PDB 6n7b

PDB Information

PDB6N7B
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Zak, M., Hanan, E.J., Lupardus, P., Brown, D.G., Robinson, C., Siu, M., Lyssikatos, J.P., Romero, F.A., Zhao, G., Kellar, T., Mendonca, R., Ray, N.C., Goodacre, S.C., Crackett, P.H., McLean, N., Hurley, C.A., Yuen, P.W., Cheng, Y.X., Liu, X., Liimatta, M., Kohli, P.B., Nonomiya, J., Salmon, G., Buckley, G., Lloyd, J., Gibbons, P., Ghilardi, N., Kenny, J.R., Johnson, A.
Bioorg.Med.Chem.Lett.
HeaderImmune System
Released2018-11-27
Resolution1.810
CATH Insert Date28 Apr, 2019

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 28 Apr, 2019 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
6n7bA01 29 Apr, 2019 3.30.200.20 Assigned
6n7bA02 29 Apr, 2019 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P23458 JAK1_HUMAN Homo sapiens Tyrosine-protein kinase JAK1