PDB 6hwe

PDB Links
Overview

PDB Information

PDB	6HWE
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae S288C
Gene Source	Saccharomyces cerevisiae S288C
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.300
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hwe

PDB 6hwe

6hwea

PDB Chain 6hwea

6hweA

PDB Chain 6hweA

6hweb

PDB Chain 6hweb

6hweB

PDB Chain 6hweB

6hweC

PDB Chain 6hweC

6hweD

PDB Chain 6hweD

6hweE

PDB Chain 6hweE

6hweF

PDB Chain 6hweF

6hweG

PDB Chain 6hweG

6hweH

PDB Chain 6hweH

6hweI

PDB Chain 6hweI

6hweJ

PDB Chain 6hweJ

6hweK

PDB Chain 6hweK

6hweL

PDB Chain 6hweL

6hweM

PDB Chain 6hweM

6hweN

PDB Chain 6hweN

6hweO

PDB Chain 6hweO

6hweP

PDB Chain 6hweP

6hweQ

PDB Chain 6hweQ

6hweR

PDB Chain 6hweR

6hweS

PDB Chain 6hweS

6hweT

PDB Chain 6hweT

6hweU

PDB Chain 6hweU

6hweV

PDB Chain 6hweV

6hweW

PDB Chain 6hweW

6hweX

PDB Chain 6hweX

6hweY

PDB Chain 6hweY

6hweZ

PDB Chain 6hweZ

6hwea00

CATH Domain 6hwea00

6hweA00

CATH Domain 6hweA00

6hweb00

CATH Domain 6hweb00

6hweB00

CATH Domain 6hweB00

6hweC00

CATH Domain 6hweC00

6hweD00

CATH Domain 6hweD00

6hweE00

CATH Domain 6hweE00

6hweF00

CATH Domain 6hweF00

6hweG00

CATH Domain 6hweG00

6hweH00

CATH Domain 6hweH00

6hweI00

CATH Domain 6hweI00

6hweJ00

CATH Domain 6hweJ00

6hweK00

CATH Domain 6hweK00

6hweL00

CATH Domain 6hweL00

6hweM00

CATH Domain 6hweM00

6hweN00

CATH Domain 6hweN00

6hweO00

CATH Domain 6hweO00

6hweP00

CATH Domain 6hweP00

6hweQ00

CATH Domain 6hweQ00

6hweR00

CATH Domain 6hweR00

6hweS00

CATH Domain 6hweS00

6hweT00

CATH Domain 6hweT00

6hweU00

CATH Domain 6hweU00

6hweV00

CATH Domain 6hweV00

6hweW00

CATH Domain 6hweW00

6hweX00

CATH Domain 6hweX00

6hweY00

CATH Domain 6hweY00

6hweZ00

CATH Domain 6hweZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hwea00	04 Feb, 2019	3.60.20.10	Assigned
6hweA00	04 Feb, 2019	3.60.20.10	Assigned
6hweb00	04 Feb, 2019	3.60.20.10	Assigned
6hweB00	04 Feb, 2019	3.60.20.10	Assigned
6hweC00	04 Feb, 2019	3.60.20.10	Assigned
6hweD00	04 Feb, 2019	3.60.20.10	Assigned
6hweE00	04 Feb, 2019	3.60.20.10	Assigned
6hweF00	04 Feb, 2019	3.60.20.10	Assigned
6hweG00	04 Feb, 2019	3.60.20.10	Assigned
6hweH00	04 Feb, 2019	3.60.20.10	Assigned
6hweI00	04 Feb, 2019	3.60.20.10	Assigned
6hweJ00	04 Feb, 2019	3.60.20.10	Assigned
6hweK00	04 Feb, 2019	3.60.20.10	Assigned
6hweL00	04 Feb, 2019	3.60.20.10	Assigned
6hweM00	04 Feb, 2019	3.60.20.10	Assigned
6hweN00	04 Feb, 2019	3.60.20.10	Assigned
6hweO00	04 Feb, 2019	3.60.20.10	Assigned
6hweP00	04 Feb, 2019	3.60.20.10	Assigned
6hweQ00	04 Feb, 2019	3.60.20.10	Assigned
6hweR00	04 Feb, 2019	3.60.20.10	Assigned
6hweS00	04 Feb, 2019	3.60.20.10	Assigned
6hweT00	04 Feb, 2019	3.60.20.10	Assigned
6hweU00	04 Feb, 2019	3.60.20.10	Assigned
6hweV00	04 Feb, 2019	3.60.20.10	Assigned
6hweW00	04 Feb, 2019	3.60.20.10	Assigned
6hweX00	04 Feb, 2019	3.60.20.10	Assigned
6hweY00	04 Feb, 2019	3.60.20.10	Assigned
6hweZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5