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T-tubule, negative regulation of Golgi to plasma membrane protein transport, vesicle membrane, peroxisomal membrane, extracellular vesicle, cellular response to hydrogen peroxide, intrinsic apoptotic signaling pathway in response to DNA damage, mitogen-activated protein kinase binding, mitotic cell cycle, neuronal cell body, non-membrane spanning protein tyrosine kinase activity, positive regulation of cytosolic calcium ion concentration, proline-rich region binding, regulation of cell adhesion, Ras guanyl-nucleotide exchange factor activity, SH3/SH2 adaptor activity, fibroblast growth factor receptor signaling pathway, insulin receptor substrate binding, leukocyte migration, Rho guanyl-nucleotide exchange factor activity, protein dimerization activity, superoxide-generating NADPH oxidase activator activity, phosphatidylinositol-3,4-bisphosphate binding, positive regulation of transcription, DNA-templated, respiratory burst, actin filament bundle assembly, barbed-end actin filament capping, postsynaptic density, plasma membrane, regulation of defense response to virus by virus, Chemotaxis protein CheW, cell-cell junction, negative regulation of transforming growth factor beta1 production, negative regulation of cell proliferation, positive regulation of transcription from RNA polymerase II promoter, phosphoprotein binding, regulation of bone resorption, Protein-tyrosine kinase, Tyrosine-protein kinase transforming protein Src, phosphatidylinositol phosphorylation, tyrosine phosphorylation of STAT protein, brain development, oligodendrocyte differentiation, behavioral response to formalin induced pain, response to mechanical stimulus, social behavior, Streptococcus sp. 'group G', keratinocyte differentiation, structural molecule activity, negative regulation of calcium-mediated signaling, Rho GTPase-activating protein 26, Epidermal growth factor receptor kinase substrate 8-like protein 3, regulation of nitric-oxide synthase activity, morphogenesis of an epithelial sheet, Tyrosine-protein kinase Yes, axon, fatty acid binding, phosphatidic acid biosynthetic process, actin cortical patch assembly, ubiquitin binding, ATPase binding, CD4 receptor binding, protein serine/threonine phosphatase activity, positive regulation of cell growth, Bacillus subtilis subsp. subtilis str. 168, insulin-like growth factor receptor signaling pathway, positive regulation of endoplasmic reticulum unfolded protein response, cell leading edge, negative regulation of BMP signaling pathway, negative regulation of ERK1 and ERK2 cascade, negative regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of mitotic cell cycle, positive regulation of ERK1 and ERK2 cascade, spleen development, cerebellar mossy fiber, node of Ranvier, protein complex binding, response to bacterium, immune response-regulating cell surface receptor signaling pathway, lamellipodium assembly, incipient cellular bud site, profilin binding, release of sequestered calcium ion into cytosol, response to lipopolysaccharide, endosomal transport, nematode larval development, Apoptosis-stimulating of p53 protein 2, voltage-gated calcium channel activity, Peroxisomal membrane protein PEX13, Protein BZZ1, actin filament organization, response to salt stress, positive regulation of Arp2/3 complex-mediated actin nucleation, Protein YSC84, C-Jun-amino-terminal kinase-interacting protein 1, glomerular basement membrane development, Non-specific serine/threonine protein kinase., sarcomere organization, cell proliferation, Grb2-EGFR complex, MAPK cascade, cellular response to ionizing radiation, negative regulation of epidermal growth factor receptor signaling pathway, nucleus, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, positive regulation of reactive oxygen species metabolic process, N-glycan processing, SH3 domain-containing kinase-binding protein 1, signal transducer activity, anatomical structure formation involved in morphogenesis, branching involved in labyrinthine layer morphogenesis, cell differentiation, Peroxisomal membrane protein PAS20, cytokine production, acetylcholine receptor binding, ionotropic glutamate receptor binding, negative regulation of receptor internalization, receptor localization to synapse, regulation of NMDA receptor activity, phosphatidylinositol-3,4,5-trisphosphate binding, regulation of B cell apoptotic process, positive regulation of fibroblast migration, Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate., Protein-tyrosine-phosphatase., Sorting nexin-9, regulation of cell size, locomotor rhythm, morphogenesis of follicular epithelium, morphogenesis of larval imaginal disc epithelium, neuromuscular junction, septate junction, Intersectin-1, kinase activator activity, negative regulation of neuron apoptotic process, microvillus, Epidermal growth factor receptor kinase substrate 8, actin polymerization-dependent cell motility, stereocilium, Tyrosine-protein kinase HCK, caveola, cytokine-mediated signaling pathway, extrinsic component of cytoplasmic side of plasma membrane, innate immune response-activating signal transduction, interferon-gamma-mediated signaling pathway, negative regulation of apoptotic process, phosphotyrosine binding, positive regulation of cell proliferation, cell periphery, forebrain development, response to beta-amyloid, antigen processing and presentation of exogenous peptide antigen via MHC class II, Rho protein signal transduction, calcium-mediated signaling, negative regulation of cell adhesion, nervous system development, myosin binding, associative learning, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, MAP kinase kinase kinase. MAP3K. MAPKKK. MEK kinase. MEKK. MLK-like mitogen-activated protein triple kinase. MLTK., Mitogen-activated protein kinase kinase kinase., negative regulation of sequence-specific DNA binding transcription factor activity, peptidyl-serine phosphorylation, engulfment of apoptotic cell, axonogenesis, positive regulation of MAPK cascade, positive regulation of R7 cell differentiation, sevenless binding, positive regulation of cap-dependent translational initiation, smoothened signaling pathway, Avian sarcoma virus RASV1441, JAK-STAT cascade involved in growth hormone signaling pathway, negative regulation of immune response, positive regulation of cellular component movement, positive regulation of stress-activated protein kinase signaling cascade, JUN kinase binding, cytoskeletal protein binding, zonula adherens, Drosophila melanogaster, intracellular membrane-bounded organelle, tertiary granule lumen, cadherin binding involved in cell-cell adhesion, Unconventional myosin-Ie, vasculogenesis, Bacteroides thetaiotaomicron VPI-5482, nucleus organization, tau protein binding, B cell receptor signaling pathway, Bergmann glial cell differentiation, microspike assembly, neuromuscular process controlling balance, neuron differentiation, positive regulation of Wnt signaling pathway, planar cell polarity pathway, I band, Myc box-dependent-interacting protein 1, centrosome, Rac guanyl-nucleotide exchange factor activity, phagocytosis, positive regulation of natural killer cell mediated cytotoxicity, regulation of GTPase activity, negative regulation of phospholipase C activity, nicotinate-nucleotide adenylyltransferase activity, regulation of axon extension, regulation of transcription, DNA-templated, Plectin, hemidesmosome, auditory receptor cell stereocilium organization, pigment granule transport, sensory perception, sensory perception of light stimulus, sensory perception of sound, apical junction complex, calcium ion transmembrane transport via high voltage-gated calcium channel, locomotory behavior, suckling behavior, endocytosis, response to osmotic stress, actin filament binding, Small G protein signaling modulator 3, electron carrier activity, extrinsic component of membrane, innate immune response, positive regulation of p38MAPK cascade, protein phosphatase binding, Fc-epsilon receptor signaling pathway, positive regulation of bicellular tight junction assembly, transcription factor activity, sequence-specific DNA binding, Protein rof, cellular bud tip, cell motility, cellular response to peptide hormone stimulus, negative regulation of kinase activity, maternal process involved in parturition, negative regulation of growth hormone secretion, positive regulation of dendritic spine development, positive regulation of long-term synaptic potentiation, smooth muscle cell proliferation, Jouberin, ciliary basal body, ciliary basal body docking, extracellular space, small GTPase mediated signal transduction, Phosphatidylinositol 3-kinase regulatory subunit beta, apoptotic process involved in development, Golgi membrane, blood vessel morphogenesis, Dedicator of cytokinesis protein 1, Nostrin, cytoskeletal adaptor activity, AMPA glutamate receptor clustering, Disks large homolog 4, dendritic spine morphogenesis, positive regulation of excitatory postsynaptic potential, Immunoglobulin G-binding protein G, Desmoplakin, Voltage-dependent L-type calcium channel subunit beta-4, Protein-tyrosine kinase 6, osmosensory signaling pathway, positive regulation of protein catabolic process, anterior/posterior axis specification, follicular epithelium, apical cortex, cell fate commitment involved in pattern specification, establishment or maintenance of neuroblast polarity, Z disc, synaptic vesicle, activation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of T cell activation, Anabaena variabilis ATCC 29413, regulation of vulval development, ion channel binding, late endosome, negative regulation of anoikis, negative regulation of telomerase activity, response to interleukin-1, transforming growth factor beta receptor signaling pathway, positive regulation of cell migration, positive regulation of endothelial cell migration, positive regulation of autophagosome assembly, endocytic adaptor activity, GRB2-related adaptor protein 2, -!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration., follicular B cell differentiation, positive regulation of type I interferon production, regulation of gene expression, intracellular, secretory granule lumen, positive regulation of RNA splicing, positive regulation of transcription factor import into nucleus, Endophilin-A2, phosphatase binding, Signal transducing adapter molecule 1, positive regulation of exosomal secretion, phagocytosis, engulfment, lipid tube, positive regulation of astrocyte differentiation, kinase activity, regulation of MAPK cascade, Intersectin-2, reactive oxygen species metabolic process, peroxisome targeting sequence binding, mitogen-activated protein kinase kinase kinase binding, ATP binding, actin monomer binding, mismatch repair, regulation of autophagy, neuromuscular synaptic transmission, ER to Golgi vesicle-mediated transport, hemopoiesis, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, Myosin tail region-interacting protein MTI1, actin cortical patch, myosin I binding, Acanthamoeba castellanii, Neutrophil cytosol factor 4, Neutrophil cytosol factor 1, positive regulation of phosphatidylinositol 3-kinase signaling, T cell receptor signaling pathway, feeding behavior, membrane raft, stimulatory C-type lectin receptor signaling pathway, regulation of actin cytoskeleton reorganization, Crk-like protein, regulation of epidermal growth factor-activated receptor activity, establishment or maintenance of polarity of larval imaginal disc epithelium, regulation of JAK-STAT cascade, regulation of epidermal growth factor receptor signaling pathway, hyperosmotic response, postsynaptic membrane, cell surface receptor signaling pathway, positive regulation of tyrosine phosphorylation of STAT protein, response to ethanol, glucose transport, Tyrosine-protein kinase BTK, protein localization to membrane, regulation of protein K63-linked ubiquitination, SH3 and cysteine-rich domain-containing protein, positive regulation of stress fiber assembly, Abl interactor 2, actin cytoskeleton reorganization, dendritic cell migration, regulation of cell shape, cytosol, integrin-mediated signaling pathway, leukocyte migration involved in immune response, protein phosphorylation, ERBB2 signaling pathway, T cell costimulation, extracellular exosome, receptor internalization, excretion, negative regulation of DNA-templated transcription, termination, Disks large homolog 1, regulation of protein localization, movement of cell or subcellular component, Neutrophil cytosol factor 2, positive regulation of NIK/NF-kappaB signaling, regulation of protein autoubiquitination, detection of mechanical stimulus involved in sensory perception of pain, cellular bud, cellular response to heat, Rho guanine nucleotide exchange factor 9, Rho guanine nucleotide exchange factor 6, regulation of small GTPase mediated signal transduction, Golgi apparatus, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase. 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase. Monophosphatidylinositol phosphodiesterase. Phosphatidylinositol phospholipase C. Phosphoinositidase C. PI-PLC. Triphosphoinositide phosphodiesterase., positive regulation of receptor internalization, Clostridium phage phiSM101, Protein enhancer of sevenless 2B, actin filament severing, dendritic spine head, lamellipodium assembly involved in ameboidal cell migration, protein homodimerization activity, eukaryotic initiation factor eIF2 binding, peptidyl-serine dephosphorylation, receptor tyrosine kinase binding, heme binding, mitochondrial inner membrane, positive regulation of small GTPase mediated signal transduction, regulation of cell-cell adhesion, scaffold protein binding, regulation of cell adhesion mediated by integrin, regulation of monocyte chemotaxis, regulation of phosphatidylinositol 3-kinase activity, negative regulation of signal transduction, positive regulation of cell cycle, neuromuscular junction development, regulation of ventricular cardiac muscle cell action potential, intracellular receptor signaling pathway, phospholipid binding, type Ib terminal bouton, Pseudomonas aeruginosa PAO1, Proline-serine-threonine phosphatase-interacting protein 1, Tyrosine-protein kinase FRK, Bacteroides ovatus ATCC 8483, inner ear receptor stereocilium organization, melanosome, visual perception, apical part of cell, podosome, Tyrosine-protein kinase Lck, Adapter molecule crk, N-acetylglucosaminidase, insulin binding, phosphatidylinositol biosynthetic process, protein stabilization, negative regulation of cell-cell adhesion, negative regulation of cellular senescence, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of neuron death, axon terminus, transmembrane receptor protein tyrosine kinase signaling pathway, Bud emergence protein 1, ErbB-3 class receptor binding, phosphatidylinositol 3-kinase signaling, Tyrosine-protein kinase Fyn, blood coagulation, costamere, establishment of protein localization, platelet-derived growth factor receptor-beta signaling pathway, positive regulation of actin filament binding, positive regulation of oxidoreductase activity, response to oxidative stress, Voltage-dependent L-type calcium channel subunit beta-3, calcium ion transmembrane transport, regulation of membrane repolarization during action potential, voltage-gated calcium channel complex, microtubule-based peroxisome localization, enzyme activator activity, Proto-oncogene tyrosine-protein kinase Src, Rac GTPase binding, actin binding, adult locomotory behavior, brush border, exit from mitosis, focal adhesion, lysosome, nucleoplasm, peptidyl-tyrosine phosphorylation, regulation of phagocytosis, regulation of sequence-specific DNA binding transcription factor activity, respiratory burst after phagocytosis, Myosin heavy chain IB, immune response, CD2-associated protein, cell migration, intracellular signal transduction, positive regulation of substrate adhesion-dependent cell spreading, positive regulation of T cell proliferation, Oryctolagus cuniculus, Tyrosine-protein kinase CSK, peroxisomal importomer complex, protein binding, bridging, protein import into peroxisome matrix, docking, Tyrosine-protein kinase ITK/TSK, excitatory synapse, neuronal ion channel clustering, positive regulation of glucose import in response to insulin stimulus, Rho GTPase binding, SLIT-ROBO Rho GTPase-activating protein 1, COPI-coated vesicle, myelin sheath, negative regulation of endocytosis, Cdc42-interacting protein 4, regulation of blood coagulation, basal protein localization, lateral plasma membrane, positive phototaxis, cell-cell signaling, endosome, insulin receptor signaling pathway, membrane organization, neurotrophin TRKA receptor binding, Escherichia coli K-12, astrocyte cell migration, cell, apoptotic process, peptidyl-threonine phosphorylation, protein serine/threonine kinase activity, Cell death abnormality protein 2, Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1, cellular protein modification process, activation of phospholipase C activity, interleukin-4 production, Bos taurus, phosphatidylinositol 3-kinase complex, negative regulation of protein tyrosine kinase activity, Cas scaffolding protein family member 4, Golgi organization, cerebellum morphogenesis, collateral sprouting, regulation of cellular senescence, varicosity, GTPase activator activity, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol., 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, guanyl-nucleotide exchange factor complex, Dedicator of cytokinesis protein 2, Sex muscle abnormal protein 5, regulation of cell projection organization, spectrin binding, NF-kappaB binding, negative regulation of cell cycle, regulation of signal transduction by p53 class mediator, regulation of neuron differentiation, Breast cancer anti-estrogen resistance protein 1, autophagic cell death, Actin cytoskeleton-regulatory complex protein SLA1, CD8 receptor binding, T cell receptor binding, protein complex scaffold, modification of postsynaptic actin cytoskeleton, Myosin-3, Signal transducing adapter molecule 2, imaginal disc-derived wing morphogenesis, olfactory learning, sevenless signaling pathway, short-term memory, positive regulation of lamellipodium morphogenesis, regulation of caveolin-mediated endocytosis, regulation of early endosome to late endosome transport, stress fiber assembly, RIM-binding protein, isoform F, cytoskeletal matrix organization at active zone, neutrophil chemotaxis, ATP + a protein = ADP + a phosphoprotein., Protein phosphokinase. Protein serine kinase. Protein serine-threonine kinase. Protein-serine kinase. Serine kinase. Serine protein kinase. Serine(threonine) protein kinase. Serine-specific protein kinase. Serine/threonine protein kinase. Threonine-specific protein kinase., extracellular matrix, intermediate filament cytoskeleton, cell projection organization, intracellular protein transport, basolateral plasma membrane, Src substrate cortactin, lamellipodium, SH2 domain-mediated complex assembly, protein tyrosine kinase binding, T cell differentiation, positive regulation of cell adhesion, protein localization to plasma membrane, neuron migration, microfilament motor activity, receptor-mediated endocytosis, protein kinase activity, regulation of actin cytoskeleton organization, syntaxin binding, titin binding, protein kinase A catalytic subunit binding, ruffle, substrate-dependent cell migration, cell extension, disordered domain specific binding, cytoskeleton of presynaptic active zone, Spectrin alpha chain, non-erythrocytic 1, regulation of Rho protein signal transduction, Dictyostelium discoideum, cell morphogenesis, asymmetric protein localization involved in cell fate determination, chemical synaptic transmission, establishment of spindle orientation, protein localization, regulation of border follicle cell delamination, septate junction assembly, synaptic vesicle endocytosis, RING-type E3 ubiquitin transferase., DNA binding, behavioral response to ethanol, protein binding, regulation of actin filament length, lipopolysaccharide-mediated signaling pathway, protein tyrosine kinase activity, Bacillus cereus ATCC 10987, Caskin-2, cellular response to transforming growth factor beta stimulus, negative regulation of protein catabolic process, tubulin binding, ion transmembrane transport, Nebulette, oxidation-reduction process, phosphatidylinositol binding, connexin binding, protein complex, 1-phosphatidylinositol-3-kinase activity, RNA binding, entry of bacterium into host cell, epidermal growth factor receptor binding, identical protein binding, calcium channel regulator activity, positive regulation of high voltage-gated calcium channel activity, tolerance induction to self antigen, positive regulation of growth hormone secretion, positive regulation of protein binding, negative regulation of interleukin-6 production, negative regulation of low-density lipoprotein particle clearance, behavioral response to cocaine, regulation of synaptic transmission, glutamatergic, Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase domain protein, possible enterotoxin, phosphatidylinositol phospholipase C activity, positive regulation of angiogenesis, establishment of protein localization to plasma membrane, regulation of protein phosphorylation, Rho guanine nucleotide exchange factor 7, site of polarized growth, positive regulation of epidermal growth factor receptor signaling pathway, negative regulation of phagocytosis, behavioral fear response, habituation, memory, regulation of protein localization to plasma membrane, Clostridium perfringens ATCC 13124, inositol phosphate metabolic process, regulation of actin filament polymerization, negative regulation of transcription from RNA polymerase II promoter, terminal bouton, clathrin-coated pit, kinesin binding, positive regulation of synaptic transmission, cilium assembly, bicellular tight junction assembly, extracellular matrix organization, Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1, Rho GTPase-activating protein 10, in utero embryonic development, kidney development, platelet-derived growth factor receptor signaling pathway, structural constituent of muscle, auditory receptor cell differentiation, photoreceptor connecting cilium, dendritic spine maintenance, mitotic spindle midzone, MAP-kinase scaffold activity, axonal growth cone, dendritic growth cone, Dipeptidyl-peptidase VI, B cell proliferation, cardiovascular system development, positive regulation of mitotic cell cycle, positive regulation of osteoblast proliferation, regulation of extracellular matrix organization, transitional one stage B cell differentiation, protein self-association, regulation of protein binding, NLP/P60, SPBc2 prophage-derived uncharacterized protein YorP, Tight junction protein ZO-3, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of mitochondrial depolarization, negative regulation of telomere maintenance via telomerase, positive regulation of protein serine/threonine kinase activity, RNA polymerase binding, cell chemotaxis, hepatocyte growth factor receptor signaling pathway, regulation of apoptotic process, positive regulation of smooth muscle contraction, negative regulation of protein serine/threonine kinase activity, positive regulation of muscle cell differentiation, postsynapse, NLP/P60 protein, G-protein coupled receptor signaling pathway, Proto-oncogene vav, HICS complex, -!- The RING domain of E3 ubiquitin transferase serves as a mediator bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin an the epsilon-amino group of an L-lysine residue of the acceptor protein. -!- The RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin (unlike the HECT domain, EC 2.3.2.26). -!- RING-type ubiquitin transferases may occur as single-chain enzymes but also in dimeric forms or in multi-subunit assemblies. -!- Formerly EC 6.3.2.19 and EC 6.3.2.21., Putative E3 ubiquitin-protein ligase SH3RF2, activation of GTPase activity, SCAR complex, Rac protein signal transduction, cell cortex, ruffle membrane, leukocyte degranulation, regulation of podosome assembly, Growth factor receptor-bound protein 2, Ras protein signal transduction, SH3 domain binding, epidermal growth factor receptor signaling pathway, nucleolus, cellular response to platelet-derived growth factor stimulus, negative regulation of gene expression, RIMS-binding protein 2, negative regulation of phosphatase activity, endosome membrane, membrane, cadherin binding, NADPH oxidase complex, cellular response to reactive oxygen species, positive regulation of JNK cascade, protein targeting to membrane, superoxide-generating NADPH oxidase activity, Saccharomyces cerevisiae S288C, guanyl-nucleotide exchange factor activity, NK T cell differentiation, epidermis development, intercalated disc, MyD88-dependent toll-like receptor signaling pathway, negative regulation of protein kinase activity, protein localization to actin cortical patch, vinculin binding, Phosphotyrosine phosphatase. PTPase., Caldanaerobacter subterraneus subsp. tengcongensis MB4, [PSI+] inducibility protein 3, cell-substrate adhesion, spore germination, Disks large 1 tumor suppressor protein, establishment or maintenance of polarity of follicular epithelium, mating behavior, motile cilium, regulation of T cell activation, regulation of DNA-templated transcription, termination, GDP-L-fucose metabolic process, Glycoprotein 6-alpha-L-fucosyltransferase., regulation of GTP binding, B cell differentiation, Osteoclast-stimulating factor 1, growth hormone receptor signaling pathway, clathrin-coated endocytic vesicle membrane, cell projection, Kalirin, NMDA selective glutamate receptor signaling pathway, SLIT-ROBO Rho GTPase-activating protein 2, negative regulation of neuron migration, Mitogen-activated protein kinase kinase kinase 10, bHLH transcription factor binding, Avian sarcoma virus PR2257/16, Tyrosine-protein kinase Tec, dendritic spine development, Rho guanine nucleotide exchange factor 4, MAGUK p55 subfamily member 5, Lodderomyces elongisporus NRRL YB-4239, Brain-specific angiogenesis inhibitor 1-associated protein 2, D1 dopamine receptor binding, postsynaptic neurotransmitter receptor diffusion trapping, lactation, smooth muscle cell migration, keratinization, regulation of heart rate by cardiac conduction, regulation of cell cycle, RIMS-binding protein 3A, Caenorhabditis elegans, positive regulation of execution phase of apoptosis, antigen receptor-mediated signaling pathway, Endophilin-B1, lysophosphatidic acid acyltransferase activity, mitochondrion organization, positive regulation of autophagy, Phosphoinositide phospholipase C., thymus development, axon initial segment, immunological synapse, pericentriolar material, insulin-like growth factor receptor binding, response to endoplasmic reticulum stress, transcription factor binding, negative regulation of PERK-mediated unfolded protein response, -!- This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, but requires MAPKKKK for activation. -!- Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. -!- While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway. -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury. -!- Formerly EC 2.7.1.37., positive regulation of distal tip cell migration, enzyme binding, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of epithelial cell migration, regulation of vascular permeability, specific granule lumen, T cell activation, positive regulation of GTPase activity, DNA damage induced protein phosphorylation, activation of protein kinase C activity, cell cycle arrest, positive regulation of peptidyl-tyrosine phosphorylation, cell-matrix adhesion, insulin receptor binding, Obscurin, sarcolemma, pigment granule localization, cell junction, Rattus norvegicus, calcium ion transport into cytosol, cerebral cortex cell migration, actin cortical patch localization, fungal-type cell wall organization, negative regulation of JUN kinase activity, platelet activation, F-BAR and double SH3 domains protein 2, Cytoplasmic protein NCK2, negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation, negative regulation of peptidyl-serine phosphorylation, signal transduction, protein C-terminus binding, protein complex assembly, structural constituent of cytoskeleton, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, cell redox homeostasis, phagolysosome, superoxide anion generation, superoxide metabolic process, ephrin receptor signaling pathway, actin cytoskeleton organization, cytoskeleton organization, positive regulation of apoptotic process, filamentous actin, Voltage-dependent L-type calcium channel subunit beta-1, Dynamin-binding protein, positive regulation of dendrite extension, Thermotoga maritima MSB8, positive regulation of establishment of protein localization to plasma membrane, Ply protein, Actin-binding protein, Vinexin, endocytic vesicle, positive regulation of ruffle assembly, Chemotaxis signal transduction protein, cell fate specification, dorsal closure, guanylate kinase activity, smooth septate junction, subsynaptic reticulum, synaptic growth at neuromuscular junction, tricellular tight junction, type I terminal bouton, Src-like-adapter, Alpha-(1,6)-fucosyltransferase, GDP-fucose--glycoprotein fucosyltransferase. GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase. GDP-L-fucose-glycoprotein fucosyltransferase. Glycoprotein fucosyltransferase. Guanosine diphosphofucose-glycoprotein fucosyltransferase., Unconventional myosin-XVB, response to gravity, dendrite morphogenesis, negative regulation of protein ubiquitination, regulation of peptidyl-tyrosine phosphorylation, High osmolarity signaling protein SHO1, filamin binding, stress fiber, apoptotic signaling pathway, Epidermal growth factor receptor kinase substrate 8-like protein 2, Mus musculus, NMDA selective glutamate receptor complex, synapse, -!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112., ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., cellular response to retinoic acid, hematopoietic progenitor cell differentiation, storage vacuole, cellular bud neck, phospholipase C activity, multivesicular body assembly, Engulfment and cell motility protein 1, transmembrane receptor protein tyrosine kinase adaptor activity, growth cone, positive regulation of MAP kinase activity, Rho GTPase-activating protein 4, Ras GTPase-activating protein 1, cilium, neuron projection, neurotransmitter receptor localization to postsynaptic specialization membrane, TORC1 signaling, protein phosphatase type 1 complex, ribosome, negative regulation of transcription, DNA-templated, Tyrosine-protein kinase Lyn, mitogen-activated protein kinase kinase binding, protein kinase C binding, regulation of endocytosis, Sorbin and SH3 domain-containing protein 1, muscle contraction, extracellular region, neutrophil degranulation, -!- This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). -!- A number of histones can act as acceptor., ATP + protein L-histidine = ADP + protein N-phospho-L-histidine., Chemotaxis protein CheA, Histidine kinase., Histidine protein kinase. HK1. Protein histidine kinase. Protein kinase. Protein kinase (histidine)., Phosphotransferases with a nitrogenous group as acceptor., Megakaryocyte-associated tyrosine-protein kinase, SH3 and PX domain-containing protein 2A, glomerular visceral epithelial cell development, nitrogen compound metabolic process, -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70., hemidesmosome assembly, ficolin-1-rich granule lumen, actin filament branching, alpha-beta T cell differentiation, negative regulation of endothelial cell apoptotic process, neural tube closure, positive regulation of interferon-gamma secretion, positive regulation of release of sequestered calcium ion into cytosol, regulation of cell proliferation, positive regulation of endocytosis, learning, Tyrosine-protein kinase ABL1, cellular response to DNA damage stimulus, cellular response to dopamine, dendrite, magnesium ion binding, perinuclear region of cytoplasm, positive regulation of microtubule binding, FYN-binding protein, NLS-bearing protein import into nucleus, receptor binding, Unconventional myosin-VIIa, inner ear morphogenesis, bicellular tight junction, cell-cell junction assembly, hippo signaling, regulation of mitophagy, Myosin-5, exocytosis, Non-specific protein-tyrosine kinase., mesoderm development, positive regulation of actin cytoskeleton reorganization, positive regulation of actin filament polymerization, protein autophosphorylation, ephrin receptor binding, phosphatidylinositol-mediated signaling, protein kinase binding, regulation of phosphatidylinositol 3-kinase signaling, phosphatidylinositol-3-phosphate binding, activation of MAPKK activity, signal transduction in response to DNA damage, Growth arrest-specific protein 7, signal transducer, downstream of receptor, with protein tyrosine kinase activity, Nebulin, muscle filament sliding, regulation of Fc receptor mediated stimulatory signaling pathway, positive regulation of dendritic spine morphogenesis, regulation of neuronal synaptic plasticity, cornified envelope, Src-like-adapter 2, negative regulation of B cell activation, Melanoma-derived growth regulatory protein, positive regulation of engulfment of apoptotic cell, programmed cell death, interferon-gamma production, P2Y1 nucleotide receptor binding, PDZ domain binding, juxtaparanode region of axon, phosphatidylinositol 3-kinase regulator activity, response to organonitrogen compound, PhnA-like protein, LIM and SH3 domain protein 1, -!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2., Ubiquitin-associated and SH3 domain-containing protein B, Epidermal growth factor receptor kinase substrate 8-like protein 1, establishment of cell polarity, mating projection tip, signal transduction involved in filamentous growth, gap junction, cardiac muscle thin filament assembly, protein heterodimerization activity, cellular zinc ion homeostasis, response to drug, negative regulation of cell motility, protein phosphorylated amino acid binding, regulation of signal transduction, regulation of transcription from RNA polymerase II promoter, cell morphogenesis involved in conjugation with cellular fusion, ESCRT-0 complex, muscle organ development, kinase binding, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of protein homooligomerization, regulation of cell cycle arrest, cellular response to hepatocyte growth factor stimulus, regulation of cell growth, 'de novo' posttranslational protein folding, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of phosphatidylinositol 3-kinase activity, activation of store-operated calcium channel activity, inositol trisphosphate biosynthetic process, Endophilin-A1, microtubule-based movement, cellular response to epidermal growth factor stimulus, negative regulation of cell-matrix adhesion, Autolytic lysozyme, regulation of dendrite development, anterior/posterior axis specification, embryo, embryonic development via the syncytial blastoderm, negative regulation of epidermal growth factor-activated receptor activity, filopodium assembly, positive regulation of translation in response to endoplasmic reticulum stress, protein deubiquitination, ossification, Phosphatidylinositol 3-kinase regulatory subunit alpha, actin cytoskeleton, glycoprotein binding, growth factor receptor binding, regulation of glucose metabolic process, microtubule cytoskeleton, spectrin, SH2 domain binding, manganese ion binding, mitochondrial depolarization, negative regulation of ubiquitin-protein transferase activity, nuclear body, peptidyl-tyrosine autophosphorylation, positive regulation of protein phosphorylation, regulation of cell motility, positive regulation of protein localization to nucleus, JNK cascade, Gallus gallus, negative regulation of Arp2/3 complex-mediated actin nucleation, protein domain specific binding, Nostoc punctiforme PCC 73102, endoplasmic reticulum, L-type voltage-gated calcium channel complex, Pex17p-Pex14p docking complex, tropomyosin binding, Sorbin and SH3 domain-containing protein 2, Guanine nucleotide exchange factor VAV2, apicolateral plasma membrane, gravitaxis, male courtship behavior, pole plasm protein localization, NAP1-binding protein 2, inactivation of MAPK activity involved in osmosensory signaling pathway, GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D- mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl- (1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N- acetyl-beta-D-glucosaminyl)asparagine = GDP + N(4)-(N-acetyl-beta-D- glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D- glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N- acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta- D-glucosaminyl)asparagine., glycoprotein 6-alpha-L-fucosyltransferase activity, RING E3 ligase. Ubiquitin transferase RING E3., S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine., presynaptic membrane, actin crosslink formation, SAM and SH3 domain-containing protein 1, G-protein coupled receptor binding, myelination, positive regulation of protein targeting to membrane, Protein kinase C and casein kinase substrate in neurons protein 1, plasma membrane tubulation, protein secretion, regulation of store-operated calcium channel activity, response to hydrogen peroxide, cellular defense response, cellular response to cadmium ion, cellular response to oxidative stress, positive regulation of epidermal growth factor-activated receptor activity, vascular endothelial growth factor receptor signaling pathway, Cytoplasmic protein tyrosine kinase., Fc-gamma receptor signaling pathway involved in phagocytosis, Homo sapiens, cell adhesion, regulation of inflammatory response, COP9 signalosome, axon guidance, cytoplasm, positive regulation of blood vessel endothelial cell migration, microtubule binding, phagocytic cup, asymmetric protein localization, establishment of mitotic spindle orientation, establishment or maintenance of epithelial cell apical/basal polarity, establishment or maintenance of polarity of embryonic epithelium, morphogenesis of a polarized epithelium, morphogenesis of an epithelium, positive regulation of synaptic growth at neuromuscular junction, lipid tube assembly, cellular response to lipopolysaccharide, neuroepithelial cell differentiation, positive regulation of interleukin-2 secretion, post-embryonic development, substrate adhesion-dependent cell spreading, GTPase binding, phosphatidylinositol 3-kinase binding, positive regulation of intrinsic apoptotic signaling pathway, negative regulation of wound healing, Clostridium perfringens str. 13, regulation of extracellular exosome assembly, male genitalia development, protein N-terminus binding, p53 binding, integrin binding, mitochondrion, positive regulation of integrin activation, positive regulation of protein kinase B signaling, regulation of epithelial cell migration, signal complex assembly, negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator, phospholipid biosynthetic process, positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, protein localization to vacuolar membrane, cortical cytoskeleton, cytoskeleton, negative regulation of programmed cell death, SAM domain-containing protein SAMSN-1, ankyrin binding, inner ear development, mechanoreceptor differentiation, phagolysosome assembly, post-embryonic animal organ morphogenesis, Tight junction protein ZO-1, Voltage-dependent L-type calcium channel subunit beta-2, apical plasma membrane, calcium ion transport, fatty acid alpha-oxidation, peroxisome, actin nucleation, bipolar cellular bud site selection, negative regulation of JNK cascade, regulation of microtubule polymerization, regulation of response to DNA damage stimulus, cell-cell adherens junction, B cell proliferation involved in immune response, B-1 B cell homeostasis, activated T cell proliferation, adherens junction, glomerular filtration, post-embryonic hemopoiesis, macroautophagy, positive regulation of lipopolysaccharide-mediated signaling pathway, protein polyubiquitination, regulation of Notch signaling pathway, inactivation of MAPK activity involved in cell wall organization or biogenesis, response to heat, beta-1 adrenergic receptor binding, dendrite cytoplasm, glutamate receptor binding, neuroligin family protein binding, protein localization to synapse, endocytic vesicle membrane, positive regulation of glucose import, adaptive immune response, Uncharacterized protein, B cell activation, positive regulation of B cell differentiation, positive regulation of NF-kappaB transcription factor activity, regulation of B cell cytokine production, vesicle, Listeria phage PSA, response to morphine, focal adhesion assembly, Rhodopseudomonas palustris CGA009, osmosensor activity, Myosin-I heavy chain, filopodium, basal plasma membrane, paranode region of axon, positive regulation of potassium ion transport, Rho guanine nucleotide exchange factor 16, ubiquitin protein ligase binding, Endophilin-A3, actin filament, negative regulation of dendritic spine maintenance, regulation of calcium ion import across plasma membrane, Nephrocystin-1, transferase activity, -!- Catalyzes a reaction similar to that of EC 2.4.1.214, but transfers the L-fucosyl group from GDP-beta-L-fucose to form an alpha-1,6- linkage rather than an alpha-1,3-linkage., oligosaccharide biosynthetic process, Probable enterotoxin, NLP/P60 family protein, ovarian follicle cell development, torso signaling pathway, Cytoplasmic protein NCK1, negative regulation of cell death, negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress, positive regulation of cap-independent translational initiation, protein kinase inhibitor activity, positive regulation of JUN kinase activity, positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, positive regulation of mast cell proliferation, positive regulation of neuron projection development, adherens junction organization, negative regulation of bone resorption, LAS seventeen-binding protein 3, maternal behavior, bundle of His cell-Purkinje myocyte adhesion involved in cell communication, cornification, ficolin-1-rich granule membrane, peptide cross-linking, B cell mediated immunity, SH3 domain-containing YSC84-like protein 1, central nervous system development, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1