PDB 6n69

PDB Information

PDB6N69
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceRattus norvegicus
Primary Citation
The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.
Deaton, D.N., Do, Y., Holt, J., Jeune, M.R., Kramer, H.F., Larkin, A.L., Orband-Miller, L.A., Peckham, G.E., Poole, C., Price, D.J., Schaller, L.T., Shen, Y., Shewchuk, L.M., Stewart, E.L., Stuart, J.D., Thomson, S.A., Ward, P., Wilson, J.W., Xu, T., Guss, J.H., Musetti, C., Rendina, A.R., Affleck, K., Anders, D., Hancock, A.P., Hobbs, H., Hodgson, S.T., Hutchinson, J., Leveridge, M.V., Nicholls, H., Smith, I.E.D., Somers, D.O., Sneddon, H.F., Uddin, S., Cleasby, A., Mortenson, P.N., Richardson, C., Saxty, G.
Bioorg. Med. Chem.
HeaderHydrolase
Released2018-11-26
Resolution2.000
CATH Insert Date31 Mar, 2019

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 31 Mar, 2019 Chopped
B 31 Mar, 2019 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
6n69A01 01 Apr, 2019 3.40.30.10 Assigned
6n69A02 01 Apr, 2019 1.20.1050.10 Assigned
6n69B01 01 Apr, 2019 3.40.30.10 Assigned
6n69B02 01 Apr, 2019 1.20.1050.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
O35543 HPGDS_RAT Rattus norvegicus Hematopoietic prostaglandin D synthase
O35543 HPGDS_RAT Rattus norvegicus Hematopoietic prostaglandin D synthase