PDB 6hv3

PDB Links
Overview

PDB Information

PDB	6HV3
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-10
Resolution	2.700
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hv3

PDB 6hv3

6hv3a

PDB Chain 6hv3a

6hv3A

PDB Chain 6hv3A

6hv3b

PDB Chain 6hv3b

6hv3B

PDB Chain 6hv3B

6hv3C

PDB Chain 6hv3C

6hv3D

PDB Chain 6hv3D

6hv3E

PDB Chain 6hv3E

6hv3F

PDB Chain 6hv3F

6hv3G

PDB Chain 6hv3G

6hv3H

PDB Chain 6hv3H

6hv3I

PDB Chain 6hv3I

6hv3J

PDB Chain 6hv3J

6hv3K

PDB Chain 6hv3K

6hv3L

PDB Chain 6hv3L

6hv3M

PDB Chain 6hv3M

6hv3N

PDB Chain 6hv3N

6hv3O

PDB Chain 6hv3O

6hv3P

PDB Chain 6hv3P

6hv3Q

PDB Chain 6hv3Q

6hv3R

PDB Chain 6hv3R

6hv3S

PDB Chain 6hv3S

6hv3T

PDB Chain 6hv3T

6hv3U

PDB Chain 6hv3U

6hv3V

PDB Chain 6hv3V

6hv3W

PDB Chain 6hv3W

6hv3X

PDB Chain 6hv3X

6hv3Y

PDB Chain 6hv3Y

6hv3Z

PDB Chain 6hv3Z

6hv3a00

CATH Domain 6hv3a00

6hv3A00

CATH Domain 6hv3A00

6hv3b00

CATH Domain 6hv3b00

6hv3B00

CATH Domain 6hv3B00

6hv3C00

CATH Domain 6hv3C00

6hv3D00

CATH Domain 6hv3D00

6hv3E00

CATH Domain 6hv3E00

6hv3F00

CATH Domain 6hv3F00

6hv3G00

CATH Domain 6hv3G00

6hv3H00

CATH Domain 6hv3H00

6hv3I00

CATH Domain 6hv3I00

6hv3J00

CATH Domain 6hv3J00

6hv3K00

CATH Domain 6hv3K00

6hv3L00

CATH Domain 6hv3L00

6hv3M00

CATH Domain 6hv3M00

6hv3N00

CATH Domain 6hv3N00

6hv3O00

CATH Domain 6hv3O00

6hv3P00

CATH Domain 6hv3P00

6hv3Q00

CATH Domain 6hv3Q00

6hv3R00

CATH Domain 6hv3R00

6hv3S00

CATH Domain 6hv3S00

6hv3T00

CATH Domain 6hv3T00

6hv3U00

CATH Domain 6hv3U00

6hv3V00

CATH Domain 6hv3V00

6hv3W00

CATH Domain 6hv3W00

6hv3X00

CATH Domain 6hv3X00

6hv3Y00

CATH Domain 6hv3Y00

6hv3Z00

CATH Domain 6hv3Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hv3a00	04 Feb, 2019	3.60.20.10	Assigned
6hv3A00	04 Feb, 2019	3.60.20.10	Assigned
6hv3b00	04 Feb, 2019	3.60.20.10	Assigned
6hv3B00	04 Feb, 2019	3.60.20.10	Assigned
6hv3C00	04 Feb, 2019	3.60.20.10	Assigned
6hv3D00	04 Feb, 2019	3.60.20.10	Assigned
6hv3E00	04 Feb, 2019	3.60.20.10	Assigned
6hv3F00	04 Feb, 2019	3.60.20.10	Assigned
6hv3G00	04 Feb, 2019	3.60.20.10	Assigned
6hv3H00	04 Feb, 2019	3.60.20.10	Assigned
6hv3I00	04 Feb, 2019	3.60.20.10	Assigned
6hv3J00	04 Feb, 2019	3.60.20.10	Assigned
6hv3K00	04 Feb, 2019	3.60.20.10	Assigned
6hv3L00	04 Feb, 2019	3.60.20.10	Assigned
6hv3M00	04 Feb, 2019	3.60.20.10	Assigned
6hv3N00	04 Feb, 2019	3.60.20.10	Assigned
6hv3O00	04 Feb, 2019	3.60.20.10	Assigned
6hv3P00	04 Feb, 2019	3.60.20.10	Assigned
6hv3Q00	04 Feb, 2019	3.60.20.10	Assigned
6hv3R00	04 Feb, 2019	3.60.20.10	Assigned
6hv3S00	04 Feb, 2019	3.60.20.10	Assigned
6hv3T00	04 Feb, 2019	3.60.20.10	Assigned
6hv3U00	04 Feb, 2019	3.60.20.10	Assigned
6hv3V00	04 Feb, 2019	3.60.20.10	Assigned
6hv3W00	04 Feb, 2019	3.60.20.10	Assigned
6hv3X00	04 Feb, 2019	3.60.20.10	Assigned
6hv3Y00	04 Feb, 2019	3.60.20.10	Assigned
6hv3Z00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (30)

Accession	Gene ID	Taxon	Description
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5