Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.
Winneroski, L.L., Erickson, J.A., Green, S.J., Lopez, J.E., Stout, S.L., Porter, W.J., Timm, D.E., Audia, J.E., Barberis, M., Beck, J.P., Boggs, L.N., Borders, A.R., Boyer, R.D., Brier, R.A., Hembre, E.J., Hendle, J., Garcia-Losada, P., Minguez, J.M., Mathes, B.M., May, P.C., Monk, S.A., Rankovic, Z., Shi, Y., Watson, B.M., Yang, Z., Mergott, D.J.
Bioorg.Med.Chem.