PDB 6hw4

PDB Links
Overview

PDB Information

PDB	6HW4
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.900
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hw4

PDB 6hw4

6hw4a

PDB Chain 6hw4a

6hw4A

PDB Chain 6hw4A

6hw4b

PDB Chain 6hw4b

6hw4B

PDB Chain 6hw4B

6hw4C

PDB Chain 6hw4C

6hw4D

PDB Chain 6hw4D

6hw4E

PDB Chain 6hw4E

6hw4F

PDB Chain 6hw4F

6hw4G

PDB Chain 6hw4G

6hw4H

PDB Chain 6hw4H

6hw4I

PDB Chain 6hw4I

6hw4J

PDB Chain 6hw4J

6hw4K

PDB Chain 6hw4K

6hw4L

PDB Chain 6hw4L

6hw4M

PDB Chain 6hw4M

6hw4N

PDB Chain 6hw4N

6hw4O

PDB Chain 6hw4O

6hw4P

PDB Chain 6hw4P

6hw4Q

PDB Chain 6hw4Q

6hw4R

PDB Chain 6hw4R

6hw4S

PDB Chain 6hw4S

6hw4T

PDB Chain 6hw4T

6hw4U

PDB Chain 6hw4U

6hw4V

PDB Chain 6hw4V

6hw4W

PDB Chain 6hw4W

6hw4X

PDB Chain 6hw4X

6hw4Y

PDB Chain 6hw4Y

6hw4Z

PDB Chain 6hw4Z

6hw4a00

CATH Domain 6hw4a00

6hw4A00

CATH Domain 6hw4A00

6hw4b00

CATH Domain 6hw4b00

6hw4B00

CATH Domain 6hw4B00

6hw4C00

CATH Domain 6hw4C00

6hw4D00

CATH Domain 6hw4D00

6hw4E00

CATH Domain 6hw4E00

6hw4F00

CATH Domain 6hw4F00

6hw4G00

CATH Domain 6hw4G00

6hw4H00

CATH Domain 6hw4H00

6hw4I00

CATH Domain 6hw4I00

6hw4J00

CATH Domain 6hw4J00

6hw4K00

CATH Domain 6hw4K00

6hw4L00

CATH Domain 6hw4L00

6hw4M00

CATH Domain 6hw4M00

6hw4N00

CATH Domain 6hw4N00

6hw4O00

CATH Domain 6hw4O00

6hw4P00

CATH Domain 6hw4P00

6hw4Q00

CATH Domain 6hw4Q00

6hw4R00

CATH Domain 6hw4R00

6hw4S00

CATH Domain 6hw4S00

6hw4T00

CATH Domain 6hw4T00

6hw4U00

CATH Domain 6hw4U00

6hw4V00

CATH Domain 6hw4V00

6hw4W00

CATH Domain 6hw4W00

6hw4X00

CATH Domain 6hw4X00

6hw4Y00

CATH Domain 6hw4Y00

6hw4Z00

CATH Domain 6hw4Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hw4a00	04 Feb, 2019	3.60.20.10	Assigned
6hw4A00	04 Feb, 2019	3.60.20.10	Assigned
6hw4b00	04 Feb, 2019	3.60.20.10	Assigned
6hw4B00	04 Feb, 2019	3.60.20.10	Assigned
6hw4C00	04 Feb, 2019	3.60.20.10	Assigned
6hw4D00	04 Feb, 2019	3.60.20.10	Assigned
6hw4E00	04 Feb, 2019	3.60.20.10	Assigned
6hw4F00	04 Feb, 2019	3.60.20.10	Assigned
6hw4G00	04 Feb, 2019	3.60.20.10	Assigned
6hw4H00	04 Feb, 2019	3.60.20.10	Assigned
6hw4I00	04 Feb, 2019	3.60.20.10	Assigned
6hw4J00	04 Feb, 2019	3.60.20.10	Assigned
6hw4K00	04 Feb, 2019	3.60.20.10	Assigned
6hw4L00	04 Feb, 2019	3.60.20.10	Assigned
6hw4M00	04 Feb, 2019	3.60.20.10	Assigned
6hw4N00	04 Feb, 2019	3.60.20.10	Assigned
6hw4O00	04 Feb, 2019	3.60.20.10	Assigned
6hw4P00	04 Feb, 2019	3.60.20.10	Assigned
6hw4Q00	04 Feb, 2019	3.60.20.10	Assigned
6hw4R00	04 Feb, 2019	3.60.20.10	Assigned
6hw4S00	04 Feb, 2019	3.60.20.10	Assigned
6hw4T00	04 Feb, 2019	3.60.20.10	Assigned
6hw4U00	04 Feb, 2019	3.60.20.10	Assigned
6hw4V00	04 Feb, 2019	3.60.20.10	Assigned
6hw4W00	04 Feb, 2019	3.60.20.10	Assigned
6hw4X00	04 Feb, 2019	3.60.20.10	Assigned
6hw4Y00	04 Feb, 2019	3.60.20.10	Assigned
6hw4Z00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5