstrand cross-link repair, actin filament binding, insulin receptor signaling pathway, positive regulation of glucose import, protein sulfation, Francisella tularensis subsp. tularensis FSC198, behavioral response to ethanol, dorsal closure, morphogenesis of an epithelium, subsynaptic reticulum, cellular iron ion homeostasis, ABC-type polar amino acid transport system, ATPase component, Thermococcus onnurineus NA1, Bacteroides thetaiotaomicron VPI-5482, trichome branching, Lipoprotein-releasing system ATP-binding protein LolD, Probable ATP-dependent RNA helicase DDX10, motile cilium, Ctf18 RFC-like complex, Rad17 RFC-like complex, spinal cord dorsal/ventral patterning, Transport protein, Sulfotransferase 1C4, Signal recognition particle receptor subunit alpha, signal recognition particle binding, fructose-2,6-bisphosphate 2-phosphatase activity, paranode region of axon, Burkholderia thailandensis E264, Heparan sulfate 2-O-sulfotransferase 1, regulation of calcium ion transport, response to ethanol, TFIIH basal transcription factor complex helicase XPB subunit, nucleotide-excision repair, preincision complex stabilization, Rab5a, GTPase, regulation of vacuole fusion, non-autophagic, GTPase/ATPase, Sulfotransferase 1A2, D1 dopamine receptor binding, protein localization to synapse, transcription factor TFIID complex, Adenylyl-sulfate kinase 1, chloroplastic, protein localization to vacuole, Escherichia coli str. K-12 substr. MDS42, gluconeogenesis, ADP-ribosylation factor 4, Molybdate/tungstate import ATP-binding protein WtpC, protein transporter activity, ADP-ribosylation factor 5, ABC transporter ATP-binding protein, myeloid cell apoptotic process, Bacillus anthracis, methylated histone binding, platelet degranulation, Guanine nucleotide-binding protein alpha-1 subunit, L-phenylalanine biosynthetic process, tyrosine biosynthetic process, Capsular polysaccharide synthesis enzyme Cap5A truncated, ATP + a 2'-deoxyribonucleoside phosphate = ADP + a 2'-deoxyribonucleoside diphosphate., Signal recognition particle receptor subunit beta, amine sulfotransferase activity, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b, regulation of double-strand break repair via homologous recombination, establishment of endothelial intestinal barrier, Trehalose 2-sulfotransferase., phragmoplast, synaptic growth at neuromuscular junction, melanosome membrane, protein localization to membrane, chaperone binding, septin filament array, Paraplegin, mitochondrial calcium ion transport, -!- Primary and secondary alcohols, including aliphatic alcohols, ascorbate, chloramphenicol, ephedrine and hydroxysteroids, but not phenolic steroids, can act as acceptors (cf. EC 2.8.2.15)., alcohol sulfotransferase activity, Bifunctional enzyme CysN/CysC, cellular response to sulfur starvation, defense response to Gram-negative bacterium, chromatin silencing at telomere, chromosome, telomeric region, nuclear heterochromatin, nucleosome binding, microtubule bundle formation, microtubule severing, nuclear envelope reassembly, nuclear membrane, recombinational repair, response to antibiotic, Sulfate adenylyltransferase, Protein translation elongation factor 1A, beta selection, integrin-mediated signaling pathway, ossification involved in bone maturation, skeletal muscle tissue development, regulation of TORC1 signaling, Adenylate dimethylallyltransferase, negative regulation by host of symbiont molecular function, Cob(I)yrinic acid a,c-diamide adenosyltransferase, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, integral component of endoplasmic reticulum membrane, ATP synthase subunit beta, chloroplastic, Sulfolobus turreted icosahedral virus 1, GH01619p, Staphylococcus aureus subsp. aureus N315, pilus retraction, IRE1-mediated unfolded protein response, ATP synthase subunit alpha, chloroplastic, GTP-binding protein Rit1, viral life cycle, regulation of endocytosis, -!- In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyze reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). -!- CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole. -!- The second branch of the nuclotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme CobU. -!- The final step in adenosylcobalamin biosynthesis is the condensation of AdoCbi-GDP with alpha-ribazole, which is catalyzed by CobS (EC 2.7.8.26), to yield adenosylcobalamin. -!- CobU is a bifunctional enzyme that has both kinase (EC 2.7.1.156) and guanylyltransferase (EC 2.7.7.62) activities. -!- However, both activities are not required at all times. -!- The kinase activity has been proposed to function only when S.typhimurium is assimilating cobinamide whereas the guanylyltransferase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin. -!- The guanylyltransferase reaction is a two-stage reaction with formation of a CobU-GMP intermediate., cellular process, pole plasm oskar mRNA localization, negative regulation of sequence-specific DNA binding transcription factor activity, negative regulation of transforming growth factor beta receptor signaling pathway, protein kinase C binding, leukotriene metabolic process, Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002, guanyl ribonucleotide binding, Conserved Archaeal protein, Rho-related GTP-binding protein RhoE, ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA., cell growth, translation release factor complex, double-strand break repair via homologous recombination, Methylobacterium extorquens AM1, dynein intermediate chain binding, polysome, CRD-mediated mRNA stability complex, nuclear stress granule, Rab family protein, ORC1-type DNA replication protein 2, Vacuolar protein sorting-associated protein 4B, regulation of mitotic spindle assembly, GTP-binding protein Rheb, Chromosome-partitioning ATPase Soj, toxin transport, ribosomal small subunit biogenesis, Meiotic recombination protein DMC1/LIM15 homolog, condensed nuclear chromosome, Small monomeric GTPase., xenobiotic metabolic process, NPH1-1, ADP-ribosylation factor-like protein 3, Haemophilus influenzae PittII, cellular response to osmotic stress, intrinsic apoptotic signaling pathway, mRNA 5'-UTR binding, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, Protein-synthesizing GTPase., -!- A bacterial multisubunit non-phosphorylated ATPase that is involved in the export of arsenite and antimonite anions., -!- Also catalyzes the selective removal of 3'-phosphate groups from DNA and oligodeoxyribonucleotides. -!- Induced in Escherichia coli by T-even phages., Polynucleotide kinase, host cell membrane, negative regulation of RNA interference, negative regulation of execution phase of apoptosis, negative regulation of release of cytochrome c from mitochondria, apical part of cell, cellular protein localization, epithelial-mesenchymal cell signaling, regulation of mitotic nuclear division, calcium ion transmembrane transport via high voltage-gated calcium channel, negative regulation of neuron apoptotic process, RNA polymerase II core promoter sequence-specific DNA binding, RuvB-like 2, cellular response to UV, chromatin remodeling, establishment of protein localization to chromatin, negative regulation of estrogen receptor binding, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1, sulfate assimilation, GTP-binding protein GTR2, lysosomal microautophagy, negative regulation of autophagy, nuclear chromatin, maturation of SSU-rRNA, post-mRNA release spliceosomal complex, nuclear envelope, Rho-related protein racC, Putative adenylate kinase, Ras-related protein Rab-14, Listeria monocytogenes EGD-e, Hpr(Ser) kinase, Cag alpha, -!- The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species. -!- This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. -!- In addition to the 5-beta-bile acid glycolithocholate, deoxycholate, 3-beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3-beta- hydroxyandrost-5-en-17-one) also act as substrates (see also EC 2.8.2.2 and EC 2.8.2.34). -!- May be identical to EC 2.8.2.2., -!- The enzyme is required for accurate and efficient protein synthesis under certain stress conditions. -!- May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. -!- Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. -!- Binds to ribosomes in a GTP-dependent manner., CTP biosynthetic process, Peptide chain release factor RF3, phagosome maturation, Jeotgalibacillus marinus, 3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate., ATP-dependent protein binding, Spliceosome RNA helicase DDX39B, Caenorhabditis elegans, Cell death protein 4, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Adenylyl-sulfate kinase, GTP-binding protein REM 2, cell periphery, Heat resistant RNA dependent ATPase, U4 snRNA binding, mRNA export from nucleus, nuclear speck, 3-OST-3. Glucosaminyl 3-O-sulfotransferase 3. Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3., glycosaminoglycan biosynthetic process, positive regulation of telomerase RNA localization to Cajal body, regulation of ERK1 and ERK2 cascade, ADP-ribosylation factor 6, regulation of Rac protein signal transduction, reticulophagy, dopamine receptor signaling pathway, Plasmodium falciparum 3D7, Ras-related protein Rab-25, Trypanosoma brucei brucei TREU927, negative regulation of toll-like receptor 2 signaling pathway, positive regulation of I-kappaB phosphorylation, scavenger receptor binding, suppression by virus of host type I interferon-mediated signaling pathway, mismatched DNA binding, cellular response to gonadotropin-releasing hormone, Anas platyrhynchos, Elongator complex protein 4, MutSalpha complex, positive regulation of helicase activity, Gallionella capsiferriformans ES-2, ATP-dependent breakage, passage and rejoining of double-stranded DNA., intracellular, protein autophosphorylation, Lipopolysaccharide export system ATP-binding protein LptB, Staphylococcus aureus subsp. aureus Mu50, phosphatidylinositol-3,4,5-trisphosphate binding, host cell Golgi apparatus, positive regulation of TORC1 signaling, Ferredoxin:protochlorophyllide reductase (ATP-dependent)., Adenylate kinase isoenzyme 6, deadenylation-dependent decapping of nuclear-transcribed mRNA, cell projection assembly, Golgi-associated vesicle membrane, chloride channel inhibitor activity, multicellular organismal water homeostasis, transepithelial water transport, neuron remodeling, receptor binding, Hepatitis C virus (isolate Con1), positive stranded viral RNA replication, translation, tRNA dimethylallyltransferase activity, Chlorobium tepidum TLS, Hepatitis C virus (isolate BK), host cell cytosol, regulation of endosome size, brain development, integral component of mitochondrial outer membrane, transmembrane transport, COPII vesicle coating, interleukin-8 secretion, positive regulation of ubiquitin protein ligase activity, -!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112., ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., Replicase large subunit, (1) ATP + (d)CMP = ADP + (d)CDP. (2) ATP + UMP = ADP + UDP., phosphotransferase activity, phosphate group as acceptor, Pseudomonas phage phi6, virion, Pseudomonas phage phi8, flavin adenine dinucleotide catabolic process, positive regulation of protein complex assembly, regulation of aerobic respiration, ceramide translocation, IPAF inflammasome complex, positive regulation of gene expression, regulation of protein stability, ATP-dependent Clp protease ATP-binding subunit ClpX, protein unfolding, -!- In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity., Formate--tetrahydrofolate ligase, transcription elongation from mitochondrial promoter, Leishmania major, positive regulation of defense response to virus by host, positive regulation of granulocyte macrophage colony-stimulating factor production, activating transcription factor binding, maltose transport complex, mitochondrial ncRNA surveillance, four-way junction helicase activity, mitotic G2 DNA damage checkpoint, cytoplasmic mRNA processing body assembly, viral RNA genome packaging, varicosity, Dethiobiotin synthase., S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4- methylthio-2-oxobutanoate + 7,8-diaminononanoate., biotin biosynthetic process, MJ0495-like protein, ATP-dependent DNA helicase RecQ, In phosphorus-containing anhydrides., ATP + D-gluconate = ADP + 6-phospho-D-gluconate., cellular response to virus, steroid sulfotransferase activity, membrane raft, negative regulation of synaptic transmission, Dugesia japonica, chloride transmembrane transport, chloride transport, positive regulation of cyclic nucleotide-gated ion channel activity, DNA unwinding involved in DNA replication, [Bacillus] caldotenax, myosin V binding, positive regulation of G2/M transition of mitotic cell cycle, ABC transporter, ATP binding protein (Glucose), Pseudomonas aeruginosa PAO1, Enterobacteria phage T7, mitochondrion, endoplasmic reticulum membrane, positive regulation of cytokinesis, protein kinase binding, ubiquitin protein ligase activity, Acidianus ambivalens, Signal recognition particle 54 kDa protein, purine-containing compound salvage, integral component of plasma membrane, protein transport by the Sec complex, Synechococcus elongatus PCC 7942, entrainment of circadian clock, endoplasmic reticulum, Golgi to plasma membrane transport, mating projection tip, vesicle fusion, rolling circle DNA replication, Thermotoga maritima MSB8, Golgi to plasma membrane protein transport, vesicle-mediated transport, Lactococcus lactis subsp. lactis Il1403, Deoxyguanylate kinase. GMP kinase. Guanosine monophosphate kinase., Mycobacterium tuberculosis H37Rv, ATP binding, Adenylate kinase, chloroplastic, cell differentiation, poly(A)+ mRNA export from nucleus, Shikimate kinase., melanosome, Elongation factor Ts, actin filament bundle assembly, positive regulation of cell adhesion, NTP + H(2)O = NDP + phosphate., Nucleoside-triphosphate phosphatase., ATP:pantothenate 4'-phosphotransferase. D-pantothenate kinase. Pantothenate kinase (phosphorylating). Pantothenic acid kinase., -!- The prokaryotic cytidine monophosphate kinase specifically phosphorylates CMP (or dCMP), using ATP as the preferred phosphoryl donor. -!- Unlike EC 2.7.4.14, a eukaryotic enzyme that phosphorylates UMP and CMP with similar efficiency, the prokaryotic enzyme phosphorylates UMP with very low rates, and this function is catalyzed in prokaryotes by EC 2.7.4.22. -!- The enzyme phosphorylates dCMP nearly as well as it does CMP., ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate., nucleoside diphosphate phosphorylation, phosphorylation, localization within membrane, response to wounding, Ribosylnicotinamide kinase., ATP-dependent zinc metalloprotease FtsH, -!- An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles. -!- Formerly EC 3.6.1.50., regulation of protein oligomerization, Interferon-induced helicase C domain-containing protein 1, MDA-5 signaling pathway, negative regulation of type I interferon production, positive regulation of interferon-alpha production, protein deubiquitination, Vitamin B12-transporting ATPase., -!- Encoded by the genome of the viruses of the hepatitis C group, and contributes to the maturation of the precursor polyproteins. -!- The enzyme is greatly activated by binding of the 54-residue NS4A 'cofactor' protein also derived from the viral polyprotein. -!- Belongs to peptidase family S29., cytoplasm, negative regulation of cell proliferation, positive regulation of transcription from RNA polymerase II promoter, lysosome organization, negative regulation of late endosome to lysosome transport, negative regulation of protein processing, positive regulation of autophagy, positive regulation of canonical Wnt signaling pathway, positive regulation of protein autoubiquitination, actin filament, Photobacterium profundum SS9, BH3686 protein, platelet dense granule membrane, Virulence associated protein, Ras-related protein Rab-9B, ATP + H(2)O + Fe(3+)(Out) = ADP + phosphate + Fe(3+)(In)., Fe(3+)-transporting ATPase., LAO/AO transport system ATPase, L27 domain binding, MPP7-DLG1-LIN7 complex, establishment of centrosome localization, intercalated disc, negative regulation of mitotic cell cycle, phosphoprotein phosphatase activity, regulation of sodium ion transmembrane transport, adenylate cyclase-activating adrenergic receptor signaling pathway, positive regulation of cAMP biosynthetic process, positive regulation of cAMP-mediated signaling, ATP + protoporphyrin IX + Mg(2+) + H(2)O = ADP + phosphate + Mg-protoporphyrin IX + 2 H(+)., establishment of protein localization to plasma membrane, positive regulation of high voltage-gated calcium channel activity, Xenobiotic-transporting ATPase., Adenylate isopentenyltransferase, Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446, mitochondrial proton-transporting ATP synthase complex, SAGA complex, negative regulation of histone exchange, Elongation factor Tu, apicolateral plasma membrane, cell fate commitment involved in pattern specification, establishment of mitotic spindle orientation, establishment of spindle orientation, establishment or maintenance of polarity of embryonic epithelium, regulation of glucose metabolic process, septate junction assembly, Phosphopentokinase., Phosphoribulokinase 1, Acting on GTP; involved in cellular and subcellular movement., Saccharomyces cerevisiae S288C, mitochondrial fission, vesicle organization, DNA metabolic process, nucleoplasm, nucleus, protein complex, protein localization to nucleolus, ATP + AMP = 2 ADP., Methanothermococcus thermolithotrophicus, T cell costimulation, apolipoprotein A-I receptor binding, establishment of protein localization to organelle, mitotic spindle assembly, SMN-Sm protein complex, cytoskeleton, repressing transcription factor binding, chloroplast outer membrane, Putative ABC transporter (ATP-binding protein), Tight junction protein ZO-1, Regulatory inactivation of DnaA Hda protein, Putative septin, Ras-related protein Rap-2a, Hydrogenase expression/formation protein (HypB), GTP-binding protein RHO1, positive regulation of protein kinase C signaling, Hemin import ATP-binding protein HmuV, Ras-related protein Rab-10, cadherin binding involved in cell-cell adhesion, specific granule membrane, Elongator complex protein 5, Putative primosome component, Streptococcus pyogenes MGAS315, protein catabolic process, [Pseudomonas syringae] pv. tomato str. DC3000, Small GTP-binding protein, ATP + D-fructose = ADP + D-fructose 6-phosphate., Ruegeria sp. TM1040, protein targeting to ER, sterol biosynthetic process, Insertion sequence IS5376 putative ATP-binding protein, Bifunctional NAD biosynthesis protein NadR, Ras-related protein Rab-18, Nitrogen assimilation regulatory protein NtrX, ciliary transition zone, protein complex scaffold, regulation of L-glutamate transport, positive regulation of growth of symbiont in host, ascospore wall, phosphatidylinositol-5-phosphate binding, protein localization to bud neck, 7S RNA binding, lipoprotein particle receptor activity, Mycobacterium avium 104, caveola neck, purine nucleotide metabolic process, AT DNA binding, positive regulation of endocytic recycling, positive regulation of myoblast fusion, Vibrio vulnificus YJ016, GTP-binding nuclear protein GSP1/CNR1, positive regulation of apoptotic signaling pathway, regulation of apoptotic DNA fragmentation, Hydrogenase/urease nickel incorporation protein HypB, GTPase NRas, Sulfate/molybdate ABC transporter, ATP-binding protein, Ras-related protein Rab-3D, MAGUK p55 subfamily member 5, Clostridium perfringens ATCC 13124, telomerase holoenzyme complex, apoplast, ATP-dependent helicase NAM7, NtrC-like two-domain protein, Ras protein signal transduction, Adenylate kinase 4, mitochondrial, Eukaryotic peptide chain release factor GTP-binding subunit, meiotic joint molecule formation, cytosol to ER transport, Methanothermobacter thermautotrophicus str. Delta H, positive regulation of cellular response to amino acid starvation, Bombyx mori, regulation of smoothened signaling pathway, ionotropic glutamate receptor binding, bacterial-type RNA polymerase core promoter sequence-specific DNA binding, regulation of bacterial-type flagellum-dependent cell motility, transcription regulatory region sequence-specific DNA binding, holo TFIIH complex, nucleotide-excision repair, DNA incision, 5'-to lesion, cell plate formation involved in plant-type cell wall biogenesis, cytokinesis by cell plate formation, microvillus, positive regulation of potassium ion transport, intraciliary transport particle B, 14-3-3 protein binding, Molybdopterin-guanine dinucleotide biosynthesis adapter protein, Human herpesvirus 3 strain Oka vaccine, positive regulation of neuron apoptotic process, positive regulation of vasoconstriction, Septin-7, Thiobacillus denitrificans ATCC 25259, glucose import, Elongation factor 1 alpha-like protein, nuclear-transcribed mRNA catabolic process, no-go decay, transcription from RNA polymerase I promoter, O-phosphoseryl-tRNA(Sec) kinase., ORC1-type DNA replication protein 3, protein depolymerization, ATPase binding, ERK1 and ERK2 cascade, calcineurin-mediated signaling, cellular response to dopamine, ADP-ribosylation factor-like protein 8B, ciliary base, GTP-binding protein YPT7, ATP-dependent Clp protease ATP-binding subunit ClpA, Pili retraction protein PilT, ATP-dependent DNA helicase Ta0057, RecBCD enzyme subunit RecC, 6-phosphofructo-2-kinase activity, border follicle cell migration, Pre-mRNA-splicing helicase BRR2, spliceosome conformational change to release U4 (or U4atac) and U1 (or U11), negative regulation of abscisic acid-activated signaling pathway, positive regulation of abscisic acid-activated signaling pathway, regulation of cell proliferation, thylakoid membrane organization, cellular response to heat, negative regulation of RNA-directed 5'-3' RNA polymerase activity, Probable branched-chain amino acid transport ATP-binding protein LivG, Ribosome-binding ATPase YchF, Replication factor C subunit 4, positive regulation of filopodium assembly, positive regulation of peptidyl-serine phosphorylation, regulation of protein heterodimerization activity, Bile salt sulfotransferase, ethanol catabolic process, regulation of lipid metabolic process, ABC transporter, ATP-binding protein, shikimate kinase activity, dADP biosynthetic process, Energy-coupling factor transporter ATP-binding protein EcfA2, Lactobacillus brevis ATCC 367, Ras-related protein Rab-43, ATP-dependent DNA helicase Hel308, ESCRT IV complex, late endosome to vacuole transport via multivesicular body sorting pathway, cellular response to interleukin-1, nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay, Protein clpf-1, phagosome acidification, calcium ion transport into cytosol, voltage-gated calcium channel activity, clearance of foreign intracellular DNA, Chromosome partition protein Smc, UV protection, flavonol 3-sulfotransferase activity, GPN-loop GTPase PAB0955, Streptomyces venezuelae ATCC 10712, response to cold, double-strand break repair via nonhomologous end joining, establishment of macromolecular complex localization to telomere, negative regulation of chromatin silencing involved in replicative cell aging, nuclear telomeric heterochromatin, telomere tethering at nuclear periphery, Adenylate kinase 2, beta-tubulin binding, mitotic cytokinesis, maternal behavior, regulation of viral process, Adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase. AdoCbi kinase/AdoCbi-phosphate guanylyltransferase., Adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase. AdoCbi kinase/AdoCbi-phosphate guanylyltransferase. GTP:adenosylcobinamide-phosphate guanylyltransferase., Shigella flexneri, Escherichia coli CFT073, Antibiotic resistance protein, B cell proliferation, response to drug, compound eye morphogenesis, oocyte microtubule cytoskeleton polarization, locomotory behavior, Polyketide synthase, protein targeting to membrane, signal recognition particle, single-stranded DNA-dependent ATP-dependent DNA helicase complex, deoxynucleotide 3'-phosphatase activity, Thermus thermophilus HB27, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of translational initiation, protein localization to cytoplasmic stress granule, stress granule assembly, Eukaryotic translation initiation factor 5B, ARF-like small GTPase, Pre-mRNA-splicing ATP-dependent RNA helicase PRP28, GTPase IMAP family member 2, DNA gyrase. DNA topoisomerase II. Type II DNA topoisomerase., apolipoprotein A-I-mediated signaling pathway, negative chemotaxis, positive regulation of neuron differentiation, regulation of actin cytoskeleton organization, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, ATP + H(2)O + Na(+)(In) = ADP + phosphate + Na(+)(Out)., proteasome regulatory particle assembly, MutSbeta complex, nuclear chromosome, telomeric region, GTP-binding protein YPT1, early endosome to Golgi transport, endocytic recycling, secretion by cell, Avena sativa, chromatin DNA binding, Type II secretion system protein (GspE-2), Ras-related C3 botulinum toxin substrate 3, growth cone, Rap protein signal transduction, establishment of endothelial barrier, Thermomonospora curvata DSM 43183, Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3, ATPase regulator activity, suppression by virus of host TRAF activity, dendritic spine organization, positive regulation of dendritic spine development, positive regulation of endocytosis, regulation of Arp2/3 complex-mediated actin nucleation, ATP-dependent RNA helicase DHH1, negative regulation of translational elongation, nucleoside triphosphate biosynthetic process, uridylate kinase activity, Polynucleotide 5'-hydroxyl-kinase., negative regulation of response to salt stress, Alcohol sulfotransferase., Helicobacter pylori 26695, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), embryonic cranial skeleton morphogenesis, Antigen peptide transporter 1, -!- Cytidine can act as acceptor. -!- GTP and ITP can act as donors., Uridine monophosphokinase., intracellular ribonucleoprotein complex, positive regulation of intracellular estrogen receptor signaling pathway, protein localization to vacuolar membrane, Toxin zeta, heart contraction, positive regulation of interferon-beta production, HslUV protease complex, protein denaturation, integral component of membrane, extrinsic component of membrane, Replicative DNA helicase, Chaperone protein ClpB, Type I restriction enzyme EcoR124II R protein, Type I site-specific deoxyribonuclease., Transferring phosphorus-containing groups., receptor internalization involved in canonical Wnt signaling pathway, heme transporter activity, porphyrin-containing compound biosynthetic process, host cell mitochondrion, Golgi membrane, Golgi organization, cargo loading into COPII-coated vesicle, peptidyl-tyrosine phosphorylation, spermatogenesis, constitutive secretory pathway, Ras-related protein R-Ras, Flemming body, cell cortex, RNA folding, proteolysis, Signal recognition particle 54 kDa protein, chloroplastic, RNA polymerase II core binding, UMP-CMP kinase, Estrogen sulfotransferase, testis isoform, estrogen metabolic process, regulation of cAMP-mediated signaling, Pyrococcus abyssi GE5, Gluconate kinase., manganese ion binding, Probable ATP-dependent RNA helicase DDX58, positive regulation of interleukin-6 production, activation of innate immune response, detection of bacterium, Ras-related protein Rab-5C, Ras-related protein Rab-8A, BH1 domain binding, BH3 domain binding, NADH metabolic process, secretory granule lumen, ubiquitin-dependent ERAD pathway, phosphatidylethanolamine-translocating ATPase activity, Staphylococcus aureus USA300-ISMMS1, pre-autophagosomal structure, sequence-specific DNA binding, negative regulation of adenylate cyclase activity, Ras-related GTP-binding protein D, 6-phosphofructo-2-kinase., Rhodobacter sphaeroides 2.4.1, Deinococcus radiodurans R1, adenylylselenate kinase activity, cell leading edge, UvrABC system protein B, RNA export from nucleus, negative regulation of cyclic-nucleotide phosphodiesterase activity, Protein translocase subunit SecA 1, replisome, regulation of protein localization to plasma membrane, spectrin binding, Uncharacterized protein, early endosome, Thymidine kinase, Thymidine kinase., negative regulation of epidermal growth factor receptor signaling pathway, positive regulation of cell growth, positive regulation of substrate adhesion-dependent cell spreading, regulation of small GTPase mediated signal transduction, cleavage furrow, Rho-related GTP-binding protein RhoD, GTPase activity, coupled, -!- Deoxyinosine can also act as acceptor., -!- Adds an N(7)-methylguanine cap to mRNA. -!- The nucleoside next to the terminal guanosine may be either guanosine or adenosine., -!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin., -!- This enzyme catalyzes the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules, which may be either guanosine or adenosine. -!- This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. -!- The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine. -!- Formerly EC 2.1.1.58., Pantothenate kinase, lysosomal membrane, chaperone-mediated protein folding, Probable ATP-dependent transporter SufC, membrane addition at site of cytokinesis, Dickeya chrysanthemi, V-type ATP synthase alpha chain, Maltose-transporting ATPase., DNA binding, DNA recombination, P-body, Eukaryotic initiation factor 4A-I, Streptococcus thermophilus LMG 18311, response to heat, Acting on acid anhydrides; catalyzing transmembrane movement of substances., Fe(2+) transporter FeoB, ferrous iron transmembrane transporter activity, ferrous iron transport, Cpro-2. Hepatitis C virus NS3 serine proteinase., host cell cytoplasm, host cell endoplasmic reticulum membrane, phospholipid biosynthetic process, tRNA dimethylallyltransferase., kinase activity, positive regulation of cell-substrate adhesion, positive regulation of microtubule polymerization, ATP synthase subunit beta, Bacillus sp. TA2.A1, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Ras-related protein Rab-27A, photoreceptor outer segment, pigment granule transport, catalytic step 2 spliceosome, receptor internalization, 7,8-diamino-pelargonic acid aminotransferase. 7,8-diaminononanoate aminotransferase. Adenosylmethionine--8-amino-7-oxononanoate aminotransferase. DAPA aminotransferase., mitochondrial membrane fission, necroptotic process, perinuclear region of cytoplasm, positive regulation of mitochondrial fission, regulation of mitochondrion organization, ubiquitin protein ligase binding, maintenance of presynaptic active zone structure, DNA helicase., positive regulation of regulated secretory pathway, GTP-binding nuclear protein, Putative flagella-related protein H, Ribulose bisphosphate carboxylase/oxygenase activase, chloroplastic, positive regulation of telomerase activity, intracellular mRNA localization, Escherichia coli O139:H28 str. E24377A, lateral plasma membrane, morphogenesis of follicular epithelium, regulation of epidermal growth factor receptor signaling pathway, Platinum sensitivity protein 3, MAPK cascade, axon guidance, cytosol, positive regulation of protein phosphorylation, positive regulation of ruffle assembly, Myo-inositol ABC transporter, ATP-binding protein InoL, GTP-binding protein YPT31/YPT8, CurM, phagocytic cup base, regulation of vesicle-mediated transport, terminal bouton, ATP + dTMP = ADP + dTDP., protein homodimerization activity, zinc ion binding, Elongation factor Tu, mitochondrial, ATP-dependent protease ATPase subunit HslU, COPII vesicle coat, endoplasmic reticulum exit site, trans-Golgi network, RNA binding, intracellular transport of virus, magnesium ion binding, mitotic spindle organization, protein heterodimerization activity, regulation of gene silencing by miRNA, Melanoma differentiation associated protein-5, transcription corepressor activity, Bos taurus, negative regulation of cellular response to growth factor stimulus, negative regulation of histone H3-K14 acetylation, rDNA binding, ATP metabolic process, K48-linked polyubiquitin binding, VCP-NPL4-UFD1 AAA ATPase complex, Vesicle-fusing ATPase., DNA nucleotidyltransferase (DNA-directed). DNA-dependent DNA polymerase., Escherichia coli K-12, G-protein coupled receptor signaling pathway, Rho protein signal transduction, 397aa long hypothetical GTP-binding protein, 8 reduced ferredoxin + 8 H(+) + N(2) + 16 ATP + 16 H(2)O = 8 oxidized ferredoxin + H(2) + 2 NH(3) + 16 ADP + 16 phosphate., Dephospho-CoA kinase., Hsp90 protein binding, interferon-gamma-mediated signaling pathway, negative regulation of ERK1 and ERK2 cascade, protein homooligomerization, Mitochondrial Rho GTPase 2, calcium ion binding, synaptic vesicle transport, vacuole inheritance, proteasome-activating nucleotidase complex, 362aa long hypothetical maltose/maltodextrin transport ATP-binding protein, Geobacillus thermodenitrificans NG80-2, AMPA glutamate receptor clustering, P2Y1 nucleotide receptor binding, kinesin binding, neuroligin family protein binding, RNA polymerase-associated protein RapA, 4 iron, 4 sulfur cluster binding, GTPase Obg, ribosomal small subunit assembly, chromosome, Golgi vesicle transport, DEAD-box ATP-dependent RNA helicase, Probable ATP-dependent RNA helicase DDX47, Rhodobacter sphaeroides, glycolytic process, cell projection membrane, clathrin-coated pit, phosphatidylinositol-4,5-bisphosphate binding, trans-Golgi network transport vesicle, ATP-dependent kinase YFH7, Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130, protein targeting to chloroplast, protein ADP-ribosylation, UPF0273 protein PH0284, Septum site-determining protein MinD, defense response, Ras-related protein Ral-B, positive regulation of autophagosome assembly, microvillus assembly, autolysosome, calcium-mediated signaling, determination of adult lifespan, ion channel binding, perikaryon, bicellular tight junction assembly, cognition, RNA binding protein, Meiothermus taiwanensis, Rac-like GTP-binding protein ARAC5, Toxin PezT, regulation of microtubule polymerization, Japanese encephalitis virus strain SA-14, positive regulation of programmed cell death, Yersinia pestis, Cytosolic sulfotransferase 12, muscle organ development, regulation of microtubule depolymerization, regulation of synaptic growth at neuromuscular junction, 1,3-beta-D-glucan synthase complex, cellular bud neck, Ras-related protein Rab-2A, Acidianus hospitalis W1, Deoxyguanosine kinase, mitochondrial, purine deoxyribonucleoside metabolic process, activation of protein kinase activity, Methionine import ATP-binding protein MetN, nonfunctional rRNA decay, L-seryl-tRNA(Sec) kinase. PSTK., Corynebacterium glutamicum ATCC 13032, Phosphate starvation-inducible protein PhoH, predicted ATPase, Eubacterium ventriosum ATCC 27560, -!- The enzyme from several bacteria (e.g. Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC 2.3.1.157., Klebsiella pneumoniae subsp. pneumoniae MGH 78578, Primosomal protein N', transcription from RNA polymerase III promoter, Ski complex, CRD-mediated mRNA stabilization, Dom34-Hbs1 complex, positive regulation of podosome assembly, positive regulation of vascular smooth muscle contraction, regulation of neuron projection development, -!- An enzyme found in Gram-negative bacteria that exports heme., Heme-transporting ATPase., Ras-related GTP-binding protein C, ATPase RavA, Methylmalonic aciduria type A protein, mitochondrial, cobalamin metabolic process, Adenylate dimethylallyltransferase (AMP-dependent)., carbohydrate transport, detection of maltose stimulus, cytosolic small ribosomal subunit, regulation of translational initiation, 7-methylguanosine mRNA capping, nucleotide-excision repair, DNA duplex unwinding, response to UV, transcription-coupled nucleotide-excision repair, DNA repair and recombination protein RadB, Ras-related protein Rab-26, regulated exocytosis, Rho-related GTP-binding protein RhoC, neural tube closure, Sulfotransferase family cytosolic 2B member 1, cholesterol binding, steroid hormone binding, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, viral budding via host ESCRT complex, Bifunctional adenosylcobalamin biosynthesis protein CobU, Trehalose/maltose import ATP-binding protein MalK, regulation of dendrite development, response to glucocorticoid, response to glucose, response to hypoxia, Septin-2, regulation of heart contraction, nucleoside monophosphate metabolic process, Edg-2 lysophosphatidic acid receptor binding, Sulfotransferase 1A3, dopamine catabolic process, R3/R4 cell fate commitment, negative regulation of JNK cascade, -!- Preference for double-stranded DNA. -!- Possesses DNA-dependent ATPase activity. -!- Acts endonucleolytically on single-stranded circular DNA. -!- Similar enzyme: Haemophilus influenzae ATP-dependent DNase., RecBCD enzyme subunit RecD, endonuclease activity, Borreliella burgdorferi, Methanococcus maripaludis S2, Elongation factor Tu-A, TAP1 binding, Elongator complex protein 6, late endosome membrane, Golgi to endosome transport, Uridine kinase., mRNA 3'-UTR binding, mRNA transcription, Rho GDP-dissociation inhibitor binding, adherens junction organization, dendritic cell migration, endosomal transport, ATP-dependent RNA helicase eIF4A, translation initiation factor activity, dendrite, Elongation factor Tu-B, toxin transporter activity, Elongation factor Tu 1, regulation of exocytosis, cellular response to estradiol stimulus, positive regulation of histone acetylation, Rho-related GTP-binding protein RhoB, endothelial tube morphogenesis, negative regulation of cell migration, chromatin silencing at silent mating-type cassette, Katanin., type IV pilus-dependent motility, ADP-ribosylation factor GTPase-activating protein 1, action potential, regulation of insulin secretion, Protein-tyrosine sulfotransferase., protein-tyrosine sulfotransferase activity, ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity, Escherichia coli str. K-12 substr. DH10B, multi-organism intracellular transport, positive regulation of exosomal secretion, calcium ion transport, estrogen catabolic process, positive regulation of fat cell differentiation, ADP-ribosylation factor 2, 3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate., histone mRNA catabolic process, positive regulation of catalytic activity, MHC class Ib protein binding, antigen processing and presentation of endogenous peptide antigen via MHC class I, Gene 2 protein, Shigella phage Sf6, Microtubule-severing ATPase., endoplasmic reticulum tubular network, Streptococcus mutans UA159, riboflavin transport, cytosolic ribosome, translational termination, UDP biosynthetic process, BAST I. Bile acid sulfotransferase I. Bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase. Bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase. Glycolithocholate sulfotransferase., proteasome regulatory particle, base subcomplex, Proteasome-activating nucleotidase, tRNA wobble uridine modification, Pseudomonas phage phi13, maintenance of DNA repeat elements, mRNA 5'-splice site recognition, Pre-mRNA-processing ATP-dependent RNA helicase PRP5, ESX secretion system protein EccC, positive regulation of chemokine (C-C motif) ligand 5 production, positive regulation of viral genome replication, translation initiation factor binding, mRNA polyadenylation, GTPase activator activity, phosphatidylinositol-3,4-bisphosphate binding, Chromatin-remodeling complex ATPase, Thermothelomyces thermophila ATCC 42464, Rab small monomeric GTPase-like protein, ATP-dependent 5'-3' DNA helicase activity, viral genome packaging, angiogenesis, ATP synthase, sodium ion specific. Na(+)-translocating ATPase. Na(+)-transporting two-sector ATPase., Enterococcus hirae ATCC 9790, RNase L inhibitor, DNA topoisomerase (ATP-hydrolyzing)., Roundabout signaling pathway, cleavage furrow formation, positive regulation of I-kappaB kinase/NF-kappaB signaling, transforming growth factor beta receptor signaling pathway, telomere maintenance, PDZ domain binding, chloride channel regulator activity, GTP-binding protein GEM, Ras-related protein Rab-27B, Staphylococcus aureus subsp. aureus COL, cell separation after cytokinesis, Uncharacterized ABC transporter ATP-binding protein TM_0288, Cajal body, Arsenical pump-driving ATPase. Arsenical resistance ATPase. Arsenite-translocating ATPase., HPr kinase/phosphorylase, -!- Also acts on 5'-dephospho-RNA 3'-mononucleotides., DEAD/H-box RNA helicase binding, heat shock protein binding, kinase binding, negative regulation of interleukin-6-mediated signaling pathway, negative regulation of protein secretion, negative regulation of toll-like receptor 7 signaling pathway, positive regulation of secretion, positive regulation of tumor necrosis factor-mediated signaling pathway, response to hormone, microtubule organizing center, positive regulation of sodium ion transmembrane transport, synaptic vesicle budding, cytoplasmic side of membrane, Adeno-associated virus 2 Srivastava/1982, Protein Rep68, uridine kinase activity, regulation of DNA recombination, Helicobacter pylori, GTP-binding protein RAD, -!- Toxic component of a toxin-antitoxin (TA) module. -!- The phosphorylation of UDP-N-acetyl-alpha-D-glucosamine results in the inhibition of EC 2.5.1.7, which is then blocked. -!- Phosphorylation is inhibited by cognate epsilon antitoxin. -!- Formerly EC 2.7.1.n7., regulation of type III interferon production, Bloom syndrome protein, lateral element, response to X-ray, strand displacement, telomeric D-loop disassembly, RNA helicase activity, exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay, Vitamin B12 import ATP-binding protein BtuD, Encephalitozoon cuniculi GB-M1, GTP-binding nuclear protein GSP1, Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed., Packaging enzyme P4, viral procapsid, apoptotic process involved in development, endopeptidase activator activity, G-protein coupled receptor binding, signal recognition particle, chloroplast targeting, bicarbonate transmembrane transporter activity, Methanocaldococcus jannaschii DSM 2661, -!- Many nucleoside triphosphates can act as donors., AMP metabolic process, GTP:AMP phosphotransferase AK3, mitochondrial, NTP + AMP = NDP + ADP., bidirectional double-stranded viral DNA replication, U6 snRNA binding, viral budding from ER membrane, positive regulation of type I interferon production, Thermococcus kodakarensis KOD1, Sulfotransferase oxamniquine resistance protein, Septin-9, septin complex, Voltage-dependent L-type calcium channel subunit beta-2, termination of RNA polymerase II transcription, -!- Two major substrates contain the tetrasaccharides: -> undetermined 2-sulfo-uronic acid->GlcN2S->IdoA2S->GlcN*-> and -> undetermined 2-sulfo-uronic acid->GlcN2S->IdoA2S->GlcN6S*-> with modification of the N-unsubstituted glucosamine residue (shown with an asterisk). -!- Modification of selected sequences containing N-sulfo-glucosamine residues cannot yet be excluded. -!- The 3-O-sulfated heparan sulfate can be utilized by Herpes simplex virus type 1 as an entry receptor to infect the target cells. -!- There are two isozymes, known as 3-OST-3(A) and 3-OST-3(B), which have identical catalytic domains but are encoded by different mammalian genes. -!- The specificity of this enzyme differs from that of the other [heparan sulfate]-glucosamine 3-sulfotransferases. -!- It is inefficient at modifying precursors of the antithrombin binding site (in contrast to EC 2.8.2.23) and it does not modify glucosamine preceded by GlcA2S (unlike EC 2.8.2.29)., [Heparan sulfate]-glucosamine 3-sulfotransferase 3., G-protein coupled receptor complex, regulation of rhodopsin mediated signaling pathway, Human papillomavirus type 18, leukocyte differentiation, regulation of protein kinase B signaling, Brucella suis 1330, Phosphofructokinase 2., canonical glycolysis, ATP + sulfate = diphosphate + adenylyl sulfate., Sulfate adenylyltransferase., sulfate adenylyltransferase (ATP) activity, COPII-coated vesicle budding, Golgi vesicle docking, RuvB-like 1, regulation of transcription from RNA polymerase II promoter, protein localization, DjVLGB, Cryptosporidium parvum Iowa II, Translocator EscN, cellular response to leucine starvation, Ras-related protein Rab-1A, autophagosome assembly, defense response to bacterium, transport vesicle membrane, helicase activity, translation factor activity, RNA binding, U5 snRNA 3'-end processing, nuclear mRNA surveillance of mRNA 3'-end processing, hepatocyte growth factor receptor signaling pathway, positive regulation of focal adhesion assembly, regulation of cell size, regulation of respiratory burst, Sinorhizobium meliloti 1021, Bacillus subtilis subsp. subtilis str. 168, autophagy, DNA translocase activity, mismatch repair, nucleotide-excision repair, Deoxyguanosine kinase., Mycoplasma mycoides subsp. mycoides SC, Guanine-7-methyltransferase. Messenger ribonucleate guanine 7-methyltransferase. Messenger RNA guanine 7-methyltransferase., Methyltransferase cap1., RNA-directed RNA polymerase., Formate--tetrahydrofolate ligase., error-free translesion synthesis, positive regulation of ATP biosynthetic process, positive regulation of protein catabolic process, Cytoplasmic protein tyrosine kinase., RNA biosynthetic process, ATP-dependent RNA helicase activity, Rho family GTPase, host cell nucleus, maltose-transporting ATPase activity, heme binding, CTP synthase, receptor-mediated endocytosis, Methanococcus maripaludis, GET complex, pheromone-dependent signal transduction involved in conjugation with cellular fusion, response to metal ion, Pisum sativum, double-stranded RNA binding, tRNA dimethylallyltransferase, mitochondrial, protein methylation, protein ubiquitination, ATPase activity, coupled, intercellular canaliculus, phospholipid translocation, pyroptosis, Atlastin-1, cytoplasmic pattern recognition receptor signaling pathway in response to virus, detection of virus, innate immune response, Cell division control protein 21, positive regulation of interleukin-8 production, vesicle docking involved in exocytosis, Dynamin-1-like protein, dynamin family protein polymerization involved in mitochondrial fission, positive regulation of protein secretion, positive regulation of release of cytochrome c from mitochondria, Homo sapiens, cell surface receptor signaling pathway, chemotaxis, ephrin receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of GTPase activity, positive regulation of MAPK cascade, Escherichia coli, Thermus aquaticus, ADP binding, MHC class I protein binding, phagocytic vesicle, protein localization to plasma membrane, recycling endosome membrane, DNA-directed DNA polymerase., Dephospho-CoA kinase, Rattus norvegicus, late endosome, GTP-binding nuclear protein Ran, midbody, protein import into nucleus, -!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118, and EC 2.7.4.9. -!- Formerly EC 2.7.1.75., Herpes simplex virus (type 1 / strain 17), Adenylate kinase, Adenylic kinase. Adenylokinase. Myokinase., Cell division inhibitor SulA, GTPase Der, macroautophagy, Elongation factor 2, positive regulation of translational elongation, Fc-gamma receptor signaling pathway involved in phagocytosis, cytoplasmic ribonucleoprotein granule, neuron projection, regulation of filopodium assembly, spindle midzone, substantia nigra development, -!- dGMP can also act as acceptor. -!- dATP can act as donor., Guanylate kinase, adenylate kinase activity, actin binding, -!- Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors., Deoxycytidine kinase., Genome polyprotein, heterotrimeric G-protein complex, in utero embryonic development, DNA repair protein RAD25, -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70., ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate., Guanine nucleotide-binding protein G(i) subunit alpha-1, adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, cell cortex region, cell division, ATP + (d)CMP = ADP + (d)CDP., mitochondrial nucleoid, late endosome to vacuole transport, Archaeoglobus fulgidus DSM 4304, vascular endothelial growth factor receptor signaling pathway, viral RNA genome replication, phosphatidylinositol biosynthetic process, Ferrous iron transport protein b, Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'., host cell endoplasmic reticulum