PDB 6hwc

PDB Links
Overview

PDB Information

PDB	6HWC
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.800
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hwc

PDB 6hwc

6hwca

PDB Chain 6hwca

6hwcA

PDB Chain 6hwcA

6hwcb

PDB Chain 6hwcb

6hwcB

PDB Chain 6hwcB

6hwcC

PDB Chain 6hwcC

6hwcD

PDB Chain 6hwcD

6hwcE

PDB Chain 6hwcE

6hwcF

PDB Chain 6hwcF

6hwcG

PDB Chain 6hwcG

6hwcH

PDB Chain 6hwcH

6hwcI

PDB Chain 6hwcI

6hwcJ

PDB Chain 6hwcJ

6hwcK

PDB Chain 6hwcK

6hwcL

PDB Chain 6hwcL

6hwcM

PDB Chain 6hwcM

6hwcN

PDB Chain 6hwcN

6hwcO

PDB Chain 6hwcO

6hwcP

PDB Chain 6hwcP

6hwcQ

PDB Chain 6hwcQ

6hwcR

PDB Chain 6hwcR

6hwcS

PDB Chain 6hwcS

6hwcT

PDB Chain 6hwcT

6hwcU

PDB Chain 6hwcU

6hwcV

PDB Chain 6hwcV

6hwcW

PDB Chain 6hwcW

6hwcX

PDB Chain 6hwcX

6hwcY

PDB Chain 6hwcY

6hwcZ

PDB Chain 6hwcZ

6hwca00

CATH Domain 6hwca00

6hwcA00

CATH Domain 6hwcA00

6hwcb00

CATH Domain 6hwcb00

6hwcB00

CATH Domain 6hwcB00

6hwcC00

CATH Domain 6hwcC00

6hwcD00

CATH Domain 6hwcD00

6hwcE00

CATH Domain 6hwcE00

6hwcF00

CATH Domain 6hwcF00

6hwcG00

CATH Domain 6hwcG00

6hwcH00

CATH Domain 6hwcH00

6hwcI00

CATH Domain 6hwcI00

6hwcJ00

CATH Domain 6hwcJ00

6hwcK00

CATH Domain 6hwcK00

6hwcL00

CATH Domain 6hwcL00

6hwcM00

CATH Domain 6hwcM00

6hwcN00

CATH Domain 6hwcN00

6hwcO00

CATH Domain 6hwcO00

6hwcP00

CATH Domain 6hwcP00

6hwcQ00

CATH Domain 6hwcQ00

6hwcR00

CATH Domain 6hwcR00

6hwcS00

CATH Domain 6hwcS00

6hwcT00

CATH Domain 6hwcT00

6hwcU00

CATH Domain 6hwcU00

6hwcV00

CATH Domain 6hwcV00

6hwcW00

CATH Domain 6hwcW00

6hwcX00

CATH Domain 6hwcX00

6hwcY00

CATH Domain 6hwcY00

6hwcZ00

CATH Domain 6hwcZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hwca00	04 Feb, 2019	3.60.20.10	Assigned
6hwcA00	04 Feb, 2019	3.60.20.10	Assigned
6hwcb00	04 Feb, 2019	3.60.20.10	Assigned
6hwcB00	04 Feb, 2019	3.60.20.10	Assigned
6hwcC00	04 Feb, 2019	3.60.20.10	Assigned
6hwcD00	04 Feb, 2019	3.60.20.10	Assigned
6hwcE00	04 Feb, 2019	3.60.20.10	Assigned
6hwcF00	04 Feb, 2019	3.60.20.10	Assigned
6hwcG00	04 Feb, 2019	3.60.20.10	Assigned
6hwcH00	04 Feb, 2019	3.60.20.10	Assigned
6hwcI00	04 Feb, 2019	3.60.20.10	Assigned
6hwcJ00	04 Feb, 2019	3.60.20.10	Assigned
6hwcK00	04 Feb, 2019	3.60.20.10	Assigned
6hwcL00	04 Feb, 2019	3.60.20.10	Assigned
6hwcM00	04 Feb, 2019	3.60.20.10	Assigned
6hwcN00	04 Feb, 2019	3.60.20.10	Assigned
6hwcO00	04 Feb, 2019	3.60.20.10	Assigned
6hwcP00	04 Feb, 2019	3.60.20.10	Assigned
6hwcQ00	04 Feb, 2019	3.60.20.10	Assigned
6hwcR00	04 Feb, 2019	3.60.20.10	Assigned
6hwcS00	04 Feb, 2019	3.60.20.10	Assigned
6hwcT00	04 Feb, 2019	3.60.20.10	Assigned
6hwcU00	04 Feb, 2019	3.60.20.10	Assigned
6hwcV00	04 Feb, 2019	3.60.20.10	Assigned
6hwcW00	04 Feb, 2019	3.60.20.10	Assigned
6hwcX00	04 Feb, 2019	3.60.20.10	Assigned
6hwcY00	04 Feb, 2019	3.60.20.10	Assigned
6hwcZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4