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regulation of autophagy, double-strand break repair via homologous recombination, Mumps virus strain Jeryl Lynn, Non-specific serine/threonine protein kinase., Ubiquitin-conjugating enzyme E2 K, positive regulation of peptidyl-threonine phosphorylation, ubiquitin-ubiquitin ligase activity, Ubiquitin carboxyl-terminal hydrolase 5, EH domain-containing and endocytosis protein 1, sex differentiation, nuclear body, Toll-like receptor binding, autophagy, response to stress, Vacuolar protein sorting-associated protein 9, late endosome to vacuole transport via multivesicular body sorting pathway, vacuole inheritance, cold acclimation, DNA-directed DNA polymerase activity, RNA-dependent DNA biosynthetic process, DNA replication, FAS-associated factor 1, Derlin-1 retrotranslocation complex, E3 ubiquitin-protein ligase AMFR, endoplasmic reticulum, endoplasmic reticulum mannose trimming, integral component of endoplasmic reticulum membrane, positive regulation of protein binding, S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L- glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N(5)-methyl-L-glutamine., cell cycle arrest, regulation of signal transduction by p53 class mediator, establishment of cell polarity, establishment or maintenance of epithelial cell apical/basal polarity, nucleus, perinuclear region of cytoplasm, D-ornithine 4,5-aminomutase subunit alpha, D-ornithine = (2R,4S)-2,4-diaminopentanoate., Thermus thermophilus HB8, Putative mRNA export protein, Glucokinase regulatory protein, negative regulation of glucokinase activity, ATP binding, ATP-dependent protease ATPase subunit HslU, protein unfolding, mitochondrial DNA-directed RNA polymerase complex, mitochondrial RNA polymerase binding promoter specificity activity, root hair elongation, DNA damage-inducible protein 1, vesicle organization, membrane, 23S rRNA (adenine(2085)-N(6))-dimethyltransferase., microtubule cytoskeleton, phosphatidic acid binding, Ubiquilin-1, aggresome, sperm midpiece, Streptococcus pneumoniae, secretory granule lumen, microtubule organizing center, S-adenosylmethionine-dependent methyltransferase activity, protein methyltransferase activity, regulation of gene expression, negative regulation of autophagy, E3 ubiquitin-protein ligase RNF31, apoplast, response to cold, response to jasmonic acid, ESCRT I complex, NIK/NF-kappaB signaling, TRIF-dependent toll-like receptor signaling pathway, regulation of necroptotic process, transcription coactivator activity, lipase inhibitor activity, transforming growth factor beta receptor signaling pathway, polyubiquitin binding, OTU domain-containing protein 7A, axon midline choice point recognition, female sex differentiation, genital disc development, imaginal disc-derived male genitalia development, positive regulation of cell death, regulation of protein catabolic process, amphisome, autophagosome, endosome organization, negative regulation of apoptotic process, protein kinase binding, Golgi to endosome transport, RecQ-mediated genome instability protein 1, cellular response to hydrogen peroxide, protein C-terminus binding, Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)., endoplasmic reticulum membrane, protein folding, mitotic spindle pole body, epidermal growth factor receptor signaling pathway, membrane organization, activation of protein kinase activity, cadherin binding, positive regulation of neuron projection development, D-ornithine 4,5-aminomutase., Nuclear RNA export factor 1, Elongation factor Ts, Ubiquitin carboxyl-terminal hydrolase 25, membrane fusion, cell-cell signaling, epithelial cell differentiation, rRNA binding, mRNA export from nucleus, ribosomal small subunit export from nucleus, ubiquitin-specific protease activity involved in positive regulation of ERAD pathway, MAPK cascade, ATP + H(2)O = ADP + phosphate., protein phosphorylation, tau-protein kinase activity, positive regulation of type I interferon-mediated signaling pathway, ubiquitin-dependent protein catabolic process, ubiquitin-protein transferase activity, HECT-type E3 ubiquitin transferase., positive regulation of gene expression, 5'-AMP-activated protein kinase catalytic subunit alpha-2, ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate., [Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase., positive regulation of macroautophagy, protein serine/threonine/tyrosine kinase activity, identical protein binding, protein binding, protein domain specific binding, proteolysis, positive regulation of protein targeting to mitochondrion, E3 ubiquitin-protein ligase CBL-B, MyD88-dependent toll-like receptor signaling pathway, autophagosome assembly, autophagosome maturation, positive regulation of ER-associated ubiquitin-dependent protein catabolic process, pre-autophagosomal structure, regulation of proteasomal ubiquitin-dependent protein catabolic process, Ubiquitin-binding protein CUE2, cell wall, chloroplast envelope, chloroplast thylakoid membrane, Holliday junction resolvase complex, SOS response, Baculoviral IAP repeat-containing protein 2, FBXO family protein binding, regulation of RIG-I signaling pathway, regulation of cysteine-type endopeptidase activity, Cyclophilin. Peptidyl-prolyl cis-trans isomerase. Peptidylprolyl cis-trans isomerase. PPIase. Rotamase., Putative peptidyl-prolyl cis-trans isomerase Cbf2, lysosome, -!- The enzyme from the antibiotic-producing bacterium Micromonospora zionensis specifically methylates guanine(1405) at N(7) in 16S rRNA, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins., 16S rRNA (guanine(1405)-N(7))-methyltransferase., S-adenosyl-L-methionine + guanine(1405) in 16S rRNA = S-adenosyl-L- homocysteine + N(7)-methylguanine(1405) in 16S rRNA., Nascent polypeptide-associated complex protein, actin cortical patch, cellular bud neck, -!- Modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity. -!- Formerly EC 2.1.1.n16., 5'-tyrosyl-DNA phosphodiesterase, Acetoanaerobium sticklandii DSM 519, S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine., progesterone receptor signaling pathway, protein polyubiquitination, -!- This enzyme, along with EC 2.7.1.170, is required for the utilization of anhydro-N-acetylmuramic acid in proteobacteria. -!- The substrate is either imported from the medium or derived from the bacterium's own cell wall murein during cell wall recycling. -!- Formerly EC 4.2.1.n1., N-acetylmuramic acid 6-phosphate etherase, N-acetylmuramic acid 6-phosphate etherase., Bos taurus, Ubiquitin domain-containing protein DSK2, regulation of glucose transport, urate metabolic process, central nervous system development, mRNA splicing, via spliceosome, negative regulation of developmental pigmentation, protein homodimerization activity, somatic sex determination, Toll-interacting protein, kinase binding, protein localization to endosome, ATPase binding, rRNA adenine N-6-methyltransferase, 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)- dimethyladenine(1519) in 16S rRNA., mRNA binding, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, UBA-like domain-containing protein 2, -!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12., chaperone binding, ubiquitin-like protein ligase binding, RNA binding, -!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase)., protein serine/threonine kinase activity, Phosphoprotein, Haemophilus influenzae Rd KW20, lipid particle organization, DNA dealkylation involved in DNA repair, Ras protein signal transduction, response to ionizing radiation, Larrea tridentata, Coxiella burnetii RSA 493, Topoisomerase V, DNA-dependent DNA replication, nucleotide-excision repair factor 2 complex, 16S rRNA (guanine(1405)-N(7))-methyltransferase, NLS-bearing protein import into nucleus, I-kappaB kinase/NF-kappaB signaling, regulation of tumor necrosis factor-mediated signaling pathway, Serine/threonine-protein kinase MARK1, phosphatidylserine binding, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, negative regulation of protein adenylylation, SH2 domain binding, endosomal transport, Agrobacterium fabrum str. C58, Uncharacterized protein, apical plasma membrane, cellular response to hypoxia, cellular response to organonitrogen compound, DNA nucleotidyltransferase (DNA-directed). DNA-dependent DNA polymerase., double-strand break repair, replication fork, E3 ubiquitin-protein ligase CBL, negative regulation of epidermal growth factor receptor signaling pathway, positive regulation of receptor-mediated endocytosis, RING-type E3 ubiquitin transferase., ubiquitin protein ligase activity involved in ERAD pathway, Protein doublesex, male courtship behavior, veined wing generated song production, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription from RNA polymerase II promoter, sex-specific pigmentation, transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding, transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding, P-body, nucleotide-activated protein kinase complex, regulation of energy homeostasis, protein K29-linked deubiquitination, regulation of transcription, DNA-templated, ubiquitin binding, Mycobacterium tuberculosis H37Rv, -!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135., Rattus norvegicus, protein K48-linked ubiquitination, negative regulation of hippo signaling, E3 ubiquitin-protein ligase UBR5, HECT E3 ligase. Ubiquitin transferase HECT-E3., negative regulation of double-strand break repair, negative regulation of histone H2A K63-linked ubiquitination, positive regulation of protein import into nucleus, translocation, -!- Activated by AMP. -!- EC 1.1.1.34 is inactivated by the phosphorylation of the enzyme protein. -!- Histones can also act as acceptors. -!- Can also phosphorylate EC 6.4.1.2 and EC 3.1.1.79. -!- Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase. -!- GTP can act instead of ATP. -!- Formerly EC 2.7.1.109., AMP-activated protein kinase activity, macroautophagy, protein kinase activity, positive regulation of ubiquitin-protein transferase activity, protein neddylation, protein secretion, positive regulation of ATPase activity, Rhomboid-like protein 15, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, Ubiquilin-4, -!- KsgA introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine(1518) and adenine(1519) in 16S rRNA. -!- Strains lacking the methylase are resistant to kasugamycin. -!- Formerly EC 2.1.1.48., ATPase activity, cytosol, magnesium ion binding, 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L- homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA., Methyltransferases., Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)., cell proliferation, protein destabilization, Arabidopsis thaliana, stromule, intracellular transport of virus, Ubiquitin-like protein 7, rRNA (adenine-N6,N6-)-dimethyltransferase activity, rRNA processing, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, -!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively., actin cortical patch organization, E3 ubiquitin-protein ligase HUWE1, positive regulation of protein ubiquitination, protein methylation, translational termination, JNK cascade, nucleotide-binding oligomerization domain containing signaling pathway, protein linear polyubiquitination, protein N-terminus binding, regulation of apoptotic process, response to caffeine, -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49., NF-kappaB binding, receptor activity, ubiquitin protein ligase activity, Thermotoga maritima MSB8, negative regulation of TORC1 signaling, entry of bacterium into host cell, positive regulation of epidermal growth factor receptor signaling pathway, UBX domain-containing protein 1, Xenopus laevis, regulation of axonogenesis, Elongation factor Ts, mitochondrial, zinc ion binding, Golgi organization, mitochondrion, protein kinase C binding, receptor tyrosine kinase binding, response to mitochondrial depolarisation, N(5)-glutamine MTase. N(5)-glutamine S-adenosyl-L-methionine dependent methyltransferase., Peptide chain release factor N(5)-glutamine methyltransferase., DNA synthesis involved in DNA repair, cellular response to ethanol, fatty acid homeostasis, negative regulation of glucose import in response to insulin stimulus, DNA polymerase alpha catalytic subunit A, protein complex, Probable ribosomal RNA small subunit methyltransferase A, -!- In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. -!- In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon- amino group of an L-lysine residue of the acceptor protein., Acetyl coenzyme A carboxylase kinase (phosphorylating). Acetyl-CoA carboxylase bound kinase. Acetyl-CoA carboxylase kinase. Acetyl-CoA carboxylase kinase (AMP-activated). Acetyl-CoA carboxylase kinase (cAMP-independent). Acetyl-coenzyme A carboxylase kinase. AMPK. I-peptide kinase., regulation of macroautophagy, signal transduction, actin filament, MurNAc-6-P etherase., ubiquitin-dependent ERAD pathway, RNA export from nucleus, single-stranded RNA binding, Escherichia coli K-12, HslUV protease complex, Ribosomal RNA small subunit methyltransferase A, Trinucleotide repeat-containing gene 6C protein, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, ATP + [tau protein] = ADP + [tau protein] phosphate., Serine/threonine-protein kinase MARK2, [Tau protein] kinase., regulation of cytoskeleton organization, four-way junction helicase activity, E2 ubiquitin-conjugating enzyme., extracellular exosome, Ribulose bisphosphate carboxylase/oxygenase activase, chloroplastic, enzyme regulator activity, Rickettsia bellii RML369-C, embryo development ending in seed dormancy, Auxilin-like clathrin uncoating factor SWA2, clathrin binding, clathrin coat disassembly, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, regulation of nucleotide-binding oligomerization domain containing signaling pathway, base-excision repair, endosome membrane, heart development, stimulatory C-type lectin receptor signaling pathway, T cell receptor signaling pathway, positive regulation of I-kappaB kinase/NF-kappaB signaling, defense response to bacterium, leaf senescence, plastoglobule, Sendai virus (strain Harris), negative stranded viral RNA replication, Protein-tyrosine-phosphatase, positive regulation of protein K63-linked ubiquitination, regulation of cell cycle, alpha DNA polymerase:primase complex, fibroblast growth factor receptor signaling pathway, positive regulation of phosphatidylinositol 3-kinase signaling, ubiquitin-specific protease binding, Methanopyrus kandleri, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Peptidylprolyl isomerase., UV excision repair protein RAD23, DNA polymerase III complex, triglyceride homeostasis, female somatic sex determination, imaginal disc-derived female genitalia development, intracellular membrane-bounded organelle, NSFL1 cofactor p47, azurophil granule lumen, extracellular region, Aquifex aeolicus VF5, cytoplasmic sequestering of NF-kappaB, heat shock protein binding, Sequestosome-1, protein binding, bridging, mitochondrial matrix, guanyl-nucleotide exchange factor activity, -!- ErmC is a methyltransferase that confers resistance to the macrolide- lincosamide-streptogramin B group of antibiotics by catalyzing the methylation of 23S rRNA at adenine(2085). -!- Formerly EC 2.1.1.48., double-stranded DNA binding, ribosomal small subunit assembly, Ubiquitin C-terminal hydrolase. Ubiquitin carboxyl-terminal hydrolase. Ubiquitin thiolesterase., protein K6-linked deubiquitination, protein stabilization, thiol-dependent ubiquitinyl hydrolase activity, Wnt signaling pathway, calcium modulating pathway, -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70., neuron migration, cytoplasm, poly(A)+ mRNA export from nucleus, ribosomal large subunit export from nucleus, protein autophosphorylation, DNA helicase., Holliday junction ATP-dependent DNA helicase RuvA, MAP/microtubule affinity-regulating kinase 3, Ubiquitin-carrier-protein E2. Ubiquitin-conjugating enzyme E2., free ubiquitin chain polymerization, Hendra virus horse/Australia/Hendra/1994, FAS-associated factor 2, Holliday junction helicase complex, activating signal cointegrator 1 complex, Ancient ubiquitous protein 1, Ribulose bisphosphate carboxylase/oxygenase activase 1, chloroplastic, Defective in cullin neddylation protein 1, ubiquitin conjugating enzyme binding, Ubiquitin carboxyl-terminal hydrolase 28, cellular response to UV, Ubiquilin-like protein, Methanothermobacter marburgensis str. Marburg, negative regulation of store-operated calcium channel activity, regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, positive regulation of viral genome replication, Fc-epsilon receptor signaling pathway, activation of MAPK activity, positive regulation of protein kinase activity, single-stranded DNA binding, Corynebacterium glutamicum ATCC 13032, Oxidoreductases., positive regulation of protein K48-linked ubiquitination, positive regulation of protein monoubiquitination, Release factor glutamine methyltransferase, Schizosaccharomyces pombe 972h-, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, protein K11-linked deubiquitination, damaged DNA binding, proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of cytokinesis, DNA binding, genital disc sexually dimorphic development, male courtship behavior, regulation of imaginal disc growth, sex determination, VCP-NSFL1C complex, MCG53927, neutrophil degranulation, specific granule lumen, protein targeting to vacuole, cell death, inclusion body, Yersinia enterocolitica subsp. palearctica Y11, protein heterooligomerization, response to activity, premeiotic DNA replication, -!- The RING domain of E3 ubiquitin transferase serves as a mediator bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin an the epsilon-amino group of an L-lysine residue of the acceptor protein. -!- The RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin (unlike the HECT domain, EC 2.3.2.26). -!- RING-type ubiquitin transferases may occur as single-chain enzymes but also in dimeric forms or in multi-subunit assemblies. -!- Formerly EC 6.3.2.19 and EC 6.3.2.21., endoplasmic reticulum unfolded protein response, movement of cell or subcellular component, Escherichia coli O157:H7, protein kinase activator activity, nuclear speck, Nicotiana tabacum, response to heat, rRNA base methylation, Bacillus subtilis, Saccharomyces cerevisiae S288C, mRNA export factor MEX67, nuclear RNA export factor complex, cysteine-type endopeptidase activity, positive regulation of ERAD pathway, ubiquitin protein ligase binding, ATP + a protein = ADP + a phosphoprotein., Protein phosphokinase. Protein serine kinase. Protein serine-threonine kinase. Protein-serine kinase. Serine kinase. Serine protein kinase. Serine(threonine) protein kinase. Serine-specific protein kinase. Serine/threonine protein kinase. Threonine-specific protein kinase., ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, lipase binding, Measles virus strain Moraten, CUE domain-containing protein 1, Ubiquitin carboxyl-terminal hydrolase 14, Activating signal cointegrator 1 complex subunit 2, Mitochondrial transcription factor 1, transcription initiation from mitochondrial promoter, SNARE binding, vesicle-mediated transport, Micromonospora zionensis, protein-glutamine N-methyltransferase activity, positive regulation of NF-kappaB transcription factor activity, response to endoplasmic reticulum stress, regulation of BMP signaling pathway, K63-linked polyubiquitin binding, negative regulation of growth of symbiont in host, UV excision repair protein RAD23 homolog A, Phosphoric diester hydrolases., SNF1-like protein kinase ssp2, DNA polymerase III subunit delta', protein K48-linked deubiquitination, proteasome complex, protein deglycosylation, Mus musculus, fructose-6-phosphate binding, response to fructose, phosphorylation, Mycobacterium leprae TN, genital disc morphogenesis, male sex differentiation, negative regulation of transcription from RNA polymerase II promoter, sex comb development, Next to BRCA1 gene 1 protein, Antitoxin VbhA, Bartonella schoenbuchensis R1, PML body, enzyme binding, positive regulation of apoptotic process, protein localization to perinuclear region of cytoplasm, regulation of I-kappaB kinase/NF-kappaB signaling, regulation of protein complex stability, 5'-AMP-activated protein kinase catalytic subunit alpha-1, positive regulation of glycolytic process, regulation of vesicle-mediated transport, [Tau-protein] kinase. Glycogen synthase kinase-3-beta. GSK. Protein tau kinase. Tau kinase. Tau-tubulin kinase. TPK. TTK., cellular response to DNA damage stimulus, -!- The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself. -!- In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage. -!- Formerly EC 6.3.2.19., cellular response to interferon-beta, positive regulation of canonical Wnt signaling pathway, positive regulation of catenin import into nucleus, -!- Phosphorylates and inactivates EC 6.4.1.2, which can be dephosphorylated and reactivated by EC 3.1.3.17. -!- More active toward the dimeric form of acetyl-CoA carboxylase than the polymeric form. -!- Phosphorylates serine residues. -!- Formerly EC 2.7.1.111 and EC 2.7.1.128., 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase. 3-hydroxy-3-methylglutaryl-CoA reductase kinase. [Hydroxymethylglutaryl-CoA reductase (NADPH(2))] kinase. AMP-activated protein kinase. AMPK. Beta-hydroxy-beta-methylglutaryl-CoA reductase kinase. HMG-CoA reductase kinase. Hydroxymethylglutaryl coenzyme A reductase kinase. Hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating). Hydroxymethylglutaryl-CoA reductase kinase. Reductase kinase., ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate., carnitine shuttle, regulation of fatty acid biosynthetic process, lateral plasma membrane, microtubule bundle, D-alpha-ornithine 5,4-aminomutase. D-ornithine aminomutase., Ubiquitin-conjugating enzyme E2 1, DNA damage checkpoint, endoplasmic reticulum inheritance, lipid particle, retrograde protein transport, ER to cytosol, Dimethyladenosine transferase 1, mitochondrial, regulation of protein stability, cullin family protein binding, ubiquitin-like protein binding, Measles virus strain Edmonston, HBS1-like protein, Serine endopeptidases., 16S rRNA methylase, cellular bud tip, regulation of protein localization, transcription cofactor activity, histone ubiquitination, phosphatidylinositol-4,5-bisphosphate binding, aggrephagy, regulation of protein ubiquitination, copper ion homeostasis, positive regulation of protein linear polyubiquitination, regulation of inflammatory response, chloroplast stroma, response to light stimulus, thylakoid, strand displacement, positive regulation of protein complex assembly, ephrin receptor binding, transcription factor activity, sequence-specific DNA binding, RING E3 ligase. Ubiquitin transferase RING E3., protein oligomerization, autolysosome, macromitophagy, protein localization, positive regulation of cell proliferation, DNA-directed DNA polymerase., VCP-NPL4-UFD1 AAA ATPase complex, SH3 domain binding, cell surface receptor signaling pathway, protein autoubiquitination, Burkholderia pseudomallei K96243, Caenorhabditis elegans, Golgi apparatus, [Acetyl-CoA carboxylase] kinase., intracellular signal transduction, peptidyl-threonine phosphorylation, Methanocaldococcus jannaschii DSM 2661, Chaetomium thermophilum var. thermophilum DSM 1495, (R)-lactate + N-acetyl-D-glucosamine 6-phosphate = N-acetylmuramate 6-phosphate + H(2)O., mitochondrial translational elongation, spindle pole body duplication, Elongation factor Tu 2, Drosophila melanogaster, protein hexamerization, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase., BAT3 complex binding, Ubiquitinyl hydrolase 1., melanocyte differentiation, nucleoplasm, protein deubiquitination, thiol-dependent ubiquitin-specific protease activity, Homo sapiens, miRNA mediated inhibition of translation, phosphatidylinositol-mediated signaling, posttranscriptional gene silencing by RNA, plasma membrane, P, S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L- cysteine., protein ubiquitination, disordered domain specific binding, mitochondrial intermembrane space, NEDD8 ultimate buster 1, nucleotide-excision repair, positive regulation of cell cycle, Ubiquitin-associated protein 1, viral life cycle, execution phase of apoptosis, regulation of cell differentiation, regulation of toll-like receptor signaling pathway, tumor necrosis factor-mediated signaling pathway, ADP binding, chloroplast, ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity, Ubiquitin-associated domain-containing protein 1, recombinational repair, Peptidylproline (omega=180) = peptidylproline (omega=0)., Escherichia coli, Sisomicin-gentamicin methyltransferase., Ubiquitin-associated protein 2-like, hematopoietic stem cell homeostasis, endocytosis, LUBAC complex, ficolin-1-rich granule lumen, protein monoubiquitination, E3 ubiquitin-protein ligase XIAP, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, regulation of cell proliferation, regulation of innate immune response, peptidyl-glutamine methylation