PDB 6hw0

PDB Links
Overview

PDB Information

PDB	6HW0
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.800
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hw0

PDB 6hw0

6hw0a

PDB Chain 6hw0a

6hw0A

PDB Chain 6hw0A

6hw0b

PDB Chain 6hw0b

6hw0B

PDB Chain 6hw0B

6hw0C

PDB Chain 6hw0C

6hw0D

PDB Chain 6hw0D

6hw0E

PDB Chain 6hw0E

6hw0F

PDB Chain 6hw0F

6hw0G

PDB Chain 6hw0G

6hw0H

PDB Chain 6hw0H

6hw0I

PDB Chain 6hw0I

6hw0J

PDB Chain 6hw0J

6hw0K

PDB Chain 6hw0K

6hw0L

PDB Chain 6hw0L

6hw0M

PDB Chain 6hw0M

6hw0N

PDB Chain 6hw0N

6hw0O

PDB Chain 6hw0O

6hw0P

PDB Chain 6hw0P

6hw0Q

PDB Chain 6hw0Q

6hw0R

PDB Chain 6hw0R

6hw0S

PDB Chain 6hw0S

6hw0T

PDB Chain 6hw0T

6hw0U

PDB Chain 6hw0U

6hw0V

PDB Chain 6hw0V

6hw0W

PDB Chain 6hw0W

6hw0X

PDB Chain 6hw0X

6hw0Y

PDB Chain 6hw0Y

6hw0Z

PDB Chain 6hw0Z

6hw0a00

CATH Domain 6hw0a00

6hw0A00

CATH Domain 6hw0A00

6hw0b00

CATH Domain 6hw0b00

6hw0B00

CATH Domain 6hw0B00

6hw0C00

CATH Domain 6hw0C00

6hw0D00

CATH Domain 6hw0D00

6hw0E00

CATH Domain 6hw0E00

6hw0F00

CATH Domain 6hw0F00

6hw0G00

CATH Domain 6hw0G00

6hw0H00

CATH Domain 6hw0H00

6hw0I00

CATH Domain 6hw0I00

6hw0J00

CATH Domain 6hw0J00

6hw0K00

CATH Domain 6hw0K00

6hw0L00

CATH Domain 6hw0L00

6hw0M00

CATH Domain 6hw0M00

6hw0N00

CATH Domain 6hw0N00

6hw0O00

CATH Domain 6hw0O00

6hw0P00

CATH Domain 6hw0P00

6hw0Q00

CATH Domain 6hw0Q00

6hw0R00

CATH Domain 6hw0R00

6hw0S00

CATH Domain 6hw0S00

6hw0T00

CATH Domain 6hw0T00

6hw0U00

CATH Domain 6hw0U00

6hw0V00

CATH Domain 6hw0V00

6hw0W00

CATH Domain 6hw0W00

6hw0X00

CATH Domain 6hw0X00

6hw0Y00

CATH Domain 6hw0Y00

6hw0Z00

CATH Domain 6hw0Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hw0a00	04 Feb, 2019	3.60.20.10	Assigned
6hw0A00	04 Feb, 2019	3.60.20.10	Assigned
6hw0b00	04 Feb, 2019	3.60.20.10	Assigned
6hw0B00	04 Feb, 2019	3.60.20.10	Assigned
6hw0C00	04 Feb, 2019	3.60.20.10	Assigned
6hw0D00	04 Feb, 2019	3.60.20.10	Assigned
6hw0E00	04 Feb, 2019	3.60.20.10	Assigned
6hw0F00	04 Feb, 2019	3.60.20.10	Assigned
6hw0G00	04 Feb, 2019	3.60.20.10	Assigned
6hw0H00	04 Feb, 2019	3.60.20.10	Assigned
6hw0I00	04 Feb, 2019	3.60.20.10	Assigned
6hw0J00	04 Feb, 2019	3.60.20.10	Assigned
6hw0K00	04 Feb, 2019	3.60.20.10	Assigned
6hw0L00	04 Feb, 2019	3.60.20.10	Assigned
6hw0M00	04 Feb, 2019	3.60.20.10	Assigned
6hw0N00	04 Feb, 2019	3.60.20.10	Assigned
6hw0O00	04 Feb, 2019	3.60.20.10	Assigned
6hw0P00	04 Feb, 2019	3.60.20.10	Assigned
6hw0Q00	04 Feb, 2019	3.60.20.10	Assigned
6hw0R00	04 Feb, 2019	3.60.20.10	Assigned
6hw0S00	04 Feb, 2019	3.60.20.10	Assigned
6hw0T00	04 Feb, 2019	3.60.20.10	Assigned
6hw0U00	04 Feb, 2019	3.60.20.10	Assigned
6hw0V00	04 Feb, 2019	3.60.20.10	Assigned
6hw0W00	04 Feb, 2019	3.60.20.10	Assigned
6hw0X00	04 Feb, 2019	3.60.20.10	Assigned
6hw0Y00	04 Feb, 2019	3.60.20.10	Assigned
6hw0Z00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5