PDB 6hwf

PDB Links
Overview

PDB Information

PDB	6HWF
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Gene Source	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.500
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hwf

PDB 6hwf

6hwfa

PDB Chain 6hwfa

6hwfA

PDB Chain 6hwfA

6hwfb

PDB Chain 6hwfb

6hwfB

PDB Chain 6hwfB

6hwfC

PDB Chain 6hwfC

6hwfD

PDB Chain 6hwfD

6hwfE

PDB Chain 6hwfE

6hwfF

PDB Chain 6hwfF

6hwfG

PDB Chain 6hwfG

6hwfH

PDB Chain 6hwfH

6hwfI

PDB Chain 6hwfI

6hwfJ

PDB Chain 6hwfJ

6hwfK

PDB Chain 6hwfK

6hwfL

PDB Chain 6hwfL

6hwfM

PDB Chain 6hwfM

6hwfN

PDB Chain 6hwfN

6hwfO

PDB Chain 6hwfO

6hwfP

PDB Chain 6hwfP

6hwfQ

PDB Chain 6hwfQ

6hwfR

PDB Chain 6hwfR

6hwfS

PDB Chain 6hwfS

6hwfT

PDB Chain 6hwfT

6hwfU

PDB Chain 6hwfU

6hwfV

PDB Chain 6hwfV

6hwfW

PDB Chain 6hwfW

6hwfX

PDB Chain 6hwfX

6hwfY

PDB Chain 6hwfY

6hwfZ

PDB Chain 6hwfZ

6hwfa00

CATH Domain 6hwfa00

6hwfA00

CATH Domain 6hwfA00

6hwfb00

CATH Domain 6hwfb00

6hwfB00

CATH Domain 6hwfB00

6hwfC00

CATH Domain 6hwfC00

6hwfD00

CATH Domain 6hwfD00

6hwfE00

CATH Domain 6hwfE00

6hwfF00

CATH Domain 6hwfF00

6hwfG00

CATH Domain 6hwfG00

6hwfH00

CATH Domain 6hwfH00

6hwfI00

CATH Domain 6hwfI00

6hwfJ00

CATH Domain 6hwfJ00

6hwfK00

CATH Domain 6hwfK00

6hwfL00

CATH Domain 6hwfL00

6hwfM00

CATH Domain 6hwfM00

6hwfN00

CATH Domain 6hwfN00

6hwfO00

CATH Domain 6hwfO00

6hwfP00

CATH Domain 6hwfP00

6hwfQ00

CATH Domain 6hwfQ00

6hwfR00

CATH Domain 6hwfR00

6hwfS00

CATH Domain 6hwfS00

6hwfT00

CATH Domain 6hwfT00

6hwfU00

CATH Domain 6hwfU00

6hwfV00

CATH Domain 6hwfV00

6hwfW00

CATH Domain 6hwfW00

6hwfX00

CATH Domain 6hwfX00

6hwfY00

CATH Domain 6hwfY00

6hwfZ00

CATH Domain 6hwfZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hwfa00	04 Feb, 2019	3.60.20.10	Assigned
6hwfA00	04 Feb, 2019	3.60.20.10	Assigned
6hwfb00	04 Feb, 2019	3.60.20.10	Assigned
6hwfB00	04 Feb, 2019	3.60.20.10	Assigned
6hwfC00	04 Feb, 2019	3.60.20.10	Assigned
6hwfD00	04 Feb, 2019	3.60.20.10	Assigned
6hwfE00	04 Feb, 2019	3.60.20.10	Assigned
6hwfF00	04 Feb, 2019	3.60.20.10	Assigned
6hwfG00	04 Feb, 2019	3.60.20.10	Assigned
6hwfH00	04 Feb, 2019	3.60.20.10	Assigned
6hwfI00	04 Feb, 2019	3.60.20.10	Assigned
6hwfJ00	04 Feb, 2019	3.60.20.10	Assigned
6hwfK00	04 Feb, 2019	3.60.20.10	Assigned
6hwfL00	04 Feb, 2019	3.60.20.10	Assigned
6hwfM00	04 Feb, 2019	3.60.20.10	Assigned
6hwfN00	04 Feb, 2019	3.60.20.10	Assigned
6hwfO00	04 Feb, 2019	3.60.20.10	Assigned
6hwfP00	04 Feb, 2019	3.60.20.10	Assigned
6hwfQ00	04 Feb, 2019	3.60.20.10	Assigned
6hwfR00	04 Feb, 2019	3.60.20.10	Assigned
6hwfS00	04 Feb, 2019	3.60.20.10	Assigned
6hwfT00	04 Feb, 2019	3.60.20.10	Assigned
6hwfU00	04 Feb, 2019	3.60.20.10	Assigned
6hwfV00	04 Feb, 2019	3.60.20.10	Assigned
6hwfW00	04 Feb, 2019	3.60.20.10	Assigned
6hwfX00	04 Feb, 2019	3.60.20.10	Assigned
6hwfY00	04 Feb, 2019	3.60.20.10	Assigned
6hwfZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7