PDB Information

PDB6NJH
MethodX-RAY DIFFRACTION
Host OrganismTrichoplusia ni
Gene SourceHomo sapiens
Primary Citation
Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.
Gurney, M.E., Nugent, R.A., Mo, X., Sindac, J.A., Hagen, T.J., Fox III, D., O'Donnell, J.M., Zhang, C., Xu, Y., Zhang, H.T., Groppi, V.E., Bailie, M., White, R.E., Romero, D.L., Vellekoop, A.S., Walker, J.R., Surman, M.D., Zhu, L., Campbell, R.F.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2019-01-03
Resolution2.150
CATH Insert Date12 May, 2019

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 12 May, 2019 Chopped
B 12 May, 2019 Chopped
C 12 May, 2019 Chopped
D 12 May, 2019 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
6njhA00 13 May, 2019 1.10.1300.10 Assigned
6njhB00 13 May, 2019 1.10.1300.10 Assigned
6njhC00 13 May, 2019 1.10.1300.10 Assigned
6njhD00 13 May, 2019 1.10.1300.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q08499 PDE4D_HUMAN Homo sapiens cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499 PDE4D_HUMAN Homo sapiens cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499 PDE4D_HUMAN Homo sapiens cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499 PDE4D_HUMAN Homo sapiens cAMP-specific 3',5'-cyclic phosphodiesterase 4D