PDB 6hwb

PDB Links
Overview

PDB Information

PDB	6HWB
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.600
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hwb

PDB 6hwb

6hwba

PDB Chain 6hwba

6hwbA

PDB Chain 6hwbA

6hwbb

PDB Chain 6hwbb

6hwbB

PDB Chain 6hwbB

6hwbC

PDB Chain 6hwbC

6hwbD

PDB Chain 6hwbD

6hwbE

PDB Chain 6hwbE

6hwbF

PDB Chain 6hwbF

6hwbG

PDB Chain 6hwbG

6hwbH

PDB Chain 6hwbH

6hwbI

PDB Chain 6hwbI

6hwbJ

PDB Chain 6hwbJ

6hwbK

PDB Chain 6hwbK

6hwbL

PDB Chain 6hwbL

6hwbM

PDB Chain 6hwbM

6hwbN

PDB Chain 6hwbN

6hwbO

PDB Chain 6hwbO

6hwbP

PDB Chain 6hwbP

6hwbQ

PDB Chain 6hwbQ

6hwbR

PDB Chain 6hwbR

6hwbS

PDB Chain 6hwbS

6hwbT

PDB Chain 6hwbT

6hwbU

PDB Chain 6hwbU

6hwbV

PDB Chain 6hwbV

6hwbW

PDB Chain 6hwbW

6hwbX

PDB Chain 6hwbX

6hwbY

PDB Chain 6hwbY

6hwbZ

PDB Chain 6hwbZ

6hwba00

CATH Domain 6hwba00

6hwbA00

CATH Domain 6hwbA00

6hwbb00

CATH Domain 6hwbb00

6hwbB00

CATH Domain 6hwbB00

6hwbC00

CATH Domain 6hwbC00

6hwbD00

CATH Domain 6hwbD00

6hwbE00

CATH Domain 6hwbE00

6hwbF00

CATH Domain 6hwbF00

6hwbG00

CATH Domain 6hwbG00

6hwbH00

CATH Domain 6hwbH00

6hwbI00

CATH Domain 6hwbI00

6hwbJ00

CATH Domain 6hwbJ00

6hwbK00

CATH Domain 6hwbK00

6hwbL00

CATH Domain 6hwbL00

6hwbM00

CATH Domain 6hwbM00

6hwbN00

CATH Domain 6hwbN00

6hwbO00

CATH Domain 6hwbO00

6hwbP00

CATH Domain 6hwbP00

6hwbQ00

CATH Domain 6hwbQ00

6hwbR00

CATH Domain 6hwbR00

6hwbS00

CATH Domain 6hwbS00

6hwbT00

CATH Domain 6hwbT00

6hwbU00

CATH Domain 6hwbU00

6hwbV00

CATH Domain 6hwbV00

6hwbW00

CATH Domain 6hwbW00

6hwbX00

CATH Domain 6hwbX00

6hwbY00

CATH Domain 6hwbY00

6hwbZ00

CATH Domain 6hwbZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hwba00	04 Feb, 2019	3.60.20.10	Assigned
6hwbA00	04 Feb, 2019	3.60.20.10	Assigned
6hwbb00	04 Feb, 2019	3.60.20.10	Assigned
6hwbB00	04 Feb, 2019	3.60.20.10	Assigned
6hwbC00	04 Feb, 2019	3.60.20.10	Assigned
6hwbD00	04 Feb, 2019	3.60.20.10	Assigned
6hwbE00	04 Feb, 2019	3.60.20.10	Assigned
6hwbF00	04 Feb, 2019	3.60.20.10	Assigned
6hwbG00	04 Feb, 2019	3.60.20.10	Assigned
6hwbH00	04 Feb, 2019	3.60.20.10	Assigned
6hwbI00	04 Feb, 2019	3.60.20.10	Assigned
6hwbJ00	04 Feb, 2019	3.60.20.10	Assigned
6hwbK00	04 Feb, 2019	3.60.20.10	Assigned
6hwbL00	04 Feb, 2019	3.60.20.10	Assigned
6hwbM00	04 Feb, 2019	3.60.20.10	Assigned
6hwbN00	04 Feb, 2019	3.60.20.10	Assigned
6hwbO00	04 Feb, 2019	3.60.20.10	Assigned
6hwbP00	04 Feb, 2019	3.60.20.10	Assigned
6hwbQ00	04 Feb, 2019	3.60.20.10	Assigned
6hwbR00	04 Feb, 2019	3.60.20.10	Assigned
6hwbS00	04 Feb, 2019	3.60.20.10	Assigned
6hwbT00	04 Feb, 2019	3.60.20.10	Assigned
6hwbU00	04 Feb, 2019	3.60.20.10	Assigned
6hwbV00	04 Feb, 2019	3.60.20.10	Assigned
6hwbW00	04 Feb, 2019	3.60.20.10	Assigned
6hwbX00	04 Feb, 2019	3.60.20.10	Assigned
6hwbY00	04 Feb, 2019	3.60.20.10	Assigned
6hwbZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7