Search CATH

orotidine-5'-phosphate decarboxylase activity, D-ribulose phosphate-3-epimerase. D-ribulose-5-phosphate epimerase. D-xylulose-5-phosphate 3-epimerase. Erythrose-4-phosphate epimerase. Pentose-5-phosphate 3-epimerase. Phosphoribulose epimerase. Xylulose phosphate 3-epimerase., -!- Formerly EC 1.6.6.8., leucine catabolic process, magnesium ion binding, Fructose-bisphosphate aldolase A, Oryctolagus cuniculus, tryptophan biosynthetic process, Tryptophan synthase alpha chain, Tryptophan synthase., Salmonella enterica subsp. enterica serovar Typhi, Fructose-bisphosphate aldolase B, centriolar satellite, fructose-1-phosphate aldolase activity, Mycobacterium tuberculosis H37Rv, Fructose-bisphosphate aldolase., TMADh., Trimethylamine dehydrogenase, Inosine-5'-monophosphate dehydrogenase 2, peroxisomal membrane, purine ribonucleoside monophosphate biosynthetic process, secretory granule lumen, lactate metabolic process, Pseudomonas aeruginosa PAO1, Phosphotriose isomerase. Triose phosphoisomerase. Triosephosphate isomerase. Triosephosphate mutase., Alpha-galactosidase A, azurophil granule lumen, -!- In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5. -!- 1-deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate., Plasmodium falciparum 3D7, 3-keto-5-aminohexanoate cleavage enzyme., 2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde., Thermoproteus tenax, pyrimidine nucleoside biosynthetic process, NADPH dehydrogenase., Lactate oxidase, positive regulation of nitric-oxide synthase biosynthetic process, signal transduction, 4-hydroxy-2-oxovalerate aldolase, 4-hydroxy-2-oxovalerate aldolase., quinolinate catabolic process, Vitis vinifera, (S)-2-hydroxy-acid oxidase., -!- Exists as two major isoenzymes; the A form preferentially oxidizes short-chain aliphatic hydroxy acids; the B form preferentially oxidizes long-chain and aromatic hydroxy acids. -!- The rat isoenzyme B also acts as EC 1.4.3.2. -!- Formerly EC 1.1.3.1., Hydroxyacid oxidase 2, Dihydroorotate dehydrogenase, lysine biosynthetic process via aminoadipic acid, lysine biosynthetic process via diaminopimelate, Tagatose 1,6-diphosphate aldolase 2, tubulin binding, drug binding, response to caffeine, response to starvation, negative regulation of proteasomal protein catabolic process, indole-3-glycerol-phosphate synthase activity, nucleobase-containing small molecule interconversion, 4-hydroxy-2-oxoglutarate aldolase., N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1- deoxy-D-ribulose 5-phosphate., Agrobacterium fabrum str. C58, transferase activity, transferring aldehyde or ketonic groups, Phospho-2-dehydro-3-deoxyheptonate aldolase, N-acylglucosamine-6-phosphate 2-epimerase., Putative N-acetylmannosamine-6-phosphate 2-epimerase, Nicotinate phosphoribosyltransferase, Nicotinate phosphoribosyltransferase., Burkholderia multivorans ATCC 17616, S-adenosyl-L-methionine binding, carbon-nitrogen lyase activity, Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho- alpha-D-ribose 1-diphosphate., Nicotinamide phosphoribosyltransferase., nicotinamide phosphoribosyltransferase activity, Galactocerebrosidase, galactosylceramidase activity, Alpha-galactosidase AgaA, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, Listeria monocytogenes EGD-e, 3-hexulose-6-phosphate synthase., With NAD(+) or NADP(+) as acceptor., chloroplast, shikimate metabolic process, Bacteroides thetaiotaomicron VPI-5482, alpha-1,4-glucosidase activity, ATP biosynthetic process, I band, RNA binding, Cryptosporidium parvum Iowa II, Staphylococcus aureus subsp. aureus Mu50, 'de novo' NAD biosynthetic process from tryptophan, cellular response to interleukin-4, Putative dihidrodipicolinate synthase, Sinorhizobium meliloti, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase., A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl- carrier protein] + H(2)O., Acetyl-CoA + n malonyl-CoA + 2n NADPH = long-chain-acyl-CoA + n CoA + n CO(2) + 2n NADP(+)., An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH., Fatty-acyl-CoA synthase., [Acyl-carrier-protein] S-acetyltransferase., lipid particle, Trypanosoma brucei brucei TREU927, M band, Z disc, protein heterodimerization activity, response to UV-B, response to salt stress, NAO. Nitroethane oxidase. Nitroethane reductase., Fructose-bisphosphate aldolase class 2, 23S rRNA (adenine(2503)-C(2))-methyltransferase., rRNA (adenine-C2-)-methyltransferase activity, Brucella melitensis ATCC 23457, 2-dehydro-3-deoxyphosphoheptonate aldolase, pentose-phosphate shunt, Putative dihydrodipicolinate synthetase, fatty acid alpha-oxidation, Shewanella halifaxensis HAW-EB4, Putative thiosugar synthase, cell redox homeostasis, 12-oxophytodienoate reductase activity, jasmonic acid biosynthetic process, response to ozone, Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821, 2-isopropylmalate synthase activity, [Pyruvate formate-lyase]-activating enzyme. Formate acetyltransferase activating enzyme. Formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L- methionine oxidoreductase (S-adenosyl-L-methionine cleaving). PFL activase. PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving)., Neisseria meningitidis, oxidoreductase activity, adhesion of symbiont to host cell, parasitism, Streptococcus pneumoniae CGSP14, Babesia bovis, glycolipid catabolic process, Zea mays, Dihydropicolinate synthase, Mycobacterium thermoresistibile ATCC 19527, 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH., Glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase. Glutamate synthetase (NADP). Glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP). Glutamine-ketoglutaric aminotransferase. GOGAT. L-glutamate synthase. L-glutamate synthetase. L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing. NADPH-dependent glutamate synthase. NADPH-glutamate synthase., Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative, Vibrio cholerae, 4-hydroxyproline catabolic process, primary root development, thylakoid, ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate., Yersinia enterocolitica subsp. enterocolitica 8081, Staphylococcus aureus, Chemotaxis protein CheY, Cytophaga hutchinsonii ATCC 33406, -!- The enzyme is a member of the superfamily of S-adenosyl-L-methionine- dependent radical (radical AdoMet) enzymes. -!- Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. -!- The reaction is part of the biosynthesis pathway of pyrrolysine, a naturally occurring amino acid found in some archaeal methyltransferases., L-lysine = (3R)-3-methyl-D-ornithine., 6-deoxy-6-sulfo-D-fructose 1-phosphate = glycerone phosphate + 2-hydroxy- 3-oxopropane-1-sulfonate., Porphyromonas gingivalis W83, Ribulose-5-phosphate 3-epimerase, Putative fructose-bisphosphate aldolase, Phosphosulfolactate synthase., Outer surface protein, Brucella abortus 2308, Putative orotidine-monophosphate-decarboxylase, cellular response to UV-B, cellular response to fibroblast growth factor stimulus, cellular response to interleukin-1, negative regulation of cell growth, positive regulation of cell growth, positive regulation of epithelial cell proliferation, S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, tRNA 4-demethylwyosine synthase (AdoMet-dependent)., Bartonella henselae, Homo sapiens, L-lactate dehydrogenase (cytochrome) activity, 2 5-aminolevulinate = porphobilinogen + 2 H(2)O., porphobilinogen synthase activity, 3-deoxy-7-phosphoheptulonate synthase activity, N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate., identical protein binding, (S)-dihydroorotate + a quinone = orotate + a quinol., DHOD. DHODase. DHOdehase. Dihydoorotic acid dehydrogenase. Dihydroorotate dehydrogenase. Dihydroorotate oxidase., UMP biosynthetic process, 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6- enoyl-CoA + acetate., 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase., Anaerococcus prevotii DSM 20548, Ribulose-phosphate 3-epimerase., GMP metabolic process, lipid metabolic process, manganese ion binding, Uncharacterized protein TM_1410, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity, Thiazole synthase, GTP 3',8-cyclase., 3,4-dihydroxybenzoate biosynthetic process, 3-dehydroquinate dehydratase activity, 3-dehydroquinate dehydratase., fructose metabolic process, fructose-bisphosphate aldolase activity, gluconeogenesis, nicotinate-nucleotide diphosphorylase (carboxylating) activity, Tagatose-bisphosphate aldolase., alpha-galactosidase activity, glycosphingolipid metabolic process, lysosomal lumen, oligosaccharide metabolic process, Orotate phosphoribosyltransferase., Uridine 5'-monophosphate synthase, (5S)-5-amino-3-oxohexanoate + acetyl-CoA = L-3-aminobutanoyl-CoA + acetoacetate., Neisseria meningitidis MC58, ADH synthase., L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + 2,3- dioxopropylaldehyde phosphate., 2-dehydro-3-deoxy-phosphogluconate aldolase., Pseudomonas putida KT2440, Thermus thermophilus HB8, ubiquitin protein ligase binding, -!- The enzyme is a member of the superfamily of S-adenosyl-L-methionine- dependent radical (radical AdoMet) enzymes. -!- Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. -!- The S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction. -!- The reaction is part of the biosynthesis pathway of queuosine., 6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH(3)., protein oligomerization, -!- The animal enzyme requires acetyl-CoA., Putative uncharacterized protein, Trypanosoma cruzi strain CL Brener, Transaldolase., Deoxyribose-phosphate aldolase., -!- Belongs in the alpha-aminoadipate pathway of lysine synthesis, along with EC 4.2.1.36. -!- Also acts with oxaloacetate as substrate, but more slowly. -!- Formerly EC 4.1.3.21., Homocitrate synthase, mitochondrial, lysine biosynthetic process, -!- Most forms of the enzyme can rapidly hydrolyze 1,6-alpha-D-glucosidic bonds when the next bond in the sequence is 1,4, and some preparations of this enzyme hydrolyze 1,6- and 1,3-alpha-D-glucosidic bonds in other polysaccharides. -!- This entry covers all such enzymes acting on polysaccharides more rapidly than on oligosaccharides. -!- EC 3.2.1.20 from mammalian intestine can catalyze similar reactions., response to drug, response to organic cyclic compound, Ribulose-phosphate 3-epimerase, chloroplastic, protein complex, carboxy-lyase activity, 2-keto-4-hydroxyglutarate aldolase. 2-oxo-4-hydroxyglutarate aldolase. 4-hydroxy-2-oxoglutarate glyoxylate-lyase. KHG-aldolase. KHGA., 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate., Deinococcus radiodurans R1, Plasmodium falciparum, pentose-phosphate shunt, non-oxidative branch, fructose 6-phosphate aldolase activity, Thermus thermophilus, 3-dehydro-L-gulonate-6-phosphate decarboxylase., 3-keto-L-gulonate-6-phosphate decarboxylase UlaD, -!- Also acts on dihydrothymine., Dihydropyrimidine dehydrogenase (NADP(+))., Sus scrofa, Pyridoxal 5'-phosphate synthase subunit PDX1.3, chlorophyll metabolic process, response to lipid hydroperoxide, XMP biosynthetic process, Retaining alpha-galactosidase, A nitroalkane + H(2)O + O(2) = an aldehyde or ketone + nitrite + H(2)O(2)., Candida glabrata CBS 138, thiamine-phosphate diphosphorylase activity, Acting on a sulfur group of donors., pyridoxal phosphate biosynthetic process, Francisella tularensis subsp. tularensis SCHU S4, Nicotinate-nucleotide pyrophosphorylase, Ethanolamine ammonia-lyase., -!- The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi- functional protein complex composed of two subunits. -!- One subunit catalyzes the reactions EC 1.1.1.100 and EC 2.3.1.41, while the other subunit catalyzes the reactions of EC 2.3.1.38, EC 2.3.1.39, EC 4.2.1.59, EC 1.3.1.10 and EC 1.1.1.279. -!- The enzyme differs from the animal enzyme (EC 2.3.1.85) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid., Acyl carrier protein malonyltransferase. Malonyl coenzyme A-acyl carrier protein transacylase. Malonyl transacylase. Malonyl transferase. Malonyl-CoA-acyl carrier protein transacylase. Malonyl-CoA/dephospho-CoA acyltransferase. MCAT., Acyl-[acyl-carrier-protein] hydrolase. S-acyl fatty acid synthase thioesterase., Yeast fatty acid synthase., [acyl-carrier-protein] S-acetyltransferase activity, [acyl-carrier-protein] S-malonyltransferase activity, long-chain fatty acid biosynthetic process, Mll9387 protein, Thermus caldophilus, Putative fructose-1,6-bisphosphate aldolase, Haemophilus influenzae Rd KW20, rRNA base methylation, Nicotinate-nucleotide diphosphorylase, Alpha-galactosidase 1, 2-dehydro-3-deoxy-L-arabinonate dehydratase activity, glycolate oxidase activity, D-tagatose-1,6-bisphosphate aldolase subunit GatZ, Shewanella oneidensis MR-1, Metallosphaera sedula DSM 5348, Sulfolobus solfataricus 98/2, Caenorhabditis elegans, L(+)-mandelate dehydrogenase. MDH., Dihydroorotate dehydrogenase (NAD(+))., vacuolar membrane, Helicobacter pylori 51, -!- A single glycine residue in EC 2.3.1.54 is oxidized to the corresponding radical by transfer of H from its CH(2) to AdoMet with concomitant cleavage of the latter. -!- The first stage is reduction of the AdoMet to give methionine and the 5'-deoxyadenosin-5'-yl radical, which then abstracts a hydrogen radical from the glycine residue., 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating). Alpha-IPM synthetase. Alpha-isopropylmalate synthase. Alpha-isopropylmalate synthetase. Alpha-isopropylmalic synthetase. Isopropylmalate synthase. Isopropylmalate synthetase., Lactobacillus acidophilus NCFM, response to raffinose, Capsule biosynthesis protein, apical cytoplasm, Pyrobaculum neutrophilum V24Sta, Homocitrate synthase, biotin metabolic process, Biotin synthase, Mycobacterium avium 104, Chlorobaculum parvum NCIB 8327, Lactobacillus brevis ATCC 367, D-allose catabolic process, (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate., 2-dehydro-3-deoxy-6-phosphogalactonate aldolase., Picrophilus torridus DSM 9790, aldehyde-lyase activity, glucose catabolic process, Escherichia coli IAI1, Putative N-acetylmannosamine-6-phosphate 2-epimerase 2, Tagatose 1,6-diphosphate aldolase 1, Thiazole tautomerase., [Ruminococcus] gnavus, Hydroxymethylglutaryl-CoA lyase, Glutamate synthase [NADPH] large chain, Triosephosphate isomerase, chloroplastic, glycerol catabolic process, triglyceride mobilization, tRNA dihydrouridine synthase activity, tRNA dihydrouridine synthesis, tRNA-dihydrouridine(16) synthase, glyoxylate catabolic process, 3-phosphoshikimate 1-carboxyvinyltransferase., Vibrio fischeri ES114, 2 iron, 2 sulfur cluster binding, S-adenosyl-L-methionine-dependent 2-deoxy-scyllo-inosamine dehydrogenase, 2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy- scyllo-inosose + 5'-deoxyadenosine + L-methionine., Streptomyces sp. Mg1, Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)', Tagatose-6-phosphate kinase., -!- The enzyme, characterized from the bacterium Escherichia coli, is involved in the degradation pathway of sulfoquinovose, the polar headgroup of sulfolipids found in the photosynthetic membranes of all higher plants, mosses, ferns, algae, and most photosynthetic bacteria, as well as the surface layer of some archaea., Sulfofructosephosphate aldolase, Anaerobic sulfatase-maturating enzyme, Haemophilus somnus 129PT, Chromobacterium violaceum ATCC 12472, cartilage development, hyaluronan catabolic process, hyalurononglucosaminidase activity, -!- The enzyme acts on the hydroxy group of the hydrated derivative of the substrate. -!- Formerly EC 1.2.1.14., protein binding, (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+)., 8-((1R,2R)-3-oxo-2-((Z)-pent-2-enyl)cyclopentyl)octanoate + NADP(+) = (15Z)-12-oxophyto-10,15-dienoate + NADPH., Solanum lycopersicum, 2-dehydro-3-deoxy-phosphoheptonate aldolase. 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase. 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase. 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase. 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase. 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating). 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating). D-erythrose-4-phosphate-lyase. D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating). DAH7-P synthase. DAHP synthase. Deoxy-D-arabino-heptulosonate-7-phosphate synthetase. DHAP synthase. DS-Co. DS-Mn. KDPH synthase. KDPH synthetase. Phospho-2-dehydro-3-deoxyheptonate aldolase. Phospho-2-keto-3-deoxyheptanoate aldolase. Phospho-2-keto-3-deoxyheptonate aldolase. Phospho-2-keto-3-deoxyheptonic aldolase. Phospho-2-oxo-3-deoxyheptonate aldolase., chorismate biosynthetic process, Triose-phosphate isomerase., N-acetylneuraminate pyruvate-lyase. N-acetylneuraminic acid aldolase., (1) 4-amino-2-methyl-5-diphosphomethylpyrimidine + 2-((2R,5Z)-2-carboxy- 4-methylthiazol-5(2H)-ylidene)ethyl phosphate = diphosphate + thiamine phosphate + CO(2). (2) 4-amino-2-methyl-5-diphosphomethylpyrimidine + 2-(2-carboxy-4- methylthiazol-5-yl)ethyl phosphate = diphosphate + thiamine phosphate + CO(2). (3) 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5- (2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate., Bacillus subtilis subsp. subtilis str. 168, Thermotoga maritima MSB8, -!- This Class 2 dihydroorotate dehydrogenase enzyme contains FMN. -!- The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane. -!- The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. -!- The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates. -!- Methyl-, ethyl-, tert-butyl and benzyl-(S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not. -!- Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- Formerly EC 1.3.99.11., Dihydroorotate dehydrogenase (quinone), Dihydroorotate dehydrogenase (quinone)., Escherichia coli K-12, 'de novo' pyrimidine nucleobase biosynthetic process, -!- The enzyme from higher eukaryotes is identical with EC 2.4.2.10., Orotidine 5'-phosphate = UMP + CO(2)., Orotidine 5'-phosphate decarboxylase, Indoleglycerol phosphate synthetase., protein tetramerization, -!- Formerly EC 4.2.1.52., 4-hydroxy-tetrahydrodipicolinate synthase, diaminopimelate biosynthetic process, lyase activity, 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-[sulfur- carrier protein ThiS] = 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)- ylidene)ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H(2)O., L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H(2)O., glycosome, triose-phosphate isomerase activity, Nicotinate-nucleotide diphosphorylase (carboxylating)., Nicotinate-nucleotide pyrophosphorylase [carboxylating], Aldolase. D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase. Fructose-1,6-bisphosphate triosephosphate-lyase., Thermoproteus tenax Kra 1, Chromate reductase, Alpha-galactosidase., Melibiase., glycosphingolipid catabolic process, lysosome, -!- The enzyme from higher eukaryotes also catalyzes the reaction listed as EC 4.1.1.23., NADPH binding, -!- Formerly EC 4.1.3.19., 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase, -!- The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55). -!- Also acts on 2-oxobutanoate., XenA, nucleoplasm, Pyruvate carboxylase., Niacin ribonucleotidase. Nicotinic acid mononucleotide glycohydrolase. Nicotinic acid mononucleotide pyrophosphorylase. Nicotinic acid phosphoribosyltransferase., Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(2)O = beta- nicotinate D-ribonucleotide + diphosphate + ADP + phosphate., 7-carboxy-7-carbaguanine synthase., NAD metabolic process, protein homooligomerization, Thermoplasma acidophilum DSM 1728, Acting on the CH-CH group of donors., Homocitrate synthase., Pseudomonas putida, Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D- glucose., calcium ion binding, NADPH dehydrogenase, regulation of mitochondrial fission, 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity, Sulfolobus solfataricus, Fructose-bisphosphate aldolase C, Solanum tuberosum, Pseudomonas sp. CF600, deoxyribonucleotide catabolic process, Tritrichomonas suis, Pyrobaculum aerophilum str. IM2, Pentaerythritol tetranitrate reductase, N-(5'-phosphoribosyl)anthranilate isomerase, 5-dehydro-4-deoxyglucarate dehydratase., Artemisinic aldehyde Delta(11(13)) reductase, Artemisinic aldehyde Delta(11(13)) reductase., Pyrococcus furiosus DSM 3638, Transaldolase B, Fructose-6-phosphate aldolase 1, Acylglucosamine phosphate 2-epimerase. Acylglucosamine-6-phosphate 2-epimerase. Acylmannosamine phosphate 2-epimerase. N-acetylglucosmamine 6-phosphate 2-epimerase. N-acetylmannosamine-6-phosphate 2-epimerase., Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819, 5,6-dihydrouracil + NADP(+) = uracil + NADPH., Dihydropyrimidine dehydrogenase [NADP(+)], NADP binding, dihydropyrimidine dehydrogenase (NADP+) activity, Nitroalkane oxidase., -!- Cf. EC 3.2.1.62., Dehydrogenase, raffinose catabolic process, stachyose metabolic process, Burkholderia pseudomallei 1710b, Leishmania major, Transferred entry: 1.3.98.1., Leishmania donovani, Clostridium subterminale, Lactococcus lactis subsp. cremoris MG1363, Oryza sativa Japonica Group, Biotin synthase., Staphylococcus aureus subsp. aureus COL, ethanolamine ammonia-lyase complex, Enoyl-ACP reductase. NADH-enoyl acyl carrier protein reductase. NADH-specific enoyl-ACP reductase., Fatty acid synthase subunit beta, enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity, Ferredoxin-dependent glutamate synthase., 3-hexulose-6-phosphate synthase, ATP binding, positive regulation by host of viral process, Paraburkholderia xenovorans LB400, -!- Best substrates for reduction contain a 2,4-diene structure with chain length C(8) or C(10)., (1) 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine(2503) in 23S rRNA + 2 oxidized [2Fe- 2S] ferredoxin. (2) 2 S-adenosyl-L-methionine + adenine(37) in tRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine(37) in tRNA + 2 oxidized [2Fe-2S] ferredoxin., Methyltransferases., Gluconobacter oxydans, Clostridioides difficile 630, Klebsiella pneumoniae subsp. pneumoniae MGH 78578, ribulose-phosphate 3-epimerase activity, Rhodopseudomonas palustris CGA009, 2-keto-3-deoxy-L-arabinonate dehydratase., Hydroxyacid oxidase 1, glycolate catabolic process, (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor., Colwellia psychrerythraea 34H, Streptococcus pyogenes NZ131, Lactococcus lactis subsp. lactis Il1403, apoplast, Pyruvate formate-lyase 1-activating enzyme, RmpD, Acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O = (2S)-2-isopropylmalate + CoA., leucine biosynthetic process, 4-hydroxy-2-oxoglutarate aldolase/2-deydro-3-deoxyphosphogluconate aldolase, -!- Previously classified as EC 1.13.11.32, but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms. -!- The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor. -!- Neither hydrogen peroxide nor superoxide were detected during enzyme turnover. -!- Active toward linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, toward propyl-2-nitronate. -!- The enzyme from N.crassa can also utilize neutral nitroalkanes, but with lower activity. -!- Formerly EC 1.13.11.32., NosL, Agrobacterium tumefaciens, Lactobacillus brevis ATCC 14869 = DSM 20054, Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate., Escherichia coli O104:H4 str. 2009EL-2071, Inosine-5'-monophosphate dehydrogenase 1, nucleic acid binding, allulose 6-phosphate 3-epimerase activity, 2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate., Thermus aquaticus, Phospho-2-dehydro-3-deoxyheptonate aldolase AroG, Phosphotagatokinase., Sinorhizobium meliloti 1021, Leishmania infantum, Phosphosulfolactate synthase, Hahella chejuensis KCTC 2396, Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, Gemmata obscuriglobus, chondroitin sulfate catabolic process, hyaluronan metabolic process, hyaluronan synthase activity, positive regulation of growth, xylulose biosynthetic process, chloroplast organization, glyceraldehyde-3-phosphate biosynthetic process, -!- The hydrogen atoms on C-7 of the substrate are retained on C-2 of the products. -!- Formerly EC 4.6.1.3., Chlamydomonas reinhardtii, 2-dehydro-3-deoxy-6-phosphogalactonate aldolase, Oxo-acid-lyases., -!- The enzyme catalyzes the asymmetric condensation and cyclization of two 5-aminolevulinate molecules, which is the first common step in the biosynthesis of tetrapyrrole pigments such as porphyrin, chlorophyll, vitamin B12, siroheme, phycobilin, and cofactor F430. -!- The enzyme is widespread, being essential in organisms that carry out respiration, photosynthesis, or methanogenesis. -!- In humans, the enzyme is a primary target for the environmental toxin Pb. -!- The enzymes from some organisms utilize a dynamic equilibrium between architecturally distinct multimeric assemblies as a means for allosteric regulation., Aminolevulinate dehydratase. Delta-aminolevulinic acid dehydratase., -!- The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. -!- Molecular oxygen can replace fumarate in vitro. -!- Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. -!- Formerly EC 1.3.3.1., DHOD. DHOdehase. DHODH., -!- Formerly EC 4.1.2.16., Aquifex aeolicus VF5, Thiamine-phosphate synthase, Orotidine-5'-phosphate decarboxylase., -!- Also acts on the hydroxy derivative of farnesoyl-CoA., 3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase, IMP dehydrogenase/GMP reductase, -!- Involved in the biosynthetic pathway of the aminoglycoside antibiotics of the butirosin family. -!- The enzyme from Bacillus circulans was shown to be a radical S-adenosyl-L-methionine (SAM) enzyme. -!- Cf. EC 1.1.1.329., NAD(P)H:flavin oxidoreductase Sye4, Enoyl-(Acyl-carrier-protein) reductase II, 2-isopropylmalate synthase (Alpha-isopropylmalate synthase Alpha-IPM synthetase), Hydroxymethylglutaryl-CoA lyase., hydroxymethylglutaryl-CoA lyase activity, Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH., -!- The enzyme catalyzes an early step in the biosynthesis of the molybdenum cofactor (MoCo). -!- The enzyme belongs to the superfamily of radical S-adenosyl-L- methionine (radical SAM) enzymes. -!- Formerly EC 4.1.99.18., GTP + S-adenosyl-L-methionine + reduced electron acceptor = (8S)-3',8- cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor., Staphylococcus aureus subsp. aureus N315, ATPase binding, fructose binding, Trimethylamine + H(2)O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein., Cytochrome b2. L-lactate ferricytochrome c oxidoreductase. Lactic acid dehydrogenase., mitochondrial intermembrane space, mitochondrion, 12-oxophytodienoate reductase., -!- Formerly EC 4.1.2.15., 3-deoxy-7-phosphoheptulonate synthase., Pyrococcus woesei, OPRT. Orotidine-5'-phosphate diphosphorylase. Orotidine-5'-phosphate pyrophosphorylase. Orotidylic acid phosphorylase., orotate phosphoribosyltransferase activity, IPP isomerase. Isopentenylpyrophosphate Delta-isomerase. Isopentenylpyrophosphate isomerase. Methylbutenylpyrophosphate isomerase., -!- The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. -!- In the direction of aldol synthesis the enzyme catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D- galactonate at a similar ratio. -!- It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. -!- Cf. EC 4.1.2.14., 2-dehydro-3-deoxy-phosphogluconate aldolase activity, NADPH + acceptor = NADP(+) + reduced acceptor., -!- Also converts D-erythrose 4-phosphate into D-erythrulose 4-phosphate and D-threose 4-phosphate., Ribulose-phosphate 3-epimerase, Dihydroorotate dehydrogenase (quinone), mitochondrial, 4 iron, 4 sulfur cluster binding, 7-carboxy-7-deazaguanine synthase, NAD biosynthesis via nicotinamide riboside salvage pathway, cell junction, circadian rhythm, nuclear speck, -!- The enzyme from the bacterium Pseudomonas putida is also stimulated by NADH. -!- In some bacterial species, the enzyme forms a bifunctional complex with EC 1.2.1.10. -!- The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.43., 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde., Dihydroxyacetone transferase. Glycerone transferase., Probable transaldolase, Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate., (S)-2-hydroxy-acid oxidase activity, mandelate metabolic process, Pyridoxal 5'-phosphate synthase subunit SNZ1, pyridoxine biosynthetic process, growth, D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate., -!- The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2., Glycerone phosphate + acetyl-CoA = 3-hydroxy-5-phosphonooxypentane-2,4- dione + coenzyme A., cadherin binding, muscle cell cellular homeostasis, ubiquinone binding, 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase, 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase., tertiary granule lumen, Synechocystis sp. PCC 6803 substr. Kazusa, cellular response to DNA damage stimulus, deoxyribose-phosphate aldolase activity, Tryptophan biosynthesis protein TrpCF, Oxaloacetate decarboxylase., Borrelia burgdorferi B31, -!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.1.48, EC 4.1.3.27, and EC 4.2.1.20)., 5-keto-4-deoxy-glucarate dehydratase. D-4-deoxy-5-ketoglucarate hydro-lyase., Artemisia annua, sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity, Pyruvic carboxylase., Rhizobium etli CFN 42, -!- The enzyme, which is involved in pyridine nucleotide recycling, can form beta-nicotinate D-ribonucleotide and diphosphate from nicotinate and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) in the absence of ATP. -!- However, when ATP is available the enzyme is phosphorylated resulting in a much lower K(m) for nicotinate. -!- The phospho-enzyme is hydrolyzed during the transferase reaction, regenerating the low affinity form. -!- The presence of ATP shifts the products/substrates equilibrium from 0.67 to 1100. -!- Formerly EC 2.4.2.11., Enterococcus faecalis V583, Kdo2-lipid A biosynthetic process, carbon utilization, lipopolysaccharide biosynthetic process, Galactosylceramidase., Encephalitozoon cuniculi GB-M1, Chorismate = prephenate., Chorismate mutase., hydroxyethylthiazole kinase activity, 3-hexulose phosphate synthase. 3-hexulosephosphate synthase. D-arabino-3-hexulose 6-phosphate formaldehyde-lyase. HPS., Corynebacterium glutamicum ATCC 13032, tRNA binding, tRNA-dihydrouridine synthase 2., Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic, Shikimate + NADP(+) = 3-dehydroshikimate + NADPH., Glucan 1,4-alpha-glucosidase SusB, Thermoanaerobacter pseudethanolicus ATCC 33223, Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier- protein]., Enoyl-[acyl-carrier-protein] reductase (NADH)., fatty acid synthase complex, 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase, 3-dehydro-L-gulonate-6-phosphate decarboxylase activity, mitotic G2 DNA damage checkpoint, 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H(+)., cellular amino acid metabolic process, Old yellow enzyme, Dihydrodipicolinate synthase, -!- While nitroethane may be the physiological substrate, the enzyme also acts on several other nitroalkanes, including 1-nitropropane, 2-nitropropane, 1-nitrobutane, 1-nitropentane, 1-nitrohexane, nitrocyclohexane and some nitroalkanols. -!- Differs from EC 1.13.12.16 in that the preferred substrates are neutral nitroalkanes rather than anionic nitronates., 12-oxophytodienoate reductase 3, Saccharomyces cerevisiae, Leptospira interrogans serovar Lai str. 56601, Transferred entry: 4.3.3.7., L-arabinose catabolic process to 2-oxoglutarate, Sulfolobus acidocaldarius DSM 639, NADH:flavin oxidoreductase Sye1, Dihydroorotate dehydrogenase A (fumarate), glutaminase activity, amine-lyase activity, response to cytokinin, 2-isopropylmalate synthase., Inosine-5-monophosphate dehydrogenase, Probable dihydrodipicolinate synthetase, [formate-C-acetyltransferase]-activating enzyme activity, Putative nicotinate phosphoribosyltransferase, Nitronate monooxygenase., keto-3-deoxy-D-manno-octulosonic acid biosynthetic process, actin polymerization or depolymerization, actin filament binding, positive regulation of ATP biosynthetic process, Fructose-1,6-bisphosphate aldolase, class II, Alpha-N-acetylgalactosaminidase, Alpha-galactosidase B. Alpha-GalNAcase. Alpha-NAGA., 4-Hydroxy-2-oxoglutarate aldolase, negative regulation of gene expression, pyruvate carboxylase activity, viral RNA genome packaging, 4-enoyl-CoA reductase (NADPH)., GMP reductase 1, Indole-3-glycerol-phosphate lyase., Bacillus cereus ATCC 10987, Bifunctional alpha-galactosidase/sucrose kinase AgaSK, Transferring phosphorus-containing groups., nucleotidyltransferase activity, Brucella melitensis bv. 1 str. 16M, Orotidine 5'-phosphate decarboxylase, putative, Burkholderia thailandensis E264, ergot alkaloid biosynthetic process, Orotidine-5'-phosphate decarboxylase, myofibril, stamen development, Spinacia oleracea, DHOD. DHODase. DHOdehase. Dihydroorotate oxidase. Orotate reductase (NADH(2)). Orotate reductase (NADH)., pyruvate biosynthetic process, Enoyl-[acyl-carrier-protein] reductase [FMN], 3-dehydroquinate synthetase. 5-dehydroquinate synthase. 5-dehydroquinic acid synthetase. Dehydroquinate synthase., 2-dehydro-3-deoxyphosphogluconate aldolase, Tenebrio molitor, Chondroitinase. Chondroitinase I. Hyaluronidase. Hyaluronoglucosidase., Hyaluronoglucosaminidase., Pyrobaculum calidifontis JCM 11548, Flavin reductase (NADPH)., Reduced riboflavin + NADP(+) = riboflavin + NADPH., Sebaldella termitidis ATCC 33386, Jonesia denitrificans DSM 20603, intramolecular transferase activity, ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate., Streptomyces ansochromogenes, Cryptococcus neoformans, tRNA-dihydrouridine synthase, sulfopyruvate decarboxylase activity, Probable spore coat polysaccharide biosynthesis protein E, cellular response to pH, hyaluronan biosynthetic process, inflammatory response, positive regulation of angiogenesis, response to reactive oxygen species, -!- This enzyme, which is a member of the superfamily of S-adenosyl-L- methionine-dependent radical (radical AdoMet) enzymes, binds two [4Fe-4S] clusters. -!- Carbons C(2) and C(3) from pyruvate are incorporated into 4-demethylwyosine. -!- The enzyme is found in eukaryotes where it is part of the pathway for wybutosine synthesis, and in archaea, where it is involved in the biosynthesis of archaeal wye bases, such as wyosine, isowyosine, and methylwyosine., Oxaloacetate decarboxylase, Morphinone reductase, oxalate metabolic process, IMP oxidoreductase. Inosinate dehydrogenase. Inosine 5'-monophosphate dehydrogenase. Inosine monophosphate oxidoreductase. Inosinic acid dehydrogenase., extracellular exosome, ficolin-1-rich granule lumen, neutrophil degranulation, Cytochrome b2, mitochondrial, mitochondrial inner membrane, -!- Also acts on N-glycoloylneuraminate, and on O-acetylated sialic acids, other than 4-O-acetylated derivatives., Imidazole glycerol phosphate synthase subunit HisF, membrane, isoprenoid catabolic process, Bacillus circulans, Coccidioides immitis, Ruegeria pomeroyi, Streptococcus pyogenes serotype M1, GMP reductase 2, purine-containing compound salvage, 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C- (3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O., Indole-3-glycerol phosphate synthase, (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate., (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase. 3-hydroxy-3-methylglutarate-CoA lyase. HMG-CoA lyase., metal ion binding, 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D- ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1- deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide., histidine biosynthetic process, Helicobacter pylori 26695, Triosephosphate isomerase, glycosomal, Indoleglycerol phosphate aldolase. L-tryptophan synthetase. Tryptophan desmolase. Tryptophan synthetase., Thermus thermophilus HB27, glycolytic process, NAD biosynthetic process, NADH oxidation, canonical glycolysis, -!- A number of alkyl-substituted derivatives of trimethylamine can also act as electron donors. -!- Phenazine methosulfate and 2,6-dichloroindophenol can act as electron acceptors. -!- Formerly EC 1.5.99.7., 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase., Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate., Sulfolobus shibatae, Aldehyde-lyases., aldonic acid catabolic process, 2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate- lyase. 2-keto-3-deoxy-6-phosphogluconate aldolase. KDPG-aldolase. Phospho-2-dehydro-3-deoxygluconate aldolase. Phospho-2-keto-3-deoxygluconate aldolase., Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)., Pyridoxal 5'-phosphate synthase subunit PdxS, -!- FMN in yeasts; FAD in plants., (11R)-dihydroartemisinic aldehyde + NADP(+) = artemisinic aldehyde + NADPH., Pyruvate carboxylase, 7-carboxy-7-deazaguanine synthase., positive regulation of cell proliferation, positive regulation of transcription from RNA polymerase II promoter, (S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate., NADPH dehydrogenase 1, Staphylococcus aureus subsp. aureus NCTC 8325, Shewanella frigidimarina, (S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2)., Schizosaccharomyces pombe 972h-, Golgi apparatus, Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha- D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids., catalytic activity, tRNA-dihydrouridine(20) synthase (NAD(P)(+))., -!- NAD(+) cannot replace NADP(+). -!- In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10., Shikimate dehydrogenase., 4-alpha-D-glucan glucohydrolase. Amyloglucosidase. Exo-1,4-alpha-glucosidase. Gamma-amylase. Glucoamylase. Lysosomal alpha-glucosidase., starch catabolic process, Giardia intestinalis, positive regulation of smooth muscle cell proliferation, actin filament organization, Transaldolase, Phosphoribosyl isomerase A, -!- In the archaeon Sulfolobus solfataricus the enzyme is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. -!- It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro- 3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency. -!- In vitro the enzyme can also catalyze the cleavage of the non- phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3- deoxy-D-galactonate with much lower catalytic efficiency. -!- Cf. EC 4.1.2.21 and EC 4.1.2.14., aromatic compound catabolic process, -!- The enzyme from Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA. -!- The process is accompanied by the extrusion of two sodium ions from cells. -!- Some animal enzymes require manganese., 4-hydroxy-2-oxoglutarate aldolase activity, KHG/KDPG aldolase, Keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase, Glutamate synthase (ferredoxin)., endomembrane system, response to non-ionic osmotic stress, Streptococcus pyogenes MGAS10750, Geobacillus kaustophilus HTA426, Clostridium perfringens ATCC 13124, nitronate monooxygenase activity, Pseudomonas aeruginosa PAO581, galactosylceramide catabolic process, Oleispira antarctica, fumarate metabolic process, Trypanosoma cruzi, Dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin., Orotidine 5' monophosphate decarboxylase, Ethanolamine = acetaldehyde + NH(3)., -!- Essential, along with EC 2.3.1.38, for the initiation of fatty-acid biosynthesis in bacteria. -!- Also provides the malonyl groups for polyketide biosynthesis. -!- The product of the reaction, malonyl-ACP, is an elongation substrate in fatty-acid biosynthesis. -!- In Mycobacterium tuberculosis, holo-ACP (the product of EC 2.7.8.7) is the preferred substrate. -!- This enzyme also forms part of the multienzyme complexes EC 4.1.1.88 and EC 4.1.1.89. -!- Malonylation of ACP is immediately followed by decarboxylation within the malonate-decarboxylase complex to yield acetyl-ACP, the catalytically active species of the decarboxylase. -!- In the enzyme from Klebsiella pneumoniae, methylmalonyl-CoA can also act as a substrate but acetyl-CoA cannot whereas the enzyme from Pseudomonas putida can use both as substrates. -!- The ACP subunit found in fatty-acid biosynthesis contains a pantetheine-4'-phosphate prosthetic group; that from malonate decarboxylase also contains pantetheine-4'-phosphate but in the form of a 2'-(5-triphosphoribosyl)-3'-dephospho-CoA prosthetic group., -!- This enzyme is responsible for the dehydration step of the dissociated (type II) fatty-acid biosynthesis system that occurs in plants and bacteria. -!- The enzyme uses fatty acyl thioesters of ACP in vivo. -!- Different forms of the enzyme may have preferences for substrates with different chain length. -!- For example, the activity of FabZ, the ubiquitous enzyme in bacteria, decreases with increasing chain length. -!- Gram-negative bacteria that produce unsaturated fatty acids, such as Escherichia coli, have another form (FabA) that prefers intermediate chain length, and also catalyzes EC 5.3.3.14. -!- Despite the differences both forms can catalyze all steps leading to the synthesis of palmitate (C16:0). -!- FabZ, but not FabA, can also accept unsaturated substrates. -!- Formerly EC 4.2.1.58, EC 4.2.1.60 and EC 4.2.1.61., Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate., Oleoyl-[acyl-carrier-protein] hydrolase., palmitoyltransferase activity, 3-dehydro-L-gulonate 6-phosphate = L-xylulose 5-phosphate + CO(2)., 3-dehydro-L-gulonate-6-phosphate carboxy-lyase. 3-keto-L-gulonate 6-phosphate decarboxylase. KGPDC., L-ascorbic acid catabolic process, Drosophila melanogaster, flavin adenine dinucleotide binding, 2,4-dienoyl-CoA reductase (NADPH) activity, fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway, Anabaena variabilis ATCC 29413, Moritella marina, Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841, Coxiella burnetii RSA 493, N-ethylmaleimide reductase, 5-phosphoribose 1-diphosphate metabolic process, chronological cell aging, 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H(2)O., glyoxylate oxidase activity, L-lysine 2,3-aminomutase, Aeropyrum pernix K1, Ralstonia eutropha JMP134, Hexulose-6-phosphate synthase SgbH, putative, (S)-mandelate dehydrogenase., Acylneuraminate lyase, copper ion binding, plasmodesma, Xenobiotic reductase B, -!- Formerly EC 4.1.3.12., potassium ion binding, Streptomyces avermitilis MA-4680 = NBRC 14893, enzyme active site formation, Ethylnitronate + O(2) = acetaldehyde + nitrite + other products., Dihydrodipicolinate synthetase, entry into host cell, Mycobacterium gastri, DNA binding, Scheffersomyces stipitis CBS 6054, -!- The enzyme catalyzes the last reaction in a D-galactose degradation pathway. -!- Cf. EC 4.1.2.55., Shewanella benthica KT99, -!- The enzyme catalyzes the irreversible aromatization of the thiazole moiety of 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate., Thiazole tautomerase, melibiose catabolic process, Nicotinate-nucleotide diphosphorylase (Carboxylating), 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate., Aspergillus fumigatus A1163, Hyaluronidase, Cricetulus griseus, Burkholderia ambifaria MC40-6, 2-nitropropane dioxygenase, Aldolase, 2-dehydro-3-deoxy-phosphogluconate aldolase, Alpha-galactosidase AgaB, Vibrio cholerae O395, Methylornithine synthase., Fructose-bisphosphate aldolase, glycosomal, (2R)-2-O-phospho-3-sulfolactate = phosphoenolpyruvate + hydrogen sulfite., (2R)-phospho-3-sulfolactate synthase. PSL synthase., Burkholderia glumae BGR1, Paenarthrobacter aurescens TC1, Streptococcus pneumoniae TIGR4, cytoplasmic vesicle, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of epithelial cell migration, positive regulation of hyaluranon cable assembly, response to antibiotic, transcription factor binding, N(1)-methylguanine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + L-methionine + 5'-deoxyadenosine + CO(2) + H(2)O., microtubule organizing center, plasma membrane, -!- Also acts on (3S,4R)-ketose 1-phosphates. -!- The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc. -!- Formerly EC 4.1.2.7., Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH., cytoplasm, N-acetylneuraminate lyase activity, -!- Involved in the conversion of linolenate into jasmonate in Zea mays., porphyrin-containing compound biosynthetic process, heme biosynthetic process, D-glyceraldehyde 3-phosphate = glycerone phosphate., FMN binding, Thiamine phosphate synthase., Thiamine-phosphate diphosphorylase. Thiamine-phosphate pyrophosphorylase. Thiamine-phosphate synthase. TMP diphosphorylase. TMP pyrophosphorylase., Prochlorococcus marinus str. MIT 9312, Methanocaldococcus jannaschii DSM 2661, 2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolase, KDG-specific aldolase., Fructose-bisphosphate aldolase, 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase., Hydroxymethylglutaryl-CoA lyase, mitochondrial, ketone body biosynthetic process, peroxisome, protein homodimerization activity, receptor binding, Probable nicotinate-nucleotide pyrophosphorylase [carboxylating], GMP reductase., -!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.3.27, EC 4.2.1.20, and EC 5.3.1.24)., Indole-3-glycerol-phosphate synthase., 4-hydroxy-tetrahydrodipicolinate synthase., -!- Involved in histidine biosynthesis., 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase., N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4- imidazolecarboxamide isomerase. Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase., -!- H(2)S can provide the sulfur in vitro. -!- Part of the pathway for thiamine biosynthesis., Dihydroorotate dehydrogenase (fumarate), Glycolate oxidase. Hydroxy-acid oxidase A. Hydroxy-acid oxidase B., glutaminase complex, Uncharacterized protein, -!- Enzyme activity is stimulated by certain divalent cations. -!- Involved in the tagatose 6-phosphate pathway of lactose catabolism in bacteria., Thermus scotoductus, Pyridoxine 5'-phosphate synthase., Methanothermobacter thermautotrophicus str. Delta H, N-acetylneuraminate synthase., Polysialic acid capsule biosynthesis protein SiaC, platelet alpha granule lumen, regulation of cell shape, striated muscle contraction, female pregnancy, Streptomyces coelicolor A3(2), 2-keto-3-deoxygluconate aldolase., Trichoderma reesei, protoporphyrinogen IX biosynthetic process, Oxalate beta-decarboxylase. Oxaloacetate carboxy-lyase., Thermococcus kodakarensis KOD1, 5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + H(2)O + CO(2)., Probable 5-dehydro-4-deoxyglucarate dehydratase, Clostridioides difficile NAP08, Eremothecium gossypii ATCC 10895, Thermomonospora curvata DSM 43183, NMN diphosphorylase. NMN pyrophosphorylase., Saccharomyces pastorianus, Inosine-5'-monophosphate dehydrogenase, Burkholderia cenocepacia J2315, putative Kdpg (2-keto-3-deoxy-6-phosphogluconate) aldolase, Transferred entry: 1.3.5.2., 5,6-dihydrouracil(20) in tRNA + NAD(P)(+) = uracil(20) in tRNA + NAD(P)H., tRNA-dihydrouridine(20/20a) synthase, Mycobacterium tuberculosis CDC1551, chloroplast stroma, Bacillus anthracis, Ethanolamine ammonia-lyase heavy chain, -!- Acts on [acyl-carrier-protein] thioesters of fatty acids from C(12) to C(18), but the derivative of oleic acid is hydrolyzed much more rapidly than any other compound tested., -!- Essential, along with EC 2.3.1.39, for the initiation of fatty-acid biosynthesis in bacteria. -!- The substrate acetyl-CoA protects the enzyme against inhibition by N-ethylmaleimide or iodoacetamide. -!- This is one of the activities associated with EC 2.3.1.180., [Acyl-carrier-protein] S-malonyltransferase., Mesorhizobium loti MAFF303099, Hydroxymethylglutaryl-CoA lyase YngG, -!- Along with EC 5.1.3.22, this enzyme is involved in a pathway for the utilization of L-ascorbate by Escherichia coli., pyridoxine 5'-phosphate synthase activity, Ferredoxin-dependent glutamate synthase 2, Dihydrothymine dehydrogenase. Dihydrouracil dehydrogenase (NADP+)., Nicotinate-nucleotide pyrophosphorylase (Carboxylating), hyperosmotic salinity response, GMP biosynthetic process, Pseudomonas aeruginosa UCBPP-PA14, 2,4-dienoyl-CoA reductase (NADPH)., 2,4-dienoyl-CoA reductase [NADPH], Dual-specificity RNA methyltransferase RlmN, 2-dehydro-3-deoxy-L-arabinonate dehydratase., L-2-keto-3-deoxyarabonate dehydratase, Methylmalonyl-CoA carboxyltransferase. Transcarboxylase., -!- This enzyme is a member of the 'AdoMet radical' (radical SAM) family. -!- It contains pyridoxal phosphate and a [4Fe-4S] cluster and binds an exchangeable S-adenosyl-L-methionine molecule. -!- Activity in vitro requires a strong reductant such as dithionite and strictly anaerobic conditions. -!- A 5'-deoxyadenosyl radical is generated during the reaction cycle by reductive cleavage of S-adenosyl-L-methionine, mediated by the iron- sulfur cluster. -!- S-adenosyl-L-methionine is regenerated at the end of the reaction., (S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate., -!- The enzyme binds a [4Fe-4S] and a [2Fe-2S] cluster. -!- In every reaction cycle, the enzyme consumes two molecules of AdoMet, each producing 5'-deoxyadenosine and a putative dethiobiotinyl carbon radical. -!- Reaction with another equivalent of AdoMet results in abstraction of the C6 methylene pro-(S) hydrogen atom from 9-mercaptodethiobiotin, and the resulting carbon radical is quenched via formation of an intramolecular C-S bond, thus closing the biotin thiophane ring. -!- The sulfur donor is believed to be the [2Fe-2S] cluster, which is sacrificed in the process, so that in vitro the reaction is a single turnover. -!- In vivo, the [2Fe-2S] cluster can be reassembled by the Isc or Suf iron-sulfur cluster assembly systems, to allow further catalysis., Amycolatopsis orientalis subsp. vinearia, Escherichia coli str. K-12 substr. DH10B, determination of adult lifespan, response to cadmium ion, response to zinc ion, Quinolinate phosphoribosyltransferase, Streptococcus pneumoniae D39, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, 2-nitropropane dioxygenase. 2-NPD. Nitroalkane oxidase. NMO., Dihydrodipicolinate synthase/N-acetylneuraminate lyase, Streptomyces actuosus, Oxidoreductases., Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids., biotin binding, positive regulation by host of viral release from host cell, Slackia heliotrinireducens DSM 20476, Acting on carbohydrates and derivatives., Bacillus clausii KSM-K16, 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate = 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate., Glutamate synthase (NADPH)., -!- The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. -!- The enzyme catalyzes the reduction of chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde. -!- This hydrolyzes spontaneously to form 6,8-dimethyl-6,7- didehydroergoline, which is converted to festuclavine by EC 1.5.1.44., Chanoclavine-I aldehyde reductase., oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor, Coccidioides immitis RS, Hyaluronidase-1, cellular response to platelet-derived growth factor stimulus, hyaluranon cable, chloroplast envelope, glyoxylate metabolic process, Hyaluronidase A, Vespula vulgaris, ATP + shikimate = ADP + shikimate 3-phosphate., Pentafunctional AROM polypeptide, Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O- (1-carboxyvinyl)-3-phosphoshikimate., Shikimate kinase., Phosphoglycerate kinase., Chloroplast triosephosphate isomerase, D-galactonate catabolic process, (S)-dihydroorotate + fumarate = orotate + succinate., Dihydroorotate oxidase (fumarate)., 2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating). 2-dehydro-3-deoxy-phosphooctonate aldolase. 2-keto-3-deoxy-8-phosphooctonic synthetase. 3-deoxy-D-manno-octulosonate-8-phosphate synthase. 3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase. 3-deoxy-D-mannooctulosonate-8-phosphate synthetase. 3-deoxyoctulosonic 8-phosphate synthetase. KDO-8-P synthase. KDO-8-phosphate synthetase. KDOP synthase. Phospho-2-keto-3-deoxyoctonate aldolase., 3-deoxy-8-phosphooctulonate synthase., OMP decarboxylase. OMPdcase. Orotidine-5'-phosphate carboxy-lyase. Orotidylic decarboxylase. UMP synthase. Uridine 5'-monophosphate synthase., Spore coat polysaccharide biosynthesis protein SpsE, -!- The enzyme from Entamoeba histolytica reduces riboflavin and galactoflavin, and, more slowly, FMN and FAD. -!- NADH is oxidized more slowly than NADPH. -!- Formerly EC 1.6.8.2., Flavin mononucleotide reductase. Flavine mononucleotide reductase. FMN reductase (NADPH). NADPH dehydrogenase (flavin). NADPH-dependent FMN reductase. NADPH-flavin reductase. NADPH-FMN reductase. NADPH-specific FMN reductase. NADPH:flavin oxidoreductase. NADPH:riboflavin oxidoreductase. Riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase. Riboflavin mononucleotide reductase. Riboflavine mononucleotide reductase., Actinomyces urogenitalis DSM 15434, Streptococcus porcinus str. Jelinkova 176, Probable tagatose 6-phosphate kinase, Methanosarcina barkeri str. Fusaro, Sulfofructosephosphate aldolase., Putative 2-nitropropane dioxygenase, Guanosine 5'-monophosphate oxidoreductase. Guanosine 5'-monophosphate reductase. Guanosine 5'-phosphate reductase. Guanosine monophosphate reductase. Guanylate reductase. NADPH:GMP oxidoreductase (deaminating). NADPH:guanosine-5'-phosphate oxidoreductase (deaminating)., Sulfolobus solfataricus P2, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, protein homotetramerization, Thiazole synthase., Trypanosoma brucei brucei, 3-dehydroquinate = 3-dehydroshikimate + H(2)O., 3-dehydroquinate dehydratase, fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate, vacuolar proton-transporting V-type ATPase complex assembly, Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3- dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate., Nicotinate-nucleotide pyrophosphorylase (carboxylating). Quinolinate phosphoribosyltransferase (decarboxylating)., cell wall, Fructose-bisphosphate aldolase class 1, Trimethylamine dehydrogenase., IMP dehydrogenase activity, IMP dehydrogenase., nucleus, L-lactate dehydrogenase (cytochrome)., protein targeting to mitochondrion, 12-oxophytodienoate reductase 1, Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D- arabino-hept-2-ulosonate 7-phosphate + phosphate., Isopentenyl diphosphate = dimethylallyl diphosphate., isopentenyl-diphosphate delta-isomerase activity, -!- The enzyme, isolated from the bacteria Fusobacterium nucleatum and Cloacimonas acidaminovorans, is involved in the anaerobic fermentation of lysine., Candidatus Cloacimonas acidaminovorans str. Evry, Probable 2-keto-3-deoxy-galactonate aldolase YagE, Leishmania mexicana, -!- The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. -!- The enzyme can also catalyze the cleavage of fructose-1,6- bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. -!- Formerly EC 4.1.2.n5., Archaeoglobus fulgidus DSM 4304, -!- The ammonia is provided by the glutaminase subunit and channeled to the active site of the lyase subunit by a 100 A tunnel. -!- The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. -!- The enzyme complex is found in aerobic bacteria, archeae, fungi and plants., mitochondrial matrix, Aerococcus viridans, Pyrococcus horikoshii OT3, Pyridoxine biosynthesis protein PDX1, putative, 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase. Deoxyriboaldolase. Phosphodeoxyriboaldolase., Deoxyribose-phosphate aldolase, Streptococcus mutans UA159, Vibrio cholerae O1 biovar El Tor str. N16961, 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating). Acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase. Homocitrate synthetase., homocitrate synthase activity, D-tagatose-1,6-bisphosphate aldolase. D-tagatose-1,6-bisphosphate triosephosphate lyase. Tagatose 1,6-diphosphate aldolase., transferase activity, transferring acyl groups other than amino-acyl groups, hydrolase activity, 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H(2)O., Yersinia pestis, shikimate 3-dehydrogenase (NADP+) activity, actin binding, actin cytoskeleton, platelet degranulation, epithelial cell differentiation, Gallus gallus, Alpha-galactosidase, lactation, neuronal cell body, positive regulation of apoptotic process, response to L-arginine, phosphoribosylanthranilate isomerase activity, Enterobacter cloacae, oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor, N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate., extracellular space, cell-cell signaling, cytokine activity, -!- The protein is composed of two domains, one hydrolyzing L-glutamine to NH(3) and L-glutamate (cf. EC 3.5.1.2), the other combining the produced NH(3) with 2-oxoglutarate to produce a second molecule of L-glutamate. -!- The NH(3) is channeled through a 24 A channel in the active protein. -!- No hydrolysis of glutamine takes place without ferredoxin and 2-oxoglutarate being bound to the protein., response to oxidative stress, Geobacillus stearothermophilus, Corynebacterium efficiens YS-314, D-galactosyl-N-acylsphingosine + H(2)O = D-galactose + N-acylsphingosine., Galactocerebrosidase. Galactocerebroside beta-galactosidase. Galactosylceramide beta-galactosidase. Galcerase., Trichomonas vaginalis, Hydroxyphenylpyruvate synthase., D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde., Putative hexulose 6 phosphate synthase, 5-dehydroshikimate reductase. 5-dehydroshikimic reductase. Dehydroshikimic reductase. DHS reductase. Shikimate 5-dehydrogenase. Shikimate oxidoreductase. Shikimate:NADP(+) 5-oxidoreductase. Shikimate:NADP(+) oxidoreductase., Arabidopsis thaliana, embryo development ending in seed dormancy, Streptococcus suis GZ1, Rhipicephalus microplus, Tagatose 1,6-diphosphate aldolase, NADH:flavin oxidoreductase/NADH oxidase, (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase. Beta-hydroxyoctanoyl thioester dehydratase. Beta-hydroxyoctanoyl-ACP-dehydrase. Beta-hydroxyoctanoyl-acyl carrier protein dehydrase. D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase., -!- The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety. -!- The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18. -!- The enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons., 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity, ACAT. Acetyl coenzyme A-acyl-carrier-protein transacylase. ACP acetyltransferase. Acyl-carrier-protein acetyltransferase., Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier- protein]., circadian regulation of gene expression, -!- The human lysosomal enzyme is involved in the degradation of blood type A epitope., Bacillus cereus ATCC 14579, FAD binding, -!- This enzyme is a member of the 'AdoMet radical' (radical SAM) family. -!- S-adenosyl-L-methionine acts as both a radical generator and as the source of the appended methyl group. -!- RlmN first transfers an CH(2) group to a conserved cysteine (Cys(355) in Escherichia coli), the generated radical from a second S-adenosyl- L-methionine then attacks the methyl group, exctracting a hydrogen. -!- The formed radical forms a covalent intermediate with the adenine group of the tRNA. -!- RlmN is an endogenous enzyme used by the cell to refine functions of the ribosome in protein synthesis. -!- The enzyme methylates adenosine by a radical mechanism with CH(2) from the S-adenosyl-L-methionine and retention of the hydrogen at C-2 of adenosine(2503) of 23S rRNA. -!- It will also methylate 8-methyladenosine(2503) of 23S rRNA (cf. EC 2.1.1.224)., tRNA methylation, Deoxyribose-phosphate aldolase putative, Azospirillum brasilense, cellular nitrogen compound metabolic process, Transaldolase NQM1, L-lysine = (3S)-3,6-diaminohexanoate., Lysine 2,3-aminomutase., Escherichia coli O157:H7, intracellular, Methylmalonyl-CoA carboxytransferase., raffinose alpha-galactosidase activity, Neisseria gonorrhoeae FA 1090, -!- The reaction takes place in the opposite direction. -!- The protein is composed of two subunits, alpha and beta. -!- The alpha subunit is composed of two domains, one hydrolyzing L-glutamine to NH(3) and L-glutamate (cf. EC 3.5.1.2), the other combining the produced NH(3) with 2-oxoglutarate to produce a second molecule of L-glutamate (cf. EC 1.4.1.4). -!- The beta subunit transfers electrons to the cosubstrate. -!- The NH(3) is channeled through a 31 A channel in the active protein. -!- In the absence of the beta subunit, coupling between the two domains of the alpha subunit is compromised and some ammonium can be produced. -!- In the intact alpha-beta complex, ammonia production only takes place as part of the overall reaction. -!- Formerly EC 2.6.1.53., Aspergillus fumigatus Af293, Chanoclavine-I aldehyde reductase easA, (S)-dihydroorotate + NAD(+) = orotate + NADH., D-tagatose-1,6-bisphosphate aldolase subunit KbaY, tagatose-bisphosphate aldolase activity, Triosephosphate isomerase, cytosolic, Inosine 5'-monophosphate dehydrogenase, [Formate-C-acetyltransferase]-activating enzyme., Streptococcus mutans, Lactobacillus acidophilus, Plasmodium yoelii yoelii, 3-deoxy-8-phosphooctulonate synthase activity, Clostridium botulinum A str. Hall, biotin synthase activity, Oceanobacillus iheyensis HTE831, Listeria monocytogenes serotype 4b str. F2365, Streptomyces sviceus ATCC 29083, response to cold, -!- Forms part of the defense mechanism against insects and microbial pathogens in the grass family, Gramineae, where it catalyzes one of the steps in the formation of the cyclic hydroxamic acids 2,4- dihydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA) and 2,4-dihydroxy-7- methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA). -!- Resembles the alpha-subunit of EC 4.2.1.20 but, unlike tryptophan synthase, its activity is independent of the beta-subunit and free indole is released., Indole-3-glycerol phosphate lyase, chloroplastic, FMN-dependent nitronate monooxygenase, cellular response to tumor necrosis factor, multicellular organism reproduction, 3-dehydroquinate synthase., Bifunctional PGK/TIM, Ehrlichia chaffeensis str. Arkansas, Histamine dehydrogenase, Apis mellifera, Porphobilinogen synthase., dihydroorotate dehydrogenase activity, cytosol, 3-hydroxy-3-isohexenylglutaryl-CoA lyase., terpene catabolic process, Streptococcus pyogenes, 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)., Possible dihydrodipicoline synthase related protein, Litopenaeus vannamei, glycoside catabolic process, Nicotinate-nucleotide pyrophosphorylase, carboxylating, With other, known, acceptors., GMP reductase activity, DHDPS. Dihydrodipicolinate synthetase., Pyruvate + L-aspartate-4-semialdehyde = (4S)-4-hydroxy-2,3,4,5- tetrahydro-(2S)-dipicolinate + H(2)O., aromatic amino acid family biosynthetic process, -!- The alpha-subunit catalyzes the conversion of 1-C-(indol-3- yl)glycerol 3-phosphate to indole and D-glyceraldehyde 3-phosphate (this reaction was listed formerly as EC 4.1.2.8). -!- The indole migrates to the beta-subunit where, in the presence of pyridoxal 5'-phosphate, it is combined with L-serine to form L-tryptophan. -!- In some organisms this enzyme is part of a multifunctional protein that also includes one or more of the enzymes EC 2.4.2.18, EC 4.1.1.48, EC 4.1.3.27 and EC 5.3.1.24. -!- In thermophilic organisms, where the high temperature enhances diffusion and causes the loss of indole, a protein similar to the beta subunit can be found (EC 4.2.1.122). -!- That enzyme cannot combine with the alpha unit of EC 4.2.1.20 to form a complex., GTP 3',8-cyclase, cytoskeletal protein binding, fructose 1,6-bisphosphate metabolic process, positive regulation of ATPase activity, -!- The reaction is catalyzed in the opposite direction. -!- Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD(+) biosynthesis enzyme shared by both eukaryotes and prokaryotes., D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate., Methylophilus methylotrophus, extracellular region, nucleotide binding, Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive, zinc ion binding, Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited, Triosephosphate isomerase, N-acetylneuraminate catabolic process, 2-dehydro-3-deoxyphosphooctonate aldolase, Delta-aminolevulinic acid dehydratase, 3-keto-5-aminohexanoate cleavage enzyme, Isopentenyl-diphosphate Delta-isomerase., Isopentenyl-diphosphate delta-isomerase, (NANA)condensing enzyme. N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating). N-acetylneuraminic acid synthase. NeuAc synthase., Phosphoenolpyruvate + N-acetyl-D-mannosamine + H(2)O = phosphate + N-acetylneuraminate., Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, 2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate., 2-dehydro-3-deoxy-D-gluconate aldolase., D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate., NADPH diaphorase., D-ribulose 5-phosphate = D-xylulose 5-phosphate., ATP + pyruvate + HCO(3)(-) = ADP + phosphate + oxaloacetate., 4-hydroxy-2-ketovalerate aldolase. 4-hydroxy-2-oxopentanoate pyruvate-lyase. 4-hydroxy-2-oxovalerate pyruvate-lyase. HOA., Agrobacterium sp. H13-3, Cryptosporidium parvum, Plasmodium berghei ANKA, Rattus norvegicus, Toxoplasma gondii VEG, Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2-hydroxybutane-1,2,4- tricarboxylate + CoA., Xenobiotic reductase, -!- Also hydrolyzes alpha-D-fucosides., PNP synthase. Pyridoxine 5-phosphate phospho lyase., Pyridoxine 5'-phosphate synthase, 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase, Prostaglandin F2a synthase, -!- The enzyme specifically modifies uracil(20) in tRNA., Glucan 1,4-alpha-glucosidase., glucan 1,4-alpha-glucosidase activity, Mus musculus, (1) 2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate. (2) 2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate., Staphylococcus aureus subsp. aureus MRSA252, 4-hydroxy-2-oxovalerate aldolase activity, carbohydrate catabolic process, Oxaloacetate = pyruvate + CO(2)., N-(5'-phosphoribosyl)anthranilate isomerase. PRAI., Phosphoribosylanthranilate isomerase., -!- The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. -!- Formerly EC 4.1.2.1 and EC 4.1.2.31., Vibrionales bacterium SWAT-3, Leishmania sp. 'siamensis', -!- Cloned from Artemisia annua. -!- In addition to the reduction of artemisinic aldehyde it is also able to a lesser extent to reduce artemisinic alcohol and artemisinic acid. -!- Part of the biosyntheis of artemisinin., Clostridium perfringens str. 13, Nicotinamide phosphoribosyltransferase, IMP catabolic process, Nitronate monooxygenase family protein, Kluyveromyces marxianus, Gram-negative-bacterium-type cell wall, -!- Specific for formaldehyde and D-ribulose 5-phosphate as substrates. -!- Ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate. -!- This enzyme, along with EC 5.3.1.27, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds. -!- The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyzes the reactions of this enzyme and EC 5.3.1.27., zymogen binding, carbohydrate metabolic process, Imidazole glycerol phosphate synthase hisHF, Pentosyltransferases., imidazoleglycerol-phosphate synthase activity, Ribulose-phosphate 3-epimerase, cytoplasmic isoform, [FeFe] hydrogenase maturase subunit HydE, NADH:flavin oxidoreductase, Bacteroides fragilis NCTC 9343, Alpha-N-acetylgalactosaminidase., alpha-N-acetylgalactosaminidase activity, Pyruvate carboxylase, mitochondrial, Thiamine phosphate pyrophosphorylase, Putative KHG/KDPG aldolase, Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5- tetradehydroacyl-CoA + NADPH., tRNA (adenine-C2-)-methyltransferase activity, Staphylococcus aureus subsp. aureus USA300, Bartonella henselae str. Houston-1, Putative periplasmic protein, Entamoeba histolytica, Isopropylmalate/homocitrate/citramalate synthase, cellular response to oxidative stress, peroxisomal matrix, Methylmalonyl-CoA carboxyltransferase 5S subunit, Propionibacterium freudenreichii subsp. shermanii, carbohydrate kinase activity, Fructose-1,6-bisphosphate aldolase, Dihydrochanoclavine-I aldehyde + NADP(+) = chanoclavine-I aldehyde + NADPH., Streptococcus pyogenes GA06023, Leishmania donovani BPK282A1, Bacteroides vulgatus ATCC 8482, Putative aldolase, response to fungus, Peroxisomal (S)-2-hydroxy-acid oxidase, (S)-mandelate dehydrogenase, -!- While all enzymes of this family oxidize the (S)-enantiomer of an alpha-hydroxy acid to an alpha-oxo acid, the ultimate oxidant (oxygen, intramolecular heme or some other acceptor) depends on the particular enzyme. -!- Transfers the electron pair from FMNH(2) to a component of the electron transport chain, most probably ubiquinone. -!- It is part of a metabolic pathway in Pseudomonads that allows these organisms to utilize mandelic acid, derivatized from the common soil metabolite amygdalin, as the sole source of carbon and energy. -!- Has a large active-site pocket and preferentially binds substrates with longer sidechains, e.g. 2-hydroxyoctanoate rather than 2-hydroxybutyrate. -!- It also prefers substrates that, like (S)-mandelate, have beta unsaturation, e.g. (indol-3-yl)glycolate compared with (indol-3- yl)lactate. -!- Esters of mandelate, such as methyl (S)-mandelate, are also substrates., -!- The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit. -!- The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. -!- Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor., Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, Mycoplasma synoviae 53, cellular carbohydrate metabolic process, vacuole, 2-isopropylmalate synthase, S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical., Nitronate monooxygenase, oxidation-reduction process, 4-hydroxy-2-oxoglutarate aldolase, mitochondrial, 3-enol-pyruvoylshikimate-5-phosphate synthase. 5-enolpyruvylshikimate-3-phosphate synthase. EPSP synthase., Pimelobacter simplex, -!- Also hydrolyzes 1,4-beta-D-glycosidic linkages between N-acetyl- galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan. -!- Formerly EC 3.2.1.34., 4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic, GTN Reductase, Streptococcus pneumoniae, biotin biosynthetic process, Paracoccus denitrificans PD1222, D-allulose-6-phosphate 3-epimerase, (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3- phosphate-lyase. Indole glycerol phosphate hydrolase. Indole synthase. Indole-3-glycerol phosphate lyase. Indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase. Indoleglycerolphosphate aldolase. Tryptophan synthase alpha. TSA., 2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate- lyase. 2-dehydro-3-deoxyphosphogalactonate aldolase. 2-oxo-3-deoxygalactonate 6-phosphate aldolase. 6-phospho-2-dehydro-3-deoxygalactonate aldolase. 6-phospho-2-keto-3-deoxygalactonate aldolase., Aliivibrio salmonicida LFI1238, Bacillus halodurans C-125, GMP reductase, Mycobacterium smegmatis str. MC2 155, Legionella pneumophila str. Paris, 3-methylornithine synthase, pyrrolysine biosynthetic process, Acinetobacter baumannii, Leishmania braziliensis, Mycobacterium tuberculosis H37Ra, -!- The enzyme from Methanococcus jannaschii catalyzes the Michael addition of sulfite to phosphoenolpyruvate. -!- It specifically requires phosphoenolpyruvate and its broad alkaline pH optimum suggests that it uses sulfite rather than hydrogensulfite., Putative triosephosphate isomerase, Glycerol trinitrate reductase, positive regulation of cell adhesion, response to virus