PDB 6hw9

PDB Links
Overview

PDB Information

PDB	6HW9
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.800
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hw9

PDB 6hw9

6hw9a

PDB Chain 6hw9a

6hw9A

PDB Chain 6hw9A

6hw9b

PDB Chain 6hw9b

6hw9B

PDB Chain 6hw9B

6hw9C

PDB Chain 6hw9C

6hw9D

PDB Chain 6hw9D

6hw9E

PDB Chain 6hw9E

6hw9F

PDB Chain 6hw9F

6hw9G

PDB Chain 6hw9G

6hw9H

PDB Chain 6hw9H

6hw9I

PDB Chain 6hw9I

6hw9J

PDB Chain 6hw9J

6hw9K

PDB Chain 6hw9K

6hw9L

PDB Chain 6hw9L

6hw9M

PDB Chain 6hw9M

6hw9N

PDB Chain 6hw9N

6hw9O

PDB Chain 6hw9O

6hw9P

PDB Chain 6hw9P

6hw9Q

PDB Chain 6hw9Q

6hw9R

PDB Chain 6hw9R

6hw9S

PDB Chain 6hw9S

6hw9T

PDB Chain 6hw9T

6hw9U

PDB Chain 6hw9U

6hw9V

PDB Chain 6hw9V

6hw9W

PDB Chain 6hw9W

6hw9X

PDB Chain 6hw9X

6hw9Y

PDB Chain 6hw9Y

6hw9Z

PDB Chain 6hw9Z

6hw9a00

CATH Domain 6hw9a00

6hw9A00

CATH Domain 6hw9A00

6hw9b00

CATH Domain 6hw9b00

6hw9B00

CATH Domain 6hw9B00

6hw9C00

CATH Domain 6hw9C00

6hw9D00

CATH Domain 6hw9D00

6hw9E00

CATH Domain 6hw9E00

6hw9F00

CATH Domain 6hw9F00

6hw9G00

CATH Domain 6hw9G00

6hw9H00

CATH Domain 6hw9H00

6hw9I00

CATH Domain 6hw9I00

6hw9J00

CATH Domain 6hw9J00

6hw9K00

CATH Domain 6hw9K00

6hw9L00

CATH Domain 6hw9L00

6hw9M00

CATH Domain 6hw9M00

6hw9N00

CATH Domain 6hw9N00

6hw9O00

CATH Domain 6hw9O00

6hw9P00

CATH Domain 6hw9P00

6hw9Q00

CATH Domain 6hw9Q00

6hw9R00

CATH Domain 6hw9R00

6hw9S00

CATH Domain 6hw9S00

6hw9T00

CATH Domain 6hw9T00

6hw9U00

CATH Domain 6hw9U00

6hw9V00

CATH Domain 6hw9V00

6hw9W00

CATH Domain 6hw9W00

6hw9X00

CATH Domain 6hw9X00

6hw9Y00

CATH Domain 6hw9Y00

6hw9Z00

CATH Domain 6hw9Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hw9a00	04 Feb, 2019	3.60.20.10	Assigned
6hw9A00	04 Feb, 2019	3.60.20.10	Assigned
6hw9b00	04 Feb, 2019	3.60.20.10	Assigned
6hw9B00	04 Feb, 2019	3.60.20.10	Assigned
6hw9C00	04 Feb, 2019	3.60.20.10	Assigned
6hw9D00	04 Feb, 2019	3.60.20.10	Assigned
6hw9E00	04 Feb, 2019	3.60.20.10	Assigned
6hw9F00	04 Feb, 2019	3.60.20.10	Assigned
6hw9G00	04 Feb, 2019	3.60.20.10	Assigned
6hw9H00	04 Feb, 2019	3.60.20.10	Assigned
6hw9I00	04 Feb, 2019	3.60.20.10	Assigned
6hw9J00	04 Feb, 2019	3.60.20.10	Assigned
6hw9K00	04 Feb, 2019	3.60.20.10	Assigned
6hw9L00	04 Feb, 2019	3.60.20.10	Assigned
6hw9M00	04 Feb, 2019	3.60.20.10	Assigned
6hw9N00	04 Feb, 2019	3.60.20.10	Assigned
6hw9O00	04 Feb, 2019	3.60.20.10	Assigned
6hw9P00	04 Feb, 2019	3.60.20.10	Assigned
6hw9Q00	04 Feb, 2019	3.60.20.10	Assigned
6hw9R00	04 Feb, 2019	3.60.20.10	Assigned
6hw9S00	04 Feb, 2019	3.60.20.10	Assigned
6hw9T00	04 Feb, 2019	3.60.20.10	Assigned
6hw9U00	04 Feb, 2019	3.60.20.10	Assigned
6hw9V00	04 Feb, 2019	3.60.20.10	Assigned
6hw9W00	04 Feb, 2019	3.60.20.10	Assigned
6hw9X00	04 Feb, 2019	3.60.20.10	Assigned
6hw9Y00	04 Feb, 2019	3.60.20.10	Assigned
6hw9Z00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5