PDB 6hvs

PDB Links
Overview

PDB Information

PDB	6HVS
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae S288C
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	3.100
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hvs

PDB 6hvs

6hvsa

PDB Chain 6hvsa

6hvsA

PDB Chain 6hvsA

6hvsb

PDB Chain 6hvsb

6hvsB

PDB Chain 6hvsB

6hvsC

PDB Chain 6hvsC

6hvsD

PDB Chain 6hvsD

6hvsE

PDB Chain 6hvsE

6hvsF

PDB Chain 6hvsF

6hvsG

PDB Chain 6hvsG

6hvsH

PDB Chain 6hvsH

6hvsI

PDB Chain 6hvsI

6hvsJ

PDB Chain 6hvsJ

6hvsK

PDB Chain 6hvsK

6hvsL

PDB Chain 6hvsL

6hvsM

PDB Chain 6hvsM

6hvsN

PDB Chain 6hvsN

6hvsO

PDB Chain 6hvsO

6hvsP

PDB Chain 6hvsP

6hvsQ

PDB Chain 6hvsQ

6hvsR

PDB Chain 6hvsR

6hvsS

PDB Chain 6hvsS

6hvsT

PDB Chain 6hvsT

6hvsU

PDB Chain 6hvsU

6hvsV

PDB Chain 6hvsV

6hvsW

PDB Chain 6hvsW

6hvsX

PDB Chain 6hvsX

6hvsY

PDB Chain 6hvsY

6hvsZ

PDB Chain 6hvsZ

6hvsa00

CATH Domain 6hvsa00

6hvsA00

CATH Domain 6hvsA00

6hvsb00

CATH Domain 6hvsb00

6hvsB00

CATH Domain 6hvsB00

6hvsC00

CATH Domain 6hvsC00

6hvsD00

CATH Domain 6hvsD00

6hvsE00

CATH Domain 6hvsE00

6hvsF00

CATH Domain 6hvsF00

6hvsG00

CATH Domain 6hvsG00

6hvsH00

CATH Domain 6hvsH00

6hvsI00

CATH Domain 6hvsI00

6hvsJ00

CATH Domain 6hvsJ00

6hvsK00

CATH Domain 6hvsK00

6hvsL00

CATH Domain 6hvsL00

6hvsM00

CATH Domain 6hvsM00

6hvsN00

CATH Domain 6hvsN00

6hvsO00

CATH Domain 6hvsO00

6hvsP00

CATH Domain 6hvsP00

6hvsQ00

CATH Domain 6hvsQ00

6hvsR00

CATH Domain 6hvsR00

6hvsS00

CATH Domain 6hvsS00

6hvsT00

CATH Domain 6hvsT00

6hvsU00

CATH Domain 6hvsU00

6hvsV00

CATH Domain 6hvsV00

6hvsW00

CATH Domain 6hvsW00

6hvsX00

CATH Domain 6hvsX00

6hvsY00

CATH Domain 6hvsY00

6hvsZ00

CATH Domain 6hvsZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hvsa00	04 Feb, 2019	3.60.20.10	Assigned
6hvsA00	04 Feb, 2019	3.60.20.10	Assigned
6hvsb00	04 Feb, 2019	3.60.20.10	Assigned
6hvsB00	04 Feb, 2019	3.60.20.10	Assigned
6hvsC00	04 Feb, 2019	3.60.20.10	Assigned
6hvsD00	04 Feb, 2019	3.60.20.10	Assigned
6hvsE00	04 Feb, 2019	3.60.20.10	Assigned
6hvsF00	04 Feb, 2019	3.60.20.10	Assigned
6hvsG00	04 Feb, 2019	3.60.20.10	Assigned
6hvsH00	04 Feb, 2019	3.60.20.10	Assigned
6hvsI00	04 Feb, 2019	3.60.20.10	Assigned
6hvsJ00	04 Feb, 2019	3.60.20.10	Assigned
6hvsK00	04 Feb, 2019	3.60.20.10	Assigned
6hvsL00	04 Feb, 2019	3.60.20.10	Assigned
6hvsM00	04 Feb, 2019	3.60.20.10	Assigned
6hvsN00	04 Feb, 2019	3.60.20.10	Assigned
6hvsO00	04 Feb, 2019	3.60.20.10	Assigned
6hvsP00	04 Feb, 2019	3.60.20.10	Assigned
6hvsQ00	04 Feb, 2019	3.60.20.10	Assigned
6hvsR00	04 Feb, 2019	3.60.20.10	Assigned
6hvsS00	04 Feb, 2019	3.60.20.10	Assigned
6hvsT00	04 Feb, 2019	3.60.20.10	Assigned
6hvsU00	04 Feb, 2019	3.60.20.10	Assigned
6hvsV00	04 Feb, 2019	3.60.20.10	Assigned
6hvsW00	04 Feb, 2019	3.60.20.10	Assigned
6hvsX00	04 Feb, 2019	3.60.20.10	Assigned
6hvsY00	04 Feb, 2019	3.60.20.10	Assigned
6hvsZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (30)

Accession	Gene ID	Taxon	Description
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5